A severe case of lipoatrophy due to human insulin and insulin analogs in a patient with diabetes: is an immunological mechanism involved?

The precipitin technique has been used in insulin resistance and immunity studies since the 1940s [7]. In the case described, the technique proved, once again, to be a valid method for choosing the most appropriate insulin. However, whether or not an immunological mechanism was involved in the lipoatrophic process remains uncertain, and further studies with adequate immunological assessment are necessary

The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line

Background: The lateral line system in zebrafish is composed of a series of organs called neuromasts, which are distributed over the body surface. Neuromasts contain clusters of hair cells, surrounded by accessory cells. Results: In this report we describe zebrafish prox1 mRNA expression in the migrating primordium and in the neuromasts of the posterior lateral line. Furthermore, using an antibody against Prox1 we characterize expression of the protein in different cell types within neuromasts, and we show distribution among the supporting cells and hair cells. Conclusion: Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts

Green manure in coffee systems in the region of Zona da Mata, Minas Gerais: characteristics and kinetics of carbon and nitrogen mineralization.

The use of green manure may contribute to reduce soil erosion and increase the soil organic matter content and N availability in coffee plantations in the Zona da Mata, State of Minas Gerais, in Southeastern Brazil. The potential of four legumes (A. pintoi, C. mucunoides, S. aterrimum and S. guianensis)to produce above-ground biomass, accumulate nutrients and mineralize N was studied in two coffee plantations of subsistence farmers under different climate conditions. The biomass production of C. mucunoides was influenced by the shade of the coffee plantation.C. mucunoides tended to mineralize more N than the other legumes due to the low polyphenol content and polyphenol/N ratio. In the first year, the crop establishment of A. pintoi in the area took longer than of the other legumes, resulting in lower biomass production and N2 fixation. In the long term, cellulose was the main factor controlling N mineralization. The biochemical characteristics, nutrient accumulation and biomass production of the legumes were greatly influenced by the altitude and position of the area relative to the sun

Liderazgo Personalista Integral. Un modelo para el liderazgo en las organizaciones

In the study of leadership ethics in organizations, a descriptive perspective predominates, which, based on the analysis of the leader’s behavior and empirical evidence, is partial and fragmented. A deeper understanding of this phenomenon requires solid anthropology, which explains the concept of the person that underlies it since how the leader conceives the person determines his leadership style and objectives. In this research, we made a literary review of Personalism to have a person’s systematic notion, which contemplates it in all its complexity. On this basis, we propose a model of Comprehensive Personalist Leadership, with an ethical and transcendent sense, in which the leader rethinks his priorities and strives to align the interests of people and the organization towards the common good.En el estudio de la ética del liderazgo en las organizaciones predomina una perspectiva descriptiva, que al fundamentarse en el análisis de las conductas del líder y en la evidencia empírica, es parcial y fragmentada. Una comprensión más profunda de este fenómeno requiere de una antropología sólida, que explique el concepto de persona que subyace en él, pues la manera en que el líder concibe a la persona determina su estilo de liderazgo y sus objetivos. En esta investigación se hace una revisión literaria del Personalismo, para disponer de una noción sistemática de la persona, que la contemple en toda su complejidad. Sobre esta base, se propone un modelo de Liderazgo Personalista Integral, con sentido ético y trascendente, en el que líder se replantea sus prioridades y se esfuerza por alinear los intereses de las personas y de la organización hacia el bien común

The ZZ' kinetic mixing in the light of the recent direct and indirect dark matter searches

Several constructions, of stringy origins or not, generate abelian gauge extensions of the Standard Model (SM). Even if the particles of the SM are not charged under this extra $U'(1)$, one cannot avoid the presence of a kinetic mixing between $U'(1)$ and the hypercharge $U_Y(1)$. In this work, we constraint drastically this kinetic mixing, taking into account the recent experimental data from accelerator physics, direct detection and indirect detection of dark matter. We show that the region respecting WMAP and experimental constraints is now very narrowed along the pole line where $M_{Z_D}\simeq 2 m_{DM}$, $Z_D$ being the gauge boson associated to the extra $U'(1)$.Comment: 9 pages, 3 figures, final version to appear in JCA

Is the determination of specific IgE against components using ISAC 112 a reproducible technique?

The allergen microarray immunoassay, ISAC 112, is a repeatable and reproducible in vitro diagnostic tool for determination of sIgE beyond the own laborator

A precise measurement of the magnetic field in the corona of the black hole binary V404 Cygni

Observations of binary stars containing an accreting black hole or neutron star often show x-ray emission extending to high energies (>10 kilo­–electron volts), which is ascribed to an accretion disk corona of energetic particles akin to those seen in the solar corona. Despite their ubiquity, the physical conditions in accretion disk coronae remain poorly constrained. Using simultaneous infrared, optical, x-ray, and radio observations of the Galactic black hole system V404 Cygni, showing a rapid synchrotron cooling event in its 2015 outburst, we present a precise 461 ± 12 gauss magnetic field measurement in the corona. This measurement is substantially lower than previous estimates for such systems, providing constraints on physical models of accretion physics in black hole and neutron star binary systems. This article has a correction. Please see: http://science.sciencemag.org/content/360/6386/eaat927

Search for composite and exotic fermions at LEP 2

A search for unstable heavy fermions with the DELPHI detector at LEP is reported. Sequential and non-canonical leptons, as well as excited leptons and quarks, are considered. The data analysed correspond to an integrated luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172 GeV and 161 GeV. The search for pair-produced new leptons establishes 95% confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2, depending on the channel. The search for singly produced excited leptons and quarks establishes upper limits on the ratio of the coupling of the excited fermio