374 research outputs found
Heterotic Sigma Models with N=2 Space-Time Supersymmetry
We study the non-linear sigma model realization of a heterotic vacuum with
N=2 space-time supersymmetry. We examine the requirements of (0,2) + (0,4)
world-sheet supersymmetry and show that a geometric vacuum must be described by
a principal two-torus bundle over a K3 manifold.Comment: 20 pages, uses xy-pic; v3: typos corrected, reference added,
discussion of constraints on Hermitian form modifie
Defining human-machine micro-task workflows for constitution making
This paper presents a novel task-oriented approach to crowdsource the drafting of a constitution. By considering micro-tasking as a particular form of crowdsourcing, it defines a workflow-based approach based on Onto2Flow, an ontology that models the basic concepts and roles to represent workflow-definitions. The approach is then applied to a prototype platform for constitution-making where human workers are requested to contribute to a set of tasks. The paper concludes by discussing previous approaches to participatory constitution-making and identifying areas for future work.This work is part-funded by FEDER Funds, by the ERDF (European Regional Development Fund) through the COMPETE Programme (Operational Programme for Competitiveness) and by National Funds through the
FCT (Portuguese Foundation for Science and Technology) within the project FCOMP-01-0124-FEDER-028980 (PTDC/EEI-SII/1386/2012). The work of Nuno Luz is supported by the doctoral grant SFRH/BD/70302/2010. The work of Marta Poblet draws from previous research within the framework of the project “Crowdsourcing: instrumentos semánticos para el desarrollo de la participación y la mediación online” (DER 2012-39492-C02-01) by the Spanish Ministry of Economy and Competitiveness.info:eu-repo/semantics/publishedVersio
Gauge and Supersymmetric Invariance of a Boundary Bagger-Lambert-Gustavsson Theory
In this paper we will discuss the effect of a having a boundary on the
supersymmetric invariance and gauge invariance of the Bagger-Lambert-Gustavsson
(BLG) Theory. We will show that even though the supersymmetry and gauge
invariance of the original BLG theory is broken due to the presence of a
boundary, it restored by the addition of suitable boundary terms. In fact, to
achieve the gauge invariance of this theory, we will have to introduce new
boundary degrees of freedom. The boundary theory obeyed by these new boundary
degrees of freedom will be shown to be a generalization of the gauged
Wess-Zumino-Witten model, with the generators of the Lie algebra replaced by
the generators of the Lie 3-algebra. The gauge and supersymmetry variations of
the boundary theory will exactly cancel the boundary terms generated by the
gauge and supersymmetric variations of the bulk theory.Comment: 15 pages, 0 figures, accepted for publication in JHE
Fermions and Type IIB Supergravity On Squashed Sasaki-Einstein Manifolds
We discuss the dimensional reduction of fermionic modes in a recently found
class of consistent truncations of type IIB supergravity compactified on
squashed five-dimensional Sasaki-Einstein manifolds. We derive the lower
dimensional equations of motion and effective action, and comment on the
supersymmetry of the resulting theory, which is consistent with N=4 gauged
supergravity in , coupled to two vector multiplets. We compute fermion
masses by linearizing around two vacua of the theory: one that breaks
N=4 down to N=2 spontaneously, and a second one which preserves no
supersymmetries. The truncations under consideration are noteworthy in that
they retain massive modes which are charged under a U(1) subgroup of the
-symmetry, a feature that makes them interesting for applications to
condensed matter phenomena via gauge/gravity duality. In this light, as an
application of our general results we exhibit the coupling of the fermions to
the type IIB holographic superconductor, and find a consistent further
truncation of the fermion sector that retains a single spin-1/2 mode.Comment: 43 pages, 2 figures, PDFLaTeX; v2: added references, typos corrected,
minor change
The Worldvolume Action of Kink Solitons in AdS Spacetime
A formalism is presented for computing the higher-order corrections to the
worldvolume action of co-dimension one solitons. By modifying its potential, an
explicit "kink" solution of a real scalar field in AdS spacetime is found. The
formalism is then applied to explicitly compute the kink worldvolume action to
quadratic order in two expansion parameters--associated with the hypersurface
fluctuation length and the radius of AdS spacetime respectively. Two
alternative methods are given for doing this. The results are expressed in
terms of the trace of the extrinsic curvature and the intrinsic scalar
curvature. In addition to conformal Galileon interactions, we find a
non-Galileon term which is never sub-dominant. This method can be extended to
any conformally flat bulk spacetime.Comment: 32 pages, 3 figures, typos corrected and additional comments adde
A combined transmission spectrum of the Earth-sized exoplanets TRAPPIST-1 b and c
Three Earth-sized exoplanets were recently discovered close to the habitable
zone of the nearby ultracool dwarf star TRAPPIST-1. The nature of these planets
