BCR-ABL Promotes PTEN Downregulation in Chronic Myeloid Leukemia.

Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translocation coding for the chimeric protein p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through non genomic loss of function mechanisms, such as protein down-regulation and impaired nuclear/cytoplasmic shuttling. Here we demonstrate that BCR-ABL promotes PTEN downregulation through a MEK dependent pathway. Furthermore, we describe a novel not recurrent N212D-PTEN point mutation found in the EM2 blast crisis cell line

Non-standard grain properties, dark gas reservoir, and extended submillimeter excess, probed by Herschel in the Large Magellanic Cloud

Context. Herschel provides crucial constraints on the IR SEDs of galaxies, allowing unprecedented accuracy on the dust mass estimates. However, these estimates rely on non-linear models and poorly-known optical properties. Aims. In this paper, we perform detailed modelling of the Spitzer and Herschel observations of the LMC, in order to: (i) systematically study the uncertainties and biases affecting dust mass estimates; and to (ii) explore the peculiar ISM properties of the LMC. Methods. To achieve these goals, we have modelled the spatially resolved SEDs with two alternate grain compositions, to study the impact of different submillimetre opacities on the dust mass. We have rigorously propagated the observational errors (noise and calibration) through the entire fitting process, in order to derive consistent parameter uncertainties. Results. First, we show that using the integrated SED leads to underestimating the dust mass by ≃50% compared to the value obtained with sufficient spatial resolution, for the region we studied. This might be the case, in general, for unresolved galaxies. Second, we show that Milky Way type grains produce higher gas-to-dust mass ratios than what seems possible according to the element abundances in the LMC. A spatial analysis shows that this dilemma is the result of an exceptional property: the grains of the LMC have on average a larger intrinsic submm opacity (emissivity index β ≃ 1.7 and opacity κ_(abs)(160 μm) = 1.6 m^2   kg^(-1)) than those of the Galaxy. By studying the spatial distribution of the gas-to-dust mass ratio, we are able to constrain the fraction of unseen gas mass between ≃10, and ≃100% and show that it is not sufficient to explain the gas-to-dust mass ratio obtained with Milky Way type grains. Finally, we confirm the detection of a 500 μm extended emission excess with an average relative amplitude of ≃15%, varying up to 40%. This excess anticorrelates well with the dust mass surface density. Although we do not know the origin of this excess, we show that it is unlikely the result of very cold dust, or CMB fluctuations

The effects of star formation on the low-metallicity ISM: NGC4214 mapped with Herschel/PACS spectroscopy

We present Herschel/PACS spectroscopic maps of the dwarf galaxy NC4214 observed in 6 far infrared fine-structure lines: [C II] 158mu, [O III] 88mu, [O I] 63mu, [O I] 146mu, [N II] 122mu, and [N II] 205mu. The maps are sampled to the full telescope spatial resolution and reveal unprecedented detail on ~ 150 pc size scales. We detect [C II] emission over the whole mapped area, [O III] being the most luminous FIR line. The ratio of [O III]/[C II] peaks at about 2 toward the sites of massive star formation, higher than ratios seen in dusty starburst galaxies. The [C II]/CO ratios are 20 000 to 70 000 toward the 2 massive clusters, which are at least an order of magnitude larger than spiral or dusty starbursts, and cannot be reconciled with single-slab PDR models. Toward the 2 massive star-forming regions, we find that L[CII] is 0.5 to 0.8% of the LTIR . All of the lines together contribute up to 2% of LTIR . These extreme findings are a consequence of the lower metallicity and young, massive-star formation commonly found in dwarf galaxies. These conditions promote large-scale photodissociation into the molecular reservoir, which is evident in the FIR line ratios. This illustrates the necessity to move to multiphase models applicable to star-forming clusters or galaxies as a whole.Comment: Accepted for publication in the A&A Herschel Special Issu

The Spitzer discovery of a galaxy with infrared emission solely due to AGN activity

We present a galaxy (SAGE1CJ053634.78-722658.5) at a redshift of 0.14 of which the IR is entirely dominated by emission associated with the AGN. We present the 5-37 um Spitzer/IRS spectrum and broad wavelength SED of SAGE1CJ053634, an IR point-source detected by Spitzer/SAGE (Meixner et al 2006). The source was observed in the SAGE-Spec program (Kemper et al., 2010) and was included to determine the nature of sources with deviant IR colours. The spectrum shows a redshifted (z=0.14+-0.005) silicate emission feature with an exceptionally high feature-to-continuum ratio and weak polycyclic aromatic hydrocarbon (PAH) bands. We compare the source with models of emission from dusty tori around AGNs from Nenkova et al. (2008). We present a diagnostic diagram that will help to identify similar sources based on Spitzer/MIPS and Herschel/PACS photometry. The SED of SAGE1CJ053634 is peculiar because it lacks far-IR emission and a clear stellar counterpart. We find that the SED and the IR spectrum can be understood as emission originating from the inner ~10 pc around an accreting black hole. There is no need to invoke emission from the host galaxy, either from the stars or from the interstellar medium, although a possible early-type host galaxy cannot be excluded based on the SED analysis. The hot dust around the accretion disk gives rise to a continuum, which peaks at 4 um, whereas the strong silicate features may arise from optically thin emission of dusty clouds within ~10 pc around the black hole. The weak PAH emission does not appear to be linked to star formation, as star formation templates strongly over-predict the measured far-IR flux levels. The SED of SAGE1CJ053634 is rare in the local universe but may be more common in the more distant universe. The conspicuous absence of host-galaxy IR emission places limits on the far-IR emission arising from the dusty torus alone.Comment: Accepted for publication in A&A, 7 pages, 6 figure

