Obesity and survival in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathological subtypes: a pooled analysis

IntroductionObesity is an unfavorable prognostic factor in breast cancer (BC) patients regardless of menopausal status and treatment received. However, the association between obesity and survival outcome by pathological subtype requires further clarification.MethodsWe performed a retrospective analysis including 5,683 operable BC patients enrolled in four randomized clinical trials (GEICAM/9906, GEICAM/9805, GEICAM/2003–02, and BCIRG 001) evaluating anthracyclines and taxanes as adjuvant treatments. Our primary aim was to assess the prognostic effect of body mass index (BMI) on disease recurrence, breast cancer mortality (BCM), and overall mortality (OM). A secondary aim was to detect differences of such prognostic effects by subtype.ResultsMultivariate survival analyses adjusting for age, tumor size, nodal status, menopausal status, surgery type, histological grade, hormone receptor status, human epidermal growth factor receptor 2 (HER2) status, chemotherapy regimen, and under-treatment showed that obese patients (BMI 30.0 to 34.9) had similar prognoses to that of patients with a BMI < 25 (reference group) in terms of recurrence (Hazard Ratio [HR] = 1.08, 95% Confidence Interval [CI] = 0.90 to 1.30), BCM (HR = 1.02, 0.81 to 1.29), and OM (HR = 0.97, 0.78 to 1.19). Patients with severe obesity (BMI ≥ 35) had a significantly increased risk of recurrence (HR = 1.26, 1.00 to 1.59, P = 0.048), BCM (HR = 1.32, 1.00 to 1.74, P = 0.050), and OM (HR = 1.35, 1.06 to 1.71, P = 0.016) compared to our reference group. The prognostic effect of severe obesity did not vary by subtype.ConclusionsSeverely obese patients treated with anthracyclines and taxanes present a worse prognosis regarding recurrence, BCM, and OM than patients with BMI < 25. The magnitude of the harmful effect of BMI on survival-related outcomes was similar across subtypes

Demostraciones prácticas para la promoción de las titulaciones de Grado en Química y Grado en Ingeniería Química

Memoria ID12-0251. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

Development and validation of a clinical score to estimate progression to severe or critical state in Covid-19 pneumonia hospitalized patients

The prognosis of a patient with Covid-19 pneumonia is uncertain. Our objective was to establish a predictive model of disease progression to facilitate early decision-making. A retrospective study was performed of patients admitted with Covid-19 pneumonia, classified as severe (admission to the intensive care unit, mechanic invasive ventilation, or death) or non-severe. A predictive model based on clinical, analytical, and radiological parameters was built. The probability of progression to severe disease was estimated by logistic regression analysis. Calibration and discrimination (receiver operating characteristics curves and AUC) were assessed to determine model performance. During the study period 1,152 patients presented with Covid-19 infection, of whom 229 (19.9%) were admitted for pneumonia. During hospitalization, 51 (22.3%) progressed to severe disease, of whom 26 required ICU care (11.4); 17 (7.4%) underwent invasive mechanical ventilation, and 32 (14%) died of any cause. Five predictors determined within 24 hours of admission were identified: Diabetes, Age, Lymphocyte count, SaO2, and pH (DALSH score). The prediction model showed a good clinical performance, including discrimination (AUC 0.87 CI 0.81, 0.92) and calibration (Brier score = 0.11). In total, 0%, 12%, and 50% of patients with severity risk scores ≤5%, 6-25%, and >25% exhibited disease progression, respectively. A simple risk score based on five factors predicts disease progression and facilitates early decision-making according to prognosis.Carlos III Health Institute, Spain, Ministry of Economy and Competitiveness (SPAIN) and the European Regional Development Fund (FEDER)Instituto de Salud Carlos II

Colaboración universidad/empresa para la promoción de las titulaciones de grado en química y grado en ingeniería química

Memoria ID-0018. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

Implementación del método del caso en docencia virtual para asignaturas prácticas y teóricas del Grado en Química y del Grado en Ingeniería Química de la Facultad de Ciencias Químicas

Memoria ID-0073. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

The reaction of sodium nitrite with neurotransmitters secreted in the stomach [Dataset]

