6 research outputs found
Effects of organic enrichment on macrofauna community structure: an experimental approach
- Author
- Alicia Sacramento
- BELAN T.A
- BORJA A.
- BORJA A.
- BORJA A.
- BORJA A.
- CALLIER M.D.
- CLARKE K.R.
- COULL B.C.
- EDGAR G.
- Eduardo Almansa
- Eva Ramos
- FOCARDI S.
- GRALL J.
- GRAY J.S.
- GUERRA-GARCIA J.M.
- LAWSON S.E.
- LUND-HANSEN L.C.
- MUXICA I.
- Myriam RodrÃguez
- NORKKO J.
- PEARSON T.H.
- RIERA R.
- RIERA R.
- RIERA R.
- Rodrigo Riera
- SANZ-LAZARO C.
- SCHRATZBERGER M.
- TATARANNI M.
- TSUTSUMI H
- WALKLEY A.
- WEBB D.G
- WU R.S.S.
- Óscar Monterroso
- Óscar Perez
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/12/2013
- Field of study
Get PDFThe determination of the resilience of benthic assemblages is a capital issue for the off-shore aquaculture industry in its attempts to minimize environmental disturbances. Experimental studies are an important tool for the establishment of thresholds for macrofaunal assemblages inhabiting sandy seabeds. An experiment was conducted with three treatments (Control, 1x and 3x),in which organic load (fish pellets) was added (1x (10 g of fish pellets) and 3x (30 g)). A reduction in abundance of individuals and species richness was found as between the control and organic-enriched treatments. Significant changes in assemblage structure were also found, mainly due to the decrease of the sensitive tanaid Apseudes talpa in organically-enriched treatments. AMBI and M-AMBI indices were calculated and a decrease of ecological status was observed in treatment 3x
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
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- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
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- Valentino F.
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- van Heel D.A.
- van Koutrik L.
- Varghese M.
- Vecchia M.
- Vedage D.
- Veerapen K.
- Venkatesh H.
- Venn L.D.
- Venturelli S.
- Vergori A.
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- Verma A.
- Verma A.
- Verma S.S.
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- Vincenti A.
- Virgilio E.
- Vitart V.
- Vizcaychipi M.P.
- Vochin A.
- Voide C.
- von Frenckell C.
- von Hohenstaufen K.A.
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- Vuylsteke A.
- Wackett T.
- Wadams B.
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- Wagstaff V.
- Wain L.V.
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- Wakefield P.
- Wakinshaw F.
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- Walker R.
- Walker S.
- Walker S.
- Walker S.
- Wall A.
- Walsh T.
- Walsh T.
- Walters R.K.
- Walton O.
- Wang B.
- Wang J.
- Wang X.
- Wanying Z.
- Ward G.
- Ward L.
- Ward M.
- Warden S.
- Warmerdam R.
- Warren D.
- Wassall H.
- Wasson C.
- Watkins C.
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- Watson G.
- Watson J.
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- Weaver J.
- Webster A.
- Webster D.
- Webster K.
- Wei S.
- Weiss S.T.
- Weldon C.H.
- Wells C.
- Welters I.D.
- Weston H.
- Whileman A.
- Whitbread J.
- White D.
- White I.
- White K.
- White M.
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- White N.
- Whiteley S.
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- Whittle H.
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- Whyte C.
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- Williams A.T.
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- Williams G.
- Williams H.
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- Willis H.
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- Willson J.
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- Wilson J.F.
- Winnard S.
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- Wyllie D.H.
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- Xavier K.
- Xue X.
- Yadav A.
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- Yassen A.M.
- Yates B.
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- Zainy T.
- Zak A.
- Zaki A.
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- Zheng C.
- Zhou W.
- Zitter L.
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- Zongo O.
- Zucchi P.
- Zyndorf M.
- Zöllner S.
