Transition metal-mediated synthesis of oxazoles

Among the synthetic methods for the formation of the oxazole ring, transition metal-mediated protocols are the most attractive in terms of selectivity, efficiency and mildness of reaction conditions. In this review we discuss methods for the preparation of oxazoles using transition metal complexes highlighting the key bonds being formed. This reveals critical gaps in the existing literature for the construction of this biologically significant ring system highlighting exciting opportunities for further research

A Requirement-centric Approach to Web Service Modeling, Discovery, and Selection

Service-Oriented Computing (SOC) has gained considerable popularity for implementing Service-Based Applications (SBAs) in a flexible\ud and effective manner. The basic idea of SOC is to understand users'\ud requirements for SBAs first, and then discover and select relevant\ud services (i.e., that fit closely functional requirements) and offer\ud a high Quality of Service (QoS). Understanding users’ requirements\ud is already achieved by existing requirement engineering approaches\ud (e.g., TROPOS, KAOS, and MAP) which model SBAs in a requirement-driven\ud manner. However, discovering and selecting relevant and high QoS\ud services are still challenging tasks that require time and effort\ud due to the increasing number of available Web services. In this paper,\ud we propose a requirement-centric approach which allows: (i) modeling\ud users’ requirements for SBAs with the MAP formalism and specifying\ud required services using an Intentional Service Model (ISM); (ii)\ud discovering services by querying the Web service search engine Service-Finder\ud and using keywords extracted from the specifications provided by\ud the ISM; and(iii) selecting automatically relevant and high QoS services\ud by applying Formal Concept Analysis (FCA). We validate our approach\ud by performing experiments on an e-books application. The experimental\ud results show that our approach allows the selection of relevant and\ud high QoS services with a high accuracy (the average precision is\ud 89.41%) and efficiency (the average recall is 95.43%)

Promotion of E-bikes for delivery of goods in European urban areas: an Italian case study

The paper presents the first results of some tasks of Pro-E-Bike, an Intelligent Energy Europe (IEE) funded project, started on March 2013 ending in February 2016. Pro-E-Bike promotes clean and energy efficient vehicles, analyses the performance of electric bicycles and electric scooters (Light Electric Vehicle, LEV) for the delivering of goods in urban areas and tests the use of these vehicles in seven European countries with twenty five companies, both delivering ones and companies that deliver their own products. Pilots will enable the demonstration of measurable effects in terms of reduction of CO2 emissions and energy savings in urban transport: related data about environmental, economic and social effects resulted by the introduction of e-bikes and e-scooters in the pilot cities will be collected. The paper will give an overlooks of the Italian pilot, that will take place in Genova, describing the subjects involved and the expected results

Are histological alterations observed in the gallbladder precancerous lesions?

INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD: Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS: Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required

Sheep predation : characteristics and risk factors

Predation has always been an important problem in extensive sheep farms, causing serious economic losses to the farmers. Official predation reports have recently been decreasing in the District of Pisa, in spite of the presence of two wolf packs in the area. The aim of the present research was to obtain reliable information on the characteristics of predation and to estimate the effectiveness of existing prevention methods in sheep farms of the southern District of Pisa, in order to set up predictive models for an improved and more focused prevention plan and support interventions by public authorities. On-farm surveys were carried out in 73 semi-extensive sheep farms. Predation events were reported by 75.3% of the farmers. Wolves seemed to be responsible for most of those events, although their actual role could be confirmed only in 34% of cases. Most of the events occurred in spring and 85.1% of them were concentrated during night time. The average number of sheep killed during each attack was 7.05. In 22.3% of cases, the number of sheep killed was 65 10. Proximity to protected areas and the presence of thick vegetation cover significantly affected the probability of a farm being subjected to chronic predation. Farm size was significantly higher in those cases. No clear indication about the effectiveness of prevention methods could be obtained from our survey. The results of this investigation highlighted the impact of predation in the Southern District of Pisa and emphasized the need for finding technical and political solutions to this problem. Attention should be focused on large farms, with thick vegetation cover and located close to protected areas. Further investigations should be carried out in order to test the effectiveness of suitable prevention methods in these farms

Synthesis of α-alkylidene cyclic carbonatesviaCO2fixation under ambient conditions promoted by an easily available silver carbamate

The simple and cost-effective compound [Ag(O2CNEt2)], in combination with PPh3, works as an effective catalytic precursor in the carboxylation of propargyl alcohols at ambient temperature and atmospheric CO2pressure, and in most cases under solventless conditions. The silver carbamate revealed a better performance than commercial silver oxide, Ag2O, and allowed to obtain a series of α-alkylidene cyclic carbonates in high yields

Measurement of transfer of colostral passive immunity in dairy calves

The administration of high quality colostrum reduces preweaning morbidity, mortality and, therefore, economic losses related to replacement animals. It also stimulates and improves calf growth, increasing milk production and longevity of the future dairy cows. The aim of the present study was to evaluate the influence of breed and parity of the dam on colostrum quality, and of breed and gender of the calf, and time from calf birth to the administration of the first colostrum meal on the transfer of passive immunity to the calf by the field test of the Failure of Passive Transfer (FPT) on calf serum. A further objective was to improve the diagnostic accuracy of the field FPT test through a second laboratory phase improving the turbidity evaluation. The amount of IgG fed to calves (IgG concentration multiplied by the volume of colostrum administered) was influenced by dam parity as significant differences (P < 0.05) were detected between first- and fourth-parity cows, and between second- and fourth-parity cows. The administration of good quality colostrum (IgG > 50 mg/ml) between 5 and 9 h of life was able to reduce the risk of FPT more effectively than the administration performed within the first 4 h of life. However, further studies on larger sample size is needed to confirm the present findings. The spectrophotometric measurements confirmed the results obtained by the field turbidity test at 14% sodium sulphite dilution. It would be interesting in future to expand the dataset and validate the spectrophometric method