6,271 research outputs found
Extending the limits of globule detection -- ISOPHOT Serendipity Survey Observations of interstellar clouds
A faint MJysr bipolar globule was discovered with the
ISOPHOT 170 m Serendipity Survey (ISOSS). ISOSS J 20246+6541 is a cold
( K) FIR source without an IRAS pointsource counterpart.
In the Digitized Sky Survey B band it is seen as a 3\arcmin size bipolar
nebulosity with an average excess surface brightness of
mag/\arcsec . The CO column density distribution determined by
multi-isotopic, multi-level CO measurements with the IRAM-30m telescope agrees
well with the optical appearance. An average hydrogen column density of
cm was derived from both the FIR and CO data. Using a
kinematic distance estimate of 400 pc the NLTE modelling of the CO, HCO,
and CS measurements gives a peak density of cm. The
multiwavelength data characterise ISOSS 20246+6541 as a representative of a
class of globules which has not been discovered so far due to their small
angular size and low 100m brightness. A significant overabundance of
CO is found . This is likely due to
isotope selective chemical processes.Comment: 5 pages, 3 figure
The first CCD photometric study of the open cluster NGC 2126
We present the first CCD photometric observations of the northern open
cluster NGC 2126. Data were taken on eight nights in February and December 2002
with a total time span of ~57 hours. Almost 1000 individual V-band frames were
examined to find short-period variable stars. We discovered six new variable
stars, of which one is a promising candidate for an eclipsing binary with a
pulsating component. Two stars were classified as delta Scuti stars and one as
Algol-type eclipsing binary. Two stars are slow variables with ambiguous
classification. From absolute VRI photometry we have estimated the main
characteristics of the cluster: m-M=11.0+/-0.5, E(V-I)=0.4+/-0.1,
E(V-R)=0.08+/-0.06 (E(B-V)=0.2+/-0.15) and d=1.3+/-0.6 kpc. Cluster membership
is suggested for three variable stars from their positions on the
colour-magnitude diagram.Comment: 7 pages, 10 figures, accepted for publication in A&
Cold-induced vasoconstriction at forearm and hand skin sites: the effect of age
During mild cold exposure, elderly are at risk of hypothermia. In humans, glabrous skin at the hands is well adapted as a heat exchanger. Evidence exists that elderly show equal vasoconstriction due to local cooling at the ventral forearm, yet no age effects on vasoconstriction at hand skin have been studied. Here, we tested the hypotheses that at hand sites (a) elderly show equal vasoconstriction due to local cooling and (b) elderly show reduced response to noradrenergic stimuli. Skin perfusion and mean arterial pressure were measured in 16 young adults (Y: 18–28 years) and 16 elderly (E: 68–78 years). To study the effect of local vasoconstriction mechanisms local sympathetic nerve terminals were blocked by bretylium (BR). Baseline local skin temperature was clamped at 33°C. Next, local temperature was reduced to 24°C. After 15 min of local cooling, noradrenalin (NA) was administered to study the effect of neural vasoconstriction mechanisms. No significant age effect was observed in vasoconstriction due to local cooling at BR sites. After NA, vasoconstriction at the forearm showed a significant age effect; however, no significant age effect was found at the hand sites. [Change in CVC (% from baseline): Forearm Y: −76 ± 3 vs. E: −60 ± 5 (P < 0.01), dorsal hand Y: −74 ± 4 vs. E: −72 ± 4 (n.s.), ventral hand Y: −80 ± 7 vs. E: −70 ± 11 (n.s.)]. In conclusion, in contrast to results from the ventral forearm, elderly did not show a blunted response to local cooling and noradrenalin at hand skin sites. This indicates that at hand skin the noradrenergic mechanism of vasoconstriction is maintained with age
Taking connected mobile-health diagnostics of infectious diseases to the field.
