Magnetic resonance imaging improves breast screening sensitivity in BRCA mutation carriers age ≥50 years: Evidence from an individual patient data meta-analysis

Purpose There is no consensus on whether magnetic resonance imaging (MRI) should be included in breast screening protocols for women with BRCA1/2 mutations age ≥ 50 years. Therefore, we investigated the evidence on age-related screening accuracy in women with BRCA1/2 mutations using individual patient data (IPD) meta-analysis. Patients and Methods IPD were pooled from six high-risk screening trials including women with BRCA1/2 mutations who had completed at least one screening round with both MRI and mammography. A generalized linear mixed model with repeated measurements and a random effect of studies estimated sensitivity and specificity of MRI, mammography, and the combination in all women and specifically in those age ≥ 50 years. Results Pooled analysis showed that in women age ≥ 50 years, screening sensitivity was not different from that in women age <50 years, whereas screening specificity was. In women age ≥ 50 years, combining MRI and mammography significantly increased screening sensitivity compared with mammography alone (94.1%; 95% CI, 77.7% to 98.7% v 38.1%; 95% CI, 22.4% to 56.7%; P < .001). The combination was not significantly more sensitive than MRI alone (94.1%; 95% CI, 77.7% to 98.7% v 84.4%; 95% CI, 61.8% to 94.8%; P =.28). Combining MRI and mammography in women age ≥ 50 years resulted in sensitivity similar to that in women age ≥ 50 years (94.1%; 95% CI, 77.7

Traité de la matière médicale ou De l'histoire, des vertus, du choix et de l'usage des remèdes simples. Tome 7,Section 2 / . Par M. Geoffroy,... Traduit... par M***,...

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Overview of ASDEX Upgrade results

ASDEX Upgrade was operated with a fully W-covered wall in 2007 and 2008. Stationary H-modes at the ITER target values and improved H-modes with H up to 1.2 were run without any boronization. The boundary conditions set by the full W wall (high enough ELM frequency, high enough central heating and low enough power density arriving at the target plates) require significant scenario development, but will apply to ITER as well. D retention has been reduced and stationary operation with saturated wall conditions has been found. Concerning confinement, impurity ion transport across the pedestal is neoclassical, explaining the strong inward pinch of high-Z impurities in between ELMs. In improved H-mode, the width of the temperature pedestal increases with heating power, consistent with a scaling. In the area of MHD instabilities, disruption mitigation experiments using massive Ne injection reach volume averaged values of the total electron density close to those required for runaway suppression in ITER. ECRH at the q = 2 surface was successfully applied to delay density limit disruptions. The characterization of fast particle losses due to MHD has shown the importance of different loss mechanisms for NTMs, TAEs and also beta-induced Alfven eigenmodes (BAEs). Specific studies addressing the first ITER operational phase show that O1 ECRH at the HFS assists reliable low-voltage breakdown. During ramp-up, additional heating can be used to vary li to fit within the ITER range. Confinement and power threshold in He are more favourable than in H, suggesting that He operation could allow us to assess H-mode operation in the non-nuclear phase of ITER operation

A New Boson with a Mass of 125 GeV Observed with the CMS Experiment at the Large Hadron Collider

The Higgs boson was postulated nearly five decades ago within the framework of the standard model of particle physics and has been the subject of numerous searches at accelerators around the world. Its discovery would verify the existence of a complex scalar field thought to give mass to three of the carriers of the electroweak force-the W+, W-, and Z(0) bosons-as well as to the fundamental quarks and leptons. The CMS Collaboration has observed, with a statistical significance of five standard deviations, a new particle produced in proton-proton collisions at the Large Hadron Collider at CERN. The evidence is strongest in the diphoton and four-lepton (electrons and/or muons) final states, which provide the best mass resolution in the CMS detector. The probability of the observed signal being due to a random fluctuation of the background is about 1 in 3 x 10(6). The new particle is a boson with spin not equal to 1 and has a mass of about 1.25 giga-electron volts. Although its measured properties are, within the uncertainties of the present data, consistent with those expected of the Higgs boson, more data are needed to elucidate the precise nature of the new particle