A generalization of the associated functional to the Lebesgue measure

AbstractIn this paper we analyse a linear functional defined in the space of Laurent polynomials which can be considered as a generalization of the Lebesgue functional. We study the regularity and the semiclassical character of the functional and we construct the corresponding sequence of orthogonal polynomials.Also, we obtain the differential equation that this family and the associated polynomials of first order satisfy

A scalar Riemann boundary value problem approach to orthogonal polynomials on the circle

8 pages, no figures.-- MSC2000 codes: 33C47; 42C05.MR#: MR2252097 (2007k:33010)Zbl#: Zbl 1130.42025A scalar Riemann boundary value problem defining orthogonal polynomials on the unit circle and the corresponding functions of the second kind is obtained. The Riemann problem is used for the asymptotic analysis of the polynomials orthogonal with respect to an analytical real-valued weight on the circle.The research was supported by INTAS Research Network NeCCA 03-51-6637. The first author was also supported by the Grants RFBR 05-01-00522, NSh-1551.2003.1 and by the program N1 DMS, RAS. The second authorwas supported by Ministerio de Ciencia y Tecnología under Grant number MTM2005-01320. The third author was supported by Ministerio de Ciencia y Tecnología under Grant number BFM2003-06335-C03-02.Publicad

Reproduction de la femelle cularde en race asturienne

International audienc

Étude génétique du caractère culard

International audienc

Antibiotic dispensation without a prescription worldwide: a systematic review

Antibiotic resistance still remains a major global public health problem and the dispensing of antibiotics without a prescription at community pharmacies is an important driver of this. MEDLINE, Pubmed and EMBASE databases were used to search and identify studies reporting the dispensing of non-prescribed antibiotics in community pharmacies or drugstores that sell drugs for human use, by applying pharmacy interviews/questionnaires methods and/or simulated patient methods. Of the 4683 studies retrieved, 85 were included, of which 59 (69.4%) were published in low-and middle-income countries. Most of the papers (83.3%) presented a percentage of antibiotic dispensing without a prescription above 60.0%. Sixty-one studies evaluated the active substance and the most sold antibiotics without a prescription were amoxicillin (86.9%), azithromycin (39.3%), ciprofloxacin (39.3%), and amoxicillin-clavulanic acid (39.3%). Among the 65 articles referencing the diseases/symptoms, this practice was shown to be mostly associated with respiratory system problems (100.0%), diarrhea (40.0%), and Urinary Tract Infections (30.8%). In sum, antibiotics are frequently dispensed without a prescription in many countries and can thus have an important impact on the development of resistance at a global level. Our results indicate the high need to implement educational and/or regulatory/administrative strategies in most countries, aiming to reduce this practice.publishe

About Nodal Systems for Lagrange Interpolation on the Circle

We study the convergence of the Laurent polynomials of Lagrange interpolation on the unit circle for continuous functions satisfying a condition about their modulus of continuity. The novelty of the result is that now the nodal systems are more general than those constituted by the n roots of complex unimodular numbers and the class of functions is different from the usually studied. Moreover, some consequences for the Lagrange interpolation on [-1,1] and the Lagrange trigonometric interpolation are obtained

Comparative population plasma and tissue pharmacokinetics of micafungin in critically ill patients with severe burn injuries and patients with complicated intra-abdominal infection

Severely burned patients have altered drug pharmacokinetics (PKs), but it is unclear how different they are from those in other critically ill patient groups. The aim of the present study was to compare the population pharmacokinetics of micafungin in the plasma and burn eschar of severely burned patients with those of micafungin in the plasma and peritoneal fluid of postsurgical critically ill patients with intra-abdominal infection. Fifteen burn patients were compared with 10 patients with intra-abdominal infection; all patients were treated with 100 to 150 mg/day of micafungin. Micafungin concentrations in serial blood, peritoneal fluid, and burn tissue samples were determined and were subjected to a population pharmacokinetic analysis. The probability of target attainment was calculated using area under the concentration-time curve from 0 to 24 h/MIC cutoffs of 285 for Candida parapsilosis and 3,000 for non-parapsilosis Candida spp. by Monte Carlo simulations. Twenty-five patients (18 males; median age, 50 years; age range, 38 to 67 years; median total body surface area burned, 50%; range of total body surface area burned, 35 to 65%) were included. A three-compartment model described the data, and only the rate constant for the drug distribution from the tissue fluid to the central compartment was statistically significantly different between the burn and intra-abdominal infection patients (0.47 +/- 0.47 versus 0.15 +/- 0.06 h(-1), respectively; P< 0.05). Most patients would achieve plasma PK/pharma-codynamic (PD) targets of 90% for non-parapsilosis Candida spp. and C. parapsilosis with MICs of 0.008 and 0.064 mg/liter, respectively, for doses of 100 mg daily and 150 mg daily. The PKs of micafungin were not significantly different between burn patients and intra-abdominal infection patients. After the first dose, micafungin at 100 mg/day achieved the PK/PD targets in plasma for MIC values of < 0.008 mg/liter and < 0.064 mg/liter for non-parapsilosis Candida spp. and Candida parapsilosis species, respectively