69 research outputs found

    So what do we really mean when we say that systems biology is holistic?

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    Background: An old debate has undergone a resurgence in systems biology: that of reductionism versus holism. At least 35 articles in the systems biology literature since 2003 have touched on this issue. The histories of holism and reductionism in the philosophy of biology are reviewed, and the current debate in systems biology is placed in context. Results: Inter-theoretic reductionism in the strict sense envisaged by its creators from the 1930s to the 1960s is largely impractical in biology, and was effectively abandoned by the early 1970s in favour of a more piecemeal approach using individual reductive explanations. Classical holism was a stillborn theory of the 1920s, but the term survived in several fields as a loose umbrella designation for various kinds of anti-reductionism which often differ markedly. Several of these different anti-reductionisms are on display in the holistic rhetoric of the recent systems biology literature. This debate also coincides with a time when interesting arguments are being proposed within the philosophy of biology for a new kind of reductionism. Conclusions: Engaging more deeply with these issues should sharpen our ideas concerning the philosophy of systems biology and its future best methodology. As with previous decisive moments in the history of biology, only those theories that immediately suggest relatively easy experiments will be winners

    Chapter 6 Financing Greek Shipping: Modern Instruments, Methods and Markets

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    The chapter discusses ship finance and analyzes modern instruments, methods and markets that shipping companies employ to fund their investment projects. In a highly dynamic and volatile business environment, ship finance becomes highly sophisticated, innovative and complex. Emphasis is placed particularly on financial innovations employed by Greek shipping companies that rank on top of international shipping. These financing instruments include new forms of bank lending, leasing and syndication, international equity initial public offerings (IPOs), private equity funding, high-yield bond issues, securitization and forward freight agreements (FFAs).

    Dynamic volatility and external security related shocks: The case of the Athens Stock Exchange

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    This paper analyses the impact of exogenous national security related shocks on the time-varying volatility structure of the Greek stock market. Alternative autoregressive conditional heteroscedastic models are estimated, in order to identify the best fit that adequately describes return volatility behavior, testing symmetric as well as asymmetric innovation responses. An external national security related shock factor is included as well as a military crisis dummy, in order to depict possible implications for the conditional variance. The empirical findings appear to support a statistically significant impact of both national security related factors on the Athens stock market returns. © 2005 Elsevier B.V. All rights reserved

    Dynamic volatility and external security related shocks: The case of the Athens Stock Exchange

    No full text
    This paper analyses the impact of exogenous national security related shocks on the time-varying volatility structure of the Greek stock market. Alternative autoregressive conditional heteroscedastic models are estimated, in order to identify the best fit that adequately describes return volatility behavior, testing symmetric as well as asymmetric innovation responses. An external national security related shock factor is included as well as a military crisis dummy, in order to depict possible implications for the conditional variance. The empirical findings appear to support a statistically significant impact of both national security related factors on the Athens stock market returns. © 2005 Elsevier B.V. All rights reserved

    An investigation of the morphology of the petrotympanic fissure using cone-beam computed tomography

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    Objectives: The purpose of the present study was: a) to examine the visibility and morphology of the petrotympanic fissure on cone-beam computed tomography images, and b) to investigate whether the petrotympanic fissure morphology is significantly affected by gender and age, or not. Material and Methods: Using Newtom VGi (QR Verona, Italy), 106 cone-beam computed tomography examinations (212 temporomandibular joint areas) of both genders were retrospectively and randomly selected. Two observers examined the images and subsequently classified by consensus the petrotympanic fissure morphology into the following three types: type 1 - widely open; type 2 - narrow middle; type 3 - very narrow/closed. Results: The petrotympanic fissure morphology was assessed as type 1, type 2, and type 3 in 85 (40.1%), 72 (34.0%), and 55 (25.9%) cases, respectively. No significant difference was found between left and right petrotympanic fissure morphology (Kappa = 0.37; P < 0.001). Furthermore, no significant difference was found between genders, specifically P = 0.264 and P = 0.211 for the right and left petrotympanic fissure morphology, respectively. However, the ordinal logistic regression analysis showed that males tend to have narrower petrotympanic fissures, in particular OR = 1.58 for right and OR = 1.5 for left petrotympanic fissure. Conclusions: The current study lends support to the conclusion that an enhanced multi-planar cone-beam computed tomography yields a clear depiction of the petrotympanic fissure's morphological characteristics. We have found that the morphology is neither gender nor age-related

    An econometric study of tourism demand: the AIDS model of US and European tourism in Mediterranean countries

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    The almost ideal demand system (AIDS) model was used to estimate tourism expenditure allocation by US and West European countries among a range of Mediterranean destinations. The approach has the advantage of an explicit basis in consumer expenditure theory and, by modelling the changes in the budget shares of expenditure among destinations, provides new information relative to that provided by the traditional single equation approach. The estimated model was econometrically satisfactory, although symmetry and homogeneity were rejected, in line with the findings of past studies of consumer demand. The expenditure elasticities demonstrated considerable differences in tourism demand preferences between origin countries, and between traditional and newly developing destinations. The own- and cross-price elasticities indicated the importance of effective prices in determining the allocation of expenditure among destinations
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