Image Super-Resolution Reconstruction Based on L1/2 Sparsity

Based on image sparse representation in the shearlet domain, we proposed a L1/2 sparsity regularized unconvex variation model for image super-resolution. The L1/2 regularizer term constrains the underlying image to have a sparse representation in shearlet domain. The fidelity term restricts the consistency with the measured imaged in terms of the data degradation model. Then, the variable splitting algorithm is used to break down the model into a series of constrained optimization problems which can be solved by alternating direction method of multipliers. Experimental results demonstrate the effectiveness of the proposed method, both in its visual effects and in quantitative terms

Convolutional Neural Networks Facilitate River Barrier Detection and Evidence Severe Habitat Fragmentation in the Mekong River Biodiversity Hotspot

Construction of river infrastructure, such as dams and weirs, is a global issue for ecosystem protection due to the fragmentation of river habitat and hydrological alteration it causes. Accurate river barrier databases, increasingly used to determine river fragmentation for ecologically sensitive management, are challenging to generate. This is especially so in large, poorly mapped basins where only large dams tend to be recorded. The Mekong is one of the world's most biodiverse river basins but, like many large rivers, impacts on habitat fragmentation from river infrastructure are poorly documented. To demonstrate a solution to this, and enable more sensitive basin management, we generated a whole‐basin barrier database for the Mekong, by training Convolutional Neural Network (CNN)–based object detection models, the best of which was used to identify 10,561 previously unrecorded barriers. Combining manual revision and merged with the existing barrier database, our new barrier database for the Mekong Basin contains 13,054 barriers. Existing databases for the Lower Mekong documented under ∼3% of the barriers recorded by CNN combined with manual checking. The Nam Chi/Nam Mun region, eastern Thailand, is the most fragmented area within the basin, with a median [95% CI] barrier density of 15.53 [0.00–49.30] per 100 km, and Catchment Area‐based Fragmentation Index value, calculated in an upstream direction, of 1,178.67 [0.00–6,418.46], due to the construction of dams and sluice gates. The CNN‐based object detection framework is effective and potentially can transform our ability to identify river barriers across many large river basins and facilitate ecologically‐sensitive management

Integration of agent-based modelling of social-spatial processes in architectural parametric design

A representation framework for modelling the social-spatial processes of inhabitation is proposed to extend the scope of parametric architectural design process. We introduce an agent-based modelling framework with a computational model of social-spatial dynamics at its core. Architectural parametric design is performed as a process of modelling the temporal characteristics of spatial changes required for members of a social group to reach social spatial comfort. We have developed a prototype agent-based modelling system using the Rhino-Grasshopper platform. The system employs a human behaviour model adapted from the PECS (Physical, Emotional, Cognitive, Social) reference model first proposed by Schmidt and Urban. The agent-based model and its application was evaluated by comparative modelling of two real Vietnamese dwellings: a traditional vernacular house in Hue and a contemporary house in Ho Chi Minh City. The evaluation shows that the system returns differentiated temporal characteristics of spatial modifications of the two dwellings as expected

A unique role of GATA1S in down syndrome acute megakaryocytic leukemia biology and therapy

Background: Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether leukemogenesis and therapeutic responses in DS AMkL patients are due to loss of the wild-type GATA1 or due to a unique function of GATA1s. Methodology: Stable clones of CMK cells with decreased GATA1s or Bcl-2 levels were generated by using GATA1- or BCL-2-specific lentivirus shRNAs. In vitro ara-C, daunorubicin, and VP-16 cytotoxicities of the shRNA stable clones were determined by using the Cell Titer-blue reagent. Apoptosis and cell cycle distribution were determined by flow cytometry analysis. Changes in gene transcript levels were determined by gene expression microarray and/or real-time RT-PCR. Changes in protein levels were measured by Western blotting. In vivo binding of GATA1s to IL1A promoter was determined by chromatin immunoprecipitation assays. Results: Lentivirus shRNA knockdown of the GATA1 gene in the DS AMkL cell line, CMK (harbors a mutated GATA1 gene and only expresses GATA1s), resulting in lower GATA1s protein levels, promoted cell differentiation towards the megakaryocytic lineage and repressed cell proliferation. Increased basal apoptosis and sensitivities to ara-C, daunorubicin, and VP-16 accompanied by down-regulated Bcl-2 were also detected in the CMK GATA1 shRNA knockdown clones. Essentially the same results were obtained when Bcl-2 was knocked down with lentivirus shRNA in CMK cells. Besides Bcl-2, down-regulation of GATA1s also resulted in altered expression of genes (e.g., IL1A, PF4, and TUBB1) related to cell death, proliferation, and differentiation. Conclusion: Our results suggest that GATA1s may facilitate leukemogenesis and potentially impact therapeutic responses in DS AMkL by promoting proliferation and survival, and by repressing megakaryocytic lineage differentiation, potentially by regulating expression of Bcl-2 protein and other relevant genes. © 2011 Xavier et al

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

SummaryAlzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Aβ42 levels without inhibiting epsilon-site cleavage of APP and Notch, the generation of the APP and Notch intracellular domains, respectively. These compounds also reduced Aβ40 levels while concomitantly elevating levels of Aβ38 and Aβ37. Immobilization of a potent GSM onto an agarose matrix quantitatively recovered Pen-2 and to a lesser degree PS-1 NTFs from cellular extracts. Moreover, oral administration (once daily) of another potent GSM to Tg 2576 transgenic AD mice displayed dose-responsive lowering of plasma and brain Aβ42; chronic daily administration led to significant reductions in both diffuse and neuritic plaques. These effects were observed in the absence of Notch-related changes (e.g., intestinal proliferation of goblet cells), which are commonly associated with repeated exposure to functional gamma-secretase inhibitors (GSIs)