Mobile Health or mHealth - The application of mobile devices, their components and related technologies to healthcare is improving patients’ access to treatment and advice. Now, in combination with connected diagnostic devices it offers new possibilities to diagnose, track and control infectious diseases and improve health system efficiencies. In this context we look at these technologies and highlight their promise but also the challenges in realising their potential to increase patient access to testing, aid in their treatment and improve the capability of public health authorities to monitor outbreaks, implement responses, and assess the impact of interventions across the world
Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design
Background TNK-S2B, an innovative, randomized,
seamless phase II/III trial of tenecteplase versus rt-PA for
acute ischemic stroke, terminated for slow enrollment before regulatory approval
of use of phase II patients in phase III
The Rise and Peak of the Luminous Type IIn SN 2017hcc/ATLAS17lsn from ASAS-SN and Swift UVOT Data
We present observations of the rise and peak of the Type IIn supernova SN 2017hcc/ATLAS17lsn obtained by the All-Sky Automated Survey for Supernovae (ASAS-SN) and Swift UVOT. The light curve of SN 2017hcc/ATLAS17lsn peaks at mag, which from the estimated redshift of the host galaxy (, Mpc) implies an absolute peak magnitude mag. The near-UV to optical spectral energy distribution of SN 2017hcc/ATLAS17lsn from Swift UVOT is consistent with a hot, but cooling blackbody with K on Oct. 28.4 and K on Nov. 19.6. The estimated peak bolometric luminosity erg s makes SN2017hcc/ATLAS17lsn one of the most luminous Type IIn supernovae studied to date. From the bolometric light curve we constrain the risetime to be days and the total radiated energy of the event to date is erg
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Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent transmission and block infection in animal models. But despite the identification of resistance mechanisms in P. falciparum, the mode of action of IZPs remains unknown. To investigate, we here combine in vitro evolution and genome analysis in Saccharomyces cerevisiae with molecular, metabolomic, and chemogenomic methods in P. falciparum. Our findings reveal that IZP-resistant S. cerevisiae clones carry mutations in genes involved in Endoplasmic Reticulum (ER)-based lipid homeostasis and autophagy. In Plasmodium, IZPs inhibit protein trafficking, block the establishment of new permeation pathways, and cause ER expansion. Our data highlight a mechanism for blocking parasite development that is distinct from those of standard compounds used to treat malaria, and demonstrate the potential of IZPs for studying ER-dependent protein processing
Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus
Pyrethroid resistance in Anopheles funestus is threatening malaria control in Africa. Elucidation of underlying resistance mechanisms is crucial to improve the success of future control programs. A positional cloning approach was used to identify genes conferring resistance in the uncharacterised rp2 quantitative trait locus (QTL) previously detected in this vector using F6 advanced intercross lines (AIL). A 113 kb BAC clone spanning rp2 was identified and sequenced revealing a cluster of 15 P450 genes and one salivary protein gene (SG7-2). Contrary to A. gambiae, AfCYP6M1 is triplicated in A. funestus, while AgCYP6Z2 orthologue is absent. Five hundred and sixty-five new single nucleotide polymorphisms (SNPs)were identified for genetic mapping from rp2 P450s and other genes revealing high genetic polymorphisms with one SNP every 36 bp. A significant genotype/phenotype association was detected for rp2 P450s but not for a cluster of cuticular
protein genes previously associated with resistance in A. gambiae. QTL mapping using F6 AIL confirms the rp2 QTL with
an increase logarithm of odds score of 5. Multiplex gene expression profiling of 15 P450s and other genes around rp2
followed by individual validation using qRT–PCR indicated a significant overexpression in the resistant FUMOZ-R strain of the P450s AfCYP6Z1, AfCYP6Z3, AfCYP6M7 and the glutathione-s-transferase GSTe2 with respective fold change of 11.2,6.3, 5.5 and 2.8. Polymorphisms analysis of AfCYP6Z1 and AfCYP6Z3 identified amino acid changes potentially associated with resistance further indicating that these genes are controlling the pyrethroid resistance explained by the rp2 QTL. The characterisation of this rp2 QTL significantly improves our understanding of resistance mechanisms in A. funestus
Haemoptysis in pregnancy caused by a well-differentiated fetal adenocarcinoma: a case report
<p>Abstract</p> <p>Introduction</p> <p>Haemoptysis in pregnancy is frequently assumed to be caused by a pulmonary embolism. However, it can also be an indicator of serious pathology.</p> <p>Case presentation</p> <p>We report the case of a 27-year-old Caucasian woman who presented with haemoptysis in pregnancy that was discovered to be caused by a well-differentiated fetal adenocarcinoma of the lung.</p> <p>Conclusion</p> <p>This case demonstrates the importance of establishing an accurate diagnosis when a pregnant woman presents with haemoptysis and that more serious pathology should be considered if the clinical symptoms persist and/or the presumed diagnosis of pulmonary embolism is not confirmed.</p
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