A process for developing and validating performance assessment rubrics for laboratory techniques

PROBLEM Achieving competence in technical skills is a key learning objective in the laboratory programs of our institution’s Pharmaceutical Science course. However, their assessment is often achieved through indirect outcome indicators since performance assessment through direct observation is time-consuming and there is a lack of validated, efficient and scalable methods. PLAN We report on our approach towards the development, validation and optimisation of a set of rubrics for the formative and summative assessment of common chemistry laboratory techniques. Efficiency and user-friendliness are key criteria in the rubric development.  Drawing on recent work by Seery et al. (2017) and Chen et al. (2013), we propose a four-stage process: Rubric design based on practitioner input, literature sources and lab observations Testing involving student self-assessment, peer evaluation and instructor assessment Optimisation and validation based on assessment data, student and instructor feedback Developing supporting procedures (e.g., instructor training). ACTION AND EVALUATION We have started implementation in two synthetic chemistry subjects, initially targeting rubrics for four techniques (reflux setup, thin-layer chromatography, vacuum filtration and recrystallisation). Rubric evaluation will involve both quantitative (assessment data) and qualitative methods (surveys/focus groups with instructors and students, human ethics application in progress). REFERENCES Chen, H. J., She, J. L., Chou, C. C., Tsai, Y. M., & Chiu, M. H. (2013). Development and application of a scoring rubric for evaluating students’ experimental skills in organic chemistry: An instructional guide for teaching assistants. Journal of Chemical Education, 90(10), 1296–1302. https://doi.org/10.1021/ed101111g Seery, M. K., Agustian, H. Y., Doidge, E. D., Kucharski, M. M., O’Connor, H. M., & Price, A. (2017). Developing laboratory skills by incorporating peer-review and digital badges. Chemistry Education Research and Practice, 18(3), 403–419. https://doi.org/10.1039/C7RP00003

TRIUMF cyclotron RF system reliability enhancement

This paper presents recent RF system improvements related to the cyclotron resonators, RF amplifiers, and transmission lines. Although the program is not complete, the downtime due to rf sparking has already been reduced by a factor of 5.Обсуждаются усовершенствования ВЧ-системы: резонаторов циклотрона, ВЧ-генераторов, питающего волновода. Часть работ к настоящему времени завершена, что привело к уменьшению простоев из-за ВЧ- пробоев в 5 раз.Обговорюються удосконалення ВЧ-системи: резонаторів циклотрона, ВЧ-генераторів, що живить хвилевід. Частина робіт вже виконана, що дало зменшення простоїв через ВЧ-пробої у 5 разів

Seeing the whole: Configurational cognition and new venture resource mobilization

Research Summary Research is scant on how multiple venture attributes combine as “whole packages” of signals (or cognitive configurations) in resource holders’ eyes, shaping a venture's ability to mobilize resources. Drawing on a qualitative comparative analysis of 1,395 crowdfunding campaigns, we identified different configurations of signals for high and low resource mobilization, theorizing abductively their underlying mechanisms through the analysis of case‐level qualitative data. Our results explain some past mixed findings, such as the contradictory effects of social value and entrepreneurial narratives, showing that these narratives can instead be successfully combined in the presence of signals of venture quality and community embeddedness. We show that there is no single best way to impress resource holders, but multiple recipes to holistically communicate a venture's value. Managerial Summary Analyzing Kickstarter crowdfunding campaigns, we examine how entrepreneurs combine four signals to raise money: 1) the venture's underlying quality; 2) social networks; 3) narratives; 4) embeddedness in the crowdfunding community. We identified four successful configurations of these signals (500% above the funding goal) and two failing configurations (4% of the funding goal). Narratives per se are not sufficient to mobilize resources, unless backed by signals of quality and community embeddedness. A simpler narrative is supported by cheaper quality signals (product images). More complex narratives (combining social value, entrepreneurial orientation, positive psychology) are supported by more costly signals (videos). Our results encourage entrepreneurs to look beyond “silver bullet” solutions and think holistically how to communicate their ventures as “whole packages”

Observables of interest for the characterisation of Spent Nuclear Fuel

The characterisation of Spent Nuclear Fuel (SNF) in view of intermediate storage and final disposal is discussed. The main observables of interest that need to be determined are the decay heat, neutron and -ray emission spectra. In addition, the inventory of specific nuclides that are important for criticality safety analysis and to verify the fuel history has to be determined. Some of the observables such as the decay heat and neutron and -ray emission rate can be determined by Non-Destructive Analysis (NDA) methods. Unfortunately, this is not always possible especially during routine operation. Hence, a characterisation of SNF will rely on theoretical calculations combined with results of NDA methods. In this work the observables of interest, also referred to as source terms, are discussed based on theoretical calculations starting from fresh UO2 and MOX fuel. The irradiation conditions are representative for PWR. The Serpent code is used to define the nuclides which have an important contribution to the observables. The emphasis is on cooling times between 1 a and 1000 a.JRC.G.2-Standards for Nuclear Safety, Security and Safeguard

