672 research outputs found

    Materials and structures for hypersonic vehicles

    Get PDF
    Hypersonic vehicles are envisioned to require, in addition to carbon-carbon and ceramic-matrix composities for leading edges heated to above 2000 F, such 600 to 1800 F operating temperature materials as advanced Ti alloys, nickel aluminides, and metal-matrix composited; These possess the necessary low density and high strength and stiffness. The primary design drivers are maximum vehicle heating rate, total heat load, flight envelope, propulsion system type, mission life requirements and liquid hydrogen containment systems. Attention is presently given to aspects of these materials and structures requiring more intensive development

    Structures and materials technology issues for reusable launch vehicles

    Get PDF
    Projected space missions for both civil and defense needs require significant improvements in structures and materials technology for reusable launch vehicles: reductions in structural weight compared to the Space Shuttle Orbiter of up to 25% or more, a possible factor of 5 or more increase in mission life, increases in maximum use temperature of the external surface, reusable containment of cryogenic hydrogen and oxygen, significant reductions in operational costs, and possibly less lead time between technology readiness and initial operational capability. In addition, there is increasing interest in hypersonic airbreathing propulsion for launch and transmospheric vehicles, and such systems require regeneratively cooled structure. The technology issues are addressed, giving brief assessments of the state-of-the-art and proposed activities to meet the technology requirements in a timely manner

    Discovery of Five New Pulsars in Archival Data

    Get PDF
    Reprocessing of the Parkes Multibeam Pulsar Survey has resulted in the discovery of five previously unknown pulsars and several as-yet-unconfirmed candidates. PSR J0922-52 has a period of 9.68 ms and a DM of 122.4 pc cm^-3. PSR J1147-66 has a period of 3.72 ms and a DM of 133.8 pc cm^-3. PSR J1227-6208 has a period of 34.53 ms, a DM of 362.6 pc cm^-3, is in a 6.7 day binary orbit, and was independently detected in an ongoing high-resolution Parkes survey by Thornton et al. and also in independent processing by Einstein@Home volunteers. PSR J1546-59 has a period of 7.80 ms and a DM of 168.3 pc cm^-3. PSR J1725-3853 is an isolated 4.79-ms pulsar with a DM of 158.2 pc cm^-3. These pulsars were likely missed in earlier processing efforts due to their high DMs and short periods and the large number of candidates that needed to be looked through. These discoveries suggest that further pulsars are awaiting discovery in the multibeam survey data.Comment: 12 pages, 2 figures, 2 tables, accepted to Ap

    Un couple fantomatique : le conte et la fable chez quelques fabulistes des Lumières

    Get PDF
    Si les fabulistes des Lumières déploient un important appareil théorique pour s’efforcer de donner au petit genre qu’ils pratiquent une poétique — tirée de l’analyse de l’œuvre de La Fontaine ou issue d’une reformulation des préceptes de la tradition didactique et rhétorique —, ils semblent n’avoir guère réfléchi sur l’articulation entre fable et conte, même dans les cas, assez nombreux, où les deux termes figurent au titre de leurs recueils : les étiquettes paraissent interchangeables et les discours liminaires comme les apologues confirment une adhésion non problématique à la définition, souvent répétée, de La Fontaine selon laquelle une fable doit être « un conte » destiné à faire passer « le précepte avec lui ». Seules les Fables nouvelles de l’abbé Aubert, dans leur édition de 1773, esquissent — sans la théoriser — une distinction entre fable et conte, en choisissant une structure originale pour le recueil : symétriquement dans chacune des deux parties, les livres de fables (à l’exception des livres conclusifs, dotés d’un simple « épilogue ») sont terminés par un « conte moral », ce qui souligne l’inflexion de l’ouvrage, à l’origine dominé par les thématiques religieuses ou politiques, vers un moralisme domestique et sensible.If the fabulists of the Enlightenment display an important theoretical apparatus to try and give a poetics to the fable—that is derived from La Fontaine or from a reformulation of the tenets of the didactic and rhetorical tradition—, they do not seem to have considered the relationship between fable and tale, even when both appear in the titles of their books. Labels seem interchangeable and prefatory discourses as well as the apologues confirm an unproblematic adhesion to La Fontaine’s often repeated definition of a fable that must be “a tale” intended to raise “the precept with it”. Only the Fables nouvelles of Abbé Aubert in their edition of 1773 outline (without theorizing it) a distinction between fable and tale by choosing an original structure for the collection: symmetrically in both parties, books of fables (except conclusive books, with a simple “epilogue”) are terminated by a “moral tale”, which underlines the shift in the tale in which the originally religious or political themes gradually turn into a domestic and sensible moralism

