Produção aeronáutica: análise do desenvolvimento nacional

Esta dissertação tem como objectivo dar a conhecer a indústria aeronáutica, caracterizar a indústria em geral, a indústria aeronáutica em Portugal e também na Europa, para assim colmatar a falta de informação que existe sobre a indústria aeronáutica portuguesa., mostrando a situação actual , projectos actuais e também estatística do sector em Portugal, também tem informação geral da indústria aeronáutica europeia e dos países relevantes para assim ter uma base de comparação. A dissertação também contem informação opinativa acerca da indústria portuguesa em questões relevantes como I&D e sobre o que a indústria nacional produz para assim servir de base e auxiliar futuros trabalhos sobre o que é feito em Portugal para melhor ter noção dos caminhos que podem seguir.This work aims to obtain information about the aviation industry, characterize the aerospace industry in general, the aerospace industry in Portugal and also in Europe, thus to address the lack of information that exists on the Portuguese aerospace industry, showing the current situation, current projects and also statistical information about sector in Portugal, it also has general information of the European aeronautics industry and the relevant countries to thus have a basis for comparison. The dissertation contains the sectors company’s opinion about the Portuguese industry on issues relevant as R&D and on the domestic industry produces well serve as a basis for and assist future work on what is done in Portugal to have better information for future studies that may follow to aid future work

Mejoramiento participativo: herramienta para la conservación de cultivos subutilizados y olvidados

A pesar de un número significativo de especies vegetales ser reconocidas como alimenticias, solo una pequeña fracción cumple con la demanda proteica de la población mundial. Los cultivos mejorados, con una base genética muy limitada, muy posiblemente no podrán contrarrestar los efectos adversos del cambio climático. Por lo contrario, los cultivos considerados subutilizados, infrautilizados, olvidados, huérfanos, obsoletos o menores,pueden contener en sus genomas las respuestas para garantizar la seguridad y la soberanía alimentaria y nutricional de las poblaciones. Esas variedades locales, debidamente adaptadas a condiciones agroclimáticas extremas, como las de maíz criollo e indígena colombiano, hacen parte del patrimonio cultural de muchosgrupos étnicos o pueblos originarios, que las seleccionan, las utilizan y las conservan. Además de estos, otro concepto se refiere a los recursos promisorios, igualmente poco utilizados, aunque por razones diferentes. Así, el Mejoramiento Participativo (MP) es una herramienta para promocionar variedades locales o cultivostradicionales subutilizados, para atender las necesidades de las comunidades. En el Fitomejoramiento Participativo, los miembros de la cadena de valores o productiva (agricultores, fitomejoradores, técnicos y otros) trabajan juntos en el proceso de desarrollo de las variedades, en un proceso descentralizado y participativo.Un programa de MP con germoplasma de maíz colombiano resultó en la promoción de algunas variedades locales. Paralelamente se describieron nuevas razas de maíz para Colombia

A global analysis of viviparity in squamates highlights its prevalence in cold climates

Aim Viviparity has evolved more times in squamates than in any other vertebrate group; therefore, squamates offer an excellent model system in which to study the patterns, drivers and implications of reproductive mode evolution. Based on current species distributions, we examined three selective forces hypothesized to drive the evolution of squamate viviparity (cold climate, variable climate and hypoxic conditions) and tested whether viviparity is associated with larger body size. Location Global. Time period Present day. Taxon Squamata. Methods We compiled a dataset of 9061 squamate species, including their distributions, elevation, climate, body mass and reproductive modes. We applied species-level and assemblage-level approaches for predicting reproductive mode, both globally and within biogeographical realms. We tested the relationships of temperature, interannual and intra-annual climatic variation, elevation (as a proxy for hypoxic conditions) and body mass with reproductive mode, using path analyses to account for correlations among the environmental predictors. Results Viviparity was strongly associated with cold climates at both species and assemblage levels, despite the prevalence of viviparity in some warm climates. Viviparity was not clearly correlated with climatic variability or elevation. The probability of being viviparous exhibited a weak positive correlation with body size. Conclusions Although phylogenetic history is important, potentially explaining the occurrence of viviparous species in regions that are warm at present, current global squamate distribution is characterized by a higher relative abundance of viviparity in cold environments, supporting the prediction of the “cold-climate” hypothesis. The roles of climatic variation and hypoxia are less important and not straightforward. Elevation probably exerts various selective pressures and influences the prevalence of viviparity primarily through its effect on temperature rather than on oxygen concentration

Conformal Orbifold Partition Functions from Topologically Massive Gauge Theory

We continue the development of the topological membrane approach to open and unoriented string theories. We study orbifolds of topologically massive gauge theory defined on the geometry $[0,1]\times\Sigma$, where $\Sigma$ is a generic compact Riemann surface. The orbifold operations are constructed by gauging the discrete symmetries of the bulk three-dimensional field theory. Multi-loop bosonic string vacuum amplitudes are thereby computed as bulk correlation functions of the gauge theory. It is shown that the three-dimensional correlators naturally reproduce twisted and untwisted sectors in the case of closed worldsheet orbifolds, and Neumann and Dirichlet boundary conditions in the case of open ones. The bulk wavefunctions are used to explicitly construct the characters of the underlying extended Kac-Moody group for arbitrary genus. The correlators for both the original theory and its orbifolds give the expected modular invariant statistical sums over the characters.Comment: 47 pages LaTeX, 3 figures, uses amsfonts and epsfig; v2: Typos corrected, reference added, clarifying comments on modular invariance inserted; v3: Further comments on modular invariance added; to be published in JHE

Efficacy and safety of elinzanetant, a selective neurokinin-1,3 receptor antagonist for vasomotor symptoms: a dose-finding clinical trial (SWITCH-1)

OBJECTIVE: Neurokinin (NK)-3 and NK-1 receptors have been implicated in the etiology of vasomotor symptoms (VMS) and sleep disturbances associated with menopause. This phase 2b, adaptive, dose-range finding study aimed to assess the efficacy and safety of multiple doses of elinzanetant (NT-814), a selective NK-1,3 receptor antagonist, in women experiencing VMS associated with menopause, and investigate the impact of elinzanetant on sleep and quality of life. METHODS: Postmenopausal women aged 40 to 65 years who experienced seven or more moderate-to-severe VMS per day were randomized to receive elinzanetant 40, 80, 120, or 160 mg or placebo once daily using an adaptive design algorithm. Coprimary endpoints were reduction in mean frequency and severity of moderate-to-severe VMS at weeks 4 and 12. Secondary endpoints included patient-reported assessments of sleep and quality of life. RESULTS: Elinzanetant 120 mg and 160 mg achieved reductions in VMS frequency versus placebo from week 1 throughout 12 weeks of treatment. Least square mean reductions were statistically significant versus placebo at both primary endpoint time points for elinzanetant 120 mg (week 4: -3.93 [SE, 1.02], P \u3c 0.001; week 12: -2.95 [1.15], P = 0.01) and at week 4 for elinzanetant 160 mg (-2.63 [1.03]; P = 0.01). Both doses also led to clinically meaningful improvements in measures of sleep and quality of life. All doses of elinzanetant were well tolerated. CONCLUSIONS: Elinzanetant is an effective and well-tolerated nonhormone treatment option for postmenopausal women with VMS and associated sleep disturbance. Elinzanetant also improves quality of life in women with VMS

SemIndex: Semantic-Aware Inverted Index

[email protected] paper focuses on the important problem of semanticaware search in textual (structured, semi-structured, NoSQL) databases. This problem has emerged as a required extension of the standard containment keyword based query to meet user needs in textual databases and IR applications. We provide here a new approach, called SemIndex, that extends the standard inverted index by constructing a tight coupling inverted index graph that combines two main resources: a general purpose semantic network, and a standard inverted index on a collection of textual data. We also provide an extended query model and related processing algorithms with the help of SemIndex. To investigate its effectiveness, we set up experiments to test the performance of SemIndex. Preliminary results have demonstrated the effectiveness, scalability and optimality of our approach.This study is partly funded by: Bourgogne Region program, CNRS, and STIC AmSud project Geo-Climate XMine, and LAU grant SOERC-1314T012.Revisión por pare

Quemando incienso en altares cercanos

El crecimiento masivo y global de las ciudades se ha convertido en uno de los más importantes retos  socioambientales del siglo XXI. Por lo tanto, es necesario un enfoque más proactivo en la búsqueda de alternativas para la conservación biológica. Este artículo analiza la importancia de los jardines domésticos urbanos como áreas estratégicas para la conservación biológica. Jardines domésticos urbanos (o quintais en portugués) se definen como espacios privados adyacentes a las viviendas, y que pueden contener, en grados variados, céspedes, polígonos con vegetación ornamental y alimentaria y fuentes de agua. É común que especies vegetales que han experimentado una disminución severa en sus hábitats silvestres, alcancen altas productividades o densidades en los jardines domésticos urbanos. Esos espacios tienen una enorme capacidad para el suporte de la biodiversidad aunque sea corriente en ellos un predominio de especies vegetales exóticas

Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil

OBJECTIVE: This work aimed to evaluate and correlate symptoms, biochemical blood test results and single nucleotide polymorphisms for lactose intolerance diagnosis. METHOD: A cross-sectional study was conducted in Fortaleza, Ceará, Brazil, with a total of 119 patients, 54 of whom were lactose intolerant. Clinical evaluation and biochemical blood tests were conducted after lactose ingestion and blood samples were collected for genotyping evaluation. In particular, the single nucleotide polymorphisms C>;T-13910 and G>;A-22018 were analyzed by restriction fragment length polymorphism/polymerase chain reaction and validated by DNA sequencing. RESULTS: Lactose-intolerant patients presented with more symptoms of flatulence (81.4%), bloating (68.5%), borborygmus (59.3%) and diarrhea (46.3%) compared with non-lactose-intolerant patients (