Slope evolution of GRB correlations and cosmology

Gamma -ray bursts (GRBs) observed up to redshifts $z>9.4$ can be used as possible probes to test cosmological models. Here we show how changes of the slope of the {\it luminosity $L^*_X$ -break time $T^*_a$} correlation in GRB afterglows, hereafter the LT correlation, affect the determination of the cosmological parameters. With a simulated data set of 101 GRBs with a central value of the correlation slope that differs on the intrinsic one by a $5\sigma$ factor, we find an overstimated value of the matter density parameter, $\Omega_M$, compared to the value obtained with SNe Ia, while the Hubble constant, $H_0$, best fit value is still compatible in 1$\sigma$ compared to other probes. We show that this compatibility of $H_0$ is due to the large intrinsic scatter associated with the simulated sample. Instead, if we consider a subsample of high luminous GRBs ($HighL$), we find that both the evaluation of $H_0$ and $\Omega_M$ are not more compatible in 1$\sigma$ and $\Omega_M$ is underestimated by the $13\%$. However, the $HighL$ sample choice reduces dramatically the intrinsic scatter of the correlation, thus possibly identifying this sample as the standard canonical `GRBs' confirming previous results presented in Dainotti et al. (2010,2011). Here, we consider the LT correlation as an example, but this reasoning can be extended also for all other GRB correlations. In literature so far GRB correlations are not corrected for redshift evolution and selection biases, therefore we are not aware of their intrinsic slopes and consequently how far the use of the observed correlations can influence the derived `best' cosmological settings. Therefore, we conclude that any approach that involves cosmology should take into consideration only intrinsic correlations not the observed ones.Comment: 8 pages, 4 figures, accepted to MNRAS Main Journa

Correction to: Experimental study of bitumen emulsion–cement mortars: mechanical behaviour and relation to mixtures

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Experimental study of bitumen emulsion–cement mortars: mechanical behaviour and relation to mixtures

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Accelerating cosmology in Rastall's theory

In an attempt to look for a viable mechanism leading to a present-day accelerated expansion, we investigate the possibility that the observed cosmic speed up may be recovered in the framework of the Rastall's theory, relying on the non-conservativity of the stress-energy tensor, i.e. $T^{\mu}_{\nu ; \mu} \neq 0$. We derive the modified Friedmann equations and show that they correspond to Cardassian-like equations. We also show that, under suitable assumptions on the equation of state of the matter term sourcing the gravitational field, it is indeed possible to get an accelerated expansion, in agreement with the Hubble diagram of both Type Ia Supernovae (SNeIa) and Gamma Ray Bursts (GRBs). Unfortunately, to achieve such a result one has to postulate a matter density parameter much larger than the typical $\Omega_M \simeq 0.3$ value inferred from cluster gas mass fraction data.Comment: 8 pages, 1 eps figure; revised to match the version accepted for publication in Il Nuovo Cimento

An application of the Michaelis–Menten model to analyze the curing process of cold recycled bituminous mixtures

Abstract In this paper the laboratory curing process of two types of cold recycled mixtures manufactured during the construction of an experimental pavement section along an Italian motorway was investigated. Specifically, a cement–bitumen treated material (CBTM) mixture and a cement treated material (CTM) mixture, produced both on site and in laboratory, were tested. Moisture loss by evaporation (DW), indirect tensile stiffness modulus (ITSM) and indirect tensile strength (ITS) were measured in order to evaluate the curing process. The measured data were analyzed using the nonlinear Michaelis–Menten (MM) model with the aim to characterize the rate at which the mixture properties evolve over time and their values at the long-term cured state. The results showed that the adopted curing variables (DW, ITSM and ITS) gave a comparable description of the curing process, when evaporation was allowed and that the MM model gave an appropriate description of the evolutive behavior of CBTMs and CTMs. Finally, the results showed that in the initial curing stage the effect of cement hydration prevailed on that of emulsion breaking