Detailed Analysis of a Contiguous 22-Mb Region of the Maize Genome

Most of our understanding of plant genome structure and evolution has come from the careful annotation of small (e.g., 100 kb) sequenced genomic regions or from automated annotation of complete genome sequences. Here, we sequenced and carefully annotated a contiguous 22 Mb region of maize chromosome 4 using an improved pseudomolecule for annotation. The sequence segment was comprehensively ordered, oriented, and confirmed using the maize optical map. Nearly 84% of the sequence is composed of transposable elements (TEs) that are mostly nested within each other, of which most families are low-copy. We identified 544 gene models using multiple levels of evidence, as well as five miRNA genes. Gene fragments, many captured by TEs, are prevalent within this region. Elimination of gene redundancy from a tetraploid maize ancestor that originated a few million years ago is responsible in this region for most disruptions of synteny with sorghum and rice. Consistent with other sub-genomic analyses in maize, small RNA mapping showed that many small RNAs match TEs and that most TEs match small RNAs. These results, performed on ∼1% of the maize genome, demonstrate the feasibility of refining the B73 RefGen_v1 genome assembly by incorporating optical map, high-resolution genetic map, and comparative genomic data sets. Such improvements, along with those of gene and repeat annotation, will serve to promote future functional genomic and phylogenomic research in maize and other grasses

The Qur'an and Identity in Contemporary Chinese Fiction

How is it possible to comprehend and assess the impact of the Qur’an on the literary expressions of Chinese Muslims (Hui) when the first full ‘translations’ of the Qur’an in Chinese made by non-Muslims from Japanese and English appeared only in 1927 and 1931, and by a Muslim from Arabic in 1932? But perhaps the fact that such a translation appeared so late in the history of the Muslim community in China, who have had a continuous presence since the ninth-century, is the best starting point. For it would be possible to address the relationship between the sacred text (as well as language) and identity among minority groups in a different way. This paper looks at the ways in which the Qur’an is imagined then embodied in literary texts authored by two prize-winning Chinese Muslim authors: Huo Da (b. 1945) and Zhang Chengzhi (b. 1948). While Huo Da, who does not have access to the Arabic language, alludes to the Chinese Qur’an in her novel, The Muslim’s Funeral (1982), transforming the its teachings into ritual performances of alterity through injecting Arabic and Persian words for religious rituals into her narrative of a Muslim family’s fortunes at the turn of the twentieth century, Zhang Chengzhi, who learned Arabic as an adult and travelled widely in the Muslim world, involves himself in reconstructing the history of the spread and persecution of the Jahriyya Sufi sect (an off-shoot of the Naqshabandiyya) in China between the seventeenth and nineteenth centuries in his only historical novel, A History of the Soul (1991), and in education reform in Muslim communities, inventing an identity for Chinese Muslims based on direct knowledge of the sacred text and tradition and informed by the history of Islam not in China alone but in the global Islamic world, especially Arabic Islamic history

Gradient elasticity and size effect for the borehole problem

© 2018, Springer-Verlag GmbH Austria, part of Springer Nature. It has been shown recently that robust gradient models of elasticity offer an effective tool to resolve existing difficulties (e.g., elimination of singularities) or predict new experimentally observed phenomena (e.g., size effects) not captured by classical theory. The price that one pays for it, however, is the need to determine extra phenomenological coefficients and invent new boundary conditions associated with the gradient terms. The modest contribution of this note is to show that even the simplest possible gradient elasticity model may yield entirely different results for different higher-order boundary conditions used. This is demonstrated by considering the borehole problem, i.e., the determination of the state of stress and strain in an externally loaded or internally pressurized body containing a cylindrical hole. The standard practice of using variationally consistent boundary conditions leads to difficulties in physically interpreting them as well as in complex solution formulae without much physical insight. Alternative, mathematically less elegant arguments, as those employed here, lead to much neater formulas, usually consisting of a sum of the classical elasticity solution and an extra gradient term. These may easily be utilized to address engineering applications, ranging from processing/fabrication of metallic specimens at the micron and nanoscales to mining/drilling operations and tunneling excavation at geo-scales. The results are by no means conclusive, only suggestive of the various possibilities and choices that one can make at present. This, in itself, points to the pressing need of further work on the issue of extra boundary conditions with the aid of new novel experiments and accompanied multiscale simulations

On an alternative framework for building virtual cities: supporting urban contextual modelling on demand

For various purposes, virtual city applications have been developed around the globe to provide users with online resources and services over the Internet. Following our research on the Sheffield Urban Contextual Databank (SUCoD) project, this paper presents an alternative framework for building virtual cities, which goes beyond conventional static urban modelling. A three-tier system framework is described in conjunction with the design and implementation of the SUCoD prototype. We demonstrate SUCoD's novel functionalities by showing that complex urban contextual information sets, including three-dimensional interactive models, multilayer interactive maps, and hypermedia documents, can be retrieved dynamically by user-specified urban contextual attributes, spatial locations, and boundaries. The three-tier framework also facilitates system development in an extensible way, allowing continuous parallel extensions of system functionalities, user-interface components, and contextual data resources. SUCoD's dynamic capabilities are considered crucial in its future uses for urban contextual modelling on demand in relation to the past, present, and future of the City of Sheffield.