AGN counts at 15um. XMM observations of the ELAIS-S1-5 sample

Context: The counts of galaxies and AGN in the mid infra-red (MIR) bands are important instruments for studying their cosmological evolution. However, the classic spectral line ratios techniques can become misleading when trying to properly separate AGN from starbursts or even from apparently normal galaxies. Aims: We use X-ray band observations to discriminate AGN activity in previously classified MIR-selected starburst galaxies and to derive updated AGN1 and (Compton thin) AGN2 counts at 15 um. Methods: XMM observations of the ELAIS-S1 15um sample down to flux limits ~2x10^-15 erg cm^-2 s^-1 (2-10 keV band) were used. We classified as AGN all those MIR sources with a unabsorbed 2-10 keV X-ray luminosity higher that ~10^42 erg/s. Results: We find that at least about 13(+/-6) per cent of the previously classified starburst galaxies harbor an AGN. According to these figures, we provide an updated estimate of the counts of AGN1 and (Compton thin) AGN2 at 15 um. It turns out that at least 24% of the extragalactic sources brighter than 0.6 my at 15 um are AGN (~13% contribution to the extragalactic background produced at fluxes brighter than 0.6 mJy).Comment: Accepted for publication on A&

The Nustar Extragalactic Surveys: Overview and Catalog from the Cosmos Field

To provide the census of the sources contributing to the X-ray background peak above 10 keV, NuSTAR is performing extragalactic surveys using a three-tier wedding cake approach. We present the NuSTAR survey of the COSMOS field, the medium sensitivity and medium area tier, covering 1.7 deg2 and overlapping with both Chandra and XMM-Newton data. This survey consists of 121 observations for a total exposure of ~3 Ms. To fully exploit these data, we developed a new detection strategy, carefully tested through extensive simulations. The survey sensitivity at 20% completeness is 5.9, 2.9 and 6.4 x 10^-14 erg/cm2/s in the 3-24 keV, 3-8 keV and 8-24 keV bands, respectively. By combining detections in 3 bands, we have a sample of 91 NuSTAR sources with 10^42 -10^45.5 erg/s luminosities and redshift z=0.04-2.5. Thirty two sources are detected in the 8-24 keV band with fluxes ~100 times fainter than sources detected by Swift-BAT. Of the 91 detections, all but four are associated with a Chandra and/or XMM-Newton point-like counterpart. One source is associated with an extended lower energy X-ray source. We present the X-ray (hardness ratio and luminosity) and optical-to-X-ray properties. The observed fraction of candidate Compton-thick AGN measured from the hardness ratio is between 13-20%. We discuss the spectral properties of NuSTAR J100259+0220.6 (ID 330) at z=0.044, with the highest hardness ratio in the entire sample. The measured column density exceeds 10^24 /cm2, implying the source is Compton-thick. This source was not previously recognized as such without the \u3e10 keV data

The multi-phase winds of Markarian 231: from the hot, nuclear, ultra-fast wind to the galaxy-scale, molecular outflow

We present the best sensitivity and angular resolution maps of the molecular disk and outflow of Mrk 231, as traced by CO observations obtained with IRAM/PdBI, and we analyze archival Chandra and NuSTAR observations. We constrain the physical properties of both the molecular disk and outflow, the presence of a highly-ionized ultra-fast nuclear wind, and their connection. The molecular outflow has a size of ~1 kpc, and extends in all directions around the nucleus, being more prominent along the south-west to north-east direction, suggesting a wide-angle biconical geometry. The maximum projected velocity of the outflow is nearly constant out to ~1 kpc, thus implying that the density of the outflowing material decreases from the nucleus outwards as $r^{-2}$. This suggests that either a large part of the gas leaves the flow during its expansion or that the bulk of the outflow has not yet reached out to ~1 kpc, thus implying a limit on its age of ~1 Myr. We find $\dot M_{OF}=[ 500-1000]~ M_{\odot}~yr^{-1}$ and $\dot E_{kin,OF}=[7-10]\times 10^{43}$ erg s$^{-1}$. Remarkably, our analysis of the X-ray data reveals a nuclear ultra-fast outflow (UFO) with velocity -20000 km s$^{-1}$, $\dot M_{UFO}=[0.3- 2.1] ~M_\odot yr^{-1}$, and momentum load $\dot P_{UFO}/\dot P_{rad}=[0.2-1.6]$.We find $\dot E_{kin,UFO}\sim \dot E_{kin,OF}$ as predicted for outflows undergoing an energy conserving expansion. This suggests that most of the UFO kinetic energy is transferred to mechanical energy of the kpc-scale outflow, strongly supporting that the energy released during accretion of matter onto super-massive black holes is the ultimate driver of giant massive outflows. We estimate a momentum boost $\dot P_{OF}/\dot P_{UFO}\approx [30-60]$. The ratios $\dot E_{kin, UFO}/L_{bol,AGN} =[ 1-5]\%$ and $\dot E_{kin,OF}/L_{bol,AGN} = [1-3]\%$ agree with the requirements of the most popular models of AGN feedback.Comment: 16 pages, 17 figures. Accepted for publication in A&

Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis

ABSTRACTIntroduction: Fingolimod, the first oral disease-modifying treatment (DMT) in multiple sclerosis (MS), is a sphingosine 1-phosphate receptor (S1PR) ligand. Approved in 2010, fingolimod has ..

The XMM-Newton survey of the ELAIS-S1 field II: optical identifications and multiwavelength catalogue of X-ray sources

We present optical identifications and a multi-band catalogue of a sample of 478 X-ray sources in the XMM and Chandra surveys of the central 0.6 deg^2 of the ELAIS-S1 field. The optical/infrared counterpart of each X-ray source was identified using R and IRAC 3.6 um bands. This method was complemented by the precise positions obtained through Chandra observations. Approximately 94% of the counterparts are detected in the R band, while the remaining are blank fields in the optical down to R~24.5, but have a near-infrared counterpart detected by IRAC within 6 arcsec from the XMM centroid. The multi-band catalogue contains photometry in ten photometric bands (B to the MIPS 24 um). We determined redshift and classification for 237 sources (~50% of the sample) brighter than R=24. We classified 47% of the sources with spectroscopic redshift as broad-line active galactic nuclei (BL AGNs) with z=0.1-3.5, while sources without broad-lines are about 46% of the spectroscopic sample and are found up to z=2.6. We identified 11 type 2 QSOs among the sources with X/O>8, with z=0.9-2.6, high 2-10 keV luminosity (log(L2-10keV)>=43.8 erg/s) and hard X-ray colors suggesting large absorbing columns at the rest frame (logN_H up to 23.6 cm^-2). BL AGNs show on average blue optical-to-near-infrared colors, softer X-ray colors and X-ray-to-optical colors typical of optically selected AGNs. Conversely, narrow-line sources show redder optical colors, harder X-ray flux ratio and span a wider range of X-ray-to-optical colors. On average the SEDs of high-luminosity BL AGNs resemble the power-law typical of unobscured AGNs. The SEDs of NOT BL AGNs are dominated by the galaxy emission in the optical/near-infrared, and show a rise in the mid-infrared which suggests the presence of an obscured active nucleus.Comment: 15 pages, A&A accepted, affiliations correcte

Unveiling obscured accretion in the Chandra Deep Field South

A large population of heavily obscured, Compton Thick AGNs is predicted by models of galaxy formation, models of Cosmic X-ray Background and by the ``relic'' super-massive black-hole mass function measured from local bulges. However, so far only a handful of Compton thick AGNs have been possibly detected using even the deepest Chandra and XMM surveys. Compton-thick AGNs can be recovered thanks to the reprocessing of the AGN UV emission in the infrared by selecting sources with AGN luminosity's in the mid-infrared and faint near-infrared and optical emission. To this purpose, we make use of deep HST, VLT, Spitzer and Chandra data on the Chandra Deep Field South to constrain the number of Compton thick AGN in this field. We show that sources with high 24$\mu$m to optical flux ratios and red colors form a distinct source population, and that their infrared luminosity is dominated by AGN emission. Analysis of the X-ray properties of these extreme sources shows that most of them (80$\pm15$) are indeed likely to be highly obscured, Compton thick AGNs. The number of infrared selected, Compton thick AGNs with 5.8$\mu$m luminosity higher than $10^{44.2}$ erg s$^{-1}$ turns out to be similar to that of X-ray selected, unobscured and moderately obscured AGNs with 2-10 keV luminosity higher than $10^{43}$ erg s$^{-1}$ in the redshift bin 1.2-2.6. This ``factor of 2'' source population is exactly what it is needed to solve the discrepancies between model predictions and X-ray AGN selection.Comment: Revised version, to be published by The Astrophysical Journa

The HELLAS2XMM survey. IX. Spectroscopic identification of super-EROs hosting AGNs

