6 research outputs found
Prevention and reversion of nonalcoholic steatohepatitis in ob/ob mice by S-nitroso-N-acetylcysteine treatment
To evaluate the role oral administration of S-nitroso-N-acetylcysteine (SNAC), a NO donor drug, in the prevention and reversion of NASH in two different animal models. Methods: NASH was induced in male ob/ob mice by methionine-choline deficient (MCD) and high-fat (H) diets. Two animal groups received or not SNAC orally for four weeks since the beginning of the treatment. Two other groups were submitted to MCD and H diets for 60 days receiving SNAC only from the 31st to the 60th day. Results: SNAC administration inhibited the development of NASH in all groups, leading to a marked decrease in macro and microvacuolar steatosis and in hepatic lipid peroxidation in the MCD group. SNAC treatment reversed the development of NASH in animals treated for 60 days with MCD or H diets, which received SNAC only from the 31st to the 60th day. Conclusions: Oral administration of SNAC markedly inhibited and reversed NASH induced by MCD and H diets in ob/ob mice.27229930
How proteolytic inhibitors interact with dentin on glass-fiber post luting over 6 months
Rastreamento sorológico para doenças infecciosas em banco de sangue como indicador de morbidade populacional Serological screening for infectious diseases in blood donors as morbidity indicator
É discutido o valor do rastreamento sorológico para doença de Chagas, sífilis, hepatite B e AIDS realizado por bancos de sangue como indicador de morbidade populacional. Foram analisados os dados referentes a 62.814 doações de sangue obtidas em dois bancos de sangue públicos e três privados correspondendo ao total das doações no período de outubro de 1985 a outubro de 1987 em Goiânia, Goiás (Brasil). A soroprevalência foi comparada com dados obtidos pela notificação compulsória das doenças e com inquéritos epidemiológicos disponíveis. Foi encontrada soroprevalência para AIDS de 0,0@% para um único exame de ELISA, estimando-se em 1.900 o número de indivíduos supostamente infectados em Goiás, número compatível com o esperado quando se trabalha com dados de notificação. Para a doença de Chagas, hepatite B e sífilis foram observadas soroprevalências de até 3,3%, 1,3% e 4,1%, respectivamente. Foram discutidas as dificuldades encontradas para validação desses resultados pela ausência de notificação compulsória e características particulares dos inquéritos sorológicos.<br>Screening tests of 62,814 blood donations carried out between October 85 and October 87 in all five blood banks of Goiânia, Central Brazil, were analysed. The private institutions (3 blood banks) collected 80% of all donations and the remaining were collected by public blood banks. Seroprevalence of HIV, HBsAg, Chagas' disease and syphilis were compared with data obtained in the surveillance system and from previous surveys in an attempt to validate this source of health information. A seroprevalence of 0.07% for AIDS (one ELISA test) was calculated, which may suggest the presence of 1900 infected individuals, in the population of the State of Goiás as a whole. This figure seems reasonably close to the official data obtained by compulsory notification. For Chagas' disease, hepatitis B and syphilis seroprevalence of 3.3%, 1.3% and 4.1% were obtained, respectively. The potential usefulness and the limitations of screening in blood banks as a source of realible morbidity indicator is discussed