The X-ray emission of z>2.5 active galactic nuclei can be obscured by their host galaxies

We present a multi-wavelength study of seven AGN at spectroscopic redshift >2.5 in the 7 Ms Chandra Deep Field South, selected to have good FIR/sub-mm detections. Our aim is to investigate the possibility that the obscuration observed in the X-rays can be produced by the interstellar medium (ISM) of the host galaxy. Based on the 7 Ms Chandra spectra, we measured obscuring column densities N$_{H, X}$ in excess of 7x10$^{22}$ cm$^{-2}$ and intrinsic X-ray luminosities L$_{X}$>10$^{44}$ erg s$^{-1}$ for our targets, as well as equivalent widths for the Fe K$\alpha$ emission line EW>0.5-1 keV. We built the UV-to-FIR spectral energy distributions by using broad-band photometry from CANDELS and Herschel catalogs. By means of an SED decomposition technique, we derived stellar masses (M$_{*}$~10$^{11}$ Msun), IR luminosities (L$_{IR}$>10$^{12}$ Lsun), star formation rates (SFR~190-1680 Msun yr$^{-1}$) and AGN bolometric luminosities (L$_{bol}$~10$^{46}$ erg s$^{-1}$) for our sample. We used an empirically-calibrated relation between gas masses and FIR/sub-mm luminosities and derived M$_{gas}$~0.8-5.4x10$^{10}$ Msun. High-resolution (0.3-0.7'') ALMA data (when available, CANDELS data otherwise) were used to estimate the galaxy size and hence the volume enclosing most of the ISM under simple geometrical assumptions. These measurements were then combined to derive the column density associated with the ISM of the host, on the order of N$_{H, ISM}$~10$^{23-24}$ cm$^{-2}$. The comparison between the ISM column densities and those measured from the X-ray spectral analysis shows that they are similar. This suggests that, at least at high redshift, significant absorption on kpc scales by the dense ISM in the host likely adds to or substitutes that produced by circumnuclear gas on pc scales (i.e., the torus of unified models). The lack of unobscured AGN among our ISM-rich targets supports this scenario.Comment: 15 pages, 3 figures. Accepted for publication in A&

The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia

Dihydroorotate Dehydrogenase (DHODH) is a key enzyme of the de novo pyrimidine biosynthesis, whose inhibition can induce differentiation and apoptosis in acute myeloid leukemia (AML). DHODH inhibitors had shown promising in vitro and in vivo activity on solid tumors, but their effectiveness was not confirmed in clinical trials, probably because cancer cells exploited the pyrimidine salvage pathway to survive. Here, we investigated the antileukemic activity of MEDS433, the DHODH inhibitor developed by our group, against AML. Learning from previous failures, we mimicked human conditions (performing experiments in the presence of physiological uridine plasma levels) and looked for synergic combinations to boost apoptosis, including classical antileukemic drugs and dipyridamole, a blocker of the pyrimidine salvage pathway. MEDS433 induced apoptosis in multiple AML cell lines, not only as a consequence of differentiation, but also directly. Its combination with antileukemic agents further increased the apoptotic rate, but when experiments were performed in the presence of physiological uridine concentrations, results were less impressive. Conversely, the combination of MEDS433 with dipyridamole induced metabolic lethality and differentiation in all AML cell lines; this extraordinary synergism was confirmed on AML primary cells with different genetic backgrounds and was unaffected by physiological uridine concentrations, predicting in human activity

Submillimetre compactness as a critical dimension to understand the main sequence of star-forming galaxies

We study the interstellar medium (ISM) properties as a function of the molecular gas size for 77 infrared-selected galaxies at z ∼ 1.3, having stellar masses 109.4 ≲ M⋆ ≲ 1012.0 M⊙ and star formation rates 12 ≲ SFRFIR ≲ 1000 M⊙ yr−1. Molecular gas sizes are measured on ALMA images that combine CO(2-1), CO(5-4), and underlying continuum observations, and include CO(4-3), CO(7-6) + [CI](3P2 − 3P1), [CI](3P1 − 3P0) observations for a subset of the sample. The ≳46 per cent of our galaxies have a compact molecular gas reservoir, and lie below the optical discs mass–size relation. Compact galaxies on and above the main sequence have higher CO excitation and star formation efficiency than galaxies with extended molecular gas reservoirs, as traced by CO(5-4)/CO(2-1) and CO(2-1)/LIR, SF ratios. Average CO + [CI] spectral line energy distributions indicate higher excitation in compacts relative to extended sources. Using CO(2-1) and dust masses as molecular gas mass tracers, and conversion factors tailored to their ISM conditions, we measure lower gas fractions in compact main-sequence galaxies compared to extended sources. We suggest that the submillimetre compactness, defined as the ratio between the molecular gas and the stellar size, is an unavoidable information to be used with the main sequence offset to describe the ISM properties of galaxies, at least above M⋆ ≥ 1010.6 M⊙, where our observations fully probe the main sequence scatter. Our results are consistent with mergers driving the gas in the nuclear regions, enhancing the CO excitation and star formation efficiency. Compact main-sequence galaxies are consistent with being an early post-starburst population following a merger-driven starburst episode, stressing the important role of mergers in the evolution of massive galaxies

The Quasar Feedback Survey: characterizing CO excitation in quasar host galaxies

\ua9 2023 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society.We present a comprehensive study of the molecular gas properties of 17 Type 2 quasars at z < 0.2 from the Quasar Feedback Survey (L > 1042.1), selected by their high [O iii] luminosities and displaying a large diversity of radio jet properties, but dominated by LIRG-like galaxies. With these data, we are able to investigate the impact of AGN and AGN feedback mechanisms on the global molecular interstellar medium. Using Atacama Pathfinder EXperiment and ALMA ACA observations, we measure the total molecular gas content using the CO(1-0) emission and homogeneously sample the carbon monoxide (CO) spectral line energy distributions, observing CO transitions (Jup = 1, 2, 3, 6, 7). We observe high r21 ratios (r21 = L\u27CO(2-1)/L\u27CO(1-0)) with a median r21 = 1.06, similar to local (U)LIRGs (with r21 ∼1) and higher than normal star-forming galaxies (with r21 ∼0.65). Despite the high r21 values, for the seven targets with the required data, we find low excitation in CO(6-5) & CO(7-6) (r61 and r62 < 0.6 in all but one target), unlike high-redshift quasars in the literature, which are far more luminous and show higher line ratios. The ionized gas traced by [O iii] exhibits systematically higher velocities than the molecular gas traced by CO. We conclude that any effects of quasar feedback (e.g. via outflows and radio jets) do not have a significant instantaneous impact on the global molecular gas content and excitation and we suggest that it only occurs on more localized scales

SUPER VI. A giant molecular halo around a z∼2 quasar

We present the discovery of copious molecular gas in the halo of cid_346, a z = 2.2 quasar studied as part of the SINFONI survey for Unveiling the Physics and Effect of Radiative feedback (SUPER). New Atacama Compact Array (ACA) CO(3−2) observations detect a much higher flux (by a factor of 14 ± 5) than measured on kiloparsec scales (r ≲ 8 kpc) using previous snapshot Atacama Large Millimeter/submillimeter Array data. Such additional CO(3−2) emission traces a structure that extends out to r ∼ 200 kpc in projected size, as inferred through direct imaging and confirmed by an analysis of the uv visibilities. This is the most extended molecular circumgalactic medium (CGM) reservoir that has ever been mapped. It shows complex kinematics, with an overall broad line profile (FWHM = 1000 km s−1) that is skewed towards redshifted velocities up to at least v ∼ 1000 km s−1. Using the optically thin assumption, we estimate a strict lower limit for the total molecular CGM mass observed by ACA of MmolCGM > 1010 M⊙. There is however room for up to MmolCGM ∼ 1.7 × 1012 M⊙, once optically thick CO emission with αCO = 3.6 M⊙ (K km s−1 pc2)−1 and L′CO(3−2)/L′CO(1−0) = 0.5 are assumed. Since cid_346 hosts quasar-driven ionised outflows and since there is no evidence of merging companions or an overdensity, we suggest that outflows may have played a crucial rule in seeding metal-enriched, dense gas on halo scales. However, the origin of such an extended molecular CGM remains unclear

Quasar feedback survey: molecular gas affected by central outflows and by ∼10-kpc radio lobes reveal dual feedback effects in \u27radio quiet\u27 quasars

\ua9 The Author(s) 2023. Published by Oxford University Press on behalf of Royal Astronomical Society. We present a study of molecular gas, traced via CO (3–2) from Atacama Large Millimeter/submillimeter Array data, of four z < 0.2, ‘radio quiet’, type 2 quasars (Lbol ∼ 1045.3–1046.2 erg s−1; L1.4 GHz ∼ 1023.7–1024.3 WHz−1). Targets were selected to have extended radio lobes (≥ 10 kpc), and compact, moderate-power jets (1–10 kpc; Pjet ∼ 1043.2–1043.7 erg s−1). All targets show evidence of central molecular outflows, or injected turbulence, within the gas discs (traced via high-velocity wing components in CO emission-line profiles). The inferred velocities (Vout = 250–440 km s−1) and spatial scales (0.6–1.6 kpc), are consistent with those of other samples of luminous low-redshift active galactic nuclei. In two targets, we observe extended molecular gas structures beyond the central discs, containing 9–53 per cent of the total molecular gas mass. These structures tend to be elongated, extending from the core, and wrap-around (or along) the radio lobes. Their properties are similar to the molecular gas filaments observed around radio lobes of, mostly ‘radio loud’, brightest cluster galaxies. They have the following: projected distances of 5–13 kpc; bulk velocities of 100–340 km s−1; velocity dispersion of 30–130 km s−1; inferred mass outflow rates of 4–20 M⊙ yr−1; and estimated kinetic powers of 1040.3–1041.7 erg s−1. Our observations are consistent with simulations that suggest moderate-power jets can have a direct (but modest) impact on molecular gas on small scales, through direct jet–cloud interactions. Then, on larger scales, jet-cocoons can push gas aside. Both processes could contribute to the long-term regulation of star formation

The WISSH QSOs project IX. Cold gas content and environment of luminous QSOs at z~2.4-4.7

Sources at the brightest end of QSO luminosity function during the peak epoch of star formation and black hole accretion (z~2-4, i.e. Cosmic noon) are privileged sites to study the feeding & feedback cycle of massive galaxies. We perform the first systematic study of cold gas properties in the most luminous QSOs, by characterising their host-galaxies and environment. We analyse ALMA, NOEMA and JVLA observations of FIR continuum, CO and [CII] emission lines in eight QSOs ($L_{\rm Bol}>3\times10^{47}$ erg/s) from the WISSH sample at z~2.4-4.7. We report a 100% emission line detection rate and a 80% detection rate in continuum emission, and we find CO emission to be consistent with the steepest CO ladders observed so far. Sub-mm data reveal presence of (one or more) bright companion galaxies around 80% of WISSH QSOs, at projected distances of 6-130 kpc. We observe a variety of sizes for the molecular gas reservoirs (1.7-10 kpc), associated with rotating disks with disturbed kinematics. WISSH QSOs typically show lower CO luminosity and higher star formation efficiency than FIR matched, z~0-3 main-sequence galaxies, implying that, given the observed SFR ~170-1100 $M_\odot$/yr, molecular gas is converted into stars on <50 Myr. Most targets show extreme dynamical to black-hole mass ratios $M_{\rm dyn}/M_{\rm BH}\sim3-10$, two orders of magnitude smaller than local relations. The molecular gas fraction in WISSH hosts is lower by a factor of ~10-100 than in star forming galaxies with similar $M_*$. WISSH QSOs undergo an intense growth phase of both the central SMBH and host-galaxy. They pinpoint high-density sites where giant galaxies assemble and mergers play a major role in the build-up of the final host-galaxy mass. The observed low molecular gas fraction and short depletion timescale are likely due to AGN feedback, as traced by fast AGN-driven ionised outflows in all our targets.Comment: Accepted for publication in A&

The effect of active galactic nuclei on the cold interstellar medium in distant star-forming galaxies

In the framework of a systematic study with the ALMA interferometer of IR-selected main-sequence and starburst galaxies at z ∼ 1 − 1.7 at typical ∼1″ resolution, we report on the effects of mid-IR- and X-ray-detected active galactic nuclei (AGN) on the reservoirs and excitation of molecular gas in a sample of 55 objects. We find widespread detectable nuclear activity in ∼30% of the sample. The presence of dusty tori influences the IR spectral energy distribution of galaxies, as highlighted by the strong correlation among the AGN contribution to the total IR luminosity budget (fAGN = LIR,  AGN/LIR), its hard X-ray emission, and the Rayleigh-Jeans to mid-IR (S1.2 mm/S24 μm) observed color, with evident consequences on the ensuing empirical star formation rate estimates. Nevertheless, we find only marginal effects of the presence and strength of AGN on the carbon monoxide CO (J = 2, 4, 5, 7) or neutral carbon ([C I](3P1  −  3P0), [C I](3P2  −  3P1)) line luminosities and on the derived molecular gas excitation as gauged by line ratios and the full spectral line energy distributions. The [C I] and CO emission up to J = 5, 7 thus primarily traces the properties of the host in typical IR luminous galaxies. However, our analysis highlights the existence of a large variety of line luminosities and ratios despite the homogeneous selection. In particular, we find a sparse group of AGN-dominated sources with the highest LIR,  AGN/LIR,  SFR ratios, ≳3, that are more luminous in CO (5−4) than what is predicted by the L′CO(5-4)−LIR, SFR relation, which might be the result of the nuclear activity. For the general population, our findings translate into AGN having minimal effects on quantities such as gas and dust fractions and star formation efficiencies. If anything, we find hints of a marginal tendency of AGN hosts to be compact at far-IR wavelengths and to display 1.8 times larger dust optical depths. In general, this is consistent with a marginal impact of the nuclear activity on the gas reservoirs and star formation in average star-forming AGN hosts with LIR > 5 × 1011 L⊙, typically underrepresented in surveys of quasars and submillimeter galaxies

The quasar feedback survey: discovering hidden Radio-AGN and their connection to the host galaxy ionized gas

We present the first results from the Quasar Feedback Survey, a sample of 42 z 1042.1 ergs s−1) with moderate radio luminosities (i.e. L1.4GHz > 1023.4 W Hz−1; median L1.4GHz = 5.9 × 1023 W Hz−1). Using high spatial resolution (∼0.3–1 arcsec), 1.5–6 GHz radio images from the Very Large Array, we find that 67 per cent of the sample have spatially extended radio features on ∼1–60 kpc scales. The radio sizes and morphologies suggest that these may be lower radio luminosity versions of compact, radio-loud AGNs. By combining the radio-to-infrared excess parameter, spectral index, radio morphology, and brightness temperature, we find radio emission in at least 57 per cent of the sample that is associated with AGN-related processes (e.g. jets, quasar-driven winds, or coronal emission). This is despite only 9.5–21 per cent being classified as radio-loud using traditional criteria. The origin of the radio emission in the remainder of the sample is unclear. We find that both the established anticorrelation between radio size and the width of the [O III] line, and the known trend for the most [O III] luminous AGNs to be associated with spatially extended radio emission, also hold for our sample of moderate radio luminosity quasars. These observations add to the growing evidence of a connection between the radio emission and ionized gas in quasar host galaxies. This work lays the foundation for deeper investigations into the drivers and impact of feedback in this unique sample

SUPER VII. morphology and kinematics of H alpha emission in AGN host galaxies at cosmic noon using SINFONI

We present spatially resolved H α properties of 21 type 1 AGN host galaxies at z ∼ 2 derived from the SUPER survey. These targets were observed with the adaptive optics capabilities of the SINFONI spectrograph, a near-infrared integral field spectrograph, that provided a median spatial resolution of 0.3 arcsec (∼2 kpc). We model the H α emission line profile in each pixel to investigate whether it traces gas in the narrow line region or if it is associated with star formation. To do this, we first investigate the presence of resolved H α emission after subtracting the AGN PSF. We find extended H α emission in 16 out of the 21 type 1 AGN host galaxies (76 per cent). Based on the BPT diagnostics, optical line flux ratios and line widths (FWHM), we show that the H α emission in five galaxies is ionized by the AGN (30 per cent), in four galaxies by star formation (25 per cent) and for the rest (45 per cent), the ionization source is unconstrained. Two galaxies show extended H α FWHM &amp;gt;600 km s−1, which is interpreted as a part of an AGN-driven outflow. Morphological and kinematic maps of H α emission in targets with sufficient signal-to-noise ratio suggest the presence of rotationally supported discs in six galaxies and possible presence of companions in four galaxies. In two galaxies, we find an anticorrelation between the locations of extended H α emission and [O iii]-based ionized outflows, indicating possible negative feedback at play. However, in the majority of galaxies, we do not find evidence of outflows impacting H α-based star formation