26 research outputs found

    Perfil hematológico de cabras Saanen e mestiças (1/2 Saanen e 1/2 Anglo-nubiana) criadas em clima tropical do Cearå

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    Objetivou-se verificar a influĂȘncia das condiçÔes climĂĄticas sobre o perfil hematolĂłgico de cabras Saanen e mestiça (1/2 Saanen x 1/2 Anglo-nubiana), bem como determinar valores de referĂȘncia para esses animais criados no CearĂĄ. Foram utilizadas 30 cabras que tiveram o sangue coletado mensalmente durante a Ă©poca chuvosa (fevereiro a maio) e seca (agosto a novembro) para realização do eritrograma e leucograma. As mĂ©dias foram comparadas pelo teste t-Student e Mann Whitney, quando constatada distribuição paramĂ©trica e nĂŁo paramĂ©trica dos dados, respectivamente, com significĂąncia quando p0,05). As hemĂĄcias e neutrĂłfilos segmentados apresentaram uma correlação negativa com a temperatura ambiente, porĂ©m positiva com a umidade do ar e a temperatura retal (p<0,05). O hematĂłcrito correlacionou-se positivamente com a temperatura ambiente e frequĂȘncia respiratĂłria (p<0,05). Os leucĂłcitos e linfĂłcitos mostraram uma correlação negativa com a temperatura retal (p<0,05). Conclui-se, portanto, que fĂȘmeas Saanen sofrem mais influĂȘncia das variaçÔes climĂĄticas e a Ă©poca chuvosa tem maior impacto negativo sobre os parĂąmetros hematolĂłgicos. Os valores obtidos poderĂŁo servir como referĂȘncia para esses genĂłtipos no CearĂĄ

    Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

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    BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
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