Los grabados de la sierra de Felipa (La Font de la Figuera, València)

En el municipio de la Font de la Figuera existe un pequeño conjunto de grabados localizados sobre una era junto a la casa de la Felipa. Aunque algunos vecinos de la población los conocen, no han sido objeto de ninguna publicación detallada. Por ello se presenta el estudio realizado sobre estos grabados, valorando las diferentes posibilidades interpretativas a la hora de aproximarnos a su función y cronología.In la Font de la Figuera there is a small set of prints located in a house next to the Felipa. Although some residents of the town know them, these prints have not been subjected to any detailed publication. Considering that, the study of these prints is presented, evaluating the different interpretative chances regarding its function and chronology

Effect of Aging Vessel (Clay-Tinaja versus Oak Barrel) on the Volatile Composition, Descriptive Sensory Profile, and Consumer Acceptance of Red Wine

Consumers look for unique wines, offering pleasant experiences. Wine producers need to open new markets and are targeting countries with fewer traditions in drinking red and complex wines, such as Poland, Russia and Germany. The use of less popular aging vessels (e.g., clay-tinajas) will help in creating unique wines. The aim of this study was to evaluate the effect of the aging vessel on the volatile and sensory profiles and consumer acceptance of red wine in Spain and Poland (model of potential new markets). Three wines were studied: (i) wine A, aged in a clay-tinaja with non-permeable coating); (ii) wine B, aged in clay-tinaja without coating; and (iii) wine C, aged in oak barrels (control). The key families in the volatile profiles were esters (wines B and C) and organic acids and terpenes (wine A). Wine A was described as sour and bitter, wine B had a distinctive mineral note, and wine C had a complex profile with typical wood notes. Finally, wines C and A were the preferred ones for Spanish and Polish consumers, respectively. Clay-tinaja wine A can be a good option to introduce clay-tinaja wines in Polish and similar markets because it is a unique product and fulfills the sensory demands/habits of Polish consumers

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

Introduction: Growth arrest-specific gene 6 protein (GAS6) and protein S (ProS) are vitamin K-dependent proteins present in plasma with important regulatory functions in systems of response and repair to damage. They interact with receptor tyrosine kinases of the Tyro3, Axl and MerTK receptor tyrosine kinase (TAM) family, involved in apoptotic cell clearance (efferocytosis) and regulation of the innate immunity. TAM-deficient mice show spontaneous lupus-like symptoms. Here we tested the genetic profile and plasma levels of components of the system in patients with systemic lupus erythematosus (SLE), and compare them with a control healthy population. Methods: Fifty SLE patients and 50 healthy controls with matched age, gender and from the same geographic area were compared. Genetic analysis was performed in GAS6 and the TAM receptor genes on SNPs previously identified. The concentrations of GAS6, total and free ProS, and the soluble forms of the three TAM receptors (sAxl, sMerTK and sTyro3) were measured in plasma from these samples. Results: Plasma concentrations of GAS6 were higher and, total and free ProS were lower in the SLE patients compared to controls, even when patients on oral anticoagulant treatment were discarded. Those parameters correlated with SLE disease activity index (SLEDAI) score, GAS6 being higher in the most severe cases, while free and total ProS were lower. All 3 soluble receptors increased its concentration in plasma of lupus patients. Conclusions: The present study highlights that the GAS6/ProS-TAM system correlates in several ways with disease activity in SLE. We show here that this correlation is affected by common polymorphisms in the genes of the system. These findings underscore the importance of mechanism of regulatory control of innate immunity in the pathology of SLE

Recensiones [Revista de Historia Económica Año VIII Otoño 1990 n. 3 pp. 679-732]

J. I. Fortea Pérez. Monarquía y Cortes en la Corona de Castilla. Las ciudades ante la política fiscal de Felipe V (Por Francisco Comín Comín).-- Guy Bois. La mutation de l'an mil. Lournand, village maconnais de l'Antiquité' au féodalisme (Por Gaspar Feliú).-- Andrés Barrera González. Casa, herencia y familia en la Cataluña rural (Por Carmen Sarasúa García).-- A. Kondo. La agricultura española del siglo XIX (Por James Simpson).-- Miguel Ángel Melón. Extremadura en el Antiguo Régimen, economía y sociedad en tierras de Cáceres, 1100-1814 (Por Enrique Llopis).-- Carlos Rodríguez Braun. La cuestión colonial y la economía clásica. De Adam Smith y Jeremy Bentham a Karl Marx (Por Salvador Almenar).-- Roberto Cortes Conde. Dinero, deuda y crisis. Evolución fiscal y monetaria en la Argentina (Por Pablo Martín Aceña).-- Mercedes Cabrera Calvo-Sotelo, Francisco Comín Comín y José Luis García Delgado (Director). Santiago Alba. Un programa de reforma económica en la España del primer tercio del siglo XX (Por Juan Pro Ruiz).-- Bill Albert y Adrian Graves (eds.). The World Sugar Economy in War and Depression, 1914-40 (Por Manuel Martín Rodríguez).-- Roque Moreno Fonseret. La crisis económica en la provincia de Alicante, 1973-1983 (Por José A. Miranda Encarnación).-- Alvaro Cuervo. La crisis bancaria en España 1977-1985. Causas, sistemas de tratamiento y coste (Por Gabriel Tortella).-- VV. AA.. L’espai viscut. Col loqui Internacional d'Historia Local (Por Salvador Calatayud Giner).-- Massimo M. Augello, Marco Bianchini, Gabriela Gioli y Piero Roggi (eds.). Le cattedre di economia politica in Italia. La diffusione di una disciplina «sospetta» (Por Carlos Rodríguez Braun)Publicad

