Modelling for research on chemical control of mammals in New Zealand

Development of predictive formulae or qualitative statements about the probable outcome of control campaigns entails knowledge of bait quality and distribution, behaviour, vagaries of weather at the time of the control campaign, and other factors which govern the probability that the target animals will accept bait. This paper collates experience in recognising, estimating and using some of these variables for predicting the outcome of large-scale poisoning, and discusses possible approaches to the solution of some hard-core problems

A Review of Mathematical Models for the Formation of\ud Vascular Networks

Mainly two mechanisms are involved in the formation of blood vasculature: vasculogenesis and angiogenesis. The former consists of the formation of a capillary-like network from either a dispersed or a monolayered population of endothelial cells, reproducible also in vitro by specific experimental assays. The latter consists of the sprouting of new vessels from an existing capillary or post-capillary venule. Similar phenomena are also involved in the formation of the lymphatic system through a process generally called lymphangiogenesis.\ud \ud A number of mathematical approaches have analysed these phenomena. This paper reviews the different modelling procedures, with a special emphasis on their ability to reproduce the biological system and to predict measured quantities which describe the overall processes. A comparison between the different methods is also made, highlighting their specific features

Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA.

Escherichia coli RecA is the defining member of a ubiquitous class of DNA strand-exchange proteins that are essential for homologous recombination, a pathway that maintains genomic integrity by repairing broken DNA. To function, filaments of RecA must nucleate and grow on single-stranded DNA (ssDNA) in direct competition with ssDNA-binding protein (SSB), which rapidly binds and continuously sequesters ssDNA, kinetically blocking RecA assembly. This dynamic self-assembly on a DNA lattice, in competition with another protein, is unique for the RecA family compared to other filament-forming proteins such as actin and tubulin. The complexity of this process has hindered our understanding of RecA filament assembly because ensemble measurements cannot reliably distinguish between the nucleation and growth phases, despite extensive and diverse attempts. Previous single-molecule assays have measured the nucleation and growth of RecA--and its eukaryotic homologue RAD51--on naked double-stranded DNA and ssDNA; however, the template for RecA self-assembly in vivo is SSB-coated ssDNA. Using single-molecule microscopy, here we directly visualize RecA filament assembly on single molecules of SSB-coated ssDNA, simultaneously measuring nucleation and growth. We establish that a dimer of RecA is required for nucleation, followed by growth of the filament through monomer addition, consistent with the finding that nucleation, but not growth, is modulated by nucleotide and magnesium ion cofactors. Filament growth is bidirectional, albeit faster in the 5'→3' direction. Both nucleation and growth are repressed at physiological conditions, highlighting the essential role of recombination mediators in potentiating assembly in vivo. We define a two-step kinetic mechanism in which RecA nucleates on transiently exposed ssDNA during SSB sliding and/or partial dissociation (DNA unwrapping) and then the RecA filament grows. We further demonstrate that the recombination mediator protein pair, RecOR (RecO and RecR), accelerates both RecA nucleation and filament growth, and that the introduction of RecF further stimulates RecA nucleation

Research on gravitational mass sensors Quarterly progress report no. 1, 15 Oct. 1964 - 14 Jan. 1965

Lunar orbiter and deep space probe gravitational sensor for determining mass distribution of moon and asteroid

Investigations of electron emission characteristics of low work function surfaces Quarterly report no. 5, 1 Oct. - 31 Dec. 1965

Electron emission characteristics of low work function surfaces from magnetic deflection probe measurements of cesium adsorption on tungste

Investigations of electron emission characteristics of low work function surfaces Quarterly report no. 2, 1 Jan. - 31 Mar. 1966

Formation and electron emission characteristics of low work function surface

Research on gravitational mass sensors quarterly progress report no. 2, 15 jan. - 14 apr. 1965

Cruciform sensor head, phase shift tuned amplifier, and air bearing support for sensor for detecting presence of small moving mass through gravitational interaction

A Topos Foundation for Theories of Physics: IV. Categories of Systems

This paper is the fourth in a series whose goal is to develop a fundamentally new way of building theories of physics. The motivation comes from a desire to address certain deep issues that arise in the quantum theory of gravity. Our basic contention is that constructing a theory of physics is equivalent to finding a representation in a topos of a certain formal language that is attached to the system. Classical physics arises when the topos is the category of sets. Other types of theory employ a different topos. The previous papers in this series are concerned with implementing this programme for a single system. In the present paper, we turn to considering a collection of systems: in particular, we are interested in the relation between the topos representation for a composite system, and the representations for its constituents. We also study this problem for the disjoint sum of two systems. Our approach to these matters is to construct a category of systems and to find a topos representation of the entire category.Comment: 38 pages, no figure

Equilibrium fluctuation theorems compatible with anomalous response

Previously, we have derived a generalization of the canonical fluctuation relation between heat capacity and energy fluctuations $C=\beta^{2}<\delta U^{2}>$, which is able to describe the existence of macrostates with negative heat capacities $C<0$. In this work, we extend our previous results for an equilibrium situation with several control parameters to account for the existence of states with anomalous values in other response functions. Our analysis leads to the derivation of three different equilibrium fluctuation theorems: the \textit{fundamental and the complementary fluctuation theorems}, which represent the generalization of two fluctuation identities already obtained in previous works, and the \textit{associated fluctuation theorem}, a result that has no counterpart in the framework of Boltzmann-Gibbs distributions. These results are applied to study the anomalous susceptibility of a ferromagnetic system, in particular, the case of 2D Ising model.Comment: Extended version of the paper published in JSTA

The Stratigraphic Record of Pre-breakup Geodynamics: Evidence from the Barrow Delta, offshore Northwest Australia

The structural and stratigraphic evolution of rift basins and passive margins has been widely studied, with many analyses demonstrating that delta systems can provide important records of post-rift geodynamic processes. However, the apparent lack of ancient syn-breakup delta systems and the paucity of seismic imaging across continent-ocean boundaries means the transition from continental rifting to oceanic spreading remains poorly understood. The Early Cretaceous Barrow Group of the North Carnarvon Basin, offshore NW Australia was a major deltaic system that formed during the latter stages of continental rifting, and represents a rich sedimentary archive, documenting uplift, subsidence and erosion of the margin. We use a regional database of 2D and 3D seismic and well data to constrain the internal architecture of the Barrow Group. Our results highlight three major depocentres: the Exmouth and Barrow sub-basins, and southern Exmouth Plateau. Over-compaction of pre-Cretaceous sedimentary rocks in the South Carnarvon Basin, and pervasive reworking of Permian and Triassic palynomorphs in the offshore Barrow Group, suggests that the onshore South Carnarvon Basin originally contained a thicker sedimentary succession, which was uplifted and eroded prior to breakup. Backstripping of sedimentary successions encountered in wells in the Exmouth Plateau depocentre indicate anomalously rapid tectonic subsidence (≤0.24 mm yr-1) accommodated Barrow Group deposition, despite evidence for minimal, contemporaneous upper crustal extension. Our results suggest that classic models of uniform extension cannot account for the observations of uplift and subsidence in the North Carnarvon Basin, and may indicate a period of depth-dependent extension or dynamic topography preceding breakup