22 research outputs found
Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells
Full text linkUltra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor®) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study
Get PDFAntiestrogens modulate MT1 melatonin receptor expression in breast and ovarian cancer cell lines
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P036 Effects of estriol on growth, gene expression and ERE activation in human breast cancer cell lines
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Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
Get PDFCinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads. (C) 2013 Elsevier Ltd. All rights reserved