has yet to be determined, since their masses remain unmeasured and no
observational constraint is available for the planetary population surrounding
ultracool dwarfs, of which the TRAPPIST-1 planets are the first transiting
example. Theoretical predictions span the entire atmospheric range from
depleted to extended hydrogen-dominated atmospheres. Here, we report a
space-based measurement of the combined transmission spectrum of the two inner
planets made possible by a favorable alignment resulting in their simultaneous
transits on 04 May 2016. The lack of features in the combined spectrum rules
out cloud-free hydrogen-dominated atmospheres for each planet at 10-
levels; TRAPPIST-1 b and c are hence unlikely to harbor an extended gas
envelope as they lie in a region of parameter space where high-altitude
cloud/haze formation is not expected to be significant for hydrogen-dominated
atmospheres. Many denser atmospheres remain consistent with the featureless
transmission spectrum---from a cloud-free water vapour atmosphere to a
Venus-like atmosphere.Comment: Early release to inform further the upcoming review of HST's Cycle 24
proposal
Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain
Participatory Epidemiology: Use of Mobile Phones for Community-Based Health Reporting
Clark Freifeld and colleagues discuss mobile applications, including their own smartphone application, that show promise for health monitoring and information sharing
Activation Status of Wnt/ß-Catenin Signaling in Normal and Neoplastic Breast Tissues: Relationship to HER2/neu Expression in Human and Mouse
Wnt/ß-catenin signaling is strongly implicated in neoplasia, but the role of this pathway in human breast cancer has been controversial. Here, we examined Wnt/ß-catenin pathway activation as a function of breast cancer progression, and tested for a relationship with HER2/neu expression, using a human tissue microarray comprising benign breast tissues, ductal carcinoma in situ (DCIS), and invasive carcinomas. Cores were scored for membranous ß-catenin, a key functional component of adherens junctions, and for nucleocytoplasmic ß-catenin, a hallmark of Wnt/ß-catenin pathway activation. Only 82% of benign samples exhibited membrane-associated ß-catenin, indicating a finite frequency of false-negative staining. The frequency of membrane positivity was similar in DCIS samples, but was significantly reduced in carcinomas (45%, P<0.001), consistent with loss of adherens junctions during acquisition of invasiveness. Negative membrane status in cancers correlated with higher grade (P = 0.04) and estrogen receptor-negative status (P = 0.03), both indices of poor prognosis. Unexpectedly, a substantial frequency of nucleocytoplasmic ß-catenin was observed in benign breast tissues (36%), similar to that in carcinomas (35%). Positive-staining basal nuclei observed in benign breast may identify putative stem cells. An increased frequency of nucleocytoplasmic ß-catenin was observed in DCIS tumors (56%), suggesting that pathway activation may be an early event in human breast neoplasia. A correlation was observed between HER2/neu expression and nucleocytoplasmic ß-catenin in node-positive carcinomas (P = 0.02). Furthermore, cytoplasmic ß-catenin was detected in HER2/neu-induced mouse mammary tumors. The Axin2NLSlacZ mouse strain, a previously validated reporter of mammary Wnt/ß-catenin signaling, was utilized to define in vivo transcriptional consequences of HER2/neu-induced ß-catenin accumulation. Discrete hyperplastic foci observed in mammary glands from bigenic MMTV/neu, Axin2NLSlacZ mice, highlighted by robust ß-catenin/TCF signaling, likely represent the earliest stage of mammary intraepithelial neoplasia in MMTV/neu mice. Our study thus provides provocative evidence for Wnt/ß-catenin signaling as an early, HER2/neu-inducible event in breast neoplasia
Socioeconomic Status Is Not Related with Facial Fluctuating Asymmetry: Evidence from Latin-American Populations
The expression of facial asymmetries has been recurrently related with poverty and/or disadvantaged socioeconomic status. Departing from the developmental instability theory, previous approaches attempted to test the statistical relationship between the stress experienced by individuals grown in poor conditions and an increase in facial and corporal asymmetry. Here we aim to further evaluate such hypothesis on a large sample of admixed Latin Americans individuals by exploring if low socioeconomic status individuals tend to exhibit greater facial fluctuating asymmetry values. To do so, we implement Procrustes analysis of variance and Hierarchical Linear Modelling (HLM) to estimate potential associations between facial fluctuating asymmetry values and socioeconomic status. We report significant relationships between facial fluctuating asymmetry values and age, sex, and genetic ancestry, while socioeconomic status failed to exhibit any strong statistical relationship with facial asymmetry. These results are persistent after the effect of heterozygosity (a proxy for genetic ancestry) is controlled in the model. Our results indicate that, at least on the studied sample, there is no relationship between socioeconomic stress (as intended as low socioeconomic status) and facial asymmetries
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