Where are the missing gamma ray burst redshifts?

In the redshift range z = 0-1, the gamma ray burst (GRB) redshift distribution should increase rapidly because of increasing differential volume sizes and strong evolution in the star formation rate. This feature is not observed in the Swift redshift distribution and to account for this discrepancy, a dominant bias, independent of the Swift sensitivity, is required. Furthermore, despite rapid localization, about 40-50% of Swift and pre-Swift GRBs do not have a measured redshift. We employ a heuristic technique to extract this redshift bias using 66 GRBs localized by Swift with redshifts determined from absorption or emission spectroscopy. For the Swift and HETE+BeppoSAX redshift distributions, the best model fit to the bias in z < 1 implies that if GRB rate evolution follows the SFR, the bias cancels this rate increase. We find that the same bias is affecting both Swift and HETE+BeppoSAX measurements similarly in z < 1. Using a bias model constrained at a 98% KS probability, we find that 72% of GRBs in z < 2 will not have measurable redshifts and about 55% in z > 2. To achieve this high KS probability requires increasing the GRB rate density in small z compared to the high-z rate. This provides further evidence for a low-luminosity population of GRBs that are observed in only a small volume because of their faintness.Comment: 5 pages, submitted to MNRA

Probing the low-luminosity GRB population with new generation satellite detectors

We compare the detection rates and redshift distributions of low-luminosity (LL) GRBs localized by Swift with those expected to be observed by the new generation satellite detectors on GLAST (now Fermi) and, in future, EXIST. Although the GLAST burst telescope will be less sensitive than Swift's in the 15--150 keV band, its large field-of-view implies that it will double Swift's detection rate of LL bursts. We show that Swift, GLAST and EXIST should detect about 1, 2 & 30 LL GRBs, respectively, over a 5-year operational period. The burst telescope on EXIST should detect LL GRBs at a rate of more than an order of magnitude greater than that of Swift's BAT. We show that the detection horizon for LL GRBs will be extended from $z \simeq 0.4$ for Swift to $z \simeq 1.1$ in the EXIST era. Also, the contribution of LL bursts to the observed GRB redshift distribution will contribute to an identifiable feature in the distribution at $z \simeq 1$.Comment: 6 pages, 4 figures, accepted by MNRA

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis

Selective silencing of the cyclooxygenase-2 (COX-2) gene with the loss of the antifibrotic mediator PGE2 contributes to the fibrotic process in idiopathic pulmonary fibrosis (IPF). This study explored the role of G9a- and EZH2-mediated methylation of histone H3 lysine 9 (H3K9me3) and 27 (H3K27me3) in COX-2 silencing in IPF. Chromatin immunoprecipitation (ChIP) and Re-ChIP assays demonstrated marked increases in H3K9me3, H3K27me3 and DNA methylation, together with their respective modifying enzymes G9a, EZH2 and DNA methyltransferases (Dnmts) and respective binding proteins heterochromatin protein 1 (HP1), polycomb protein complex 1 (PRC1) and MeCP2, at the COX-2 promoter in lung fibroblasts from IPF patients (F-IPF) compared with fibroblasts from non-fibrotic lungs (F-NL). HP1, EZH2 and MeCP2 in turn were associated with additional repressive chromatin modifiers in F-IPF. G9a and EZH2 inhibitors and siRNAs and Dnmt1 inhibitor markedly reduced H3K9me3 (49-79%), H3K27me3 (44-81%) and DNA methylation (61-97%) at the COX-2 promoter. This was correlated with increased histone H3 and H4 acetylation, resulting in COX-2 mRNA and protein re-expression in F-IPF. Our results support a central role for G9a- and EZH2-mediated histone hypermethylation and a model of bidirectional, mutually reinforcing and interdependent crosstalk between histone hypermethylation and DNA methylation in COX-2 epigenetic silencing in IPF

Mechanisms controlling primary and new production in a global ecosystem model ? Part I: The role of the large-scale upper mixed layer variability

International audienceA global general circulation model coupled to a simple six-compartment ecosystem model is used to study the extent to which global variability in primary and export production can be realistically predicted on the basis of advanced parameterizations of upper mixed layer physics, without recourse to introducing extra complexity in model biology. The ''K profile parameterization'' (KPP) scheme employed, combined with 6-hourly external forcing, is able to capture short-term periodic and episodic events such as diurnal cycling and storm-induced deepening. The model realistically reproduces various features of global ecosystem dynamics that have been problematic in previous global modelling studies, using a single generic parameter set. The realistic simulation of deep convection in the North Atlantic, and lack of it in the North Pacific and Southern Oceans, leads to good predictions of chlorophyll and primary production in these contrasting areas. Realistic levels of primary production are predicted in the oligotrophic gyres due to high frequency external forcing of the upper mixed layer (accompanying paper Popova et al., 2006) and novel parameterizations of zooplankton excretion. Good agreement is shown between model and observations at various JFOFS time series sites: BATS, KERFIX, Papa and station India. One exception is that the high zooplankton grazing rates required to maintain low chlorophyll in high-nutrient low-chlorophyll and oligotrophic systems lessened agreement between model and data in the northern North Atlantic, where mesozooplankton with lower grazing rates may be dominant. The model is therefore not globally robust in the sense that additional parameterizations were needed to realistically simulate ecosystem dynamics in the North Atlantic. Nevertheless, the work emphasises the need to pay particular attention to the parameterization of mixed layer physics in global ocean ecosystem modelling as a prerequisite to increasing the complexity of ecosystem models

Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism

Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing α4 and β2 subunits (α4β2*) functionally interact with G-protein-coupled dopamine (DA) D_2 receptors in basal ganglia. We hypothesized that if a functional interaction between these receptors exists, then mice expressing an M2 point mutation (Leu9'Ala) rendering 4 nAChRs hypersensitive to ACh may exhibit altered sensitivity to a D_2-receptor agonist. When challenged with the D_(2)R agonist, quinpirole (0.5–10 mg/kg), Leu9'Ala mice, but not wild-type (WT) littermates, developed severe, reversible motor impairment characterized by rigidity, catalepsy, akinesia, and tremor. While striatal DA tissue content, baseline release, and quinpirole-induced DA depletion did not differ between Leu9'Ala and WT mice, quinpirole dramatically increased activity of cholinergic striatal interneurons only in mutant animals, as measured by increased c-Fos expression in choline acetyltransferase (ChAT)-positive interneurons. Highlighting the importance of the cholinergic system in this mouse model, inhibiting the effects of ACh by blocking muscarinic receptors, or by selectively activating hypersensitive nAChRs with nicotine, rescued motor symptoms. This novel mouse model mimics the imbalance between striatal DA/ACh function associated with severe motor impairment in disorders such as Parkinson’s disease, and the data suggest that a D_(2)R–α4*-nAChR functional interaction regulates cholinergic interneuron activity.—Zhao-Shea, R., Cohen, B. N., Just, H., McClure-Begley, T., Whiteaker, P., Grady, S. R., Salminen, O., Gardner, P. D., Lester, H. A., Tapper, A. R. Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive α4 nicotinic receptors via a cholinergic-dependent mechanism

The Unseen Face of E-Business Project Development

The purpose of this paper is intent on identify and analyze the unseen factors of successful or failure of e-business project development. The IT managers must take into account both all costs involved in e-business development and all phases (analysis, design, testing, implementation, maintenance and operation) according to principle of project management for software/systems life cycle development. There are many solutions to exceed these factors of failure among could be counted outsourcing, a good project management, involvement of senior management, a real cost estimation etc.Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 zostało dofinansowane ze środków MNiSW w ramach działalności upowszechniającej nauk

Gravitational wave background from sub-luminous GRBs: prospects for second and third generation detectors

We assess the detection prospects of a gravitational wave background associated with sub-luminous gamma-ray bursts (SL-GRBs). We assume that the central engines of a significant proportion of these bursts are provided by newly born magnetars and consider two plausible GW emission mechanisms. Firstly, the deformation-induced triaxial GW emission from a newly born magnetar. Secondly, the onset of a secular bar-mode instability, associated with the long lived plateau observed in the X-ray afterglows of many gamma-ray bursts (Corsi & Meszaros 2009a). With regards to detectability, we find that the onset of a secular instability is the most optimistic scenario: under the hypothesis that SL-GRBs associated with secularly unstable magnetars occur at a rate of (48; 80)Gpc^{-3}yr^{-1} or greater, cross-correlation of data from two Einstein Telescopes (ETs) could detect the GW background associated to this signal with a signal-to-noise ratio of 3 or greater after 1 year of observation. Assuming neutron star spindown results purely from triaxial GW emissions, we find that rates of around (130;350)Gpc^{-3}yr^{-1} will be required by ET to detect the resulting GW background. We show that a background signal from secular instabilities could potentially mask a primordial GW background signal in the frequency range where ET is most sen- sitive. Finally, we show how accounting for cosmic metallicity evolution can increase the predicted signal-to-noise ratio for background signals associated with SL-GRBs.Comment: Accepted by MNRA

Decay of eddies at the South-West Indian Ridge

The South-West Indian Ridge in the Indian sector of the Southern Ocean is a region recognised for the creation of particularly intense eddy disturbances in the mean flow of the Antarctic Circumpolar Current. Eddies formed at this ridge have been extensively studied over the past decade using hydrographic, satellite, drifter and float data and it is hypothesised that they could provide a vehicle for localised meridional heat and salt exchange. The effectiveness of this process is dependent on the rate of decay of the eddies. However, in order to investigate eddy decay, logistically difficult hydrographic monitoring is required. This study presents the decay of cold eddies at the South-West Indian Ridge, using outputs from a highresolution ocean model. The model's representation of the dynamic nature of this region is fully characteristic of observations. On average, 3-4 intense and well-defined cold eddies are generated per year; these eddies have mean longevities of 5.0±2.2 months with average advection speeds of 5±2 km/day. Most simulated eddies reach their peak intensity within 1.5-2.5 months after genesis and have depths of 2000 m - 3000 m. Thereafter they dissipate within approximately 3 months. The decay of eddies is generally characterised by a decrease in their sea surface height signature, a weakening in their rotation rates and a modification in their temperature-salinity characteristics. Subantarctic top predators are suspected to forage preferentially along the edges of eddies. The process of eddy dissipation may thus influence their feeding behaviour

Jizz and the joy of pattern recognition:virtuosity, discipline and the agency of insight in UK naturalists’ arts of seeing

Approaches to visual skilling from anthropology and STS have tended to highlight the forces of discipline and control in understanding how shared visual accounts of the world are created in the face of potential differences brought about by multi-sensorial perception. Drawing upon a range of observational and interview material from an immersion in naturalist training and biological recording activities between 2003 and 2009, I focus upon jizz, a distinct form of gestalt perception much coveted by naturalist communities in the UK. Jizz is described as a tacit and embodied way of seeing that instantaneously reveals the identity of a species, relying upon but simultaneously suspending the arduous and meticulous study of an organism’s diagnostic characteristics. I explore the potential and limitations of jizz to allow for both visual precision and an enchanted and varied form of encounter with nature. In so doing, I explore how the specific characteristics of wild, intangible and irreverent virtuoso performance work closely together with disciplining taxonomic standards. As such, discipline and irreverence work together, are mutually enabling, and allow for an accommodation rather than a segregation of potential difference brought about by perceptual variety