Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B

The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood. We examined the intrahepatic HBV reservoir, the occurrence of HBV DNA integration and its impact on the hepatocyte transcriptome in hepatitis B 'e' antigen (HBeAg)-negative chronic hepatitis B (CHB)

Relationship between low Ankle-Brachial Index and rapid renal function decline in patients with atrial fibrillation: a prospective multicentre cohort study

OBJECTIVE: To investigate the relationship between Ankle-Brachial Index (ABI) and renal function progression in patients with atrial fibrillation (AF). DESIGN: Observational prospective multicentre cohort study. SETTING: Atherothrombosis Center of I Clinica Medica of 'Sapienza' University of Rome; Department of Medical and Surgical Sciences of University Magna Græcia of Catanzaro; Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study. PARTICIPANTS: 897 AF patients on treatment with vitamin K antagonists. MAIN OUTCOME MEASURES: The relationship between basal ABI and renal function progression, assessed by the estimated Glomerular Filtration Rate (eGFR) calculated with the CKD-EPI formula at baseline and after 2 years of follow-up. The rapid decline in eGFR, defined as a decline in eGFR >5 mL/min/1.73 m(2)/year, and incident eGFR<60 mL/min/1.73 m(2) were primary and secondary end points, respectively. RESULTS: Mean age was 71.8±9.0 years and 41.8% were women. Low ABI (ie, ≤0.90) was present in 194 (21.6%) patients. Baseline median eGFR was 72.7 mL/min/1.73 m(2), and 28.7% patients had an eGFR<60 mL/min/1.73 m(2). Annual decline of eGFR was -2.0 (IQR -7.4/-0.4) mL/min/1.73 m(2)/year, and 32.4% patients had a rapid decline in eGFR. Multivariable logistic regression analysis showed that ABI ≤0.90 (OR 1.516 (95% CI 1.075 to 2.139), p=0.018) and arterial hypertension (OR 1.830 95% CI 1.113 to 3.009, p=0.017) predicted a rapid eGFR decline, with an inverse association for angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blockers (OR 0.662 95% CI 0.464 to 0.944, p=0.023). Among the 639 patients with AF with eGFR >60 mL/min/1.73 m(2), 153 (23.9%) had a reduction of the eGFR <60 mL/min/1.73 m(2). ABI ≤0.90 was also an independent predictor for incident eGFR<60 mL/min/1.73 m(2) (HR 1.851, 95% CI 1.205 to 2.845, p=0.005). CONCLUSIONS: In patients with AF, an ABI ≤0.90 is independently associated with a rapid decline in renal function and incident eGFR<60 mL/min/1.73 m(2). ABI measurement may help identify patients with AF at risk of renal function deterioration

Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 \ub1 11 years; 56% men) with complete data to define LVH were selected. ARAPACIS is a multicenter, observational, prospective, longitudinal on-going study designed to estimate prevalence of peripheral artery disease in patients with NVAF. We found a high prevalence of LVH (52%) in patients with NVAF. Compared to those without LVH, patients with AF with LVH were older and had a higher prevalence of hypertension, diabetes, and previous myocardial infarction (MI). A higher prevalence of ankle-brachial index 640.90 was seen in patients with LVH (22 vs 17%, p = 0.0392). Patients with LVH were at significantly higher thromboembolic risk, with CHA2DS2-VASc 652 seen in 93% of LVH and in 73% of patients without LVH (p <0.05). Women with LVH had a higher prevalence of concentric hypertrophy than men (46% vs 29%, p = 0.0003). Logistic regression analysis demonstrated that female gender (odds ratio [OR] 2.80, p <0.0001), age (OR 1.03 per year, p <0.001), hypertension (OR 2.30, p <0.001), diabetes (OR 1.62, p = 0.004), and previous MI (OR 1.96, p = 0.001) were independently associated with LVH. In conclusion, patients with NVAF have a high prevalence of LVH, which is related to female gender, older age, hypertension, and previous MI. These patients are at high thromboembolic risk and deserve a holistic approach to cardiovascular prevention

