A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Di erences

Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or strains which have been used to best characterize the virus since its discovery in 1956, and discuss the implications for genetic and functional variations between the established laboratory strains and the recently identified clinical isolates

Comfort in English and Swedish country houses, c.1760-1820

Comfort as an idea and ideal has attracted growing interest, especially in an Anglo-American context. Much of the discussion has centred either on improvements in physical comfort, not least through new technologies, or on emotional comfort and the social construction of the home. This paper brings together these ideas in a comparative analysis of English and Swedish landowners. It draws on a range of correspondence to uncover more about the ways in which members of the elite themselves conceived and achieved comfort in very different geographical, economic and cultural contexts. Whilst ‘English comfort’ became widespread as an idealisation of elite lifestyles by the early nineteenth century, both in Sweden and elsewhere, we argue that many of its social and physical imperatives were commonplace much earlier. This involved shared concerns with warmth and airiness, and the ways in which these were linked to health and wellbeing, but also with the construction of appropriate social settings. And yet it was the emotional and non-material dimensions of comfort that dominated the correspondence in both countries: a concern with family and with home as a place defined by relationships with people rather than things

Performance of baited underwater video for estimating abundance of spiny lobsters

Baited underwater video (BUV) is increasingly been used to sample fish species but lobsters are potentially good candidates for sampling with BUV as they are attracted to bait due to their scavenging habits. We built a cost effective BUV system to sample Palinurus elephas, a Mediterranean deep-water lobster. Camera deployments were performed at the Columbretes Islands MPA. We compared the standard method of estimating abundance with BUV, by recording the maximum number (Nmax) of individuals at any one point on the tape, with the estimated true number of lobsters having attended the bait (Ntot). We found it possible to use images of unique body patterns for identifying individuals over time. The highest Nmax - 6 lobsters in the field of view - was lower than the total number of lobsters estimated by identifying individuals in all three recordings - total of 7 to 11 individual lobsters. This highlights the extent of underestimation of abundance derived from Nmax estimates (Mean Nmax = 4 as opposed to Ntot= 8.6 by tracking individuals). Measurement of lobster size was trouble free with the coefficient of variation of all measurements being low. However, all measurements were biassed due to calibration problems related to lobster height above the bait bag. Taking into account the relatively low cost of the units, coupled with the ability of this system to work to depths impractical for visual surveys, we propose that this non-intrusive method will be useful for sampling deep water lobster

A Systematic Review of the Evidence of the Impact on Students, Teachers and the Curriculum of the Process of Using Assessment by Teachers for Summative Purposes

First paragraph: The ALRSG was created as one of the first wave of the Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre) Review Groups in 2000 and undertook its first review from February 2001 to January 2002. This was entitled 'A systematic review of the impact of summative assessment and testing on students' motivation for learning' and was published in the Research Evidence in Education Library (REEL) in 2002 (Harlen and Deakin Crick, 2002). The second review, conducted from February 2002 to January 2003, was concerned with the impact on students and teachers of the use of Information and Communication Technologies (ICT) for assessment of creative and critical thinking skills, and was published on REEL in 2003 (Harlen and Deakin Crick, 2003a)

'I would rather die': reasons given by 16-year-olds for not continuing their study of mathematics

Improving participation rates in specialist mathematics after the subject ceases to be compulsory at age 16 is part of government policy in England. This article provides independent and recent support for earlier findings concerning reasons for non- participation, based on free response and closed items in a questionnaire with a sample of over 1500 students in 17 schools, close to the moment of choice. The analysis supports findings that perceived difficulty and lack of confidence are important reasons for students not continuing with mathematics, and that perceived dislike and boredom, and lack of relevance, are also factors. There is a close relationship between reasons for non-participation and predicted grade, and a weaker relation to gender. An analysis of the effects of schools, demonstrates that enjoyment is the main factor differentiating schools with high and low participation indices. Building on discussion of these findings, ways of improving participation are briefly suggested

The potential of thermoelectric generator in parallel hybrid vehicle applications

