A social pedagogical intervention to support children in care:Back on Track

This paper focuses on an intervention project, Back on Track (BoT), implemented as a part of the Resilience Revolution: HeadStart Blackpool (RR:HS) programme in the UK. Whilst it is a famous family holiday resort, Blackpool is also one of the most deprived towns in England. This makes life challenging for young people (YP) to maintain wellbeing and reach their potential. Blackpool also has an above average and growing proportion of children in care. They are at a higher risk of developing mental health difficulties and of being permanently excluded from school. BoT aimed to support fostered children who have been referred by schools or social workers to the project for having emotional and behavioural struggles. As a consequence of their difficulties, they were at risk of permanent exclusion from the school. The intervention was grounded in a social pedagogical approach and Resilient Therapy. Resilience Coaches (i.e., wellbeing practitioners) had the role of enhancing communication between YP, family, social care, and school, whilst working with YP to co-produce coping strategies. Between November 2016 and June 2021, 39 YP (61.5% male) aged 10 to 15 (M = 12.74, SD = 1.60) received BoT support over a period lasting between 4 months to 2.5 years (M = 14 months, SD = 6.8 months). Using a mixed-methods design, this paper explored the BoT implementation. YP completed questionnaires before and after BoT. Triangulation interviews were conducted with a randomly selected YP, foster parent and the Resilience Coach. Results showed the benefit of equipping YP with ‘resilient moves’ and joining up systems to work together and better support YP and families. YP reported reduced difficulties, improved strengths (i.e., prosocial behaviour) and educational outcomes. This helped build resilience and reduce the risk of permanent exclusions from school. Policy and practice implications for children in care are discussed

A novel dimethylformamide (DMF) free bar-cast method to deposit organolead perovskite thin films with improved stability

We report a solvent-free approach to synthesizing organolead perovskites by using solid state reactions to coat perovskite crystals onto Al2O3 or TiO2 nanoparticles followed by addition of terpineol affording perovskite inks. We have bar cast these inks to produce photoactive perovskite thin films which are significantly more stable to humidity than solution-processed films. This new method also avoids the use of toxic DMF solvent

The Grizzly, October 6, 2011

Fong, CPPC Developing Strategic Plan • Study Abroad Undergoes Major Changes, Relocation • Art Department Sponsors Trip to New York City • Residence Life Sponsors First-Ever Sexual Olympics • Senior Spends Summer Researching Parkinson\u27s • International Film Festival: A Glimpse Into Other Cultures • Wismer on Wheels Offers Helping Hand • Club Promotes Suicide Awareness • Anti-anxiety Group Aims to Relieve Stress • UC Club Soccer Kicks Off First Full Season • UC Fencing Club Looking to Increase its Numbers • Coach Profile: Mark Feinberg, Swimminghttps://digitalcommons.ursinus.edu/grizzlynews/1842/thumbnail.jp

The Grizzly, October 27, 2011

New U Fair Welcomes 40+ Vendors • String Ensemble to Make Debut Tomorrow • IT Department Hosts Tech Expo • Internship Profile: Rebecca Kamm • UCARE Community Week • Saturday Night Fun with the Nerf Club • PostSecret Comes to Ursinus College • Opinions: Graduation Change Irritates Students; Campus Safety is a Necessity, Not a Luxury • Roller Hockey Team Resurrected at Ursinus • Stortz and Narang Lead Bears into Cross Country Championships • Senior Spotlight: Jess Porcelan, Women\u27s Soccerhttps://digitalcommons.ursinus.edu/grizzlynews/1844/thumbnail.jp

The Grizzly, November 10, 2011

Dean Judith Levy Announces Retirement • Faculty to Challenge Students in Charity Game • Students Offered Working World Experience • Student Spearheads Peer Advocacy Program • Which Fork? Prepares Students • Senior Spends Summer Interning at Arts Center • Committee Kicks Off Preparation for 29th Annual Airband Event • UC Junior Wins Miss NJ Most Photogenic • Best Buddies Forms Lasting Bonds • Opinion: Graduation Date Change Helps More Than Hurts; Bring Back Baby Bio for Non-Science Majors • Men\u27s Basketball is Young, but Well-Prepared • Women\u27s Basketball Turns to Senior Leadership • Women\u27s Track & Field Ready for Championship Runhttps://digitalcommons.ursinus.edu/grizzlynews/1846/thumbnail.jp