Correction to: Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

none372In the original publication, one of the ARAPACIS collaborators Dr. “Leonardo Di Gennaro” name has been erroneously mentioned as “Leonardo De Gennaro”.noneRaparelli V.; Pastori D.; Pignataro S.F.; Vestri A.R.; Pignatelli P.; Cangemi R.; Proietti M.; Davi G.; Hiatt W.R.; Lip G.Y.H.; Corazza G.R.; Perticone F.; Violi F.; Basili S.; Alessandri C.; Serviddio G.; Palange P.; Greco E.; Bruno G.; Averna M.; Giammanco A.; Sposito P.; DeCristofaro R.; Carulli L.; DiGennaro L.; Pellegrini E.; Cominacini L.; Mozzini C.; Pasini A.F.; Sprovieri M.; Spagnuolo V.; Cerqua G.; Cerasola G.; Mule G.; Barbagallo M.; Lo Sciuto S.; Monteverde A.; Saitta A.; Lo Gullo A.; Malatino L.; Cilia C.; Terranova V.; Pisano M.; Pinto A.; DiRaimondo D.; Tuttolomondo A.; Conigliaro R.; Signorelli S.; DePalma D.; Galderisi M.; Cudemo G.; Galletti F.; Fazio V.; DeLuca N.; Meccariello A.; Caputo D.; DeDonato M.T.; Iannuzi A.; Bresciani A.; Giunta R.; Utili R.; Iorio V.; Adinolfi L.E.; Sellitto C.; Iuliano N.; Bellis P.; Tirelli P.; Sacerdoti D.; Vanni D.; Iuliano L.; Ciacciarelli M.; Pacelli A.; Palazzuoli A.; Cacciafesta M.; Gueli N.; Lo Iacono C.; Brusco S.; Verrusio W.; Nobili L.; Tarquinio N.; Pellegrini F.; Vincentelli G.M.; Ravallese F.; Santini C.; Letizia C.; Petramala L.; Zinnamosca L.; Minisola S.; Cilli M.; Colangelo L.; Falaschi P.; Martocchia A.; Pastore F.; Bertazzoni G.; Attalla El Halabieh E.; Paradiso M.; Lizzi E.M.; Timmi S.; Battisti P.; Cerci S.; Ciavolella M.; DiVeroli C.; Malci F.; DeCiocchis A.; Abate D.; Castellino P.; Zanoli L.; Fidone F.; Mannarino E.; Pasqualini L.; Oliverio G.; Pende A.; Artom N.; Ricchio R.; Fimognari F.L.; Alletto M.; Messina S.; Sesti G.; Arturi F.; Succurro E.; Fiorentino T.V.; Pedace E.; Scarpino P.E.; Carullo G.; Maio R.; Sciacqua A.; Frugiuele P.; Battaglia G.; Atzori S.; Delitala G.; Angelucci E.; Sestili S.; Traisci G.; DeFeudis L.; DiMichele D.; Fava A.; Balsano C.; DeCiantis P.; Desideri G.; Camerota A.; Mezzetti M.; Gresele P.; Vedovati C.; Fierro T.; Puccetti L.; Bertolotti M.; Mussi C.; Boddi M.; Savino A.; Contri S.; Degl'Innocenti G.; Saller A.; Fabris F.; Pesavento R.; Filippi L.; Vedovetto V.; Puato M.; Treleani M.; DeLuca E.; DeZaiacomo F.; Giantin V.; Semplicini A.; Minuz P.; Romano S.; Fantin F.; Manica A.; Stockner I.; Pattis P.; Gutmann B.; Catena C.; Colussi G.; Sechi L.A.; Annoni G.; Bruni A.A.; Castagna A.; Spinelli D.; Miceli E.; Padula D.; Schinco G.; Spreafico S.; Secchi B.; Vanoli M.; Casella G.; Pulixi E.A.; Sansone L.; Serra M.G.; Longo S.; Antonaci S.; Belfiore A.; Frualdo M.; Palasciano G.; Ricci L.; Ventrella F.; Bianco C.; Santovito D.; Cipollone F.; Nicolai S.; Salvati F.; Rini G.B.; Scozzari F.; Muiesan