Metal ion co-ordination in the DNA binding domain of the yeast transcriptional activator GAL4

AbstractThe structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the ‘native’ zinc (Zn(Il)-GAL4). The results suggest that the structure of the DNA binding domain of GAL4 contains a two metal ion cluster distinguishing it from the ‘zinc finger’ proteins typified by the Xenopus laevis transcription factor TFIIIA

Synthesis structure magnetic properties of [Cu5(bta)6L4] (bta=benzotriazolate;L=β-diketonate) Clusters

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