A não homologação do plano de pagamentos na insolvência singular : um caso

Sumário:§ 1 Colocação da questão § 2 Do Incidente do Plano de Pagamentos; 2.1 Pressupostos; 2.2 Apresentação do Plano de Pagamentos; 2.3 Conteúdo do Plano de Pagamentos; 2.4 Efeitos da Apresentação; 2.5 Tramitação do Plano de Pagamentos; 2.6 Da aprovação; § 3 Da (necessária e correta) aprovação do Plano de Pagamentos; § 4 Por uma correta interpretação do artigo 256.º, n.º 5 do C.I.R.E; 4.1 Natureza do Preceito; 4.2 Da interpretação do Preceito; 4.3 Do Suprimento § 5 Conclusõe

Os primeiros arroubos de exaltação patriótica e liberal do académico Garrett

Quando estamos perante um génio da Literatura como Almeida Gar rett, mesmo os vestígios mais remotos da sua produção literária, por mais insignificantes e pueris que possam parecer perante o cânone dos títulos publicados, acabam por revelar facetas recônditas que ajudarão a definir ou acentuar as linhas de uma personalidade e de um talento em pr ogresso. É o caso das suas primícias teatrais, enquanto estudante de Coimbra. Entre os fragmentos autógrafos desses textos, encontra-se um elogio dramático com o título O Amor da Pátria, escrito em 1819, para festejar o nascimento da futura rainha D. Maria II. Publicada uma primeira versão muito incompleta, nas Obras Póstumas, em 1914, damos agora a conhecer a versão final desse texto, posta em confronto com todas as variantes textuais anteriores, permitindo ao leitor acompanhar o pulsar da inspiração e o fluir da escrita, reprimida em certos momentos pelo rigor da expressão.peerreviewe

Material idea: on the legibility of culture

What we call “the real” is also the result of a protocol of reading. Such a reading is unavoidably historical and contingent, as a product of a specific temporary sense. It also stands within a complex correlation of marked and unmarked spaces, therefore in a spatial sense too. But this latter framework also carries the evidence of time. Such “marks”, taken as individual projections or choices, are not only constantly changing, according for instance to the daylight (or nocturnal illumination, or twilight palettes), to the instant temper or mood, to the physical conditions and the cultural antecedents of the perceiving and exposing subject – to sum up, according to a whole package of conditions and circumstances. If we put together the myriads of individuals on the global surface, we constantly have to redraw the lines of intersection and re-read the mappings of an interactive geography made of partly individual options, partly mimetic movements. Like ruins, views are constantly being destroyed and rebuilt; like lines, they are constantly being erased and rewritten. But this never happens completely anew. Culture work may also be seen as a patient attempt to read palimpsests – which are, as we well know, marked spaces par excellence.info:eu-repo/semantics/publishedVersio

Hyaluronic acid nanocapsules for the intracellular delivery of anticancer drugs

The main goal of this thesis has been the development of hyaluronic acid nanocapsules (HA-NCs) as a multifunctional platform for the encapsulation and delivery of diverse anticancer drugs, such as hydrophobic drugs and hydrophilic biomolecules. The first step was the development of a spontaneous emulsification method, where HA-NCs were formulated without the need of organic solvents, heat or high energy input, providing conditions for the incorporation of sensible biomolecules while decreasing the environmental impact. Another advantage of this system is based on the use of a hydrophobically modified HA derivative that allowed the preparation of HA-NCs by hydrophobic interactions rather than by electrostatic forces, and thus, it reduced the toxicity associated to the addition of a cationic surfactant as counterion. Once formulated, HA-NCs had a size around 130 nm and a negative zeta potential about -20 mV. Moreover, these NCs were markedly stable under storage conditions and diluted in human plasma, taking forward this system as a potential carrier for intravenous administration. The versatility of this nanocarrier was confirmed by the incorporation of different drug models: docetaxel, a cytostatic drug, was incorporated into the oil core, whereas anti-gasdermin B, a monoclonal antibody, was entrapped into the polymeric shell. Docetaxel was highly encapsulated, released in a sustained manner and its cytotoxicity in A549 lung cancer cell line was maintained. Finally, anti-gasdermin B was successfully associated to the polymeric shell of HA-NCs and its intracellular delivery confirmed by confocal microscopy. Once inside the cell, anti-gasdermin B was able to escape the endosomal compartment and to target the intracellular protein gasdermin B, promoting an important decrease in the migratory and invasive behavior of HCC1954 breast cancer cell line. All these results highlight the potential of self-emulsifying HA-NCs as multifunctional systems to carry diverse anticancer drugs, with special emphasis in the intracellular delivery of monoclonal antibodies, an ambitious challenge that could open new avenues to fight cancer

