A graph theory-based multi-scale analysis of hierarchical cascade in molecular clouds : Application to the NGC 2264 region

The spatial properties of small star-clusters suggest that they may originate from a fragmentation cascade of the cloud for which there might be traces up to a few dozen of kAU. Our goal is to investigate the multi-scale spatial structure of gas clumps, to probe the existence of a hierarchical cascade and to evaluate its possible link with star production in terms of multiplicity. From the Herschel emission maps of NGC 2264, clumps are extracted using getsf software at each of their associated spatial resolution, respectively [8.4, 13.5, 18.2, 24.9, 36.3]". Using the spatial distribution of these clumps and the class 0/I Young Stellar Object (YSO) from Spitzer data, we develop a graph-theoretic analysis to represent the multi-scale structure of the cloud as a connected network. From this network, we derive three classes of multi-scale structure in NGC 2264 depending on the number of nodes produced at the deepest level: hierarchical, linear and isolated. The structure class is strongly correlated with the column density $N_{\rm H_2}$ since the hierarchical ones dominate the regions whose N$_{\rm H_2} > 6 \times 10^{22}$cm$^{-2}$. Although the latter are in minority, they contain half of the class 0/I YSOs proving that they are highly efficient in producing stars. We define a novel statistical metric, the fractality coefficient F that measure the fractal index describing the scale-free process of the cascade. For NGC 2264, we estimate F = 1.45$\pm$0.12. However, a single fractal index fails to fully describe a scale-free process since the hierarchical cascade starts at a 13 kAU characteristic spatial scale. Our novel methodology allows us to correlate YSOs with their multi-scale gaseous environment. This hierarchical cascade that drives efficient star formation is suspected to be both hierarchical and rooted by the larger-scale gas environment up to 13 kAU

Colloidal Gels: Equilibrium and Non-Equilibrium Routes

We attempt a classification of different colloidal gels based on colloid-colloid interactions. We discriminate primarily between non-equilibrium and equilibrium routes to gelation, the former case being slaved to thermodynamic phase separation while the latter is individuated in the framework of competing interactions and of patchy colloids. Emphasis is put on recent numerical simulations of colloidal gelation and their connection to experiments. Finally we underline typical signatures of different gel types, to be looked in more details in experiments.Comment: topical review, accepted in J. Phys. Condens. Matte

The model of dynamo with small number of modes and magnetic activity of T Tauri stars

The model that describes operation of dynamo in fully convective stars is presented. It is based on representation of stellar magnetic field as a superposition of finite number of poloidal and toroidal free damping modes. In the frame of adopted low of stellar differential rotation we estimated minimal value of dynamo number D, starting from which generation of cyclic magnetic field in stars without radiative core is possible. We also derived expression for period of the cycle. It was found that dynamo cycles of fully convective stars and stars with thin convective envelopes differ in a qualitative way: 1) distribution of spots over latitude during the cycle is different in these stars; 2) the model predicts that spot formation in fully convective stars should be strongly suppressed at some phases of the cycle. We have analyzed historical lightcurve of WTTS star V410 Tau and found that long term activity of the star is not periodic process. Rather one can speak about quasi cyclic activity with characteristic time of $\sim 4$ yr and chaotic component over imposed. We concluded also that redistribution of cool spots over longitude is the reason of long term variations of V410 Tau brightness. It means that one can not compare directly results of photometric observations with predictions of our axially symmetric (for simplicity) model which allows to investigate time evolution of spot's distribution over latitude. We then discuss what kind of observations and in which way could be used to check predictions of the dynamo theory.Comment: 18 pages, 5 figures, accepted to Astron. Let

Peptidotriazolamers Inhibit A beta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model

In peptidotriazolamers every second peptide bond is replaced by a 1H-1,2,3-triazole. Such foldamers are expected to bridge the gap in molecular weight between small-molecule drugs and protein-based drugs. Amyloid beta (A beta) aggregates play an important role in Alzheimer's disease. We studied the impact of amide bond replacements by 1,4-disubstituted 1H-1,2,3-triazoles on the inhibitory activity of the aggregation "hot spots" (KLVFF20)-L-16 and G(39)VVIA(42) in A beta(1-42). We found that peptidotriazolamers act as modulators of the A beta(1-42) oligomerization. Some peptidotriazolamers are able to interfere with the formation of toxic early A beta oligomers, depending on the position of the triazoles, which is also supported by computational studies. Preliminary in vitro results demonstrate that a highly active peptidotriazolamer is also able to cross the blood-brain-barrier.Peer reviewe