- Ã…svold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Get PDFCritical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Influence of OSHV-1 oyster mortality episode on dissolved inorganic fluxes: An ex situ experiment at the individual scale
- Author
- Aminot
- Anestis
- Arzul
- Asmus
- Barbosa Solomieu
- Barbosa-Solomieu
- Bartoli
- Bayne
- Bernard
- Bougrier
- Buestel
- Buzin
- C. Montagnani
- Callier
- Callier
- Chapelle
- Chelsky
- Clarke
- Comeau
- Corporeau
- Cranford
- D. Munaron
- Dame
- Dame
- Dame
- Dapeng
- Davison
- Dupuy
- Dégremont
- E. Roque d'Orbcastel
- Fagerbakke
- Filgueira
- Filgueira
- Filgueira
- Flye-Sainte-Marie
- Forrest
- Froján
- G. Messiaen
- Gale
- Garcia
- Girard
- Goldman
- Gosling
- Gosling
- Goulletquer
- Goulletquer
- Green
- Green
- He
- J. Bourreau
- Jansen
- Jansen
- Jouaux
- Justic
- Kasper
- Lacoste
- Le Deuff
- Lomstein
- Lyman
- M. Fortune
- M. Richard
- M.D. Callier
- Mackin
- Madigan
- Mazouni
- McKindsey
- Meseck
- Mineur
- Minson
- Moreau
- Mostajir
- Newell
- Nicolas
- P. Le Gall
- Paul-Pont
- Paul-Pont
- Pepin
- Pernet
- Pernet
- Pernet
- Pernet
- Petton
- Petton
- Peñuelas
- Redfield
- Renault
- Renault
- Renault
- Renault
- Richard
- Richard
- Robert
- Sauvage
- Schikorski
- Schikorski
- Segarra
- Segarra
- Segarra
- Smaal
- Soletchnik
- Soletchnik
- Souchu
- Souchu
- Stroud
- Suquet
- Tamayo
- Tran
- Trottet
- Tsiola
- V. Ouisse
- van Broekhoven
- Wan-soo
- West
- Whittington
- Willson
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textImplications for Estrogens in Parkinson’s Disease
- Author
- Alkayed N.J.
- Alkayed N.J.
- Alkayed N.J.
- Ascherio A.
- Baldereschi M.
- Benedetti M.D.
- Bernstein L.
- Bower J.H.
- Brinton R.D.
- Callier S.
- Currie L.J.
- de Rijk M.C.
- Dorgan J.F.
- Dubal D.B.
- G. SAVETTIERI
- Hall E.D.
- Hruska R.E.
- Kompoliti K.
- M. D'AMELIO
- Marder K.
- Mayeux R.
- Moore J.W.
- Moore J.W.
- Morissette M.
- Olanow C.W.
- P. RAGONESE
- Pasqualini C.
- Popat R.A.
- Ragonese P.
- Ragonese P.
- Rusa R.
- Sampei K.
- Saunders-Pullman R.
- Simpkins J.W.
- Singer C.A.
- Toung T.J.K.
- Windham G.C.
- Xie T.
- Xie T.
- Xu K.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2006
- Field of study
No full textEvidence from experimental and epidemiological studies suggests a role of sex hormones in the pathogenic process leading to neurodegenerative diseases, (i.e., Alzheimer's and Parkinson's disease). The effects of sexual steroid hormones are complex and vary with the events of women's fertile life. Estrogens are supposed to influence dopamine synthesis, metabolism, and transport; however, there is no consensus regarding the direction, locus, and mechanism of the effect of estrogens on the dopaminergic system. A neuroprotective effect of estrogens has been demonstrated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-animal models of Parkinson's disease (PD). Epidemiological studies indicate gender differences regarding the onset and the prognosis of PD. Most of the analytical studies explored the relationship between PD and exogenous estrogens. Only three studies investigated the role of endogenous estrogens in the risk of developing PD. These studies reported an increased risk of PD in conditions causing an early reduction in endogenous estrogens (early menopause, reduced fertile life length). Longer cumulative length of pregnancies has also been associated with an increased PD risk. A lack of consensus still exists on the effect of the type of menopause (surgical vs. natural) on PD risk. Finally, the effect of postmenopausal estrogen replacement therapy is still debated. Inconsistencies across studies are in part explained by the complexity of the mechanisms of action of sexual hormones and by the paucity of analytical studies
Implications for Estrogens in Parkinson's Disease: An Epidemiological Approach
- Author
- Alkayed N.J.
- Alkayed N.J.
- Alkayed N.J.
- Ascherio A.
- Baldereschi M.
- Benedetti M.D.
- Bernstein L.
- Bower J.H.
- Brinton R.D.
- Callier S.
- Currie L.J.
- de Rijk M.C.
- Dorgan J.F.
- Dubal D.B.
- G. SAVETTIERI
- Hall E.D.
- Hruska R.E.
- Kompoliti K.
- M. D'AMELIO
- Marder K.
- Mayeux R.
