217 research outputs found
Introduction revisiting the Argentine crisis a decade on: changes and continuities
This introductory chapter to the book "Argentina Since the 2001 Crisis Recovering the Past, Reclaiming the Future" analyses crisis and its associated responses and subsequent recovery in the context of Argentinaâs multiple implosion of 2001-02 whilst also assessing its legacies for the countryâs social, cultural, economic and political realms during the last decade. It recognises that "crisis" is a term that is much used in the post-Lehman Brothers world and that the subsequent responses and associated recoveries (or lack of) have been the subject of a cascade of academic, government, media, and think-tank investigation ever since. The chapter instead seeks to understand the nature of how crisis and its impacts should be investigated and interrogated, by rejecting false dichotomies of âoldâ and ânewâ and synthesising understanding to form an analysis that draws both elements of continuity and elements of change. Secondly, it argues that crisis manifests itself in a number of realms, and that heuristic devices employed to investigate them must subsequently also be drawn from across a range of disciplinary perspectives. Thirdly, it examines how the 2001-02 crisis in Argentina led to a series of responses that both rejected the neoliberal model yet also recovered elements of it. Finally it outlines the structure of the rest of the book, briefly summarising the chapters in turn
Planck pre-launch status: HFI beam expectations from the optical optimisation of the focal plane
Planck is a European Space Agency (ESA) satellite, launched in May 2009, which will map the cosmic microwave background anisotropies in intensity and polarisation with unprecedented detail and sensitivity. It will also provide full-sky maps of astrophysical foregrounds. An accurate knowledge of the telescope beam patterns is an essential element for a correct analysis of the acquired astrophysical data. We present a detailed description of the optical design of the High Frequency Instrument (HFI) together with some of the optical performances measured during the calibration campaigns. We report on the evolution of the knowledge of the pre-launch HFI beam patterns when coupled to ideal telescope elements, and on their significance for the HFI data analysis procedure
A Circularly Symmetric Antenna Design With High Polarization Purity and Low Spillover
We describe the development of two circularly symmetric antennas with high
polarization purity and low spillover. Both were designed to be used in an
all-sky polarization and intensity survey at 5 GHz (the C-Band All-Sky Survey,
C-BASS). The survey requirements call for very low levels of cross-polar
leakage and far-out sidelobes. Two different existing antennas, with 6.1-m and
7.6-m diameter primaries, were adapted by replacing the feed and secondary
optics, resulting in identical beam performances of 0.73deg FWHM,
cross-polarization better than -50 dB, and far-out sidelobes below -70 dB. The
polarization purity was realized by using a symmetric low-loss dielectric foam
support structure for the secondary mirror, avoiding the need for secondary
support struts. Ground spill-over was largely reduced by using absorbing
baffles around the primary and secondary mirrors, and by the use of a
low-sidelobe profiled corrugated feedhorn. The 6.1-m antenna and receiver have
been completed and test results show that the optics meet their design goals.Comment: accepted for publication in IEEE Transactions on Antennas and
Propagatio
The association of leg length and offset reconstruction after total hip arthroplasty with clinical outcomes
Radiofrequency denervation of the lumbar facet joints: guidelines for the RADICAL randomised controlled trial
ACBAR: The Arcminute Cosmology Bolometer Array Receiver
We describe the Arcminute Cosmology Bolometer Array Receiver (ACBAR); a
multifrequency millimeter-wave receiver designed for observations of the Cosmic
Microwave Background (CMB) and the Sunyaev-Zel'dovich effect in clusters of
galaxies. The ACBAR focal plane consists of a 16-pixel, background-limited, 240
mK bolometer array that can be configured to observe simultaneously at 150,
220, 280, and 350 GHz. With 4-5' FWHM Gaussian beam sizes and a 3 degree
azimuth chop, ACBAR is sensitive to a wide range of angular scales. ACBAR was
installed on the 2 m Viper telescope at the South Pole in January 2001. We
describe the design of the instrument and its performance during the 2001 and
2002 observing seasons.Comment: 59 pages, 16 figures -- updated to reflect version published in ApJ
Effectiveness and Cost-effectiveness of Outpatient Physiotherapy After Knee Replacement for Osteoarthritis: Study Protocol for a Randomised Controlled Trial
Background: Primary total knee replacement is a common operation that is performed to provide pain relief and restore functional ability. Inpatient physiotherapy is routinely provided after surgery to enhance recovery prior to hospital discharge. However, international variation exists in the provision of outpatient physiotherapy after hospital discharge. While evidence indicates that outpatient physiotherapy can improve short-term function, the longer term benefits are unknown. The aim of this randomised controlled trial is to evaluate the long-term clinical effectiveness and cost-effectiveness of a 6-week group-based outpatient physiotherapy intervention following knee replacement.
Methods/design: Two hundred and fifty-six patients waiting for knee replacement because of osteoarthritis will be recruited from two orthopaedic centres. Participants randomised to the usual-care group (n = 128) will be given a booklet about exercise and referred for physiotherapy if deemed appropriate by the clinical care team. The intervention group (n = 128) will receive the same usual care and additionally be invited to attend a group-based outpatient physiotherapy class starting 6 weeks after surgery. The 1-hour class will be run on a weekly basis over
6 weeks and will involve task-orientated and individualised exercises.