[EN] Nitroso-compounds are potentially mutagenic and carcinogenic compounds due to their ability to alkylate DNA bases. One of the most common sources of human exposure to nitroso-compounds is their formation in the acidic environment of the stomach by the reaction between electron-rich molecules present in the lumen and sodium nitrite ingested in the diet. To date, the formation of nitroso-compounds by the reaction of nitrite with food components has been investigated in depth, but little attention has been paid to substances secreted in the stomach, such as dopamine or serotonin, whose reaction products with nitrite have proven mutagenic properties. In this article we present a kinetic study with UV-visible spectroscopy of the nitrosation reactions of both molecules, as well as of L-tyrosine, the amino-acid precursor of dopamine. As a result, we have determined their reaction mechanisms, which show that in all of them the favoured reaction product is a stable nitroso-compound and that the molecule whose product is the most mutagenic, serotonin, undergoes two consecutive nitrosation reactions. These findings suggest that more research is needed to understand how this reaction alters the function of these neurotransmitters as well as the potential toxic effects they may have once nitrosated.a) Ministerio de Economía y Competitividad and the European Regional Development Fund. b) Universidad de Salamanca. M.G.J. had got a PhD. grant of the Ministerio de Economía y Competitividad J.A.V. had got a PhD. grant of the Junta de Castilla y León for a PhD. grant.Carpeta 1. Tirosine: 1. Extinction coefficient , 2. Extinction coefficient nitrosotirosine, 3. Reaction orders, 4. Influence Ionic ,Strength, 5. Influence Temperature, 6. Influence pH, 7. KIE. Carpeta 2. Dopamine: 1. Extinction coefficient, 2. Selfoxidation dopamine, 3. Extinction coefficient nitrosodopamine, 4. Catalysis by chloride ions, 5. Reaction orders, 6. Influence Ionic Strength, 7. Influence Temperature, 8. KIE. Carpeta 3. Serotonin: 1. Extinction coefficient, 2. Extinction coefficient nitrosated serotonin, 3. Influence Ionic Strength, 4. Reaction orders, 5. Influence pH, 6. Influence Temperature, 7. KI

Proyecto de Prevención de Drogodependencias

Se pretende responder a las necesidades de salud en general y a los problemas de consumo de drogas, planteados en el centro escolar. Los objetivos son sensibilizar al conjunto de la comunidad educativa sobre la necesidad de prevenir el consumo de drogas en el marco de la Educación para la Salud, incorporar la prevención de las drogodependencias como tarea propia del centro educativo, y desarrollar en la población escolarizada las actitudes, conocimientos, hábitos y comportamientos que favorezcan una vida sana. Incluye objetivos generales, específicos, didácticos y actividades para cada una de las áreas. La evaluación se hace a través de la observación directa, hojas de registro, encuesta, registro de reuniones de trabajo y de actividades, y se evalúa la organización del equipo docente, la gestión de los recursos, la participación de alumnos y padres y la colaboración con instituciones y entidades del entorno.Madrid (Comunidad Autónoma). Consejería de Educación y Cultura. Ministerio de Educación y Cultura. Ayuntamiento de MadridMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

Colaboración Universidad/Empresa para la promoción de las titulaciones de Grado en Química y Grado en Ingeniería Química

Memoria ID-018. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

La química en nuestra vida. Pasado, presente y futuro. Una puerta abierta al conocimiento de la ciencia

Memoria ID-0078. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Incidence and regression of metabolic syndrome in a representative sample of the Spanish population: results of the cohort [email protected] study

Introduction: Metabolic syndrome (MetS) is an important predictor of cardiovascular mortality. Identification of occurrence and regression trends of MetS could permit elaboration of preventive strategies with new targets. The objective of this study was to analyze the occurrence and regression rates of MetS and its associated factors in the representative cohort of Spain of the [email protected] study. Research design and methods: The [email protected] study is a prospective cohort where 5072 people representative of the Spanish population over 18 years of age were randomly selected between 2009 and 2010. Follow-up was a median of 7.5 (IQR 7.2-7.9) years, with 2408 (47%) participating subjects. A total of 1881 (78%) subjects had all the pertinent data available and were included in this study. Results: Of the 1146 subjects without baseline criteria for MetS, 294 (25.7%) developed MetS during follow-up, while of the 735 patients with prior MetS, 148 (20.1%) presented regression. Adjusted MetS incidence per 1000 person-years was 38 (95% CI 32 to 44), while regression incidence was 36 (95% CI 31 to 41). Regression rate was independently higher than incidence rate in the following: women, subjects aged 18-45, university-degree holders, patients without central obesity, without hypertension, as well as those with body mass index of 11 in both groups and with >500 and>2000 MET-min/week of physical activity, respectively. Conclusions: This study provides MetS incidence and regression rates, and identifies the target population for intervention strategies in Spain and possibly in other countries