- Moore J.W.
- Moore J.W.
- Morissette M.
- Olanow C.W.
- P. RAGONESE
- Pasqualini C.
- Popat R.A.
- Ragonese P.
- Ragonese P.
- Rusa R.
- Sampei K.
- Saunders-Pullman R.
- Simpkins J.W.
- Singer C.A.
- Toung T.J.K.
- Windham G.C.
- Xie T.
- Xie T.
- Xu K.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
No full textWhole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi Ali
- Amitrano Sara
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson Madeleine
- Anderson Peter
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew Angela
- Andrew B.
- Andrew Gratrix
- Andrews E.
- Andrews Shea J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe David
- Antinori Andrea
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino Maia
- Arabi Y.M.
- Aravindan Latha
- Arbane Gill
- Archer Katie
- Arden T.
- Arias Sonia Sousa
- Arif S.
- Armstrong Jacob
- Armstrong Lisa
- Armstrong Ruth
- Arning N.
- Arnold Sophie
- Arranz MarÃa Jesús
- Arribas E.
- Artuso R.
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Saima
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain Raine
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin Karen
- Austin Pauline
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie John Kenneth
- Baines Balvinder
- Baines D.
- Baines K.
- Baird Yolanda
- Bakthavatsalam Dhanalakshmi
- Balaconis Mary K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford Peter
- Banach Dorota
- Bancroft Hollie
- Band G.
- Bandini M.
- Bandla Nageswar
- Bano S.
- Baptista David
- Barakeh D.
- Baras Aris
- Baratti S.
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- Barbieri C.
- Barclay Lucy
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- Barhoush E.
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- Barnes K.C.
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- Barry P.
- Bartels M.
- Bartley Shauna
- Baruah R.
- Bashyal Archana
- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates Michelle
- Batini Chiara
- Battle Ceri
- Bauchmuller K.
- Baxter N.
- Baya N.
- Bayo L.A.
- Beadle Jane
- Bean S.
- Beaumont K.
- Beavis S.
- Beck A.
- Beckmann Noam D.
- Bedini J. L.
- Bee Catherine E.
- Beech E.
- Beech Valerie
- Beekes M.
- Beesley K.
- Begg Colin
- Beguin Y.
- Behan T.
- Beith C.M.
- Belagodu Zakaula
- Belbin Gillian Morven
- Belfield H.
- Belhaj Y.
- Beligni G.
- Belisle A.
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- Bell G.
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- Bell S.
- Bellamy Mary
- Belli M.A.
- Bellini A.
- Bellwood R.
- Below Jennifer
- Bemand T.
- Benetti E.
- Benham Leonie
- Bennett D.
- Bennett Sara
- Bentley David
- Bentley M.
- Benyon S.
- Beranova E.
- Bercades G.
- Bergantini L.
- Bergomi P.
- Berkowitz Nathan
- Bernardo D.
- Bevan E.
- Bewley J.
- Bhatia Nikhil
- Bhatterjee Ravi
- Bhuie Parminder
- Bi R.
- Biagio A.D.
- Bianchi F.
- Bibert S.
- Bibi Fatima
- Biddle Jack
- Biggs Heather
- Birch J.
- Birch J.
- Birch Sophie.
- Birchall K.
- Birchall K.
- Bird S.
- Birkinshaw Isobel
- Birt M.
- Biscarini F.
- Black E.
- Black K.
- Blackledge B.
- Blackman H.
- Blakemore H.
- Blay Natalia
- Blow Sara
- Blunt M.
- Board S.
- Bochud P.Y.
- Bociek Aneta
- Boezen M.
- Boillat N.
- Bokhari M.
- Bolton Matthew
- Bolton Rachel
- Bonner Stephen
- Booker L.
- Borislavova B.
- Borra Catherine
- Botello A.
- Botfield Liam
- Bottà G.
- Bouab M.
- Bough L.
- Boughton A.P.
- Bowes A.
- Bowles Ruth
- Boyle P.
- Boyle R.
- Boz Ceilia
- Bradford Y.
- Bradley C.
- Bradley P.
- Bradley-Potts Joanne
- Bradshaw Zena
- Brady A.
- Brady M.
- Brady R.
- Brandwood C.
- Branney D.
- Brantwood Craig
- Brassard N.
- Brayne A.
- Brealey D.
- Bremmer P.
- Brenner B.
- Bretherick Andrew D.