Measuring lensing ratios with future cosmological surveys

The ratio between the CMB lensing/galaxy counts and the galaxy shear/galaxy counts cross-correlations combines the information from different cosmological probes to infer cosmographic measurements that are less dependent on astrophysical uncertainties and can constrain the geometry of the Universe. We discuss the future perspectives for the measurement of this lensing ratio as previously introduced, i.e., with the use of the Limber and flat-sky approximations and neglecting all the effects on the galaxy survey from observing on the past light cone. We then show how the cosmological information in this estimator is affected by the Limber approximation and by the inclusion of the redshift space distortions (RSD) and lensing magnification contributions to the galaxy number counts

Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on peripheral blood mononuclear cells

Abstract Using a transcriptomic approach, we performed a pilot study in healthy subjects to evaluate the changes in gene expression induced by grape consumption. Blood from twenty subjects was collected at baseline (T0), after 21 days of grape-rich diet (T1) and after one-month washout (T2). Gene expression profiling of peripheral blood mononuclear cells from six subjects identified 930 differentially expressed transcripts. Gene functional analysis revealed changes (at T1 and/or T2) suggestive of antithrombotic and anti-inflammatory effects, confirming and extending previous finding on the same subjects. Moreover, we observed several other favourable changes in the transcription of genes involved in crucial processes such as immune response, DNA and protein repair, autophagy and mitochondrial biogenesis. Finally, we detected significant changes in many long non-coding RNAs genes, whose regulatory functions are being increasingly appreciated. Altogether, our data suggest that a grape diet may exert its beneficial effects by targeting different strategic pathways

Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein

Rona Barron - ORCID: 0000-0003-4512-9177 https://orcid.org/0000-0003-4512-9177Item not available in this repository.The association between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt–Jakob disease (vCJD) has demonstrated that cattle transmissible spongiform encephalopathies (TSEs) can pose a risk to human health and raises the possibility that other ruminant TSEs may be transmissible to humans. In recent years, several novel TSEs in sheep, cattle and deer have been described and the risk posed to humans by these agents is currently unknown. In this study, we inoculated two forms of atypical BSE (BASE and H-type BSE), a chronic wasting disease (CWD) isolate and seven isolates of atypical scrapie into gene-targeted transgenic (Tg) mice expressing the human prion protein (PrP). Upon challenge with these ruminant TSEs, gene-targeted Tg mice expressing human PrP did not show any signs of disease pathology. These data strongly suggest the presence of a substantial transmission barrier between these recently identified ruminant TSEs and humans.https://doi.org/10.1099/vir.0.042507-093pubpub

The role of stakeholder involvement in the evolving EU HTA process:Insights generated through the European Access Academy’s multi-stakeholder pre-convention questionnaire

Involvement of all relevant stakeholders will be of utmost importance for the success of the developing EU HTA harmonization process. A multi-step procedure was applied to develop a survey across stakeholders/collaborators within the EU HTA framework to assess their current level of involvement, determine their suggested future role, identify challenges to contribution, and highlight efficient ways to fulfilling their role. The ‘key’ stakeholder groups identified and covered by this research included: patients‘, clinicians‘, regulatory, and Health Technology Developer representatives. The survey was circulated to a wide expert audience including all relevant stakeholder groups in order to determine self-perception by the ‘key’ stakeholders regarding involvement in the HTA process (self-rating), and in a second, slightly modified version of the questionnaire, to determine the perception of ‘key’ stakeholder involvement by HTA bodies, payers, and policymakers (external rating). Predefined analyses were conducted on the submitted responses. Fifty-four responses were received (patients 9; clinicians: 8; regulators: 4; HTDs 14; HTA bodies: 7; Payers: 5; policymakers 3; others 4). The mean self-perceived involvement score was consistently lower for each of the ‘key’ stakeholder groups than the respective external ratings. Based on the qualitative insights generated in the survey, a RACI Chart (Responsible/Accountable/Consulted/Informed) was developed for each of the stakeholder groups to determine their roles and involvement in the current EU HTA process. Our findings suggest extensive effort and a distinct research agenda are required to ensure adequate involvement of the key stakeholder groups in the evolving EU HTA process.</p