We present VLT near-IR spectroscopic observations of three X-ray sources characterized by extremely high X-ray-to-optical ratios (X/O>40), extremely red colors (6.3<R-K<7.4, i.e. EROs) and bright infrared magnitudes (17.6<K<18.3). These objects are very faint in the optical, making their spectroscopic identification extremely challenging. Instead, our near-IR spectroscopic observations have been successful in identifying the redshift of two of them (z=2.08 and z=1.35), and tentatively even of the third one (z=2.13). When combined with the X-ray properties, our results clearly indicate that all these objects host obscured QSOs (4e44 < L(2-10keV) < 1.5e45 erg/s, 2e22 < N_H < 4e23 cm-2) at high redshift. The only object with unresolved morphology in the K band shows broad Halpha emission, but not broad Hbeta, implying a type 1.9 AGN classification. The other two objects are resolved and dominated by the host galaxy light in the K band, and appear relatively quiescent: one of them has a LINER-like emission line spectrum and the other presents only a single, weak emission line which we tentatively identify with Halpha. The galaxy luminosities for the latter two objects are an order of magnitude brighter than typical local L* galaxies and the derived stellar masses are well in excess of 10^11 Msun. For these objects we estimate black hole masses higher than 10^9 Msun and we infer that they are radiating at Eddington ratios L/L_Edd < 0.1. We discuss the implications of these findings for the coevolution of galaxies and black hole growth. Our results provide further support that X-ray sources with high X/O ratios and very red colors tend to host obscured QSO in very massive galaxies at high redshift.Comment: 7 pages, 5 figures, accepted for publication in A&

Long non-coding RNAs play a role in the pathogenesis of psoriatic arthritis by regulating microRNAs and genes involved in inflammation and metabolic syndrome

Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10-30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, driven by autoreactive T cells directed against autoantigens present in the skin and in the joints. However, an autoinflammatory origin has recently been proposed. Long noncoding RNAs (lncRNAs) are RNAs more than 200 nucleotides in length that do not encode proteins. LncRNAs play important roles in several biological processes, including chromatin remodeling, transcription control, and post-transcriptional processing. Several studies have shown that lncRNAs are expressed in a stage-specific or lineage-specific manner in immune cells that have a role in the development, activation, and effector functions of immune cells. LncRNAs are thought to play a role in several diseases, including autoimmune disorders. Indeed, a few lncRNAs have been identified in systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. Although several high-throughput studies have been performed to identify lncRNAs, their biological and pathological relevance are still unknown, and most transcriptome studies in autoimmune diseases have only assessed protein-coding transcripts. No data are currently available on lncRNAs in PsA. Therefore, by microarray analysis, we have investigated the expression profiles of more than 50,000 human lncRNAs in blood samples from PsA patients and healthy controls using Human Clariom D Affymetrix chips, suitable to detect rare and low-expressing transcripts otherwise unnoticed by common sequencing methodologies. Network analysis identified lncRNAs targeting highly connected genes in the PsA transcriptome. Such genes are involved in molecular pathways crucial for PsA pathogenesis, including immune response, glycolipid metabolism, bone remodeling, type 1 interferon, wingless related integration site, and tumor necrosis factor signaling. Selected lncRNAs were validated by RT-PCR in an expanded cohort of patients. Moreover, modulated genes belonging to meaningful pathways were validated by RT-PCR in PsA PBMCs and/or by ELISA in PsA sera. The findings indicate that lncRNAs are involved in PsA pathogenesis by regulating both microRNAs and genes and open new avenues for the identification of new biomarkers and therapeutical targets

Relativistic iron K X-ray Reverberation in NGC 4151

Recent X-ray observations have enabled the study of reverberation delays in AGN for the first time. All the detections so far are in sources with a strong soft excess, and the measured delay is between the hard (1-3 keV) direct continuum and the soft excess (0.5-1 keV), interpreted as the reflection continuum smeared by relativistic effects. There is however an inherent ambiguity in identifying and studying the details of the lines in the soft excess. Here we report the first detection of reverberation in the iron K band in any AGN. Using XMM-Newton observations of NGC 4151, we find delays of order 2000 s on time-scales of 10e5 s between the 5-6 keV band and 2-3 and 7-8 keV bands, with a broad lag profile resembling a relativistically-broadened iron line. The peak of the lag spectra shifts to lower energies at higher frequencies, consistent with the red wing of the line being emitted at smaller radii, as expected from reflection off the inner accretion disk. This is a first detection of a broad iron line using timing studies.Comment: final version, corrected small typo