Implementasi Lean Manufacuring pada Proses Produksi untuk Mengurangi Pemborosan Persediaan

Penelitian ini dilakukan pada Perusahaan manufaktur sepatu bertaraf Internasional. Saat ini, terdapat penumpukan persediaan yang terjadi di setiap stasiun kerja. Penelitian ini mengidentifikasi alat yang tepat untuk memetakan secara detail aliran nilai (value stream), mengidentifikasi faktor penyebab terjadinya pemborosan, memberikan dan mengimplementasikan usulan tindakan perbaikan untuk meminimalkan pemborosan persediaan pada proses produksi. Mengacu pada pendekatan lean manufacturing, penelitian ini dimulai dengan memetakan aliran proses saat ini dengan menggunakan Value Stream Mapping (VSM). Tahap berikutnya, dilakukan identifikasi pemborosan dengan menggunakan Waste Assessment Model (WAM) dan menetapkan alat yang cocok untuk memetakan secara detail aliran nilai dengan menggunakan VALSAT. Selanjutnya, menganalisis penyebab dominan dari pemborosan persediaan dengan menggunakan fishbone diagram. Alat yang tepat untuk memetakan aliran nilai secara detail dengan menggunakan VALSAT adalah Process Activity Mapping (PAM) dengan total skor 500,12. Kemudian, faktor dominan yang menjadi penyebab terjadinya pemborosan persediaan disebabkan oleh 3 faktor yaitu manusia, metode, dan material. Tahap penyelesaian masalah dilakukan dengan merancang sistem kanban dan diimplementasikan ke value stream tersebut. Setelah mengimplementasikan usulan tindakan, diperoleh jumlah persediaan berkurang. Pada kondisi aktual sebelum diterapkan sistem kanban, jumlah persediaan tercatat 12.945 pasang. Setelah diterapkan sistem kanban, jumlah persediaan menjadi 11.602 pasang

Benchmarking of cell type deconvolution pipelines for transcriptomics data

Many computational methods have been developed to infer cell type proportions from bulk transcriptomics data. However, an evaluation of the impact of data transformation, pre-processing, marker selection, cell type composition and choice of methodology on the deconvolution results is still lacking. Using five single-cell RNA-sequencing (scRNA-seq) datasets, we generate pseudo-bulk mixtures to evaluate the combined impact of these factors. Both bulk deconvolution methodologies and those that use scRNA-seq data as reference perform best when applied to data in linear scale and the choice of normalization has a dramatic impact on some, but not all methods. Overall, methods that use scRNA-seq data have comparable performance to the best performing bulk methods whereas semi-supervised approaches show higher error values. Moreover, failure to include cell types in the reference that are present in a mixture leads to substantially worse results, regardless of the previous choices. Altogether, we evaluate the combined impact of factors affecting the deconvolution task across different datasets and propose general guidelines to maximize its performance. Inferring cell type proportions from transcriptomics data is affected by data transformation, normalization, choice of method and the markers used. Here, the authors use single-cell RNAseq datasets to evaluate the impact of these factors and propose guidelines to maximise deconvolution performance

Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways

Breast cancer is the most aggressive form of all cancers, with high incidence and mortality rates. The purpose of the present study was to investigate the molecular mechanism by which methylsulfonylmethane (MSM) inhibits breast cancer growth in mice xenografts. MSM is an organic sulfur-containing natural compound without any toxicity. In this study, we demonstrated that MSM substantially decreased the viability of human breast cancer cells in a dose-dependent manner. MSM also suppressed the phosphorylation of STAT3, STAT5b, expression of IGF-1R, HIF-1α, VEGF, BrK, and p-IGF-1R and inhibited triple-negative receptor expression in receptor-positive cell lines. Moreover, MSM decreased the DNA-binding activities of STAT5b and STAT3, to the target gene promoters in MDA-MB 231 or co-transfected COS-7 cells. We confirmed that MSM significantly decreased the relative luciferase activities indicating crosstalk between STAT5b/IGF-1R, STAT5b/HSP90α, and STAT3/VEGF. To confirm these findings in vivo, xenografts were established in Balb/c athymic nude mice with MDA-MB 231 cells and MSM was administered for 30 days. Concurring to our in vitro analysis, these xenografts showed decreased expression of STAT3, STAT5b, IGF-1R and VEGF. Through in vitro and in vivo analysis, we confirmed that MSM can effectively regulate multiple targets including STAT3/VEGF and STAT5b/IGF-1R. These are the major molecules involved in tumor development, progression, and metastasis. Thus, we strongly recommend the use of MSM as a trial drug for treating all types of breast cancers including triple-negative cancers