    Spelling in adolescents with dyslexia: errors and modes of assessment

    Get PDF
    In this study we focused on the spelling of high-functioning students with dyslexia. We made a detailed classification of the errors in a word and sentence dictation task made by 100 students with dyslexia and 100 matched control students. All participants were in the first year of their bachelor’s studies and had Dutch as mother tongue. Three main error categories were distinguished: phonological, orthographic, and grammatical errors (on the basis of morphology and language-specific spelling rules). The results indicated that higher-education students with dyslexia made on average twice as many spelling errors as the controls, with effect sizes of d ≥ 2. When the errors were classified as phonological, orthographic, or grammatical, we found a slight dominance of phonological errors in students with dyslexia. Sentence dictation did not provide more information than word dictation in the correct classification of students with and without dyslexia

    Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.

    Get PDF
    A nuclear factor-κB (NF-κB) luciferase assay has been employed to identify the bengamides, previously known for their anti-tumor activity, as a new class of immune modulators. A unique element of this study was that the bengamide analogs were isolated from two disparate sources, Myxococcus virescens (bacterium) and Jaspis coriacea (sponge). Comparative LC-MS/ELSD and NMR analysis facilitated the isolation of M. viriscens derived samples of bengamide E (8) and two congeners, bengamide E\u27 (13) and F\u27 (14) each isolated as an insperable mixture of diastereomers. Additional compounds drawn from the UC, Santa Cruz repository allowed expansion of the structure activity relationship (SAR) studies. The activity patterns observed for bengamide A (6), B (7), E (8), F (9), LAF 389 (12) and 13-14 gave rise to the following observations and conclusions. Compounds 6 and 7 display potent inhibition of NF-κB (at 80 and 90 nM, respectively) without cytotoxicity to RAW264.7 macrophage immune cells. Western blot and qPCR analysis indicated that 6 and 7 reduce the phosphorylation of IκBα and the LPS-induced expression of the pro-inflammatory cytokines/chemokines TNFα, IL-6 and MCP-1 but do not effect NO production or the expression of iNOS. These results suggest that the bengamides may serve as therapeutic leads for the treatment of diseases involving inflammation, that their anti-tumor activity can in part be attributed to their ability to serve as immune modulating agents, and that their therapeutic potential against cancer merits further consideration

    Filling the Gaps in the Pharmacy Workforce in Post-Conflict Areas: Experience from Four Countries in Sub-Saharan Africa

    Get PDF
    From MDPI via Jisc Publications RouterHistory: accepted 2021-07-28, pub-electronic 2021-07-31Publication status: PublishedFunder: World Health Organization; Grant(s): WHO Kobe Centre – WKC: K18009Background: While the pharmacy workforce is the third largest professional healthcare group worldwide, the pharmacy workforce landscape remains unclear in post-conflict areas in sub-Saharan Africa. Method: Key informants were selected for semi-structured interviews due to their role in providing pharmacy services in the selected country: the Central African Republic (CAR), the Democratic Republic of Congo (DRC), Ethiopia, and South Sudan. Transcripts from the interviews were anonymized, coded, and analyzed. Results: Nine participants were recruited (CAR: 2; DRC: 2; Ethiopia: 2; South Sudan: 3), and all except two were pharmacists. Conflict-specific challenges in pharmacy service delivery were identified as the following: unpredictable health needs and/or mismatched pharmaceutical supply, transport difficulties due to insecure roads, and shortage of pharmacy workforce due to brain drain or interrupted schooling. Barriers to health workforce retention and growth were identified to be brain drain as a result of suboptimal living and working conditions or remuneration, the perception of an unsafe work environment, and a career pathway or commitment duration that does not fit the diaspora or expatriate staff. Conclusion: To tackle the barriers of pharmacy health workforce retention and growth, policy solutions will be required and efforts that can bring about long-term improvement should be prioritized. This is essential to achieve universal health coverage and the targets of the sustainable development goals for conflict affected areas, as well as to “leave no one behind”
    • …
    corecore