Radiative Mechanism to Light Fermion Masses in the MSSM

In a previous work we have showed that the ${\cal Z}_{2}^{\prime}$ Symmetry, imply that the light fermions, the electron and the quarks, $u,d$ and $s$, get their masses only at one loop level. Here, we considere the more general hypothesis for flavour mixing in the sfermion sector in the MSSM. Then, we present our results to the masses of these light fermions and as a final result we can explain why the $s$ quark is heavier than the $u,d$ quarks. This mechanism is in agrement with the experimental constraint on the sfermion's masses values.Comment: 22 pages, 8 figures, TeX mistakes corrected, accepted for publication in JHE

Особенности создания импульсных магнитных полей для магнитоуправляемой электрошлаковой плавки

Рассмотрены некоторые особенности создания импульсных магнитных полей для воздействия на кристаллизацию металла в процессе магнитоуправляемой электрошлаковой плавки. Предложены способы интенсификации электромагнитного воздействия на металлургическую ванну, основанные на использовании энергии электрических разрядов емкостных накопителей на внешний магнитный контур. Разработана экспериментальная аппаратура, включающая источник питания для генерирования электрических разрядов энергией до 1850 Дж, и магнитный контур в виде соленоида с дисковыми обмотками, охватывающими кристаллизатор. Изучены характеристики электрических разрядов при различном количестве витков магнитного контура. Показана целесообразность комплексного подхода к интенсификации электромагнитного воздействия посредством оптимизации параметров как источника разрядов, так и соответствующих магнитных контуров. Проведены экспериментальные исследования влияния импульсных магнитных полей на режимы плавки и кристаллизацию металла в процессе выплавки слитков титановых сплавов. Показана возможность при достаточной энергии разрядов и оптимальном количестве витков магнитного контура управлять порционными тепловложениями в процессе плавки, а также кристаллизацией металла слитков. При этом для улучшения качества поверхности слитков предложено воздействие осуществлять сериями импульсов, чередующихся с паузами.Some features of inducing pulsed magnetic fields for acting on metal solidification during magnetically-controlled electroslag melting are considered. Methods of intensification of electromagnetic impact on metallurgical bath are proposed, which are based on application of energy of capacitive storage electric discharges to external magnetic circuit. Experimental system has been developed, including a power source for generation of electric discharges with up to 1850 J energy, and a magnetic circuit in the form of a solenoid with disc windings enclosing the mould. Characteristics of electric discharges at different number of magnetic circuit turns have been studied. The paper shows the rationality of an integrated approach to electromagnetic impact intensification through optimization of parameters of both the discharge source and the respective magnetic circuits. Experimental investigations of the influence of pulsed magnetic fields on metal melting and solidification modes during melting of titanium alloy ingots have been performed. Ability to control discrete heat input during melting, as well as ingot metal solidification at sufficient discharge energy and optimum number of magnetic circuit turns, is demonstrated. To improve ingot surface quality, it is proposed to apply the impact in the form of series of pulses alternating with pauses

S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver

Cysteinyl-leukotrienes can cause cholestasis and liver damage when administered at nanomolar concentrations. Using the isolated and perfused rat liver we analyzed whether S-adenosyl-L-methionine (SAMe) may protect this organ against the noxious effects of leukotriene-D4 (LTD4). We observed that a 2 nmol bolus of this compound decreased bile flow (-12.6% +/- 1.6%, P < .02), and bile salt excretion (-23.5% +/- 2.2%, P < .02; both compared with baseline values), caused the release of glutamic-oxaloacetic transaminase (GOT) and lactic dehydrogenase (LDH) to the hepatic effluent, and increased significantly the perfusion pressure as compared with a control group not receiving LTD4 (6.0 +/- 1.1 vs. 0.2 +/- 0.02 mm hg, respectively; P < .001). The cholestatic effect of LTD4 was attenuated by infusion of SAMe which, at rates of 67 and 100 microg/min, totally prevented the decrease in bile salt excretion. Likewise, in SAMe infused livers, the release to the effluent of GOT and LDH was lower than in the group receiving LTD4 only, and was even lower than in the control group. We also found that the increase in perfusion pressure induced by LTD4 was prevented by SAMe in a dose-dependent manner. Of interest, SAMe increased the biliary excretion of the eicosanoid in a dose-related fashion. We conclude that SAMe reverts the cholestatic, cytotoxic, and hemodynamic effects of LTD4 on the liver, and that these protective effects might be partly because of a stimulation of the biliary excretion of the leukotriene