Effect of Aging Vessel (Clay-Tinaja versus Oak Barrel) on the Volatile Composition, Descriptive Sensory Profile, and Consumer Acceptance of Red Wine

13 páginas.- 2 ilustraciones.- 3 tablas.- 23 referenciasConsumers look for unique wines, offering pleasant experiences. Wine producers need to open new markets and are targeting countries with fewer traditions in drinking red and complex wines, such as Poland, Russia and Germany. The use of less popular aging vessels (e.g., clay-tinajas) will help in creating unique wines. The aim of this study was to evaluate the effect of the aging vessel on the volatile and sensory profiles and consumer acceptance of red wine in Spain and Poland (model of potential new markets). Three wines were studied: (i) wine A, aged in a clay-tinaja with non-permeable coating); (ii) wine B, aged in clay-tinaja without coating; and (iii) wine C, aged in oak barrels (control). The key families in the volatile profiles were esters (wines B and C) and organic acids and terpenes (wine A). Wine A was described as sour and bitter, wine B had a distinctive mineral note, and wine C had a complex profile with typical wood notes. Finally, wines C and A were the preferred ones for Spanish and Polish consumers, respectively. Clay-tinaja wine A can be a good option to introduce clay-tinaja wines in Polish and similar markets because it is a unique product and fulfills the sensory demands/habits of Polish consumers.This research has been financed through an Innovation Project (Valorización de materiales tradicionales para vinificación de vinos de calidad, GOVALMAVIN, file number 20180020012104) 80% co-financed by the European Agricultural Fund for Rural Development (EAFRD) of the European Union and 20% by the Spanish Ministry of Agriculture, Fisheries and Food, within the framework of the National Program for Rural Development 2014–2020.Peer reviewe

Does ecotourism impact biodiversity? An assessment using dung beetles (Coleoptera: Scarabaeinae) as bioindicators in a tropical dry forest natural park

Ecotourism can be defined as an environmental activity that takes place in well-preserved areas for recreation and with the responsibility of promoting their conservation. Nowadays, ecotourism is seen as a friendly pastime, but it can potentially affect negatively community diversity and structure by a number of processes such as soil compaction, erosion, and habitat alteration, among many others. Nonetheless, there is hardly any information on the impact of ecotourism in the Tropical Dry Forests and protected areas of the Neotropical region. In an attempt to fill this knowledge gap, the effect of ecotourism was evaluated in a study of a Tropical Dry Forest in the Tayrona National Natural Park of Colombia using dung beetles as bioindicators. A large-scale sampling of three sites with different levels of tourism intensity (no tourism – NT, low tourism – LT, and high tourism – HT) was performed using pitfall tramps baited with human/pig dung during two climatic seasons (rainy and dry). A total of 3238 individuals belonging to nine genera and 15 species were collected. Significant differences in abundances, richness, and the Shannon Wiener diversity index were observed between areas with tourism and those without. These differences disappeared during the dry season in response to the strong reduction in species abundance and richness associated to that time of year. All areas maintained a homogeneous beetle structure in terms of functional groups present irrelevant of the intensity level of tourism. Beta diversity analysis shows that the dung beetle assemblage has a nested structure, indicating that the pressure exerted by tourism entails the loss of particular species. Our results advocate that it is necessary to implement conservation strategies in order to reduce the negative impact of tourism on the National Park's biodiversity

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

Introduction: Growth arrest-specific gene 6 protein (GAS6) and protein S (ProS) are vitamin K-dependent proteins present in plasma with important regulatory functions in systems of response and repair to damage. They interact with receptor tyrosine kinases of the Tyro3, Axl and MerTK receptor tyrosine kinase (TAM) family, involved in apoptotic cell clearance (efferocytosis) and regulation of the innate immunity. TAM-deficient mice show spontaneous lupus-like symptoms. Here we tested the genetic profile and plasma levels of components of the system in patients with systemic lupus erythematosus (SLE), and compare them with a control healthy population. Methods: Fifty SLE patients and 50 healthy controls with matched age, gender and from the same geographic area were compared. Genetic analysis was performed in GAS6 and the TAM receptor genes on SNPs previously identified. The concentrations of GAS6, total and free ProS, and the soluble forms of the three TAM receptors (sAxl, sMerTK and sTyro3) were measured in plasma from these samples. Results: Plasma concentrations of GAS6 were higher and, total and free ProS were lower in the SLE patients compared to controls, even when patients on oral anticoagulant treatment were discarded. Those parameters correlated with SLE disease activity index (SLEDAI) score, GAS6 being higher in the most severe cases, while free and total ProS were lower. All 3 soluble receptors increased its concentration in plasma of lupus patients. Conclusions: The present study highlights that the GAS6/ProS-TAM system correlates in several ways with disease activity in SLE. We show here that this correlation is affected by common polymorphisms in the genes of the system. These findings underscore the importance of mechanism of regulatory control of innate immunity in the pathology of SLE