This paper reports on an investigation into the potential for a thermoelectric generator (TEG) to improve the fuel economy of a mild hybrid vehicle. A simulation model of a parallel hybrid vehicle equipped with a TEG in the exhaust system is presented. This model is made up by three sub-models: a parallel hybrid vehicle model, an exhaust model and a TEG model. The model is based on a quasi-static approach, which runs a fast and simple estimation of the fuel consumption and CO2 emissions. The model is validated against both experimental and published data. Using this model, the annual fuel saving, CO2 reduction and net present value (NPV) of the TEG’s life time fuel saving are all investigated. The model is also used as a flexible tool for analysis of the sensitivity of vehicle fuel consumption to the TEG design parameters. The analysis results give an effective basis for optimization of the TEG design

Performance of Baited Underwater Video: Does It Underestimate Abundance at High Population Densities?

Funding: This work was supported by a grant from the Spanish National Plan for Scientific and Technological Research and Innovation, the RECMARE project (CTM2012-36982 MAR) and by the SGP (Spanish Ministry of Agriculture, Environment and Fisheries) for the ERICOL project. The South Australian Research Institute provided inkind funding support.Abstract Video survey techniques are now commonly used to estimate animal abundance under the assumption that estimates relate to true abundance, a key property needed to make video a valid survey tool. Using the spiny lobster Palinurus elephas as our model organism, we evaluate the effectiveness of baited underwater video (BUV) for estimating abundance in areas with widely different population density. We test three BUV abundance metrics and compare the results with an independently obtained abundance index from trammel-net surveys (Trammel). Video metrics used to estimate relative abundance include a value for total number of individuals per recording (TotN), the traditional maximum number of fish observed in a single video frame (MaxN) and the recently suggested alternative, the average of the mean MaxN from 5-minute periods throughout the duration of the recording (MeanN). This is the first video study of a wild population to include an estimate for TotN. Comparison of TotN with the other two BUV relative abundance metrics demonstrates that both of the latter lack resolution at high population densities. In spite of this, the three BUV metrics tested, as well as the independent estimate Trammel, distinguished high density areas from low density areas. Thus they could all be used to identify areas of differing population density, but MaxN and MeanN would not be appropriate metrics for studies aimed at documenting increases in abundance, such as those conducted to assess marine protected area effectiveness, as they are prone to sampling saturation. We also demonstrate that time of first arrival (T1) is highly correlated with all of the abundance indices,suggesting T1 may be a potentially useful index of abundance. However, these relationships require further investigation as our data suggests T1 may also become sampling-saturated as lobster abundance increases.Publicad

Exploration of the inter-annual variability and multi-scale environmental drivers of European spiny lobster, Palinurus elephas (Decapoda: Palinuridae) settlement in the NW Mediterranean

Determining the drivers of key ecological processes of commercial marine species is important to acquire basic and essential knowledge for fisheries management and conservation. Here we report on a long-term monitoring of the settlement of the European spiny lobster, Palinurus elephas, the most commercially important spiny lobster species in the Mediterranean and north-eastern Atlantic. Densities of recently settled individuals (early benthic juveniles –EBJs) were recorded annually, as an approximation to annual settlement, from 2000 to 2016 (17 years) in three zones of the north-western Mediterranean: Catalonia (CAT), the Columbretes Islands (COL), and the Balearic Islands (BAL). Settlement, the end point that integrate most of the variability occurred during dispersion, is a complex ecological process governed by the interaction of biotic and abiotic factors that can be in turn influenced by the atmospheric and oceanographic conditions. Using linear regression of the size structure of EBJs, we demonstrate that settlement occurs synchronously in the three study zones. Densities of EBJs were handled as time series, and regression analysis revealed that CAT and COL covaried significantly, but none of them with BAL. Therefore, CAT and COL were analysed together using generalized linear model and much of their joint variability was explained by the mesoscale oceanographic index IDEA. Settlement in BAL showed a different pattern, explained by the joint effect of the atmospheric oscillations NAO and WEMO. Complexity of P. elephas settlement cannot be fully accounted neither for CAT-COL nor for BAL because settlement seems be driven by more complex unknown multi-factorial processes. Therefore, further studies are necessary to gain insight into other factors that allow short-or medium-term predictions of settlement. Expanding the study area across the Mediterranean would also allow establishing a complete knowledge of the ecology of the species applicable to the management of the fishery.Versión del edito