Short-term effects of a randomized controlled worksite relaxation intervention in Greece

objective. To evaluate the short-term benefits of simple relaxation techniques in white-collar employees. materials and methods. The study was a two-arm parallel group randomized controlled trial. 152 employees were randomly assigned to receive the 8-week programme (N=80) (relaxation breathing and progressive muscle relaxation, twice a day) or not (wait-list group N=72). Self-reported validated measures were used to evaluate perceived stress, health locus of control, job and lifestyle related variables. Saliva cortisol were also sampled and measured. Adjusted mean changes on outcomes were estimated by linear mixed model analysis. 127 employees were finally analyzed (68 in the intervention and 59 in the control group). results. Specific stress-related symptoms, psychological job demands and cortisol levels were found to be significantly decreased after 8-weeks in the intervention group. The result was probably affected by the general socio-economic condition during the study period. Cortisol levels were also significantly related with age, family situation, gender and sampling time. conclusions. Simple relaxation training (diaphragmatic breathing and progressive muscle relaxation) could benefit employees and it is strongly proposed that these and other similar techniques should be tested in various labour setting

Análisis estadístico neutrosófico en la aplicación de ejercicios físicos en la rehabilitación del adulto mayor con gonartrosis.

Envejecer es un proceso dinámico, natural e irreversible que comienza con el nacimiento del hombre y que progresivamente va disminuyendo las capacidades del mismo [1], [2]. Se puede afirmar que es una etapa natural de la vida; es una forma muy especial del movimiento de la materia; es un complejo y variado proceso que no solo depende de las causas biológicas, sino también de las condiciones socioeconómicas en las cuales se desarrolla el individuo como ser social [3].El padecimiento de gonartrosis representa una enfermedad degenerativa que afecta a los adultos mayores. Aplicar un tratamiento correcto que disminuya la incidencia de la enfermedad, garantiza una mejora en la calidad de vida de los pacientes afectados con esta patología. La ciencia ha abordado la problemática planteada a partir de la rehabilitación física. La presente investigación propone un análisis estadístico neutrosófico de la aplicación de ejercicio físico para la rehabilitación de pacientes con gonartrosis

El cáncer de mama: Bases fisiopatológicas y beneficios de la rehabilitación física y ocupacional

El cáncer de mama constituye un problema de salud a nivel mundial, por su gran impacto social y económico, que afecta fundamentalmente a mujeres en edades tempranas y repercute enormemente en sus vidas debido a complicaciones propias de la enfermedad y al abordaje terapéutico. Por tal motivo se realizó una revisión bibliográfica sobre las diferentes modalidades de rehabilitación física y ocupacional en las pacientes con cáncer de mama en el proceso de cuidados continuos.Breast cancer is a health problem worldwide, with a great social and economic impact, which fundamentally affects women at an early age with great repercussion in their life due to complications associated with the disease and the therapeutic approach. For this reason, a bibliographic review was carried out on the different modalities of physical andoccupational rehabilitation in patients with breast cancer in the process of continuous care

Sistema de recomendaciones de ejercicios físicos para la rehabilitación de pacientes mastectomizadas por cáncer de mama.

El cáncer de mama no es una enfermedad actual, pues hay registros de su existencia desde el antiguo Egipto, en el año 1.600 a.C. Sin embargo, el hecho de que su incidencia sea creciente, y que las pacientes tengan mayor supervivencia gracias a los tratamientos actuales, ha convertido a esta enfermedad en un importante problema de salud que genera un gran impacto entre la población y el sistema sanitario. Es la enfermedad maligna más frecuente y la primera causa de muerte por cáncer en el sexo femenino.En los últimos años se evidencia un crecimiento de pacientes mastectomizadas por cáncer de mama. La rehabilitación física y ocupacional sustentada en la alta incidencia y prevalencia de ésta enfermedad a nivel mundial y nacional, constituye una actividad de vital importancia. Generar alternativas que mejoren la calidad de vida de estos pacientes representa una tarea altamente sensible. La presente investigación, describe una solución a la problemática planteada mediante el desarrollo de un sistema de recomendaciones de ejercicios físicos para la rehabilitación de pacientes mastectomizadas