1,117 research outputs found
Life events and acute cardiovascular reactions to mental stress: a cohort study
Objective: This study addressed the issue of whether frequent exposure to life events is associated with aggravation or blunting of cardiovascular reactions to acute mental stress. Methods: In a substantial cohort of 585 healthy young adults, systolic and diastolic blood pressure and pulse rate were recorded at rest and in response to a mental arithmetic stress task. Participants indicated, from a list of 50 events, those they had experienced in the last year. Results: There was an overall association between life events and blunted cardiovascular reactivity that was driven by variations in the frequency of exposure to desirable events. The total number of events and the number of personal events were negatively associated with systolic blood pressure and pulse rate reactions to acute stress, whereas the number of work-related events was negatively associated with diastolic blood pressure and pulse rate reactivity. The negative association between total events and systolic blood pressure reactivity was stronger for women than men, whereas men exposed to frequent undesirable events showed enhanced diastolic blood pressure reactivity. The blunting of pulse rate reactivity associated with frequent personal life events was evident particularly for those who had a relatively large number of close friends. Conclusions: The nature and extent of the association between life events exposure and stress reactivity in young adults depends on the valence of the events together with the sex of the individual and their social network size
The geometry of thermodynamic control
A deeper understanding of nonequilibrium phenomena is needed to reveal the
principles governing natural and synthetic molecular machines. Recent work has
shown that when a thermodynamic system is driven from equilibrium then, in the
linear response regime, the space of controllable parameters has a Riemannian
geometry induced by a generalized friction tensor. We exploit this geometric
insight to construct closed-form expressions for minimal-dissipation protocols
for a particle diffusing in a one dimensional harmonic potential, where the
spring constant, inverse temperature, and trap location are adjusted
simultaneously. These optimal protocols are geodesics on the Riemannian
manifold, and reveal that this simple model has a surprisingly rich geometry.
We test these optimal protocols via a numerical implementation of the
Fokker-Planck equation and demonstrate that the friction tensor arises
naturally from a first order expansion in temporal derivatives of the control
parameters, without appealing directly to linear response theory
Fragment properties at the catastrophic disruption threshold: The effect of the parent body's internal structure
Numerical simulations of asteroid break-ups, including both the fragmentation
of the parent body and the gravitational interactions between the fragments,
have allowed us to reproduce successfully the main properties of asteroid
families formed in different regimes of impact energy, starting from a
non-porous parent body. In this paper, using the same approach, we concentrate
on a single regime of impact energy, the so-called catastrophic threshold
usually designated by Q*D, which results in the escape of half of the target's
mass. Thanks to our recent implementation of a model of fragmentation of porous
materials, we can characterize Q*D for both porous and non-porous targets with
a wide range of diameters. We can then analyze the potential influence of
porosity on the value of Q*D, and by computing the gravitational phase of the
collision in the gravity regime, we can characterize the collisional outcome in
terms of the fragment size and ejection speed distributions, which are the main
outcome properties used by collisional models to study the evolutions of the
different populations of small bodies. We also check the dependency of Q*D on
the impact speed of the projectile. In the strength regime, which corresponds
to target sizes below a few hundreds of meters, we find that porous targets are
more difficult to disrupt than non-porous ones. In the gravity regime, the
outcome is controlled purely by gravity and porosity in the case of porous
targets. In the case of non-porous targets, the outcome also depends on
strength. We then propose some power-law relationships between Q*D and both
target's size and impact speed that can be used in collisional evolution
models.Comment: 18 pages, 19 Figures. Accepted for publication in Icaru
Spinors, Inflation, and Non-Singular Cyclic Cosmologies
We consider toy cosmological models in which a classical, homogeneous, spinor
field provides a dominant or sub-dominant contribution to the energy-momentum
tensor of a flat Friedmann-Robertson-Walker universe. We find that, if such a
field were to exist, appropriate choices of the spinor self-interaction would
generate a rich variety of behaviors, quite different from their widely studied
scalar field counterparts. We first discuss solutions that incorporate a stage
of cosmic inflation and estimate the primordial spectrum of density
perturbations seeded during such a stage. Inflation driven by a spinor field
turns out to be unappealing as it leads to a blue spectrum of perturbations and
requires considerable fine-tuning of parameters. We next find that, for simple,
quartic spinor self-interactions, non-singular cyclic cosmologies exist with
reasonable parameter choices. These solutions might eventually be incorporated
into a successful past- and future-eternal cosmological model free of
singularities. In an Appendix, we discuss the classical treatment of spinors
and argue that certain quantum systems might be approximated in terms of such
fields.Comment: 12 two-column pages, 3 figures; uses RevTeX
Use and Adoption Challenges of Wearable Activity Trackers
Wearable activity trackers are becoming widely adopted, yet challenges continue to exist in effective long-term use and adoption. Existing research focuses mostly on the use and adoption challenges associated with technical- or device-related issues and respective workaround strategies. Little is known about how personal preferences and other individual characteristics affect use and adoption of wearable activity trackers. In this paper, we present a six-week user study of 30 users using physical activity trackers embedded in clip-on and smart watch physical devices. We describe novel implications of the usage patterns, including the need to help people be mindful of their physical activity trackers, to understand and further articulate gender differences in use and adoption of wearable devices, to incorporate big data analytics in informing and coaching peopleâs practices, and to reframe data inaccuracy as a byproduct of mismanagement of expectations of the deviceâs capabilities and its expected usage.ye
Reverberation Mapping of the Kepler-Field AGN KA1858+4850
KA1858+4850 is a narrow-line Seyfert 1 galaxy at redshift 0.078 and is among
the brightest active galaxies monitored by the Kepler mission. We have carried
out a reverberation mapping campaign designed to measure the broad-line region
size and estimate the mass of the black hole in this galaxy. We obtained 74
epochs of spectroscopic data using the Kast Spectrograph at the Lick 3-m
telescope from February to November of 2012, and obtained complementary V-band
images from five other ground-based telescopes. We measured the H-beta light
curve lag with respect to the V-band continuum light curve using both
cross-correlation techniques (CCF) and continuum light curve variability
modeling with the JAVELIN method, and found rest-frame lags of lag_CCF = 13.53
(+2.03, -2.32) days and lag_JAVELIN = 13.15 (+1.08, -1.00) days. The H-beta
root-mean-square line profile has a width of sigma_line = 770 +/- 49 km/s.