Control of a water delivery canal with cooperative distributed MPC

This article addresses the problem of controlling pool levels in a water delivery canal using a novel cooperative distributed MPC control algorithm that incorporates stability constraints. According to a distributed control strategy, a local control agent is associated to all canal gates (actuators). In order to achieve cooperative action, each control agent computes the corresponding gate position (manipulated variable) by performing the minimization of a cost function that considers not only its local control objectives, but also the ones of their immediate neighbors. For this purpose, a MPC algorithm with stability constraints is used (SIORHC). At the beginning of each sampling interval, local control agents exchange information with their neighbors and adjust their decision in an iterative way. The resulting distributed MPC is denoted D-SIORHC and yields a stable closed-loop. Experimental results are provided to show the influence of the controller configuration parameters on the resulting performance

Relatório final de estágio realizado na Escola Secundária Fernando Namora.

Mestrado em Ensino da Educação Física nos Ensinos Básico e SecundárioEste relatório tem como objetivo ser um documento descritivo e reflexivo das vivências realizadas ao longo do estágio pedagógico como professor de EF na ESFN ao longo do ano letivo de 2013/2014. Assim, este documento começa por apresentar uma contextualização do meio envolvente (localização, agrupamento, escola e turma). De seguida, desenvolve uma descrição crítica sobre o experienciado nas quatro áreas constituintes do estágio pedagógico: área um – organização e gestão do ensino e aprendizagem; área dois – inovação e investigação pedagógica; área três – participação na escola; área quatro – relação com a comunidade. No final serão realçadas conclusões, com o intuito de destacar os principais fatores do desenvolvimento pessoal e profissional decorrente deste ano de formação, através das vivências realizadas no decorrer do processo de ensino - aprendizagem ao longo deste ano letivo

Talkdesk internationalization strategy to the Netherlands

The underlying project was carried out with the aim of defining internationalization strategy for Talkdesk in Europe. This project focuses on the analysis of the firm’s current activities , exploring sustainable competitive advantages, followed by a complex analysis of potential markets, which led to the conclusion that the Netherlands is the preferred market to carry out the strategy. After a close examination of the market landscape, the most appropriate mode of entry was determined. Finally, marketing strategy is proposed along with a detailed implementation plan aligned with the strategic objectives that will ensure successful internationalization

3D Printed Graphene Based Supercapacitors

This thesis aims to develop graphene-based supercapacitors. There is an emerging interest in the development of lightweight, high capacity and high durability supercapacitors. As the electronic equipment are getting lighter and lighter but simultaneously requiring more power supply, the energy density of batteries and/or supercapacitors should respond to this demand. Therefore, graphene-based supercapacitors have been investigated as potential material for high capacity power sources. The graphene is a very light material and has a huge surface area together with high conductivity, thus it is ideal for charge accumulation. In this work graphene was obtained by electrochemical exfoliation as a greener and harmless technique when compared to Hummer’s method. Two rods of graphite we used as electrodes for electrochemical exfoliation in a bath of H2SO4 , being studied the influence of acid concentration and applied potential on the graphite/graphene powder quality. That was evaluated by XRD, SEM and micro Raman spectroscopy. The obtained graphene-oxide powder was mixed with a polymeric binder agent and then used to print electrodes. The conductive of electrodes was optimized with a thermal treatment around 350ºC in different atmospheres. The performances of supercapacitors were tested for two different geometries, vertical (sandwich type) and planar (inter-digital configuration). These devices were studied for their stability and capacitance by CV curves and electrochemical impedance spectroscopy. This work proves that it is possible to use graphene-oxide powder, produced via electrochemical exfoliation, to make 3D printable inks for supercapacitors applications

Understanding individual workforce resilience of women in selected Durban organisational settings.