M.L.; Salvetti M.; Bazza A.; Picardi A.; Vespasiani-Gentilucci U.; DeVincentis A.; Cosio P.; Terzolo M.; Madaffari B.; Parasporo B.; Fenoglio L.; Bracco C.; Melchio R.; Gentili T.; Salvi A.; Nitti C.; Gabrielli A.; Martino G.P.; Capucci A.; Brambatti M.; Sparagna A.; Tirotta D.; Andreozzi P.; Ettorre E.; Viscogliosi G.; Servello A.; Musumeci M.; Delfino M.; Giorgi A.; Glorioso N.; Melis G.; Marras G.; Matta M.; Sacco A.; Stellitano E.; Scordo A.; Russo F.; Caruso A.A.; Porreca E.; Tana M.; Ferri C.; Cheli P.; Portincasa P.; Muscianisi G.; Giordani S.; Stanghellini V.; Sabba C.; Mancuso G.; Bartone M.; Calipari D.; Arcidiacono G.; Bellanuova I.; Ferraro M.; Marigliano G.; Cozzolino D.; Lampitella A.; Acri V.; Galasso D.; Mazzei F.; Buratti A.; Galasso S.; Porta M.; Brizzi M.F.; Fattorini A.; Sampietro F.; D'Angelo A.; Manfredini R.; Pala M.; Fabbian F.; Moroni C.; Valente L.; Lopreiato F.; Parente F.; Granata M.; Moia M.; Braham S.; Rossi M.; Pesce M.; Gentile A.; Catozzo V.; Baciarello G.; Cosimati A.; Ageno W.; Rancan E.; Guasti L.; Ciccaglioni A.; Negri S.; Polselli M.; Prisco D.; Marcucci R.; Ferro D.; Perri L.; Saliola M.; DelBen M.; Angelico F.; Baratta F.; Migliacci R.; Porciello G.; Corrao S.; Napoleone L.; Talerico G.; Amoroso D.; Romiti G.F.; Ruscio E.; Toriello F.; Sperduti N.; Todisco T.; DiTanna G.; Sacchetti M.L.; Puddu P.E.; Farcomeni A.; Anzaldi M.; Bazzini C.; Bianchi P.I.; Boari B.; Buonauro A.; Butta C.; Buzzetti E.; Calabria S.; Capeci W.; Caradio F.; Carleo P.; Carrabba M.D.; Castorani L.; Cecchetto L.; Cicco S.; Cimini C.; Colombo B.M.; De Giorgi A.; DeVuono S.; DelCorso L.; Denegri A.; DiGiosia P.; Durante Mangoni E.; Falsetti L.; Forgione A.; Giorgini P.; Grassi D.; Grembiale A.; Hijazi D.; Iamele L.; Lorusso G.; Marchese A.; Marra A.M.; Masala M.; Miceli G.; Montebianco Abenavoli L.; Murgia G.; Naccarato P.; Pattoneri P.; Perego F.; Pesce P.; Piano S.; Pinna M.; Pinto D.; Pretti V.; Pucci G.; Salinaro F.; Salzano A.; Santilli F.; Scarpini F.; Scicali R.; Sirico D.; Suppressa P.; Talia M.; Tassone E.J.; Torres D.; Vazzana N.; Vecchio C.R.; Vidili G.; Vitale F.; Zaccone V.Raparelli, V.; Pastori, D.; Pignataro, S. F.; Vestri, A. R.; Pignatelli, P.; Cangemi, R.; Proietti, M.; Davi, G.; Hiatt, W. R.; Lip, G. Y. H.; Corazza, G. R.; Perticone, F.; Violi, F.; Basili, S.; Alessandri, C.; Serviddio, G.; Palange, P.; Greco, E.; Bruno, G.; Averna, M.; Giammanco, A.; Sposito, P.; Decristofaro, R.; Carulli, L.; Digennaro, L.; Pellegrini, E.; Cominacini, L.; Mozzini, C.; Pasini, A. F.; Sprovieri, M.; Spagnuolo, V.; Cerqua, G.; Cerasola, G.; Mule, G.; Barbagallo, M.; Lo Sciuto, S.; Monteverde, A.; Saitta, A.; Lo