Impact of the European Clinical Trials Directive on prospective academic clinical trials associated with BMT

The European Clinical Trials Directive (EU 2001; 2001/20/EC) was introduced to improve the efficiency of commercial and academic clinical trials. Concerns have been raised by interested organizations and institutions regarding the potential for negative impact of the Directive on non-commercial European clinical research. Interested researchers within the European Group for Blood and Marrow Transplantation (EBMT) were surveyed to determine whether researcher experiences confirmed this view. Following a pilot study, an internet-based questionnaire was distributed to individuals in key research positions in the European haemopoietic SCT community. Seventy-one usable questionnaires were returned from participants in different EU member states. The results indicate that the perceived impact of the European Clinical Trials Directive has been negative, at least in the research areas of interest to the EBMT

Discovery of 59ms Pulsations from 1RXS J141256.0+792204 (Calvera)

We report on a multi-wavelength study of the compact object candidate 1RXS J141256.0+792204 (Calvera). Calvera was observed in the X-rays with XMM/EPIC twice for a total exposure time of ~50 ks. The source spectrum is thermal and well reproduced by a two component model composed of either two hydrogen atmosphere models, or two blackbodies (kT_1~ 55/150 eV, kT_2~ 80/250 eV, respectively, as measured at infinity). Evidence was found for an absorption feature at ~0.65 keV; no power-law high-energy tail is statistically required. Using pn and MOS data we discovered pulsations in the X-ray emission at a period P=59.2 ms. The detection is highly significant (> 11 sigma), and unambiguously confirms the neutron star nature of Calvera. The pulse profile is nearly sinusoidal, with a pulsed fraction of ~18%. We looked for the timing signature of Calvera in the Fermi Large Area Telescope (LAT) database and found a significant (~5 sigma) pulsed signal at a period coincident with the X-ray value. The gamma-ray timing analysis yielded a tight upper limit on the period derivative, dP/dt < 5E-18 s/s (dE_rot/dt <1E33 erg/s, B<5E10 G for magneto- dipolar spin-down). Radio searches at 1.36 GHz with the 100-m Effelsberg radio telescope yielded negative results, with a deep upper limit on the pulsed flux of 0.05 mJy. Diffuse, soft (< 1 keV) X-ray emission about 13' west of the Calvera position is present both in our pointed observations and in archive ROSAT all-sky survey images, but is unlikely associated with the X-ray pulsar. Its spectrum is compatible with an old supernova remnant (SNR); no evidence for diffuse emission in the radio and optical bands was found. The most likely interpretations are that Calvera is either a central compact object escaped from a SNR or a mildly recycled pulsar; in both cases the source would be the first ever member of the class detected at gamma-ray energies.Comment: 20 pages, 15 figures and 4 tables. Accepted for publication in MNRA

Snapshots in time: MicroCT scanning of pottery sherds determines early domestication of sorghum (Sorghum bicolor) in East Africa

MicroCT visualisations of organic inclusions within pottery sherds from Khashm el Girba 23 (KG23), Sudan, reveal domesticated sorghum (Sorghum bicolor subsp. bicolor) at c. 3700–2900 BCE. The percentage of non-shattering spikelet bases was c. 73% of identifiable visualizations, with c. 27% representing wild types. These analyses demonstrate the domestication of sorghum is significantly earlier than suggested by previous archaeological research. These results also demonstrate that microCT scanning is a major qualitative and quantitative advance on pre-existing methods for the investigation of crop remains in pottery sherds, which hitherto have been reliant on surface impressions; it is non-destructive, provides higher resolution 3D imaging of organic inclusions, and enables greater archaeobotanical recovery of inclusions within a sherd. MicroCT analysis of ceramics, mudbrick and other building materials has considerable potential for improving the chronologies and resolution for the domestication of other cereals in the past

Interfacing GHz-bandwidth heralded single photons with a room-temperature Raman quantum memory

Photonics is a promising platform for quantum technologies. However, photon sources and two-photon gates currently only operate probabilistically. Large-scale photonic processing will therefore be impossible without a multiplexing strategy to actively select successful events. High time-bandwidth-product quantum memories - devices that store and retrieve single photons on-demand - provide an efficient remedy via active synchronisation. Here we interface a GHz-bandwidth heralded single-photon source and a room-temperature Raman memory with a time-bandwidth product exceeding 1000. We store heralded single photons and observe a clear influence of the input photon statistics on the retrieved light, which agrees with our theoretical model. The preservation of the stored field's statistics is limited by four-wave-mixing noise, which we identify as the key remaining challenge in the development of practical memories for scalable photonic information processing

Status Update of the Parkes Pulsar Timing Array

The Parkes Pulsar Timing Array project aims to make a direct detection of a gravitational-wave background through timing of millisecond pulsars. In this article, the main requirements for that endeavour are described and recent and ongoing progress is outlined. We demonstrate that the timing properties of millisecond pulsars are adequate and that technological progress is timely to expect a successful detection of gravitational waves within a decade, or alternatively to rule out all current predictions for gravitational wave backgrounds formed by supermassive black-hole mergers.Comment: 10 pages, 3 figures, Amaldi 8 conference proceedings, accepted by Classical & Quantum Gravit

Characterization of At- species in simple and biological media by high performance anion exchange chromatography coupled to gamma detector.

Astatine is a rare radioelement belonging to the halogen group. Considering the trace amounts of astatine produced in cyclotrons, its chemistry cannot be evaluated by spectroscopic tools. Analytical tools, provided that they are coupled with a radioactive detection system, may be an alternative way to study its chemistry. In this research work, High Performance Anion Exchange Chromatography (HPAEC) coupled to a gamma detector (γ) was used to evaluate astatine species under reducing conditions. Also, to strengthen the reliability of the experiments, a quantitative analysis using a reactive transport model has been done. The results confirm the existence of one species bearing one negative charge in the pH range 27.5. With respect to the other halogens, its behavior indicates the existence of negative ion, astatide At-. The methodology was successfully applied to the speciation of the astatine in human serum. Under fixed experimental conditions (pH 7.47.5 and redox potential of 250 mV) astatine exists mainly as astatide At- and does not interact with the major serum components. Also, the method might be useful for the in vitro stability assessment of 211At-labelled molecules potentially applicable in nuclear medicine