Joint topology optimization, power control and spectrum allocation for intra-vehicular multi-hop sensor networks using dandelion-encoded heuristics

In the last years the interest in multi-hop communications has gained momentum within the research community due to the challenging characteristics of the intra-vehicular radio environment and the stringent robustness imposed on critical sensors within the vehicle. As opposed to point-to-point network topologies, multi-hop networking allows for an enhanced communication reliability at the cost of an additional processing overhead. In this context this manuscript poses a novel bi-objective optimization problem aimed at jointly minimizing (1) the average Bit Error Rate (BER) of sensing nodes under a majority fusion rule at the central data collection unit; and (2) the mean delay experienced by packets forwarded by such nodes due to multi-hop networking, frequency channel switching time multiplexing at intermediate nodes. The formulated paradigm is shown to be computationally tractable via a combination of evolutionary meta-heuristic algorithms and Dandelion codes, the latter capable of representing tree-like structures like those modeling the multi-hop routing approach. Simulations are carried out for realistic values of intra-vehicular radio channels and co-channel interference due to nearby IEEE 802.11 signals. The obtained results are promising and pave the way towards assessing the practical performance of the proposed scheme in real setups

Relation between health literacy, self-care and adherence to treatment with oral anticoagulants in adults: a narrative systematic review.

Background Oral anticoagulants (OAC) are widely used in patients with cardiovascular diseases. However, for optimal OAC self-care patients must have skills, among which health literacy (HL) is highlighted. We aimed to describe the relation between HL and self-care in cardiovascular patients on OAC treatment. Methods Electronic searches were carried out in the PubMed, Scopus, Embase, CINAHL, Web of Science, Cochrane Library, SciELO, IME-Biomedicina, CUIDEN Plus and LILACS databases, limited to Spanish and English language and between January 2000-December 2016. Papers reported on adults older than 18 years, taking OAC by themselves for at least three months. PRISMA guidelines were used for paper selection. Results We identified 142 articles and finally included 10; almost all of them about warfarin. Our results suggest that in patients taking OAC treatments there is a positive relationship between HL and the level of knowledge. In addition, a small percentage of participants on the selected papers recognized the side effects and complications associated with OAC treatment. Lower HL level was associated with greater knowledge deficits and less adherence to treatment. Conclusion There is a paucity of research evaluating the effect of HL on diverse aspects of OAC treatments. There is a need to expand the evidence base regarding appropriate HL screening tools, determinants of adequate knowledge and optimal behaviours related to OAC self-management

Chlamydia trachomatis heat shock proteins 60 and 10 induce apoptosis in endocervical epithelial cells

The potential role of chlamydial heat shock proteins (cHSP) 60 and cHSP10 in apoptosis of primary cervical epithelial cells was investigated

Dantrolene can reduce secondary damage after spinal cord injury

The aim of this experimental study was to investigate the possible protective effects of dantrolene on traumatic spinal cord injury (SCI). Twenty-four New Zealand rabbits were divided into three groups: Sham (no drug or operation, n = 8), Control (SCI + 1 mL saline intraperitoneally (i.p.), n = 8), and DNT (SCI + 10 mg/kg dantrolene in 1 mL, i.p., n = 8). Laminectomy was performed at T10 and balloon catheter was applied extradurally. Four and 24 h after surgery, rabbits were evaluated according to the Tarlov scoring system. Blood, cerebrospinal fluid and tissue sample from spinal cord were taken for measurements of antioxidant status or detection of apoptosis. After 4 h SCI, all animals in control or DNT-treated groups became paraparesic. Significant improvement was observed in DNT-treated group, 24 h after SCI, with respect to control. Traumatic SCI led to an increase in the lipid peroxidation and a decrease in enzymic or non-enzymic endogenous antioxidative defense systems, and increase in apoptotic cell numbers. DNT treatment prevented lipid peroxidation and augmented endogenous enzymic or non-enzymic antioxidative defense systems. Again, DNT treatment significantly decreased the apoptotic cell number induced by SCI. In conclusion, experimental results observed in this study suggest that treatment with dantrolene possess potential benefits for traumatic SCI