The determination of drag in the gliding phase in swimming

The hydrodynamic drag forces produced by the swimmer during the sub aquatic gliding have been analyzed appealing to experimental investigation methods (e.g., Lyttle et al., 2000). However, the obtained results varied, which can translate some of the main inherent difficulties involved in the experimental studies. Thus, through application of a numerical method of Computational Fluid Dynamics (CFD), we intended to study the hydrodynamic drag forces, created during the displacement of the swimmer in different gliding positions, attempting to address some practical concerns to swimmers and coaches

Effect of methylprednisolone on perivascular pulmonary edema, inflammatory infiltrate, VEGF and TGF-beta immunoexpression in the remaining lungs of rats after left pneumonectomy

Pneumonectomy is associated with high rates of morbimortality, with postpneumonectomy pulmonary edema being one of the leading causes. An intrinsic inflammatory process following the operation has been considered in its physiopathology. The use of corticosteroids is related to prevention of this edema, but no experimental data are available to support this hypothesis. We evaluated the effect of methylprednisolone on the remaining lungs of rats submitted to left pneumonectomy concerning edema and inflammatory markers. Forty male Wistar rats weighing 300 g underwent left pneumonectomy and were randomized to receive corticosteroids or not. Methylprednisolone at a dose of 10 mg/kg was given before the surgery. After recovery, the animals were sacrificed at 48 and 72 h, when the pO2/FiO2 ratio was determined. Right lung perivascular edema was measured by the index between perivascular and vascular area and neutrophil density by manual count. Tissue expression of vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-β) were evaluated by immunohistochemistry light microscopy. There was perivascular edema formation after 72 h in both groups (P = 0.0031). No difference was observed between operated animals that received corticosteroids and those that did not concerning the pO2/FiO2 ratio, neutrophil density or TGF-β expression. The tissue expression of VEGF was elevated in the animals that received methylprednisolone both 48 and 72 h after surgery (P = 0.0243). Methylprednisolone was unable to enhance gas exchange and avoid an inflammatory infiltrate and TGF-β expression also showed that the inflammatory process was not correlated with pulmonary edema formation. However, the overexpression of VEGF in this group showed that methylprednisolone is related to this elevation

Tonal calls as a bioacoustic novelty in two Atlantic Forest species of Physalaemus (Anura: Leptodactylidae)

The frog genus Physalaemus has almost 50 species with vocalizations that are mostly composed of a single note. This note tends to have a broad harmonic structure or a pulsed structure. The sister species P. lateristriga and P. olfersii have pulsed advertisement calls that have been described as a noisy and long-lasting warbling sound. We provide the first account of inclusion of tonal sounds as part of the vocal repertoire of these species. Pure tones can (1) be long and form the entire call; (2) form prefixes of variable length separated by silence from the advertisement call; (3) be brief and form the onset or the offset of the regular advertisement call. Tonal calls may be an evolutionary novelty and they are not known from other populations of P. olfersii and P. lateristriga. Identification of the mechanism of sound production and of the behavioural role of these unique calls may help elucidate the evolution of call complexity in frogs

Perfil de ácidos grasos y comportamiento reológico de aceite y grasa de semillas de achiote (Bixa orellana), y de cacao blanco (Theobroma grandiflorum) y sus mezclas

Annatto seed oil (ASO) and cupuassu seed fat (CSF) were combined at the ratios: 30:70, 50:50, and 70:30 (% w/w). Their fatty acid profile, nutritional quality, FTIR (Fourier Transform Infrared) spectra, and rheological behavior were evaluated. ASO increased the content of polyunsaturated fatty acids in the blends; whereas CSF conferred higher contents of monounsaturated fatty acids. The blends exhibited low atherogenicity and thrombogenicity indices, suggesting nutritional advantages. The Newtonian fluid behavior and FTIR results suggested that mixing ASO and CSF at different proportions did not affect the functional groups. ASO showed an activation energy value which indicated that this fat viscosity was more sensitive to temperature changes. The Newtonian model proved to be suitable to describe the behavior of samples, according to statistical fit parameters R2, χ2, and RSS. The resulting blends presented improved physicochemical properties and nutritional attributes, indicating their feasibility for the development of new products.Se combinaron aceite de semilla de achiote (ASO) y grasa de semilla de cacao blanco (CSF) en las proporciones: 30:70, 50:50 y 70:30 (% p/p), respectivamente. Se evaluó su perfil de ácidos grasos, calidad nutricional, espectros FTIR (Fourier Transform Infrared) y comportamiento reológico. ASO incrementó el contenido de ácidos grasos poliinsaturados en las mezclas, mientras que CSF confirió mayores contenidos de ácidos grasos monoinsaturados. Las mezclas exhibieron bajos índices de aterogenicidad y trombogenicidad, lo que sugiere ventajas nutricionales. El comportamiento del fluido newtoniano y los resultados de FTIR sugirieron que mezclar ASO y CSF en diferentes proporciones no afectó a los grupos funcionales. ASO mostró un valor de energía de activación que indicó que la viscosidad de esta grasa era más sensible a los cambios de temperatura. El modelo newtoniano demostró ser adecuado para describir el comportamiento de las muestras, según los parámetros de ajuste estadístico R2, χ2 y RSS. Las mezclas resultantes presentaron propiedades fisicoquímicas y atributos nutricionales mejorados, lo que indica su viabilidad para el desarrollo de nuevos productos

Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years

Objectives: To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. Methods: A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59). Results: Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018). Conclusion: This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies

Geographic Information Systems (GIS) in Assessing Dental Health

The present study investigated the distribution profile of dental caries and its association with areas of social deprivation at the individual and contextual level. The cluster sample consisted of 1,002 12-year-old schoolchildren from Piracicaba, SP, Brazil. The DMFT Index was used for dental caries and the Care Index was used to determine access to dental services. On the individual level, variables were associated with a better oral status. On the contextual level, areas were not associated with oral status. However, maps enabled determining that the central districts have better social and oral conditions than the deprived outlying districts

Sleep-Related Falling Out of Bed in Parkinson's Disease

Background and purposeSleep-related falling out of bed (SFOB), with its potential for significant injury, has not been a strong focus of investigation in Parkinson's disease (PD) to date. We describe the demographic and clinical characteristics of PD patients with and without SFOB.MethodsWe performed a retrospective analysis of 50 consecutive PD patients, who completed an REM sleep behavior disorder screening questionnaire (RBDSQ), questionnaires to assess for RBD clinical mimickers and questions about SFOB and resulting injuries. Determination of high risk for RBD was based on an RBDSQ score of 5 or greater.ResultsThirteen patients reported history of SFOB (26%). Visual hallucinations, sleep-related injury, quetiapine and amantadine use were more common in those patients reporting SFOB. Twenty-two patients (44%) fulfilled criteria for high risk for RBD, 12 of which (55%) reported SFOB. Five patients reported injuries related to SFOB. SFOB patients had higher RBDSQ scores than non-SFOB patients (8.2±3.0 vs. 3.3±2.0, p<0.01). For every one unit increase in RBDSQ score, the likelihood of SFOB increased two-fold (OR 2.4, 95% CI 1.3-4.2, p<0.003).ConclusionsSFOB may be a clinical marker of RBD in PD and should prompt confirmatory polysomnography and pharmacologic treatment to avoid imminent injury. Larger prospective studies are needed to identify risk factors for initial and recurrent SFOB in PD