Master of Commerce in Human Resource Management. University of KwaZulu-Natal, Durban, 2017.BACKGROUND: Over the past decades there has been an enormous increase in scientific research publications, targeting resilience of women within the workplace environment. Despite the potentially adverse effects that women may experience following adversities within their environments, many of them thrive through exercising mindfulness, self-efficacy, coping skills, while trying to manage the effects of neuroticism. Given the overall aim and purpose of this study vis-à-vis: to understand individual workforce resilience of women in selected Durban organisational settings; these factors are presented in terms of a ‘Biopsychological Model of Resilience’ indicating their connections to promoting psychological resilience. Further in the thesis, women experiences are discussed in light of feminism tenets to uncover their significance to resilience in the context of experiences of women beyond the workplace settings. METHODOLOGY: The study applied a qualitative approach, supported by the social constructivism paradigm. Ten women were chosen to be an instrumental part in this study, and were sourced based on preliminary set of criteria using purposive and snowballing sampling methods. Participants were interviewed to allow comprehensive collection of baseline insights and experiences on resilience over life history interviews. All interviews were recorded, transcribed verbatim, and analysed thematically. A pilot study was performed to address potential challenges to the achievement of the study prior to the launch of the research process. FINDINGS: The multi-dimensional constructs of resilience and feminism theories reviewed, have indicated a good fit with the analysed findings, regarding the participants’ perceptions toward resilience. Overall, the findings supported the hypothesis that biopsychosocial dimensions influence the development of resilience. By not displaying resilience qualities, adverse experiences had greater undesirable impacts on women. Women reported experiences of different kinds of adversities including domestic violence, divorce, workplace harassment and discrimination, breast cancer, and death of a loved one. Despite experiencing challenges women reported using different strategies which helped them cope with setbacks. The findings revealed that the attribute of resilience can be exhibited by nurturing and applying resilience knowledge toward adverse experiences. Overall, the study facilitates knowledge sharing on resilience of women which may be insightful or increase awareness to different audiences regarding the theoretical underpinning of resilience. CONCLUSION: A biopsychosocial model of resilience was used to understand how factors such as mindfulness, self-efficacy, coping, neuroticism influenced resilience of women. Moreover, the association between resilience of women and feminism is evident in this study, and serves to highlight how the experiences of women from diverse personal and organisational backgrounds fit into the model of resilience. IMPLICATIONS: The study provides initial understandings of the multidimensional nature of psychological resilience which may throw new light into how women in circumstances of adversity can thrive more effectively. The Human Resource Management [HRM] should deepen understanding of individual workforce resilience to develop and implement meaningful policies to encourage resilience. Further studies should be conducted to explore the actual effect size of the individual resilience model toward mitigating the outcomes of adversities

Ischemia/reperfusion-induced changes in cardiac contractile proteins

Heart disease, often results in the development of ischemia/reperfusion (I/R) injury, and is one of the major causes of morbidity and mortality. I/R injury is usually characterized by the development of cardiac contractile dysfunction, which is one of the major indicators of recovery. The understanding of the mechanisms underlying the development cardiac contractile dysfunction in response to I/R is crucial for the prevention and treatment of I/R injury. Using a proteomics approach to an isolated heart model we identified myosin light chain 1 (MLC1) as an important contractile protein, phosphorylated by myosin light chain kinase (MLCK) and degraded by matrix metalloproteinase-2 (MMP-2) due to I/R. Prevention of MLC1 phosphorylation, with an MLCK inhibitor (ML-7) or a myosin light chain phosphatase – MLCP – stimulator (Y-27632), and degradation with an MMPs inhibitor (doxycycline) protects the heart from contractile dysfunction, associated with a preservation of MLC1 protein levels. The combined use of these three drugs (ML-7, Y-27632 and doxycycline) at subthreshold concentrations resulted in a full protection of both contractile function and MLC1 in hearts subjected to I/R. The MLCP indirect activator Y-27632 (a Rho kinase inhibitor) showed the best degree of protection of contractile function at full protective doses, independent of MLC1 preservation. A proteomics approach revealed that the administration of Y-27632 to hearts subjected to I/R results, not only in a protection of MLC1 from phosphorylation and degradation, but also a modulation of enzymes involved in energy production (lactate dehydrogenase and glyceraldehyde 3-phosphate dehydrogenase). This modulation of energy metabolism is potentially an importa effect of Rho kinase inhibitors, secondary to direct protection of cardiac contractile proteins from degradation in response to I/R. The data presented here show a novel paradigm in the development of I/R-induced cardiac contractile dysfunction. Moreover, we establish a new therapeutic approach (multidrug treatment) that can be of crucial importance in the development of new preventive or treatment strategies against cardiac injury