Using legume-based mixtures to enhance the nitrogen use efficiency and economic viability of cropping systems - Final report (LK09106/HGCA3447)

As costs for mineral fertilisers rise, legume-based leys are recognised as a potential alternative nitrogen source for crops. Here we demonstrate that including species-rich legume-based leys in rotations helps to maximise synergies between agricultural productivity and other ecosystem services. By using functionally diverse plant species mixtures, these services can be optimised and fine-tuned to regional and farm-specific needs. Replicated field experiments were conducted over three years at multiple locations, testing the performance of 12 legume species and 4 grass species sown in monocultures, as well as in a mixture of 10 of the legumes and all 4 grasses (called the All Species Mix, ASM). In addition, we compared this complex mixture to farmer-chosen ley mixtures on 34 sites across the UK. The trials showed that there is a large degree of functional complementarity among the legume species. No single species scored high on all evaluation criteria. In particular, the currently most frequently used species, white clover, is outscored by other legume species on a number of parameters such as early development and resistance to decomposition. Further complementarity emerged from the different responses of legume species to environmental variables, with soil pH and grazing or cutting regime being among the more important factors. For example, while large birdsfoot trefoil showed better performance on more acidic soils, the opposite was true for sainfoin, lucerne and black medic. In comparison with the monocultures, the ASM showed increased ground cover, increased above-ground biomass and reduced weed biomass. Benefits of mixing species with regard to productivity increased over time. In addition, the stability of biomass production across sites was greater in the ASM than in the legume monocultures. Within the on-farm trials, we further found that on soils low in organic matter the biomass advantage of the ASM over the Control ley was more marked than on the soils with higher organic matter content. Ecological modelling revealed that the three best multifunctional mixtures all contained black medic, lucerne and red clover. Within the long term New Farming Systems (NFS) rotational study, the use of a clover bi-crop showed improvement to soil characteristics compared to current practice (e.g. bulk density and water infiltration rate). Improvements in wheat yield were also noted with respect to the inclusion of a clover bi-crop in 2010, but there was evidence of a decline in response as the N dose was increased. Cumulatively, over both the wheat crop and the spring oilseed rape crop, the clover bi-crop improved margin over N. The highest average yield response (~9%) was associated with the ASM legume species mix cover cropping approach

Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer.

Introduction Ovarian cancer (OC) is associated with non-specific symptoms such as bloating, making accurate diagnosis challenging: only 1 in 3 women with OC presents through primary care referral. National Institute for Health and Care Excellence guidelines recommends sequential testing with CA125 and routine ultrasound in primary care. However, these diagnostic tests have limited sensitivity or specificity. Improving accurate triage in women with vague symptoms is likely to improve mortality by streamlining referral and care pathways. The Refining Ovarian Cancer Test Accuracy Scores (ROCkeTS; HTA 13/13/01) project will derive and validate new tests/risk prediction models that estimate the probability of having OC in women with symptoms. This protocol refers to the prospective study only (phase III). Methods and analysis ROCkeTS comprises four parallel phases. The full ROCkeTS protocol can be found at http://www.birmingham.ac.uk/ROCKETS. Phase III is a prospective test accuracy study. The study will recruit 2450 patients from 15 UK sites. Recruited patients complete symptom and anxiety questionnaires, donate a serum sample and undergo ultrasound scored as per International Ovarian Tumour Analysis (IOTA) criteria. Recruitment is at rapid access clinics, emergency departments and elective clinics. Models to be evaluated include those based on ultrasound derived by the IOTA group and novel models derived from analysis of existing data sets. Estimates of sensitivity, specificity, c-statistic (area under receiver operating curve), positive predictive value and negative predictive value of diagnostic tests are evaluated and a calibration plot for models will be presented. ROCkeTS has received ethical approval from the NHS West Midlands REC (14/WM/1241) and is registered on the controlled trials website (ISRCTN17160843) and the National Institute of Health Research Cancer and Reproductive Health portfolios