Combining these two results and assuming a virial scale factor of f = 5.13, we
obtained a virial estimate of M_BH = 8.06 (+1.59, -1.72) x 10^6 M_sun for the
mass of the central black hole and an Eddington ratio of L/L_Edd ~ 0.2. We also
obtained consistent but slightly shorter emission-line lags with respect to the
Kepler light curve. Thanks to the Kepler mission, the light curve of
KA1858+4850 has among the highest cadences and signal-to-noise ratios ever
measured for an active galactic nucleus; thus, our black hole mass measurement
will serve as a reference point for relations between black hole mass and
continuum variability characteristics in active galactic nuclei
Measurements of atmospheric layers from the NASA DC-8 and P-3B aircraft during PEM-Tropics A
Tropospheric vertical structure was analyzed using in situ measurements of Oâ, CO, CHâ, and HâO taken on board the NASA DC-8 aircraft during three Pacific Exploratory Missions (PEMs): PEM-West A, September-October 1991 in the western Pacific; PEM-West B, February-March 1994 in the western Pacific; and PEM-Tropics A, September-October 1996 in the central and eastern Pacific. PEM-Tropics A added measurements from the NASA P3-B aircraft. We used a new mode-based method to define a background against which to find layers. Using only Oâ and HâO, we found 472 layers in PEM-Tropics A (0.72 layers per vertical kilometer profiled), 237 layers in PEM-West A (0.54 layers/km), and 158 layers in PEM-West B (0.41 layers/km). Using all constituents, we found 187 layers in PEM-Tropics A (0.43 layers/km), 128 layers in PEM-West A (0.29 layers/km), and 80 layers in PEM-West B (0.21 layers/km). Stratospheric air, sometimes mixed with trapped pollution, was the dominant layer source in all three missions. The larger number of layers per kilometer in PEM-Tropics A was probably due to repeated profiling of several âsuperlayersâ visible in many of the mission lidar and potential voracity profiles. The thickness of the superlayers was of order 1 km, and the horizontal extent was of order 1000 km. We found that layers have an important effect on the thermal structure. An example based on ozonesonde data from Tahiti is shown, where a dry, subsiding layer was stabilized by much greater radiative cooling at the base than at the top. The stabilized layer can trap pollution and force vertical plumes to spread into horizontal layers.United States. National Aeronautics and Space Administration (Grant NAG1-1758)United States. National Aeronautics and Space Administration (Grant NAG1-1901
Teleost Growth Factor Independence (Gfi) Genes Differentially Regulate Successive Waves of Hematopoiesis
Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development and lineage specification. In mammals, Gfi1a regulates hematopoietic stem cells (HSC), myeloid and lymphoid populations, while its paralog, Gfi1b, regulates HSC, megakaryocyte and erythroid development. In zebrafish, gfi1aa is essential for primitive hematopoiesis; however, little is known about the role of gfi1aa in definitive hematopoiesis or about additional gfi factors in zebrafish. Here, we report the isolation and characterization of an additional hematopoietic gfi factor, gfi1b. We show that gfi1aa and gfi1b are expressed in the primitive and definitive sites of hematopoiesis in zebrafish. Our functional analyses demonstrate that gfi1aa and gfi1b have distinct roles in regulating primitive and definitive hematopoietic progenitors, respectively. Loss of gfi1aa silences markers of early primitive progenitors, scl and gata1. Conversely, loss of gfi1b silences runx-1, c-myb, ikaros and cd41, indicating that gfi1b is required for definitive hematopoiesis. We determine the epistatic relationships between the gfi factors and key hematopoietic transcription factors, demonstrating that gfi1aa and gfi1b join lmo2, scl, runx-1 and c-myb as critical regulators of teleost HSPC. Our studies establish a comparative paradigm for the regulation of hematopoietic lineages by gfi transcription factors.Stem Cell and Regenerative Biolog
Simply imagining sunshine, lollipops and rainbows will not budge the bias: The role of ambiguity in interpretive bias modification
Imagery-based interpretive bias modification (CBM-I) involves repeatedly imagining scenarios that are initially ambiguous before being resolved as either positive or negative in the last word/s. While the presence of such ambiguity is assumed to be important to achieve change in selective interpretation, it is also possible that the act of repeatedly imagining positive or negative events could produce such change in the absence of ambiguity. The present study sought to examine whether the ambiguity in imagery-based CBM-I is necessary to elicit change in interpretive bias, or, if the emotional content of the imagined scenarios is sufficient to produce such change. An imagery-based CBM-I task was delivered to participants in one of four conditions, where the valence of imagined scenarios were either positive or negative, and the ambiguity of the scenario was either present (until the last word/s) or the ambiguity was absent (emotional valence was evident from the start). Results indicate that only those who received scenarios in which the ambiguity was present acquired an interpretive bias consistent with the emotional valence of the scenarios, suggesting that the act of imagining positive or negative events will only influence patterns of interpretation when the emotional ambiguity is a consistent feature
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