Ionic liquids breakdown by Fenton oxidation

Fenton oxidation has proved to be an efficient treatment for the degradation of ionic liquids (ILs) of different families viz. imidazolium, pyridinium, ammonium and phosphonium, in water. The intensification of the process, defined as the improvement on the efficiency of H2O2 consumption, by increasing the temperature is necessary to avoid high reaction times and the need of large excess of H2O2. In this work, temperatures within the range of 70-90°C have been used, which allowed an effective breakdown of the ILs tested (1 g L-1 initial concentration) with the stoichiometric amount of H2O2 and a relatively low Fe3+dose (50 mg L-1). Under these conditions conversion of the ILs was achieved in less than 10 min, with TOC reductions higher than 60% upon 4 h reaction time, except for the phosphonium IL. The remaining TOC corresponded mainly to short-chain organic acids. The treatment reduced substantially the ecotoxicity up to final values below 0.01 TU in most cases and a significant improvement of the biodegradability was achieved. Upon Fenton oxidation of the four ILs tested hydroxylated compounds of higher molecular weight than the starting ILs, fragments of ILs partially oxidized and short-chain organic acids were identified as reaction by-products. Reaction pathways are proposedThis research has been supported by the Spanish MICINN through the projects CTQ2008-03988 and CTQ2010-14807 and by the CM through the project S-2009/AMB-158

Dynamical mean-field theory of spiking neuron ensembles: response to a single spike with independent noises

Dynamics of an ensemble of $N$-unit FitzHugh-Nagumo (FN) neurons subject to white noises has been studied by using a semi-analytical dynamical mean-field (DMF) theory in which the original $2 N$-dimensional {\it stochastic} differential equations are replaced by 8-dimensional {\it deterministic} differential equations expressed in terms of moments of local and global variables. Our DMF theory, which assumes weak noises and the Gaussian distribution of state variables, goes beyond weak couplings among constituent neurons. By using the expression for the firing probability due to an applied single spike, we have discussed effects of noises, synaptic couplings and the size of the ensemble on the spike timing precision, which is shown to be improved by increasing the size of the neuron ensemble, even when there are no couplings among neurons. When the coupling is introduced, neurons in ensembles respond to an input spike with a partial synchronization. DMF theory is extended to a large cluster which can be divided into multiple sub-clusters according to their functions. A model calculation has shown that when the noise intensity is moderate, the spike propagation with a fairly precise timing is possible among noisy sub-clusters with feed-forward couplings, as in the synfire chain. Results calculated by our DMF theory are nicely compared to those obtained by direct simulations. A comparison of DMF theory with the conventional moment method is also discussed.Comment: 29 pages, 2 figures; augmented the text and added Appendice

Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver

BACKGROUND/AIMS: Cysteinyl-containing leukotrienes seem to exert a cholestatic effect. However, leukotriene inhibitors were found to reduce bile salt efflux in isolated rat hepatocytes, suggesting a role for leukotrienes in bile flow formation. METHODS: In the isolated rat liver, the effects of two different concentrations of leukotriene C4 on bile flow and bile salt excretion are analyzed, as well as the possible effect of taurocholate on the hepatic production of cysteinyl-containing leukotrienes. RESULTS: Leukotriene C4 (0.25 fmol) increased bile salt excretion (+22.2%; P < 0.05), whereas a much higher dose (0.25 x 10(6) fmol) showed the known cholestatic effect, reducing bile salt excretion (-25.9%; P < 0.01). These dose-dependent biphasic effects were specific because they could be prevented by the simultaneous administration of cysteinyl-containing leukotriene antagonists. On the other hand, taurocholate administration induced a dose-dependent increase in biliary excretion of cysteinyl-containing leukotrienes. Furthermore, taurocholate increased messenger RNA levels of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis. Taurocholate increase of hepatocyte intracellular calcium was not significant, suggesting that taurocholate effects are not mediated by stimulation of calcium metabolism. CONCLUSIONS: These results constitute evidence for the existence of a positive feedback mechanism by which bile salts stimulate the synthesis of leukotrienes that, in turn, stimulate bile salt excretion

Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies

BACKGROUND: Signal transducers and activators of transcription (STATs) play a critical role in antiviral defence. STAT3 is also important in cell protection against inflammatory damage. STAT proteins are activated by interferons and by hepatoprotective cytokines of the interleukin 6 superfamily, including cardiotrophin 1. METHODS: We analysed the status of STATs in hepatitis C virus (HCV) infected livers and the relationship between expression and activation of STATs and HCV replication in Huh7 cells transfected with HCV genomic replicon. RESULTS: STAT3alpha expression was reduced in HCV infected livers showing an inverse correlation with serum alanine aminotransferase. In patients with HCV infection, nuclear staining for phosphorylated STAT3 was faint in parenchymal cells (although conspicuous in infiltrating leucocytes), in contrast with strong nuclear staining in hepatocytes from control livers. Expression and activation of STAT1 (a factor activated by both interferon (IFN)-alpha and IFN-gamma) were increased in HCV infected livers, particularly in those with high inflammatory activity. Conversely, phosphorylated STAT2 (a factor selectively activated by IFN-alpha) was undetectable in livers with HCV infection, a finding that was associated with marked downregulation of the two functional subunits of the IFN-alpha receptor. HCV replication in Huh7 cells caused STAT3alpha downregulation and blocked STAT3 phosphorylation by either IFN-alpha or cardiotrophin 1. HCV replication in Huh7 cells also inhibited STAT1 and STAT2 activation by IFN-alpha while there was no impairment of STAT1 phosphorylation by the proinflammatory cytokine IFN-gamma. CONCLUSIONS: STAT3 is downregulated in HCV infected livers and in Huh7 cells bearing the full length HCV replicon. HCV replication is associated with impaired Jak-STAT signalling by antiviral and cytoprotective cytokines. These effects may favour viral replication while facilitating the progression of liver diseas

Melting and Dimensionality of the Vortex Lattice in Underdoped YBa2Cu3O6.60

Muon spin rotation measurements of the magnetic field distribution in the vortex state of the oxygen deficient high-Tc superconductor YBa{2}Cu{3}O{6.60} reveal a vortex-lattice melting transition at much lower temperature than that in the fully oxygenated material. The transition is best described by a model in which adjacent layers of ``pancake'' vortices decouple in the liquid phase. Evidence is also found for a pinning-induced crossover from a solid 3D to quasi-2D vortex lattice, similar to that observed in the highly anisotropic superconductor Bi{2+x}Sr{2-x}CaCu{2}O{8+y}.Comment: 8 pages, 4 figures, 5 postscript file

Different Methods for the Two-Nucleon T-Matrix in the Operator Form

We compare three methods to calculate the nucleon-nucleon t-matrix based on the three-dimensional formulation of J. Golak et al., Phys. Rev. C 81, 034006, (2010). In the first place we solve a system of complex linear inhomogeneous equations directly for the t-matrix. Our second method is based on iterations and a variant of the Lanczos algorithm. In the third case we obtain the t-matrix in two steps, solving a system of real linear equations for the k-matrix expansion coefficients and then solving an on-shell equation, which connects the scalar coefficients of the k- and t-matrices. A very good agreement among the three methods is demonstrated for selected nucleon-nucleon scattering observables using a chiral next-to-next-to-leading-order neutron-proton potential. We also apply our three-dimensional framework to the demanding problem of proton-proton scattering, using a corresponding version of the nucleon-nucleon potential and supplementing it with the (screened) Coulomb force, taken also in the three-dimensional form. We show converged results for two different screening functions and find a very good agreement with other methods dealing with proton-proton scattering.Comment: 18 pages, 10 figures (54 eps files

Feasibility of a self-help web-based intervention targeting young cancer patients with sexual problems and fertility distress

PURPOSE: The purpose of the study is to evaluate the feasibility of a self-help web-based intervention to alleviate sexual problems and fertility distress in adolescents and young adults with cancer. METHODS: Twenty-three persons with cancer (19 women and 4 men, age 18-43, 1-5 years post-diagnosis of lymphoma, breast, gynecologic, central nervous system, or testicular cancer) were recruited to test a 2-month web-based program targeting sexual problems or fertility distress. The programs were organized in modules with educational and behavior change content, including texts, illustrations, exercises, and video vignettes. The program also included a discussion forum and an "ask the expert" forum. In addition, the sexuality program offered two telephone consultations. Feasibility (regarding demand, acceptability, preliminary efficacy, and functionality) was evaluated with the website system data, telephone interviews, continuous online evaluations, and study-specific measures. RESULTS: Fifteen participants completed four modules or more. Most of the program features were used and well accepted by these "committed users." The web-based format enabled flexible use by participants with diverse needs. Preliminary efficacy was indicated by self-reported increased knowledge and skill in handling sexual problems and fertility distress. The website was easy to use and functioned well technically. CONCLUSIONS: The present study indicated that this web-based intervention was feasible for adolescents and young adults with cancer. The effectiveness of the intervention in decreasing sexual problems and fertility distress will be tested in a population-based randomized controlled trial for adolescents and young adults with cancer. TRIAL REGISTRATION: ISRCTN36621459