11 research outputs found
SHRIMP U–Pb zircon dating of anatexis in high-grade migmatite complexes of Central Spain: implications in the Hercynian evolution of Central Iberia
U–Pb SHRIMP ages obtained in zircons
from the Sotosalbos and Toledo anatectic complexes
in Central Spain give new constraints to the evolution
of the inner part of the Hercynian Iberian belt. Pre-
Hercynian ages in zircons from the Sotosalbos complex
(~464 Ma) are well preserved and reveal that an
age diversity of the Lower Paleozoic magmatism in
the area exists, as previous data on westernmost orthogneisses
yield significant older ages. Zircon ages in
the pelite-derived granites from the Toledo complex
also show an important Neoproterozoic age component
which points to a metasedimentary protolith
deposited maximally 560 Ma ago. Younger zircon
populations in both complexes at ~330 Ma in the
Sotosalbos region and ~317 Ma in the Toledo complex
indicate an important diachronism between the
anatectic processes in both areas but also that these
processes are mainly unrelated to the generation of
the later Hercynian granite batholith of Central
Spain, which could be of deeper crustal derivation. In
addition, as migmatization occurred late in the
metamorphic cycle, after peak conditions were attained,
the age of anatexis is younger than the age of
the main Hercynian metamorphic event, which still is
not well constrained
Libert Froidmont’s conception and imagination of space in three early works: Peregrinatio cœlestis (1616), De cometa (1618), Meteorologica (1627)
International audienc
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
The human brain has enormously complex cellular diversity and connectivities fundamental to our neural functions, yet difficulties in interrogating individual neurons has impeded understanding of the underlying transcriptional landscape. We developed a scalable approach to sequence and quantify RNA molecules in isolated neuronal nuclei from post-mortem brain, generating 3,227 sets of single neuron data from six distinct regions of the cerebral cortex. Using an iterative clustering and classification approach, we identified 16 neuronal subtypes that were further annotated on the basis of known markers and cortical cytoarchitecture. These data demonstrate a robust and scalable method for identifying and categorizing single nuclear transcriptomes, revealing shared genes sufficient to distinguish novel and orthologous neuronal subtypes as well as regional identity within the human brain
Efficacy of 904 nm laser therapy in the management of musculoskeletal disorders: a systematic review
Perspectives on ENCODE
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.11Nsciescopu