Semiconductor nanostructures engineering: Pyramidal quantum dots

Pyramidal quantum dots (QDs) grown in inverted recesses have demonstrated over the years an extraordinary uniformity, high spectral purity and strong design versatility. We discuss recent results, also in view of the Stranski-Krastanow competition and give evidence for strong perspectives in quantum information applications for this system. We examine the possibility of generating entangled and indistinguishable photons, together with the need for the implementation of a, regrettably still missing, strategy for electrical control

Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial

Abstract Decompressive hemicraniectomy (DHC) can improve outcomes for patients with severe forms of acute ischemic stroke (AIS), but the evidence is mainly derived from non-thrombolyzed patients. We aimed to determine the characteristics and outcomes of early DHC in thrombolyzed AIS participants of the international Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Post-hoc analyses of ENCHANTED, an international, partial-factorial, open, blinded outcome-assessed, controlled trial in 4557 thrombolysis-eligible AIS patients randomized to low- versus standard-dose intravenous alteplase (Arm A, n = 2350), intensive versus guideline-recommended blood pressure control (Arm B, n = 1280), or both (Arms A + B, n = 947). Logistic regression models were used to identify baseline variables associated with DHC, with inverse probability of treatment weights employed to eliminate baseline imbalances between those with and without DHC. Logistic regression was also used to determine associations of DHC and clinical outcomes of death/disability, major disability, and death (defined by scores 2–6, 3–5, and 6, respectively, on the modified Rankin scale) at 90 days post-randomization. There were 95 (2.1%) thrombolyzed AIS patients who underwent DHC, who were significantly younger, of non-Asian ethnicity, and more likely to have had prior lipid-lowering treatment and severe neurological impairment from large vessel occlusion than other patients. DHC patients were more likely to receive other management interventions and have poor functional outcomes than non-DHC patients, with no relation to different doses of intravenous alteplase. Compared to other thrombolyzed AIS patients, those who received DHC had a poor prognosis from more severe disease despite intensive in-hospital management

Active Semiconductor Nanophotonics based on Deterministic Quantum Wire and Dot Systems

investigate the use of MOVPE-grown ordered nanostructures on non-planar substrates for quantum nano-photonics and quantum electrodynamics-based applications. The mastering of surface adatom fluxes on patterned GaAs substrates allows for forming nanostrucutres confining well-defined charge carrier states. An example given is the formation of quantum dot (QD) molecules tunneled-coupled by quantum wires (QWRs), in which both electron and hole states are hybridized. In addition, it is shown that the high degree of symmetry of QDs grown on patterned (111) B substrates makes them efficient entangled-photons emitters. Thanks to the optimal control over their position and emission wavelength, the fabricated nanostructures can be efficiently coupled to photonic nano-cavities. Low-threshold, optically pumped QWR laser incorporating photonic crystal (PhC) membrane cavities are demonstrated. Moreover, phonon-mediated coupling of QD exciton states to PhC cavities is observed. This approach should be useful for integrating more complex systems of QWRs and QDs for forming a variety of active nano-photonic structures

Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity

BACKGROUND: The limited availability of prevalence data based on a representative sample of the general population, and the limited number of diseases considered in studies about co-morbidity are the critical factors in study of autoimmune diseases. This paper describes the prevalence of 12 autoimmune diseases in a representative sample of the general population in the South of Sardinia, Italy, and tests the hypothesis of an overall association among these diseases. METHODS: Data were obtained from 21 GPs. The sample included 25,885 people. Prevalence data were expressed with 95% Poisson C.I. The hypothesis of an overall association between autoimmune diseases was tested by evaluating the co-occurrence within individuals. RESULTS: Prevalence per 100,000 are: 552 rheumatoid arthritis, 124 ulcerative colitis, 15 Crohn's disease, 464 type 1 diabetes, 81 systemic lupus erythematosus, 124 celiac disease, 35 myasthenia gravis, 939 psoriasis/psoriatic arthritis, 35 systemic sclerosis, 224 multiple sclerosis, 31 Sjogren's syndrome, and 2,619 autoimmune thyroiditis. An overall association between autoimmune disorders was highlighted. CONCLUSIONS: The comparisons with prevalence reported in current literature do not show outlier values, except possibly for a few diseases like celiac disease and myasthenia gravis. People already affected by a first autoimmune disease have a higher probability of being affected by a second autoimmune disorder. In the present study, the sample size, together with the low overall prevalence of autoimmune diseases in the population, did not allow us to examine which diseases are most frequently associated with other autoimmune diseases. However, this paper makes available an adequate control population for future clinical studies aimed at exploring the co-morbidity of specific pairs of autoimmune disease