Reasonable ecstasies: Shaftesbury and the languages of libertinism

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Histories of Celebrity in Post-Revolutionary England

The history of celebrity has been revised in recent years. Particular claims have been made for the invention of a recognizably modern form of celebrity at various points in the ‘long 18th century.’ This putative rise of modern celebrity has been linked with the rise of a modern public sphere and in many ways is understood as an offshoot of it. Furthermore, modern celebrity is often presented as a commercial enterprise and perhaps another aspect of the equally popular claim that the 18th century witnessed a ‘consumer revolution.’ This essay argues that there is also a political history of celebrity that has its origins in traditional forms of charisma and public devotion to famous figures. The pre-modern histories of monarchy and sainthood are not irrelevant to the history of modern celebrity and these perspectives can and should be incorporated into any understanding of how celebrity emerged as a form of public notoriety and influence in the long 18th century

Special libraries: ten essential technologies

This report describes ten technologies of use in special libraries

A Simple Model for r-Process Scatter and Halo Evolution

Recent observations of heavy elements produced by rapid neutron capture (r-process) in the halo have shown a striking and unexpected behavior: within a single star, the relative abundances of r-process elements heavier than Eu are the same as the same as those of solar system matter, while across stars with similar metallicity Fe/H, the r/Fe ratio varies over two orders of magnitude. In this paper we present a simple analytic model which describes a star's abundances in terms of its ``ancestry,'' i.e., the number of nucleosynthesis events (e.g., supernova explosions) which contributed to the star's composition. This model leads to a very simple analytic expression for the abundance scatter versus Fe/H, which is in good agreement with the data and with more sophisticated numerical models. We investigate two classes of scenarios for r-process nucleosynthesis, one in which r-process synthesis events occur in only \sim 4% of supernovae but iron synthesis is ubiquitous, and one in which iron nucleosynthesis occurs in only about 9% of supernovae. (the Wasserburg- Qian model). We find that the predictions in these scenarios are similar for [Fe/H] \ga -2.5, but that these models can be readily distinguished observationally by measuring the dispersion in r/Fe at [Fe/H] \la -3.Comment: AASTeX, 21 pages, includes 4 figure

Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC–MS metabolomics

INTRODUCTION: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. OBJECTIVES: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys(10), Cys(13))) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obesity (DIO) C57BL6/J mice. METHODS: Untargeted LC-HRMS metabolomics experiments were carried out in ESI + mode with plasma extracts from both groups of animals. Data were normalised, multivariate and univariate statistical analysis performed and metabolites of interest putatively identified. RESULTS: In lean mice, 39 metabolites were significantly changed by obestatin treatment and the majority of these were increased, including various C16 and C18 moieties of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and monoacylglycerol, along with vitamin A, vitamin D3, tyrosine, acetylcarnitine and 2α-(hydroxymethyl)-5α-androstane-3β,17β-diol. Decreased concentrations of glycolithocholic acid, 3-dehydroteasterone and various phospholipids were observed. In DIO mice, 25 metabolites were significantly affected and strikingly, the magnitudes of changes here were generally much greater in DIO mice than in lean mice, and in contrast, the majority of metabolite changes were decreases. Four metabolites affected in both groups included glycolithocholic acid, and three different long-chain (C18) phospholipid molecules (phosphatidylethanolamine, platelet activating factor (PAF), and monoacylglycerol). Metabolites exclusively affected in DIO mice included various phosphatidylcholines, lysophosphatidylcholines and fatty acyls, as well as creatine and oxidised glutathione. CONCLUSION: This investigation demonstrates that obestatin treatment affects phospholipid turnover and influences lipid homeostasis, whilst providing convincing evidence that obestatin may be acting to ameliorate diet-induced impairments in lipid metabolism, and it may influence steroid, bile acid, PAF and glutathione metabolism. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11306-016-1063-0) contains supplementary material, which is available to authorized users

The EVIL-MC Model for Ellipsoidal Variations of Planet-Hosting Stars and Applications to the HAT-P-7 System

We present a new model for Ellipsoidal Variations Induced by a Low-Mass Companion, the EVIL-MC model. We employ several approximations appropriate for planetary systems to substantially increase the computational efficiency of our model relative to more general ellipsoidal variation models and improve upon the accuracy of simpler models. This new approach gives us a unique ability to rapidly and accurately determine planetary system parameters. We use the EVIL-MC model to analyze Kepler Quarter 0-2 (Q0-2) observations of the HAT-P-7 system, an F-type star orbited by a nearly Jupiter-mass companion. Our analysis corroborates previous estimates of the planet-star mass ratio q = (1.10 +/- 0.06) x 10^(-3), and we have revised the planet's dayside brightness temperature to 2680 +10/-20 K. We also find a large difference between the day- and nightside planetary flux, with little nightside emission. Preliminary dynamical+radiative modeling of the atmosphere indicates this result is qualitatively consistent with high altitude absorption of stellar heating. Similar analyses of Kepler and CoRoT photometry of other planets using EVIL-MC will play a key role in providing constraints on the properties of many extrasolar systems, especially given the limited resources for follow-up and characterization of these systems. However, as we highlight, there are important degeneracies between the contributions from ellipsoidal variations and planetary emission and reflection. Consequently, for many of the hottest and brightest Kepler and CoRoT planets, accurate estimates of the planetary emission and reflection, diagnostic of atmospheric heat budgets, will require accurate modeling of the photometric contribution from the stellar ellipsoidal variation.Comment: Accepted to ApJ; minor revisions to original submission; An IDL version of the EVIL-MC model is publicly available at http://www.lpl.arizona.edu/~bjackson/idl_code/index.htm