Gaia on-board metrology: basic angle and best focus

The Gaia payload ensures maximum passive stability using a single material, SiC, for most of its elements. Dedicated metrology instruments are, however, required to carry out two functions: monitoring the basic angle and refocusing the telescope. Two interferometers fed by the same laser are used to measure the basic angle changes at the level of $\mu$as (prad, micropixel), which is the highest level ever achieved in space. Two Shack-Hartmann wavefront sensors, combined with an ad-hoc analysis of the scientific data are used to define and reach the overall best-focus. In this contribution, the systems, data analysis, procedures and performance achieved during commissioning are presentedComment: 18 pages, 14 figures. To appear in SPIE proceedings 9143-30. Space Telescopes and Instrumentation 2014: Optical, Infrared, and Millimeter Wav

Herschel Observations of a Newly Discovered UX Ori Star in the Large Magellanic Cloud

The LMC star, SSTISAGE1C J050756.44-703453.9, was first noticed during a survey of EROS-2 lightcurves for stars with large irregular brightness variations typical of the R Coronae Borealis (RCB) class. However, the visible spectrum showing emission lines including the Balmer and Paschen series as well as many Fe II lines is emphatically not that of an RCB star. This star has all of the characteristics of a typical UX Ori star. It has a spectral type of approximately A2 and has excited an H II region in its vicinity. However, if it is an LMC member, then it is very luminous for a Herbig Ae/Be star. It shows irregular drops in brightness of up to 2 mag, and displays the reddening and "blueing" typical of this class of stars. Its spectrum, showing a combination of emission and absorption lines, is typical of a UX Ori star that is in a decline caused by obscuration from the circumstellar dust. SSTISAGE1C J050756.44-703453.9 has a strong IR excess and significant emission is present out to 500 micron. Monte Carlo radiative transfer modeling of the SED requires that SSTISAGE1C J050756.44-703453.9 has both a dusty disk as well as a large extended diffuse envelope to fit both the mid- and far-IR dust emission. This star is a new member of the UX Ori subclass of the Herbig Ae/Be stars and only the second such star to be discovered in the LMC.Comment: ApJ, in press. 9 pages, 5 figure

Dust in the bright supernova remnant N49 in the LMC

We investigate the dust associated with the supernova remnant (SNR) N49 in the Large Magellanic Cloud (LMC) as observed with the Herschel Space Observatory. N49 is unusually bright because of an interaction with a molecular cloud along its eastern edge. We have used PACS and SPIRE to measure the far IR flux densities of the entire SNR and of a bright region on the eastern edge of the SNR where the SNR shock is encountering the molecular cloud. Using these fluxes supplemented with archival data at shorter wavelengths, we estimate the dust mass associated with N49 to be about 10 Msun. The bulk of the dust in our simple two-component model has a temperature of 20-30 K, similar to that of nearby molecular clouds. Unfortunately, as a result of the limited angular resolution of Herschel at the wavelengths sampled with SPIRE, the uncertainties are fairly large. Assuming this estimate of the dust mass associated with the SNR is approximately correct, it is probable that most of the dust in the SNR arises from regions where the shock speed is too low to produce significant X-ray emission. The total amount of warm 50-60 K dust is ~0.1 or 0.4 Msun, depending on whether the dust is modeled in terms of carbonaceous or silicate grains. This provides a firm lower limit to the amount of shock heated dust in N49.Comment: accepted by the Astronomy & Astrophysics Lette

IRAS F02044+0957: radio source in interacting system of galaxies

The steep spectrum of IRAS F02044+0957 was obtained with the RATAN-600 radio telescope at four frequencies. Optical spectroscopy of the system components, was carried out with the 2.1m telescope of the Guillermo Haro Observatory. Observational data allow us to conclude that this object is a pair of interacting galaxies, a LINER and a HII galaxy, at $z=0.093$.Comment: 2 pages, 2 EPS-figures, uses newpasp.sty. To appear in Proc. IAU Colloq. 184, AGN Surveys, ed. R. F. Green, E. Ye. Khachikian, & D. B. Sanders (San Francisco: ASP

The youngest massive protostars in the Large Magellanic Cloud

We demonstrate the unique capabilities of Herschel to study very young luminous extragalactic young stellar objects (YSOs) by analyzing a central strip of the Large Magellanic Cloud obtained through the HERITAGE Science Demonstration Program. We combine PACS 100 and 160, and SPIRE 250, 350, and 500 microns photometry with 2MASS (1.25-2.17 microns) and Spitzer IRAC and MIPS (3.6-70 microns) to construct complete spectral energy distributions (SEDs) of compact sources. From these, we identify 207 candidate embedded YSOs in the observed region, ~40% never-before identified. We discuss their position in far-infrared color-magnitude space, comparing with previously studied, spectroscopically confirmed YSOs and maser emission. All have red colors indicating massive cool envelopes and great youth. We analyze four example YSOs, determining their physical properties by fitting their SEDs with radiative transfer models. Fitting full SEDs including the Herschel data requires us to increase the size and mass of envelopes included in the models. This implies higher accretion rates (greater than or equal to 0.0001 M_sun/yr), in agreement with previous outflow studies of high-mass protostars. Our results show that Herschel provides reliable longwave SEDs of large samples of high-mass YSOs; discovers the youngest YSOs whose SEDs peak in Herschel bands; and constrains the physical properties and evolutionary stages of YSOs more precisely than was previously possible.Comment: Main text: 4 pages, 3 figures, 1 table; Online material: 3 figures, 1 table; to appear in the A&A Herschel Special Issu