The Grizzly, September 22, 2011

Hundreds Gather for Family Day • Fefu Offers Questions, not Answers • Phonathon Raising the Bar • Internship Profile: The Hill School • New Psychology Professor Looks to Promote Research • Woman to Watch: Kelly Reynolds • Campus Alcohol Policies Being Strongly Enforced • Organization Helps with Self-Esteem Issues • Opinion: Students Should Question the Meaning of Education; Academics Should Take Precedence Over Parties; Letter to the Editor: An Open Letter Too Closed-Minded, Rude • Coach\u27s Corner: Meet Diana Clavin • Turf Field Among New Traditions of Homecoming • Field Hockey Aims to Continue Championship Wayshttps://digitalcommons.ursinus.edu/grizzlynews/1840/thumbnail.jp

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.

Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating measurement of markers of systemic metabolism, dynamic FDG-PET-CT, transcriptomics, and metabolomics at paired time points to profile the bioactivity of metformin in primary breast cancer. We show metformin reduces the levels of mitochondrial metabolites, activates multiple mitochondrial metabolic pathways, and increases 18-FDG flux in tumors. Two tumor groups are identified with distinct metabolic responses, an OXPHOS transcriptional response (OTR) group for which there is an increase in OXPHOS gene transcription and an FDG response group with increased 18-FDG uptake. Increase in proliferation, as measured by a validated proliferation signature, suggested that patients in the OTR group were resistant to metformin treatment. We conclude that mitochondrial response to metformin in primary breast cancer may define anti-tumor effect

ActEarly: a City Collaboratory approach to early promotion of good health and wellbeing.

Economic, physical, built, cultural, learning, social and service environments have a profound effect on lifelong health. However, policy thinking about health research is dominated by the 'biomedical model' which promotes medicalisation and an emphasis on diagnosis and treatment at the expense of prevention. Prevention research has tended to focus on 'downstream' interventions that rely on individual behaviour change, frequently increasing inequalities. Preventive strategies often focus on isolated leverage points and are scattered across different settings. This paper describes a major new prevention research programme that aims to create City Collaboratory testbeds to support the identification, implementation and evaluation of upstream interventions within a whole system city setting. Prevention of physical and mental ill-health will come from the cumulative effect of multiple system-wide interventions. Rather than scatter these interventions across many settings and evaluate single outcomes, we will test their collective impact across multiple outcomes with the goal of achieving a tipping point for better health. Our focus is on early life (ActEarly) in recognition of childhood and adolescence being such critical periods for influencing lifelong health and wellbeing

The scene of the crime: inventing the serial killer

This article examines the meanings of the crime scene in serial killings, and the tensions between the real and the imagined in the circulation of those meanings. Starting with the Whitechapel Murders of 1888 it argues that they, as well as forming an origin for the construction of the identity of 'the serial killer', initiate certain ideas about the relationship of subjects to spaces and the existence of the self in the modern urban landscape. It suggests that these ideas come to play an integral part in the contemporary discourse of serial killing, both in the popular imagination and in professional analysis. Examining the Whitechapel Murders, more recent cases and modern profiling techniques, it argues that popular and professional representations of crime scenes reveal more of social anxieties about the nature of the public and the private than they do about serial killers. It suggests that 'the serial killer' is not a coherent type, but an invention produced from the confusions of persons and places. Copyright 2006 SAGE Publications. All rights reserved. Not for commercial use or unauthorized distribution

Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence

Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Pattern of recurrence after pancreatectomy is heterogenous, with some studies illustrating that site of recurrence can be associated with prognosis.1 Another study suggested that tumors that develop local and distant recurrence can be regarded as a homogenous disease with similar outcomes.2 Here we investigate novel molecular determinants of recurrence pattern after pancreatectomy for PC