Psi-series solutions of the cubic H\'{e}non-Heiles system and their convergence

The cubic H\'enon-Heiles system contains parameters, for most values of which, the system is not integrable. In such parameter regimes, the general solution is expressible in formal expansions about arbitrary movable branch points, the so-called psi-series expansions. In this paper, the convergence of known, as well as new, psi-series solutions on real time intervals is proved, thereby establishing that the formal solutions are actual solutions

Evaluation of protection in a mouse model after vaccination with Mycobacterium avium subsp. paratuberculois protein cocktails

Whole-cell vaccines successfully reduce signs of clinical disease and fecal shedding of Mycobacterium avium subsp. paratuberculosis (MAP), however, these vaccines have some limitations. The present study was conducted to identify MAP proteins that might be candidates for the development of an improved vaccine. MAP proteins were screened for immunogenicity in naturally infected cattle and selected based upon reactivity in the interferon- (IFN-) and Western blot assays. Proteins (MAP1087, MAP1204, MAP1272c, and MAP2077c) were arrayed into 4 overlapping cocktails containing 3 proteins each. The efficacy of the proteins within these cocktails as vaccine candidates was evaluated by subcutaneous immunization of mice, followed by challenge with live, virulent MAP. All MAP protein cocktails significantly reduced the recovery of live MAP from the ileum, while cocktails 1 and 3 reduced colonization in the liver. No significant differences were seen in the mesenteric lymph node or spleen, however, cocktail 1 reduced viable MAP in the mesenteric lymph node compared to other treatments. Stimulation of splenocytes upregulated antigen-specific IFN- and IL-23 secretion in all treatment groups, regardless of vaccination. Interestingly, IL-4 was moderately downregulated for vaccinates compared to control infected mice. An increase in total CD25 expression was noted for 3 of the 4 vaccinate groups upon stimulation of splenocytes with a whole-cell sonicate of MAP, with this effect becoming more significant within CD4CD25+ and CD8CD25+ subpopulations. The present study demonstrated that MAP proteins are useful as vaccine candidates to reduce MAP tissue burden

High Speed Solution of Spacecraft Trajectory Problems Using Taylor Series Integration

Taylor series integration is implemented in a spacecraft trajectory analysis code-the Spacecraft N-body Analysis Program (SNAP) - and compared with the code s existing eighth-order Runge-Kutta Fehlberg time integration scheme. Nine trajectory problems, including near Earth, lunar, Mars and Europa missions, are analyzed. Head-to-head comparison at five different error tolerances shows that, on average, Taylor series is faster than Runge-Kutta Fehlberg by a factor of 15.8. Results further show that Taylor series has superior convergence properties. Taylor series integration proves that it can provide rapid, highly accurate solutions to spacecraft trajectory problems

On the supersymmetric vacua of the Veneziano-Wosiek model

We study the supersymmetric vacua of the Veneziano-Wosiek model in sectors with fermion number F=2, 4 at finite 't Hooft coupling lambda. We prove that for F=2 there are two zero energy vacua for lambda > lambda_c = 1 and none otherwise. We give the analytical expressions of both vacua. One of them was previously known, the second one is obtained by solving the cohomology of the supersymmetric charges. At F=4 we compute the would-be supersymmetric vacua at high order in the the strong coupling expansion and provide strong support to the conclusion that lambda = 1 is a critical point in this sector too. It separates a strong coupling phase with two symmetric vacua from a weak coupling phase with positive spectrum.Comment: 17 pages, 2 eps figure

Kinetic Parameters Evaluation for Isoprene Mixed with Aluminum Oxide

AbstractWe analyzed the basic hazard characteristics for isoprene in the manufacturing process by evaluating the runaway reaction, kinetic parameters and safety parameters in this study. Experiments were carried out by calculating the thermal decomposition reactions for isoprene and mixed with aluminum oxide in non-isothermal conditions by differential scanning calorimetry (DSC). Afterwards results indicated that isoprene had a conjugated double bond of unstable structure, and therefore it was prone to produce exothermic reaction during the process of polymerization. Aluminum oxide was applied to mix with isoprene, which could increase the heat release rate. Based on the results, safety information should be provided to government and relevant industries for prevention the accident occur in relevant plants

Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma

Recent studies indicated nm23-H1 played a role in cancer progression. Therefore, we investigated clinical significance of nm23-H1 expression in oral squamous cell carcinoma (OSCC). In total, 86 OSCC specimens were immunohistochemically stained with nm23-H1-specific monoclonal antibodies. Immunohistochemical staining of nm23-H1 was confirmed by immunoblotting. The relations between nm23-H1 expression and clinicopathologic variables were evaluated by chi(2) analysis. As increased size of primary tumour could escalate metastatic potential and the data of patients at the late T stage might confound statistical analyses, we thus paid special attention to 54 patients at the early T stage of OSCC. Statistical difference of survival was compared by a log-rank test. Immunohistochemically, nm23-H1 expression was detected in 48.8% (42 out of 86) of tumorous specimens. It positively correlated with larger primary tumour size (P = 0.03) and inversely with cigarette-smoking habit (P = 0.042). In patients at the early T stage, decreased nm23 expression was associated with increased incidence of lymph node metastasis (P = 0.004) and indicated poor survival (P = 0.014). Tumour nm23-H1 expression is a prognostic factor for predicting better survival in OSCC patients at the early T stage, which may reflect antimetastatic potential of nm23. Therefore, modulation of nm23-H1 expression in cancer cells can provide a novel possibility of improving therapeutic strategy at this stage. In addition, our results further indicated cigarette smoking could aggravate the extent of nm23-H1 expression and possibly disease progression of OSCC patients. (C) 2004 Cancer Research UK

Contributions of dry and wet depositions of polychlorinated dibenzo-p-dioxins and dibenzofurans to a contaminated site resulting from a penetachlorophenol manufacturing process

The soils at a factory for manufacturing pentachlorophenol were heavily contaminated by polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). In order to verify the contributions of dry and wet deposition of PCDD/Fs from the ambient air, the concentration of PCDD/Fs in ambient air and soil were measured, the partition of particle- and gas-phases of atmospheric PCDD/Fs was calculated, and the annual fluxes of total dry and wet PCDD/F depositions were modeled. Average atmospheric PCDD/F concentration was 1.24 ng Nm (-aEuro parts per thousand 3) (or 0.0397 ng I-TEQ Nm (-aEuro parts per thousand 3)). Moreover, over 92.8% of total PCDD/Fs were in the particle phase, and the dominant species were high chlorinated congeners. The total PCDD/F fluxes of dry and wet deposition were 119.5 ng m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1) (1.34 ng I-TEQ m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1)) and 82.0 ng m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1) (1.07 ng I-TEQ m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1)), respectively. By scenario simulation, the total fluxes of dry and wet PCDD/F depositions were 87.1 and 68.6 ng I-TEQ, respectively. However, the estimated PCDD/F contents in the contaminated soil were 839.9 mu g I-TEQ. Hence, the contributions of total depositions of atmospheric PCDD/F were only 0.02%. The results indicated that the major sources of PCDD/F for the contaminated soil could be attributed to the pentachlorophenol manufacturing process

Indenopyridine hydrochloride induced testicular spermatogenesis failure with high seminal alkaline phosphatase levels in male dog

Indenopyridine hydrochloride (IH), an antispermatogenic agent, was tested to determine the testicular pathological changes, seminal spermatozoa concentrations and seminal plasma alkaline phosphatase levels in male dogs. A single oral dosage of 30 mg IH/kg BW induced the dissociation and premature release of germ cells into the lumens of seminiferous tubules. Ring-shaped spermatid nuclei, nuclear pykonosis of spermatocytes and multinucleated cell associations were also observed. Thereafter, the spermatogenic index (SI) significantly decreased one day after IH administration. Moreover, seminal spermatozoa concentrations decreased two weeks after drug treatment; and there was a statistically significant difference in spermatozoa production inhibited by IH compared to the control. Reversible spermatogenesis was noted 7 weeks after IH treatment in male dogs. Meanwhile, seminal plasma alkaline phosphatase levels also significantly increased two weeks after IH treatment. These data confirm that IH might induce a two-month inhibition of spermatogenesis in male dogs

Measurement of the Intrinsic Radiopurity of Cs-137/U-235/U-238/Th-232 in CsI(Tl) Crystal Scintillators

The inorganic crystal scintillator CsI(Tl) has been used for low energy neutrino and Dark Matter experiments, where the intrinsic radiopurity is an issue of major importance. Low-background data were taken with a CsI(Tl) crystal array at the Kuo-Sheng Reactor Neutrino Laboratory. The pulse shape discrimination capabilities of the crystal, as well as the temporal and spatial correlations of the events, provide powerful means of measuring the intrinsic radiopurity of Cs-137 as well as the U-235, U-238 and Th-232 series. The event selection algorithms are described, with which the decay half-lives of Po-218, Po-214, Rn-220, Po-216 and Po-212 were derived. The measurements of the contamination levels, their concentration gradients with the crystal growth axis, and the uniformity among different crystal samples, are reported. The radiopurity in the U-238 and Th-232 series are comparable to those of the best reported in other crystal scintillators. Significant improvements in measurement sensitivities were achieved, similar to those from dedicated massive liquid scintillator detector. This analysis also provides in situ measurements of the detector performance parameters, such as spatial resolution, quenching factors, and data acquisition dead time.Comment: 28 pages, 12 figure

Does entropic force always imply the Newtonian force law?

We study the entropic force by introducing a bound $S \le A^{3/4}$ between entropy and area which was derived by imposing the non-gravitational collapse condition. In this case, applying a modified entropic force to this system does not lead to the Newtonian force law.Comment: 11 pages, version to appear in EPJ