The crystal ball, the spider and other stories: a journey around the test tower of the M4 adaptive mirror

M4 is the adaptive mirror of ELT, currently at its FDR. It is composed by 6 thin shell mirror segments, controlled by 5136 voice coil actuators. Before its installation at the telescope, it will be optically calibrated on a test facility (OTT) in Italy. The calibration includes the computation of the flattening command and the segments co-phasing, i.e. the correction of the differential piston amongst them. Given the large complexity of the deformable mirror and the very tight requests on the measurement accuracy, we set-up a risk-mitigation activity based on the laboratory demonstration of some key elements within the test tower. In this paper we present the results of the experimentation. We measured at nanometer level the interferometric cavity; we investigated how the interferometer reacts in presence of spider arms dividing the test mirror into separated islands; we integrated and tested a multi wavelength sensor to measure the inter-segment absolute differential piston; we aligned and tested for stability the pupil relaying optical system to be installed on the OTT. Such activity is performed in the AO laboratory at INAF-Arcetri in Italy, in preparation of the M4 optical calibration on the OTT, scheduled to start in 2020. The M4 project is led by the Italian consortium AdOptica under an ESO contract

The Gamma-Flash data acquisition system for observation of terrestrial gamma-ray flashes

Gamma-Flash is an Italian project funded by the Italian Space Agency (ASI) and led by the National Institute for Astrophysics (INAF), devoted to the observation and study of high-energy phenomena, such as terrestrial gamma-ray flashes and gamma-ray glows produced in the Earth's atmosphere during thunderstorms. The project's detectors and the data acquisition and control system (DACS) are placed at the "O. Vittori" observatory on the top of Mt. Cimone (Italy). Another payload will be placed on an aircraft for observations of thunderstorms in the air. This work presents the architecture of the data acquisition and control system and the data flow.Comment: 4 pages, 1 figure, Astronomical Data Analysis Software and System XXXII (2022

Vers une nouvelle érudition : numérisation et recherche en histoire du livre

En décembre 1999, à l\u27Enssib, s’est déroulé le colloque "Vers une nouvelle érudition : numérisation et recherche en histoire du livre", organisé dans le cadre des 12e Entretiens du Centre Jacques Cartier sous la responsabilité de Dominique Varry (enssib), Annie Charon (école nationale des chartes) et Guylaine Baudry (Université de Montréal)

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Influence of workload and posture on handcycling efficiency

Handbike (HB) is an arm propelled device of locomotion for subjects with lower limbs disabilities. Handcycling has become a Paralympics discipline, increasing the need to study how lesion level may influence posture on HB and energy cost during exercise. The aim was also to test how postures different from the free chosen one might influence functional parameters during exercise

Matthew Barney. Polimorfismo, multimodalità, neobarocco

Quella di Matthew Barney è un'opera ipertrofica e transmediale, che il volume affronta in modo interdisciplinare. Nelle serie DRESSING FIELD (orifill) (1989, 2007), DRAWING RESTRAINT (1987-2010) e nel ciclo di film CREMASTER (1994-2002), Barney esplora media, linguaggi e formati differenti: performance e cinema, scultura, disegno, video e installazioni site specific, ma anche fotografia, moda e design. Per questo i saggi raccolti nel volume, in dialogo tra loro, muovono da diverse prospettive epistemologiche e da diverse pratiche critiche, intrecciando la storia dell'arte, l'estetica e la semiotica, la storia del cinema e la sociologia dei media, per cercare una mappatura delle questioni più rilevanti che il lavoro di Barney introduce nell’ambito delle pratiche artistiche dagli anni Novanta ad oggi

Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50\ue2\u80\u9375 years with type 2 diabetes inadequately controlled with metformin monotherapy (2\ue2\u80\u933 g per day) were recruited from 57 diabetes clinics in Italy. Patients were randomly assigned (1:1), by permuted blocks randomisation (block size 10), stratified by site and previous cardiovascular events, to add-on pioglitazone (15\ue2\u80\u9345 mg) or a sulfonylurea (5\ue2\u80\u9315 mg glibenclamide, 2\ue2\u80\u936 mg glimepiride, or 30\ue2\u80\u93120 mg gliclazide, in accordance with local practice). The trial was unblinded, but event adjudicators were unaware of treatment assignment. The primary outcome, assessed with a Cox proportional-hazards model, was a composite of first occurrence of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularisation, assessed in the modified intention-to-treat population (all randomly assigned participants with baseline data available and without any protocol violations in relation to inclusion or exclusion criteria). This study is registered with ClinicalTrials.gov, number NCT00700856. Findings Between Sept 18, 2008, and Jan 15, 2014, 3028 patients were randomly assigned and included in the analyses. 1535 were assigned to pioglitazone and 1493 to sulfonylureas (glibenclamide 24 [2%], glimepiride 723 [48%], gliclazide 745 [50%]). At baseline, 335 (11%) participants had a previous cardiovascular event. The study was stopped early on the basis of a futility analysis after a median follow-up of 57\uc2\ub73 months. The primary outcome occurred in 105 patients (1\uc2\ub75 per 100 person-years) who were given pioglitazone and 108 (1\uc2\ub75 per 100 person-years) who were given sulfonylureas (hazard ratio 0\uc2\ub796, 95% CI 0\uc2\ub774\ue2\u80\u931\uc2\ub726, p=0\uc2\ub779). Fewer patients had hypoglycaemias in the pioglitazone group than in the sulfonylureas group (148 [10%] vs 508 [34%], p<0\uc2\ub70001). Moderate weight gain (less than 2 kg, on average) occurred in both groups. Rates of heart failure, bladder cancer, and fractures were not significantly different between treatment groups. Interpretation In this long-term, pragmatic trial, incidence of cardiovascular events was similar with sulfonylureas (mostly glimepiride and gliclazide) and pioglitazone as add-on treatments to metformin. Both of these widely available and affordable treatments are suitable options with respect to efficacy and adverse events, although pioglitazone was associated with fewer hypoglycaemia events. Funding Italian Medicines Agency, Diabete Ricerca, and Italian Diabetes Society