Innovative methods of assessment in law:the value of open book exams as a catalyst for improving teaching and learning in the law school

The question of whether open-book examinations (OBE) are preferable to closed book examinations (CBE) is not a new one. However, little has been written on the question of the use of OBE in the discipline of law or as a means of promoting more effective teaching and learning. This article will examine the arguments for and against the utilisation of OBE as opposed to CBE for students of law at university level. Utilising secondary data, as well as a primary small-scale empirical study the author explores student views of OBE and CBE and their significance for teaching and learning in law. It is suggested that the issue may not be simply a question of choice of assessment methods and their value but rather involves examining and evaluating approaches to teaching, learning and curriculum design. In conclusion it is argued that there are several factors which need to be taken into account when deciding what form of assessment is the most appropriate for these students but that the key requirement is that the course design and teaching, learning and assessment methods are aligned and considered as a whole, matching learning outcomes to teaching and learning activities and to the form of assessment chosen. Only within this context can OBE promote more effective learning

Foregrounding socio-economic rights in transitional justice:realising justice for violations of economic and social rights

Transitional justice has traditionally ignored or sidelined violations of economic and social rights, focussing on violations of civil and political rights as the primary grave human rights violations to be addressed when seeking justice for past atrocities. This paper explores the omission of these rights from the field and uncovers the shortcomings of such an approach. It will argue that there is a need for transitional justice to address both deliberate violations of economic and social rights resulting from conflict or repression, but also structural violations which have acted as root causes of conflict within the State. It is submitted that past experiences of prosecutorial and restorative justice illustrate that violations of economic and social rights have been acknowledged as background information rather than primary concerns for transitional justice. In conclusion it is contended that economic and social rights need to be brought to the foreground of transitional justice processes in order to ensure effective transitional justice which reflects the needs and rights of the local population, and addresses the root causes of conflict, thus preventing conflict reoccurring around the same sources. The inclusion of economic and social rights concerns within transitional justice mechanisms will therefore contribute to a more holistic and inclusive transitional justice process

Reclaiming the peacebuilding agenda:economic and social rights as a legal framework for building positive peace : a human security plus approach to peace-building

This article examines the exclusion of economic and social rights from peacebuilding. The peacebuilding process has become dominated by a liberal agenda resulting in a ‘one size fits all’ model of peacebuilding. As a consequence, the inclusion of human rights within the mandate of peacebuilding has also been limited to a liberal conception of human rights constituting only civil and political rights. It is argued that an alternative approach is required which refocuses the peacebuilding agenda on human security: a hybrid ‘human security plus’ approach to peacebuilding (or a ‘inclusive’ human rights approach) will ensure the protection and promotion of economic, social and cultural rights, while maintaining protection of civil and political rights, throughout the whole peacebuilding process: from peace agreements to post-conflict reconstruction. The result will be a reclaiming of the peacebuilding agenda to improve its effectiveness and provide a legal framework for building positive peace

Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa

BACKGROUND\ud \ud GlaxoSmithKline Biologicals and the PATH Malaria Vaccine Initiative are working in partnership to develop a malaria vaccine to protect infants and children living in malaria endemic regions of sub-Saharan Africa, which can be delivered through the Expanded Programme on Immunization. The RTS,S/AS candidate vaccine has been evaluated in multiple phase I/II studies and shown to have a favourable safety profile and to be well-tolerated in both adults and children. This paper details the design of the phase III multicentre efficacy trial of the RTS,S/AS01 malaria vaccine candidate, which is pivotal for licensure and policy decision-making.\ud \ud METHODS\ud \ud The phase III trial is a randomized, controlled, multicentre, participant- and observer-blind study on-going in 11 centres associated with different malaria transmission settings in seven countries in sub-Saharan Africa. A minimum of 6,000 children in each of two age categories (6-12 weeks, 5-17 months) have been enrolled. Children were randomized 1:1:1 to one of three study groups: (1) primary vaccination with RTS,S/AS01 and booster dose of RTS,S/AS01; (2) primary vaccination with RTS,S/AS01 and a control vaccine at time of booster; (3) primary vaccination with control vaccine and a control vaccine at time of booster. Primary vaccination comprises three doses at monthly intervals; the booster dose is administered at 18 months post-primary course. Subjects will be followed to study month 32. The co-primary objectives are the evaluation of efficacy over one year post-dose 3 against clinical malaria when primary immunization is delivered at: (1) 6-12 weeks of age, with co-administration of DTPwHepB/Hib antigens and OPV; (2) 5-17 months of age. Secondary objectives include evaluation of vaccine efficacy against severe malaria, anaemia, malaria hospitalization, fatal malaria, all-cause mortality and other serious illnesses including sepsis and pneumonia. Efficacy of the vaccine against clinical malaria under different transmission settings, the evolution of efficacy over time and the potential benefit of a booster will be evaluated. In addition, the effect of RTS,S/AS01 vaccination on growth, and the safety and immunogenicity in HIV-infected and malnourished children will be assessed. Safety of the primary course of immunization and the booster dose will be documented in both age categories.\ud \ud CONCLUSIONS\ud \ud This pivotal phase III study of the RTS,S/AS01 candidate malaria vaccine in African children was designed and implemented by the Clinical Trials Partnership Committee. The study will provide efficacy and safety data to fulfil regulatory requirements, together with data on a broad range of endpoints that will facilitate the evaluation of the public health impact of the vaccine and will aid policy and implementation decisions.\ud \ud TRIAL REGISTRATION\ud \ud Clinicaltrials.gov NCT00866619

Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area

This study advances the clinical development of the RTS,S/AS01B candidate malaria vaccine to malaria endemic populations. As a primary objective it compares the safety and reactogenicity of RTS,S/AS01B to the more extensively evaluated RTS,S/AS02A vaccine.A Phase IIb, single centre, double-blind, controlled trial of 6 months duration with a subsequent 6 month single-blind follow-up conducted in Kisumu West District, Kenya between August 2005 and August 2006. 255 healthy adults aged 18 to 35 years were randomized (1ratio1ratio1) to receive 3 doses of RTS,S/AS02A, RTS,S/AS01B or rabies vaccine (Rabipur; Chiron Behring GmbH) at months 0, 1, 2. The primary objective was the occurrence of severe (grade 3) solicited or unsolicited general (i.e. systemic) adverse events (AEs) during 7 days follow up after each vaccination.Both candidate vaccines had a good safety profile and were well tolerated. One grade 3 systemic AE occurred within 7 days of vaccination (RTS,S/AS01B group). No unsolicited AEs or SAEs were related to vaccine. A marked increase in anti-CS antibody GMTs was observed post Dose 2 of both RTS,S/AS01B (31.6 EU/mL [95% CI: 23.9 to 41.6]) and RTS,S/AS02A (16.7 EU/mL [95% CI: 12.9 to 21.7]). A further increase was observed post Dose 3 in both the RTS,S/AS01B (41.4 EU/mL [95% CI: 31.7 to 54.2]) and RTS,S/AS02A (21.4 EU/mL [95% CI: 16.0 to 28.7]) groups. Anti-CS antibody GMTs were significantly greater with RTS,S/AS01B compared to RTS,S/AS02A at all time points post Dose 2 and Dose 3. Both candidate vaccines produced strong anti-HBs responses. Vaccine efficacy in the RTS,S/AS01B group was 29.5% (95% CI: -15.4 to 56.9, p = 0.164) and in the RTS,S/AS02A group 31.7% (95% CI: -11.6 to 58.2, p = 0.128).Both candidate malaria vaccines were well tolerated over a 12 month surveillance period. A more favorable immunogenicity profile was observed with RTS,S/AS01B than with RTS,S/AS02A.Clinicaltrials.gov NCT00197054

Evaluation of two formulations of adjuvanted RTS, S malaria vaccine in children aged 3 to 5 years living in a malaria-endemic region of Mozambique: a Phase I/IIb randomized double-blind bridging trial

BACKGROUND: Previous trials of the RTS, S malaria candidate vaccine have shown that this vaccine is safe, tolerated and immunogenic. The development plan for this vaccine aims at administering it in the first year of life through the Expanded Program on Immunization (EPI). The objective was to evaluate the safety and reactogenicity of RTS, S/AS02D (0.5 ml dose), a pediatric formulation of GlaxoSmithKline Biologicals' current malaria candidate vaccine RTS, S/AS02A (0.25 ml dose). A 0.5 ml dose of AS02D is composed of the same active ingredients in the same quantities as in a 0.25 ml dose of AS02A and has been developed to be easily introduced into routine EPI practices. METHODS: We performed a phase I/IIb randomized double-blind bridging study in a malaria-endemic region of Mozambique, to compare the safety and immunogenicity of both candidate vaccines with the aim of replacing RTS, S/AS02A with RTS, S/AS02D as the candidate pediatric vaccine. 200 Mozambican children aged 3 to 5 years were randomized 1:1 to receive one of the 2 vaccines according to a 0, 1, 2 month schedule. RESULTS: Both vaccines were safe and had similar reactogenicity profiles. All subjects with paired pre and post-vaccination samples showed a vaccine response with respect to anti-circumsporozoite (CS) antibodies irrespective of initial anti-CS serostatus. Geometric mean titers (GMTs) were 191 EU/ml (95% CI 150–242) in recipients of RTS, S/AS02D compared to 180 EU/ml (95% CI 146–221) in recipients of RTS, S/AS02A. For the anti-hepatitis B surface antigen (HBsAg), all subjects were seroprotected at day 90, and the GMTs were 23978 mIU/ml (95% CI 17896–32127) in RTS, S/AS02D recipients and 17410 mIU/ml (95% CI 13322–22752) in RTS, S/AS02A recipients. There was a decrease in anti-CS GMTs between months 3 and 14 in both groups (191 vs 22 EU/mL in RTS, S/AS02D group and 180 vs 29 EU/mL in RTS, S/AS02A group). CONCLUSION: Our data show that the RTS, S/AS02D is safe, well tolerated, and demonstrates non-inferiority (defined as upper limit of the 95% confidence interval of the anti-CS GMT ratio of RTS, S/AS02A to RTS, S/AS02D below 3.0) of the antibody responses to circumsporozoite and HBsAg induced by the RTS, S/AS02D as compared to the RTS, S/AS02A

Squaring the circle: Balancing the economic benefits of unconventional hydrocarbon extraction with the inimitable cultural significance of environments

Hydrocarbon extraction will continue for the foreseeable future, and undoubtedly impact upon regions and environments which this industry or indeed modern infrastructure had not done so previously. In light of this the paper considers how decisions with regard to the permitting or licensing of such projects might include the cultural significance of such environments more effectively. Focusing on the extraction of oil sands in Alberta, Canada as a model, the paper will establish the failings of established methods of assessing such values and whether human rights law, more accomplished in dealing with such subjective considerations, offers an alternative. Finally the paper will suggest a framework which, whilst incapable of solving all of the inherent issues in the inclusion of such subjective considerations in an industry so focused on quantification, might better balance them with the overbearing economic arguments for extraction

The inclusion of LGBT+ health issues within undergraduate healthcare education and professional training programmes: A systematic review

BACKGROUND: An inclusive health curriculum within undergraduate and continuing professional development programmes (CPD) should include issues related to people whom identify as LGBT+. OBJECTIVES: The aim of this systematic review was to examine the education and training requirements of undergraduate students and health professionals regarding the inclusion of LGBT+ health issues. DESIGN: A systematic review of the available published empirical studies. DATA SOURCES: A systematic literature search was undertaken of the following databases: CINAHL, PubMed, PsycINFO, Embase and Sociological Abstracts. All papers reviewed were from the years 2007 to 2017 and written in English. REVIEW METHODS: Three research questions informing the literature review were: (i) What are the education and training requirements of undergraduate students and health professionals regarding the health needs of LGBT+ people? (ii) What are the approaches utilized in the education and training of undergraduate students and health professionals regarding the health needs of LGBT+ people? (iii) What are the best practice examples of the education and training of undergraduate students and health professionals? Following the application of definitive criteria, 22 papers were included in the review. Quality appraisal and data extraction was undertaken by the two authors. RESULTS: The 22 papers were reviewed in detail in the final data analysis and synthesis where four main themes were identified: (1) Cultural competence and inclusivity. (2) Existing knowledge of LGBT+ health-related issues. (3) Curriculum developments and outcomes. (4) Evidence of best practice in education delivery. CONCLUSION: The review highlights the importance of the inclusion of LGBT+ health-related issues within the health curriculum and continuing professional development programmes and the implications for education and training, clinical practice and research