809 research outputs found
Fetal and Early Childhood Undernutrition, Mortality, and Lifelong Health
http://dx.doi.org/10.1126/science.122461
Identification of the slow E3 transition 136mCs -> 136Cs with conversion electrons
We performed at ISOLDE the spectroscopy of the decay of the 8- isomer in
136Cs by and conversion-electron detection. For the first time the excitation
energy of the isomer and the multipolarity of its decay have been measured. The
half-life of the isomeric state was remeasured to T1/2 = 17.5(2) s. This isomer
decays via a very slow 518 keV E3 transition to the ground state. In addition
to this, a much weaker decay branch via a 413 keV M4 and a subsequent 105 keV
E2 transition has been found. Thus we have found a new level at 105 keV with
spin 4+ between the isomeric and the ground state. The results are discussed in
comparison to shell model calculations.Comment: Phys. Rev. C accepted for publicatio
A magnetically-driven piston pump for ultra-clean applications
A magnetically driven piston pump for xenon gas recirculation is presented.
The pump is designed to satisfy extreme purity and containment requirements, as
is appropriate for the recirculation of isotopically enriched xenon through the
purification system and large liquid xenon TPC of EXO-200. The pump, using
sprung polymer gaskets, is capable of pumping more than 16 standard liters per
minute (SLPM) of xenon gas with 750 torr differential pressure.Comment: 6 pages, 5 figure
Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury
Purpose. Onset of transfusion-related acute lung injury (TRALI) is suggested to be a threshold-event. Data is lacking on the relation between titer of antibodies infused and onset of TRALI. We determined whether onset of TRALI is dependent on the titer of MHC-I antibodies infused in a combined model of ventilator-induced lung injury and antibody-induced TRALl. Methods. BALB/c mice were ventilated for five hours with low (7.5 ml/kg) or high (15 ml/kg) tidal volume. After three hours of MV, TRALI was induced by infusion of 0.5 mg/kg, 2.0 mg/kg or 4.5 mg/kg MHC-I antibodies. Control animals received vehicle. After five hours of MV, animals were sacrificed. Results. MV with high tidal volumes resulted in increased levels of all markers of lung injury compared to animals ventilated with low tidal MV. In ventilator-induced lung injury, infusion of 4.5 mg/kg of antibodies further increased pulmonary wet-to-dry ratio, pulmonary neutrophil influx and pulmonary KC levels, whereas infusion of lower dose of antibodies did not augment lung injury. In contrast, mice ventilated with low tidal volumes did not develop lung injury, irrespective of the dose of antibody used. Conclusions. In the presence of injurious MV, onset of TRALI depends on the titer of antibodies infused
Characterization of 30 Ge enriched Broad Energy Ge detectors for GERDA Phase II
The GERmanium Detector Array (GERDA) is a low background experiment located
at the Laboratori Nazionali del Gran Sasso in Italy, which searches for
neutrinoless double beta decay of Ge into Se+2e. GERDA has
been conceived in two phases. Phase II, which started in December 2015,
features several novelties including 30 new Ge detectors. These were
manufactured according to the Broad Energy Germanium (BEGe) detector design
that has a better background discrimination capability and energy resolution
compared to formerly widely-used types. Prior to their installation, the new
BEGe detectors were mounted in vacuum cryostats and characterized in detail in
the HADES underground laboratory in Belgium. This paper describes the
properties and the overall performance of these detectors during operation in
vacuum. The characterization campaign provided not only direct input for GERDA
Phase II data collection and analyses, but also allowed to study detector
phenomena, detector correlations as well as to test the strength of pulse shape
simulation codes.Comment: 29 pages, 18 figure
The Legacy of Hope Summit: A Consensus-Based Initiative and Report on Eating Disorders in the U.S. and Recommendations for the Path Forward
Background: Several unsuccessful attempts have been made to reach a cross-disciplinary consensus on issues fundamental to the field of eating disorders in the United States (U.S.). In January 2020, 25 prominent clinicians, academicians, researchers, persons with lived experience, and thought leaders in the U.S. eating disorders community gathered at the Legacy of Hope Summit to try again. This paper articulates the points on which they reached a consensus. It also: (1) outlines strategies for implementing those recommendations; (2) identifies likely obstacles to their implementation; and (3) charts a course for successfully navigating and overcoming those challenges.
Methods: Iterative and consensual processes were employed throughout the Summit and the development of this manuscript.
Results: The conclusion of the Summit culminated in several consensus points, including: (1) Eating disorder outcomes and prevention efforts can be improved by implementing creative health education initiatives that focus on societal perceptions, early detection, and timely, effective intervention; (2) Such initiatives should be geared toward parents/guardians, families, other caretakers, and frontline healthcare providers in order to maximize impact; (3) Those afflicted with eating disorders, their loved ones, and the eating disorders community as a whole would benefit from greater accessibility to affordable, quality care, as well as greater transparency and accountability on the part of in-hospital, residential, and outpatient health care providers with respect to their qualifications, methodologies, and standardized outcomes; (4) Those with lived experience with eating disorders, their loved ones, health care providers, and the eating disorders community as a whole, also would benefit from the establishment and maintenance of treatment program accreditation, professional credentialing, and treatment type and levels of care guidelines; and (5) The establishment and implementation of effective, empirically/evidence-based standards of care requires research across a diverse range of populations, adequate private and government funding, and the free exchange of ideas and information among all who share a commitment to understanding, treating, and, ultimately, markedly diminishing the negative impact of eating disorders.
Conclusions: Widespread uptake and implementation of these recommendations has the potential to unify and advance the eating disorders field and ultimately improve the lives of those affected. A cross-disciplinary group of eating disorder professionals, thought leaders, and persons with lived experience have come together and reached a consensus on issues that are fundamental to the battle against the life-threatening and life-altering illnesses that are eating spectrum disorders. Those issues include: (1) the need for early detection, intervention, prevention, and evidenced-based standards of care; (2) the critical need to make specialized care more accessible and affordable to all those in need; (3) the importance of developing uniform, evidenced-based standards of care; (4) the need for funding and conducting eating spectrum disorder research; and (5) the indispensability of advocacy, education, and legislation where these illnesses are concerned. During the consensus process, the authors also arrived at strategies for implementing their recommendations, identified likely obstacles to their implementation, and charted a course for successfully navigating and overcoming those challenges. Above all else, the authors demonstrated that consensus in the field of eating spectrum disorders is possible and achievable and, in doing so, lit a torch of hope that is certain to light the path forward for years to come
Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain
The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble intracellular deposits central to the development of Alzheimer’s disease (AD) and other tauopathies. Full‐length tau requires the addition of anionic cofactors such as heparin to enhance assembly. We have shown that a fragment from the proteolytically stable core of the PHF, tau 297‐391 known as ‘dGAE’, spontaneously forms cross‐β‐containing PHFs and straight filaments under physiological conditions. Here, we have analysed and compared the structures of the filaments formed by dGAE in vitro with those deposited in the brains of individuals diagnosed with AD. We show that dGAE forms PHFs that share a macromolecular structure similar to those found in brain tissue. Thus, dGAEs may serve as a model system for studying core domain assembly and for screening for inhibitors of tau aggregation
The background in the neutrinoless double beta decay experiment GERDA
The GERmanium Detector Array (GERDA) experiment at the Gran Sasso underground
laboratory (LNGS) of INFN is searching for neutrinoless double beta decay of
76Ge. The signature of the signal is a monoenergetic peak at 2039 keV, the
Q-value of the decay, Q_bb. To avoid bias in the signal search, the present
analysis does not consider all those events, that fall in a 40 keV wide region
centered around Q_bb. The main parameters needed for the neutrinoless double
beta decay analysis are described. A background model was developed to describe
the observed energy spectrum. The model contains several contributions, that
are expected on the basis of material screening or that are established by the
observation of characteristic structures in the energy spectrum. The model
predicts a flat energy spectrum for the blinding window around Q_bb with a
background index ranging from 17.6 to 23.8*10^{-3} counts/(keV kg yr). A part
of the data not considered before has been used to test if the predictions of
the background model are consistent. The observed number of events in this
energy region is consistent with the background model. The background at Q-bb
is dominated by close sources, mainly due to 42K, 214Bi, 228Th, 60Co and alpha
emitting isotopes from the 226Ra decay chain. The individual fractions depend
on the assumed locations of the contaminants. It is shown, that after removal
of the known gamma peaks, the energy spectrum can be fitted in an energy range
of 200 kev around Q_bb with a constant background. This gives a background
index consistent with the full model and uncertainties of the same size
The first search for bosonic super-WIMPs with masses up to 1 MeV/c with GERDA
We present the first search for bosonic super-WIMPs as keV-scale dark matter
candidates performed with the GERDA experiment. GERDA is a neutrinoless
double-beta decay experiment which operates high-purity germanium detectors
enriched in Ge in an ultra-low background environment at the Laboratori
Nazionali del Gran Sasso (LNGS) of INFN in Italy. Searches were performed for
pseudoscalar and vector particles in the mass region from 60 keV/c to 1
MeV/c. No evidence for a dark matter signal was observed, and the most
stringent constraints on the couplings of super-WIMPs with masses above 120
keV/c have been set. As an example, at a mass of 150 keV/c the most
stringent direct limits on the dimensionless couplings of axion-like particles
and dark photons to electrons of and
at 90% credible interval,
respectively, were obtained.Comment: 6 pages, 3 figures, submitted to Physical Review Letters, added list
of authors, updated ref. [21
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