- Brett Michael
- Brett Stephen
- Brickell K.
- Bridgett V.
- Brimfield Lutece
- Brinkworth Elaine
- Briton Kate
- Britvan Bari
- Bromley M.
- Brooke Hollie
- Brooks S.
- Brown A.
- Brown Adam
- Brown C.W.
- Brown Ellen
- Brown Joanna
- Bruce M.
- Brumpton Ben M.
- Bruno Raffaele
- Brunton Mark
- Bruttini M.
- Bryant J.
- Bryant S.
- Buckley C.
- Buckley Sarah
- Bunni L.
- Burda D.
- Buring Julie E
- Burn I.
- Burnett C.
- Burns K.
- Burt K.
- Burtenshaw Andrew
- Burton Maudrian
- Busani S.
- Bussotti M.
- Butcher D.
- Butler Aaron
- Butler Joanna
- Butler S.
- Butler-Laporte G.
- Butterworth A.S.
- Butterworth-Cowin N.
- Button H.
- Buxbaum Joseph D
- Cabrelli Louise
- Cagova L.
- Caldarelli G.P.
- Callaghan Marie
- Callier S.
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Campbell Helen
- Campbell Rachael
- Campbell Suzanne
- Campos Sara
- Camsooksai J.
- Canaccini A.
- Cantarini L.
- Cantor M.N.
- Capasso M.
- Capitani K.
- Cappelli S.
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- Carella M.
- Carey D.J.
- Carmody Margaret
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- Carnahan M.
- Carreras A.
- Carriero M.L.
- Carter A.
- Carter David
- Carter E.
- Carter Joseph
- Carter S.
- Carungcong J.
- Casey Matt
- Castaño-Vinyals G.
- Castelli F.
- Castle K.
- Castori M.
- Caswell Melanie
- Catena E.
- Caterson Jess
- Cathcart Susanne
- Catlow L.
- Caulfield Mark J.
- Cavazza Anna
- Cawley Kathryn
- Cawthron K.
- Ceri S.
- Chablani M.
- Chadbourn Indra
- Chamnanphon Monpat
- Chan Georgia
- Chan R.
- Chandler B.
- Chang Xiao
- Chapman Susan
- Chariyavilaskul Pajaree
- Charles B.
- Charlesworth Ruth
- Charney Alexander W.
- Charnock R.
- Chasman D.I.
- Chassé M.
- Chaudhary Kumardeep
- Chavan S.
- Cheema Yusuf
- Chen Hung-Hsin
- Chen Jiantao
- Cheng N.
- Cherian Shiney
- Chetam L.
- Chetruengchai Wanna
- Cheyne C.
- Childs D.
- Chittoor G.
- Cho Judy H.
- Cho K.
- Choi Sam
- Choudhury Yasmin
- Christine Almaden-Boyle None
- Chukkambotla Srikanth
- Churchhouse C.
- Chwialkowska Karolina
- Claassen S.
- Clamp Sarah
- Clapham M.
- Claringbould A.
- Clark Amy
- Clark M.
- Clark Martynn
- Clark Richard
- Clark Sarah
- Clark Victoria
- Clarke D.
- Clarke N.
- Clarkson M.
- Clayton Sarah
- Clement Ian
- Clements S.
- Coates Charlotte
- Cockrell Maeve
- Coetzee S.
- Coghlan Phoebe
- Coignet M.
- Coiro G.
- Coker D.
- Cole J.
- Cole J.
- Cole Stephen
- Coleman Dabheoc
- Coles Holly
- Colley Julie
- Collier D.
- Collier David
- Collins Amy
- Collins Brett L.
- Collins C.
- Collins E.
- Collins E.
- Collins Katy
- Collins Rebecca
- Collis M.
- Colobrán R.
- Colombo R.
- Combes Edward
- Connolly K.
- Conticini E.
- Convery K.
- Conyngham J.A.
- Cooper J.
- Cooper L.
- Corcoran Eleanor
- Cordioli Mattia
- Cornell S.
- Corral M.A.
- Corridi M.
- Cortés B.
- Cosgrove D.
- Cosier T.
- Cossarizza A.
- Cother Naiara
- Coto E.
- Coton Z.
- Coulding Martina
- Coutts Audrey
- Coventry T.
- Coviello D.A.
- Cowley A.
- Cowley Nicholas
- Cowton Amanda
- Cox Amber
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
No full textAltres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