Gullo, A.; Malatino, L.; Cilia, C.; Terranova, V.; Pisano, M.; Pinto, A.; Diraimondo, D.; Tuttolomondo, A.; Conigliaro, R.; Signorelli, S.; Depalma, D.; Galderisi, M.; Cudemo, G.; Galletti, F.; Fazio, V.; Deluca, N.; Meccariello, A.; Caputo, D.; Dedonato, M. T.; Iannuzi, A.; Bresciani, A.; Giunta, R.; Utili, R.; Iorio, V.; Adinolfi, L. E.; Sellitto, C.; Iuliano, N.; Bellis, P.; Tirelli, P.; Sacerdoti, D.; Vanni, D.; Iuliano, L.; Ciacciarelli, M.; Pacelli, A.; Palazzuoli, A.; Cacciafesta, M.; Gueli, N.; Lo Iacono, C.; Brusco, S.; Verrusio, W.; Nobili, L.; Tarquinio, N.; Pellegrini, F.; Vincentelli, G. M.; Ravallese, F.; Santini, C.; Letizia, C.; Petramala, L.; Zinnamosca, L.; Minisola, S.; Cilli, M.; Colangelo, L.; Falaschi, P.; Martocchia, A.; Pastore, F.; Bertazzoni, G.; Attalla El Halabieh, E.; Paradiso, M.; Lizzi, E. M.; Timmi, S.; Battisti, P.; Cerci, S.; Ciavolella, M.; Diveroli, C.; Malci, F.; Deciocchis, A.; Abate, D.; Castellino, P.; Zanoli, L.; Fidone, F.; Mannarino, E.; Pasqualini, L.; Oliverio, G.; Pende, A.; Artom, N.; Ricchio, R.; Fimognari, F. L.; Alletto, M.; Messina, S.; Sesti, G.; Arturi, F.; Succurro, E.; Fiorentino, T. V.; Pedace, E.; Scarpino, P. E.; Carullo, G.; Maio, R.; Sciacqua, A.; Frugiuele, P.; Battaglia, G.; Atzori, S.; Delitala, G.; Angelucci, E.; Sestili, S.; Traisci, G.; Defeudis, L.; Dimichele, D.; Fava, A.; Balsano, C.; Deciantis, P.; Desideri, G.; Camerota, A.; Mezzetti, M.; Gresele, P.; Vedovati, C.; Fierro, T.; Puccetti, L.; Bertolotti, M.; Mussi, C.; Boddi, M.; Savino, A.; Contri, S.; Degl'Innocenti, G.; Saller, A.; Fabris, F.; Pesavento, R.; Filippi, L.; Vedovetto, V.; Puato, M.; Treleani, M.; Deluca, E.; Dezaiacomo, F.; Giantin, V.; Semplicini, A.; Minuz, P.; Romano, S.; Fantin, F.; Manica, A.; Stockner, I.; Pattis, P.; Gutmann, B.; Catena, C.; Colussi, G.; Sechi, L. A.; Annoni, G.; Bruni, A. A.; Castagna, A.; Spinelli, D.; Miceli, E.; Padula, D.; Schinco, G.; Spreafico, S.; Secchi, B.; Vanoli, M.; Casella, G.; Pulixi, E. A.; Sansone, L.; Serra, M. G.; Longo, S.; Antonaci, S.; Belfiore, A.; Frualdo, M.; Palasciano, G.; Ricci, L.; Ventrella, F.; Bianco, C.; Santovito, D.; Cipollone, F.; Nicolai, S.; Salvati, F.; Rini, G. B.; Scozzari, F.; Muiesan, M. L.; Salvetti, M.; Bazza, A.; Picardi, A.; Vespasiani-Gentilucci, U.; Devincentis, A.; Cosio, P.; Terzolo, M.; Madaffari, B.; Parasporo, B.; Fenoglio, L.; Bracco, C.; Melchio, R.; Gentili, T.; Salvi, A.; Nitti, C.; Gabrielli, A.; Martino, G. P.; Capucci, A.; Brambatti, M.; Sparagna, A.; Tirotta, D.; Andreozzi, P.; Ettorre, E.; Viscogliosi, G.; Servello, A.; Musumeci, M.; Delfino, M.; Giorgi, A.; Glorioso, N.; Melis, G.; Marras, G.; Matta, M.; Sacco, A.; Stellitano, E.; Scordo, A.; Russo, F.; Caruso, A. A.; Porreca, E.; Tana, M.; Ferri, C.; Cheli, P.; Portincasa, P.; Muscianisi, G.; Giordani, S.; Stanghellini, V.; Sabba, C.; Mancuso, G.; Bartone, M.; Calipari, D.; Arcidiacono, G.; Bellanuova, I.; Ferraro, M.; Marigliano, G.; Cozzolino, D.; Lampitella, A.; Acri, V.; Galasso, D.; Mazzei, F.; Buratti, A.; Galasso, S.; Porta, M.; Brizzi, M. F.; Fattorini, A.; Sampietro, F.; D'Angelo, A.; Manfredini, R.; Pala, M.; Fabbian, F.; Moroni, C.; Valente, L.; Lopreiato, F.; Parente, F.; Granata, M.; Moia, M.; Braham, S.; Rossi, M.; Pesce, M.; Gentile, A.; Catozzo, V.; Baciarello, G.; Cosimati, A.; Ageno, W.; Rancan, E.; Guasti, L.; Ciccaglioni, A.; Negri, S.; Polselli, M.; Prisco, D.; Marcucci, R.; Ferro, D.; Perri, L.; Saliola, M.; Delben, M.; Angelico, F.; Baratta, F.; Migliacci, R.; Porciello, G.; Corrao, S.; Napoleone, L.; Talerico, G.; Amoroso, D.; Romiti, G. F.; Ruscio, E.; Toriello, F.; Sperduti, N.; Todisco, T.; Ditanna, G.; Sacchetti, M. L.; Puddu, P. E.; Farcomeni, A.; Anzaldi, M.; Bazzini, C.; Bianchi, P. I.; Boari, B.; Buonauro, A.; Butta, C.; Buzzetti, E.; Calabria, S.; Capeci, W.; Caradio, F.; Carleo, P.; Carrabba, M. D.; Castorani, L.; Cecchetto, L.; Cicco, S.; Cimini, C.; Colombo, B. M.; De Giorgi, A.; Devuono, S.; Delcorso, L.; Denegri, A.; Digiosia, P.; Durante Mangoni, E.; Falsetti, L.; Forgione, A.; Giorgini, P.; Grassi, D.; Grembiale, A.; Hijazi, D.; Iamele, L.; Lorusso, G.; Marchese, A.; Marra, A. M.; Masala, M.; Miceli, G.; Montebianco Abenavoli, L.; Murgia, G.; Naccarato, P.; Pattoneri, P.; Perego, F.; Pesce, P.; Piano, S.; Pinna, M.; Pinto, D.; Pretti, V.; Pucci, G.; Salinaro, F.; Salzano, A.; Santilli, F.; Scarpini, F.; Scicali, R.; Sirico, D.; Suppressa, P.; Talia, M.; Tassone, E. J.; Torres, D.; Vazzana, N.; Vecchio, C. R.; Vidili, G.; Vitale, F.; Zaccone, V

Correction to: Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study (Internal and Emergency Medicine, (2018), 13, 5, (651-660), 10.1007/s11739-018-1835-9)

In the original publication, one of the ARAPACIS collaborators Dr. “Leonardo Di Gennaro” name has been erroneously mentioned as “Leonardo De Gennaro”

Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease : the ARAPACIS study

Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0&nbsp;months follow-up, 186 patients experienced MACE: vascular death (n\u2009=\u200972), MI (n\u2009=\u200957), stroke/TIA (n\u2009=\u200957). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan-Meier curves show that NVAF patients with COPD are at higher risk for MACE (p\u2009&lt;\u20090.001), CV death (p\u2009&lt;\u20090.001) and all-cause death (p\u2009&lt;\u20090.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20-2.61; p\u2009=\u20090.004), CV death (HR 2.73, 95% CI 1.76-4.23; p\u2009&lt;\u20090.0001) and all-cause death (HR 2.16, 95% CI 1.48-3.16; p\u2009&lt;\u20090.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients