130 research outputs found
Product Groups, Discrete Symmetries, and Grand Unification
We study grand unified theories based on an SU(5)xSU(5) gauge group in which
the GUT scale, M_{GUT}, is the VEV of an exact or approximate modulus, and in
which fast proton decay is avoided through a combination of a large triplet
mass and small triplet couplings. These features are achieved by discrete
symmetries. In many of our models, M_{GUT} is generated naturally by the
balance of higher dimension terms that lift the GUT modulus potential, and soft
supersymmetry breaking masses. The theories often lead to interesting patterns
of quark and lepton masses. We also discuss some distinctions between grand
unified theories and string unification.Comment: 23 pages; no figures; revtex
Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation
Publication history: Accepted - 11 October 2020; Published online - 15 January 2021Homeorhetic mechanisms assist dairy cows in the transition from pregnancy to lactation. Less successful cows develop severe negative energy balance (NEB), placing them at risk of metabolic and infectious diseases and reduced fertility. We have previously placed multiparous Holstein Friesian cows from 4 herds into metabolic clusters, using as biomarkers measurements of plasma nonesterified fatty acids, ÎČ-hydroxybutyrate, glucose and IGF-1 collected at 14 and 35 d in milk (DIM). This study characterized the global transcriptomic profiles of liver and circulating leukocytes from the same animals to determine underlying mechanisms associated with their metabolic and immune function. Liver biopsy and whole-blood samples were collected around 14 DIM for RNA sequencing. All cows with available RNA sequencing data were placed into balanced (BAL, n = 44), intermediate (n = 44), or imbalanced (IMBAL, n = 19) metabolic cluster groups. Differential gene expression was compared between the 3 groups using ANOVA, but only the comparison between BAL and IMBAL cows is reported. Pathway analysis was undertaken using DAVID Bioinformatic Resources (https://david.ncifcrf.gov/). Milk yields did not differ between BAL and IMBAL cows but dry matter intake was less in IMBAL cows and they were in greater energy deficit at 14 DIM (â4.48 v â11.70 MJ/d for BAL and IMBAL cows). Significantly differentially expressed pathways in hepatic tissue included AMPK signaling, glucagon signaling, adipocytokine signaling, and insulin resistance. Genes involved in lipid metabolism and cholesterol transport were more highly expressed in IMBAL cows but IGF1 and IGFALS were downregulated. Leukocytes from BAL cows had greater expression of histones and genes involved in nucleosomes and cell division. Leukocyte expression of heat shock proteins increased in IMBAL cows, suggesting an unfolded protein response, and several key genes involved in immune responses to pathogens were upregulated (e.g., DEFB13, HP, OAS1Z, PTX3, and TLR4). Differentially expressed genes upregulated in IMBAL cows in both tissues included CD36, CPT1, KFL11, and PDK4, all central regulators of energy metabolism. The IMBAL cows therefore had greater difficulty maintaining glucose homeostasis and had dysregulated hepatic lipid metabolism. Their energy deficit was associated with a reduced capacity for cell division and greater evidence of stress responses in the leukocyte population, likely contributing to an increased risk of infectious disease.This project received funding from the European Union's Seventh Framework Programme (Brussels, Belgium) for research, technological development, and demonstration under grant agreement no. 61368
Natural Theories of Ultra-Low Mass PNGB's: Axions and Quintessence
We consider the Wilson Line PNGB which arises in a U(1)^N gauge theory,
abstracted from a latticized, periodically compactified extra dimension U(1).
Planck scale breaking of the PNGB's global symmetry is suppressed, providing
natural candidates for the axion and quintessence. We construct an explicit
model in which the axion may be viewed as the 5th component of the U(1)_Y gauge
field in a 1+4 latticized periodically compactified extra dimension. We also
construct a quintessence PNGB model where the ultra-low mass arises from
Planck-scale suppressed physics itself.Comment: 20 pages, fixed typo and reference
Phase Diagram of the Heisenberg Spin Ladder with Ring Exchange
We investigate the phase diagram of a generalized spin-1/2 quantum
antiferromagnet on a ladder with rung, leg, diagonal, and ring-exchange
interactions. We consider the exactly soluble models associated with the
problem, obtain the exact ground states which exist for certain parameter
regimes, and apply a variety of perturbative techniques in the regime of strong
ring-exchange coupling. By combining these approaches with considerations
related to the discrete Z_4 symmetry of the model, we present the complete
phase diagram.Comment: 17 pages, 10 figure
Search for the radiative decay in the SND experiment at VEPP-2M
The decay was investigated by the SND detector
at VEPP-2M collider in the reaction .
Here we present the results and some details of this study. We report an upper
limit (90% c.l.) as our
final result. Our upper limit does not contradict the earlier measurement by
GAMS spectrometer. To facilitate future studies a rather detailed review of the
problem is also given.Comment: 24 pages, 6 figures, LaTex. To be published in Nucl. Phys.
Magnetic Catalysis: A Review
We give an overview of the magnetic catalysis phenomenon. In the framework of
quantum field theory, magnetic catalysis is broadly defined as an enhancement
of dynamical symmetry breaking by an external magnetic field. We start from a
brief discussion of spontaneous symmetry breaking and the role of a magnetic
field in its a dynamics. This is followed by a detailed presentation of the
essential features of the phenomenon. In particular, we emphasize that the
dimensional reduction plays a profound role in the pairing dynamics in a
magnetic field. Using the general nature of underlying physics and its
robustness with respect to interaction types and model content, we argue that
magnetic catalysis is a universal and model-independent phenomenon. In support
of this claim, we show how magnetic catalysis is realized in various models
with short-range and long-range interactions. We argue that the general nature
of the phenomenon implies a wide range of potential applications: from certain
types of solid state systems to models in cosmology, particle and nuclear
physics. We finish the review with general remarks about magnetic catalysis and
an outlook for future research.Comment: 37 pages, to appear in Lect. Notes Phys. "Strongly interacting matter
in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A.
Schmitt, H.-U. Yee. Version 2: references adde
Quark Matter in a Strong Magnetic Background
In this chapter, we discuss several aspects of the theory of strong
interactions in presence of a strong magnetic background. In particular, we
summarize our results on the effect of the magnetic background on chiral
symmetry restoration and deconfinement at finite temperature. Moreover, we
compute the magnetic susceptibility of the chiral condensate and the quark
polarization at zero temperature. Our theoretical framework is given by chiral
models: the Nambu-Jona-Lasinio (NJL), the Polyakov improved NJL (or PNJL) and
the Quark-Meson (QM) models. We also compare our results with the ones obtained
by other groups.Comment: 34 pages, survey. To appear in Lect. Notes Phys. "Strongly
interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K.
Landsteiner, A. Schmitt, H.-U. Ye
Uso de atracĂșrio para o bloqueio da musculatura extrĂnseca do bulbo ocular em cĂŁes submetidos Ă anestesia inalatĂłria sob ventilação espontĂąnea
Modern temporal network theory: A colloquium
The power of any kind of network approach lies in the ability to simplify a
complex system so that one can better understand its function as a whole.
Sometimes it is beneficial, however, to include more information than in a
simple graph of only nodes and links. Adding information about times of
interactions can make predictions and mechanistic understanding more accurate.
The drawback, however, is that there are not so many methods available, partly
because temporal networks is a relatively young field, partly because it more
difficult to develop such methods compared to for static networks. In this
colloquium, we review the methods to analyze and model temporal networks and
processes taking place on them, focusing mainly on the last three years. This
includes the spreading of infectious disease, opinions, rumors, in social
networks; information packets in computer networks; various types of signaling
in biology, and more. We also discuss future directions.Comment: Final accepted versio
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk
Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored.
Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium.
Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 Ă 10â4; OR, 1.04; 95% confidence interval (CI), 1.02â1.07] and rs77928427 (P = 1.86 Ă 10â4; OR, 1.04; 95% CI, 1.02â1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 â„ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factorâbinding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue.
Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2.
Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk
- âŠ