The primary outcome will be the Lower Extremity Functional Scale at 12 months post-operative. Secondary outcomes include: quality of life, knee pain and function, depression, anxiety and satisfaction. Data collection will be by questionnaire prior to surgery and 3, 6 and 12 months after surgery and will include a resource-use questionnaire to enable a trial-based economic evaluation. Trial participation and satisfaction with the classes will be evaluated through structured telephone interviews. The primary statistical and economic analyses will be conducted on an intention-to-treat basis with and without imputation of missing data. The primary economic result will estimate the incremental cost per quality-adjusted life year gained from this intervention from a National Health Services (NHS) and personal social services perspective.
Discussion: This research aims to benefit patients and the NHS by providing evidence on the long-term effectiveness and cost-effectiveness of outpatient physiotherapy after knee replacement. If the intervention is found to be effective and cost-effective, implementation into clinical practice could lead to improvement in patientsâ outcomes and improved health care resource efficiency
Evolutionary consequences of environmental effects on gamete performance
Variation in pre- and post-release gamete environments can influence evolutionary processes by altering fertilization outcomes and offspring traits. It is now widely accepted that offspring inherit epigenetic information from both their mothers and fathers. Genetic and epigenetic alterations to eggs and sperm-acquired post-release may also persist post-fertilization with consequences for offspring developmental success and later-life fitness. In externally fertilizing species, gametes are directly exposed to anthropogenically induced environmental impacts including pollution, ocean acidification and climate change. When fertilization occurs within the female reproductive tract, although gametes are at least partially protected from external environmental variation, the selective environment is likely to vary among females. In both scenarios, gamete traits and selection on gametes can be influenced by environmental conditions such as temperature and pollution as well as intrinsic factors such as male and female reproductive fluids, which may be altered by changes in male and female health and physiology. Here, we highlight some of the pathways through which changes in gamete environments can affect fertilization dynamics, gamete interactions and ultimately offspring fitness. We hope that by drawing attention to this important yet often overlooked source of variation, we will inspire future research into the evolutionary implications of anthropogenic interference of gamete environments including the use of assisted reproductive technologies. This article is part of the theme issue 'How does epigenetics influence the course of evolution?
First Observations of G-Band Radar Doppler Spectra
The first Doppler spectra ever acquired by an atmospheric radar at 200 GHz (G-band) are presented. The observations were taken during a light precipitation event in May (rain rates <2 mm hrâ1) at Chilbolton Observatory, UK, with coincident Ka-band and W-band Doppler radar measurements. The collected rain spectra agree with Mie theory predictions: at G-band they show significant reductions in the spectral power returnâas compared to theoretical Rayleigh scatteringâcorresponding to high Doppler velocities (i.e., large raindrops) with the presence of multiple peaks and âMie notchesâ in correspondence to the maxima and minima of the raindrop backscattering cross sections. The first two G-band Mie troughs correspond to smaller velocities/sizes than the first W-band Mie notch. These features offered by G-band radars pave the way toward applying, in rain, Mie notch vertical wind retrievals and multifrequency drop size distribution microphysical retrievals to smaller rain rates and smaller characteristic sizes than ever before
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CostâEffectiveness of GroupâBased Outpatient Physical Therapy After Total Knee Replacement: Results From the Economic Evaluation Alongside the ARENA Multicenter Randomized Controlled Trial
Objective
To assess the cost-utility and cost-effectiveness of a group-based outpatient physical therapy intervention delivered 6âweeks after primary total knee replacement (TKR) compared with usual care, alongside the Activity-Orientated Rehabilitation Following Knee Arthroplasty (ARENA) multicenter, randomized, controlled trial.
Methods
The economic analyses were performed from the perspective of the health and social care payer. We collected resource use for health and social care and productivity losses and patient outcomes for 12 months after surgery to derive costs and quality-adjusted life years (QALYs). Results were expressed in incremental cost-effectiveness ratios (ICERs), and incremental net monetary benefit statistics (INMBs) for a society willingness-to-pay (WTP) threshold of ÂŁ20,000 per QALY gained, with sensitivity analyses to model specification and perspective.
Results
The cost of the ARENA physical therapy classes was meanâ±âSD ÂŁ179â±â39 per patient. Treatment in the year following surgery cost was, on average, ÂŁ1,739 (95% confidence interval [95% CI] âÂŁ742, ÂŁ4,221) per patient in the intervention group (n = 89), which was an additional ÂŁ346 (95% CI ÂŁ38, ÂŁ653) per patient compared with usual care (n = 91) (ÂŁ1,393 [95% CI âÂŁ780, ÂŁ3,568]). QALY benefits were 0.0506 higher (95% CI 0.009, 0.09) in the intervention group, corresponding to an additional 19âdays in âperfect health.â The ICER for the intervention group was ÂŁ6,842 per QALY gained, and the INMB was ÂŁ665 (95% CI ÂŁ139, ÂŁ1,191), with a 92% probability of being cost-effective, and no less than 73% in all sensitivity analysis scenarios.
Conclusion
The addition of group-based outpatient physical therapy classes to usual care improves quality of life and is a cost-effective treatment option following TKR for a society WTP threshold of ÂŁ20,000 per QALY gained
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