Dynamo Processes in the T Tauri star V410 Tau

We present new brightness and magnetic images of the weak-line T Tauri star V410 Tau, made using data from the NARVAL spectropolarimeter at Telescope Bernard Lyot (TBL). The brightness image shows a large polar spot and significant spot coverage at lower latitudes. The magnetic maps show a field that is predominantly dipolar and non-axisymmetric with a strong azimuthal component. The field is 50% poloidal and 50% toroidal, and there is very little differential rotation apparent from the magnetic images. A photometric monitoring campaign on this star has previously revealed V-band variability of up to 0.6 magnitudes but in 2009 the lightcurve is much flatter. The Doppler image presented here is consistent with this low variability. Calculating the flux predicted by the mapped spot distribution gives an peak-to-peak variability of 0.04 magnitudes. The reduction in the amplitude of the lightcurve, compared with previous observations, appears to be related to a change in the distribution of the spots, rather than the number or area. This paper is the first from a Zeeman-Doppler imaging campaign being carried out on V410 Tau between 2009-2012 at TBL. During this time it is expected that the lightcurve will return to a high amplitude state, allowing us to ascertain whether the photometric changes are accompanied by a change in the magnetic field topology.Comment: 12 pages, 11 figures, accepted by MNRA

Multisite observations of SU Aurigae

We present results from the 1996 MUSICOS (MUlti-SIte COntinuous Spectroscopy) campaign on the T Tauri star SU Aurigae. We find a 2.7-d periodicity in the He I (587.6 nm) line and somewhat longer, less well-pronounced periodicities in the Balmer lines and in Na D. Our observations support the suggestion that the wind and infall signatures are out of phase on SU Aur. We present Doppler images of SU Aur that have been obtained from least-squares deconvolved profiles. Images taken about one rotation apart show only limited overlap, in particular at low latitudes. This is in part due to limitations in signal-to-noise, and in part due to line profile deformations that arise from short-lived and/or non-surface features. The agreement at high latitudes is better and suggests that at least some longer-lived features are present. The analysis of Stokes V profiles yields a marginal magnetic field detection during one of the phases.Comment: 22 pages, 20 figures, accepted for publication in MNRA

Insecticide resistance status in Anopheles gambiae in southern Benin

BACKGROUND: The emergence of pyrethroid resistance in Anopheles gambiae has become a serious concern to the future success of malaria control. In Benin, the National Malaria Control Programme has recently planned to scaling up long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) for malaria prevention. It is, therefore, crucial to monitor the level and type of insecticide resistance in An. gambiae, particularly in southern Benin where reduced efficacy of insecticide-treated nets (ITNs) and IRS has previously been reported. METHODS: The protocol was based on mosquito collection during both dry and rainy seasons across forty districts selected in southern Benin. Bioassay were performed on adults collected from the field to assess the susceptibility of malaria vectors to insecticide-impregnated papers (permethrin 0.75%, delthamethrin 0.05%, DDT 4%, and bendiocarb 0.1%) following WHOPES guidelines. The species within An. gambiae complex, molecular form and presence of kdr and ace-1 mutations were determined by PCR. RESULTS: Strong resistance to permethrin and DDT was found in An. gambiae populations from southern Benin, except in Aglangandan where mosquitoes were fully susceptible (mortality 100%) to all insecticides tested. PCR showed the presence of two sub-species of An. gambiae, namely An. gambiae s.s, and Anopheles melas, with a predominance for An. gambiae s.s (98%). The molecular M form of An. gambiae was predominant in southern Benin (97%). The kdr mutation was detected in all districts at various frequency (1% to 95%) whereas the Ace-1 mutation was found at a very low frequency (<or= 5%). CONCLUSION: This study showed a widespread resistance to permethrin in An. gambiae populations from southern Benin, with a significant increase of kdr frequency compared to what was observed previously in Benin. The low frequency of Ace-1 recorded in all populations is encouraging for the use of bendiocarb as an alternative insecticide to pyrethroids for IRS in Benin

Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications

Nighttime organ transplantation aims to decrease cold ischemia duration, yet conflicting data exists on its impact on graft function and perioperative complications. This multicenter TRANSPLANT’AFUF study including 2,854 patients, transplanted between 1 January 2011, and 31 December 2022, investigated nighttime kidney transplantation’s impact (8:00 p.m.–8:00 a.m.) versus daytime (8:00 a.m.–8:00 p.m.) on surgical complications and graft survival. Overall, 2043 patients (71.6%) underwent daytime graft, while 811 (28.4%) underwent nighttime graft. No impact was observed of timing of graft surgery on graft survival with a median survival of 98 months and 132 months for daytime and nightime grafting, respectively (p = 0.1749). Moreover, no impact was observed on early surgical complications (Clavien I-II = 20.95% for DG and 20.10% for NG; Clavien III-IV-V = 15.42% for DG and 12.94% for NG; p = 0.0889) and late complications (&gt;30 days) (Clavien I-II = 6.80% for DG and 5.67% for NG; Clavien III-IV-V = 12.78% for DG and 12.82% for NG; p = 0.2444). Noteworthy, we found a significant increase in Maastricht 3 donors’ rates in nighttime transplantation (5.53% DG vs. 21.45% NG; p &lt; 0.0001). In conclusion, nighttime kidney transplantation did not impact early/late surgical complications nor graft survival

Traitement radar par filtrage Doppler adaptatif

Dans les radars à impulsions l'utilisation de l'information Doppler permet, par un filtrage sélectif d'améliorer considérablement la visibilité des échos d'avions. Malheureusement ces mêmes techniques s'avèrent insuffisantes en présence de réflexions sur des obstacles lentement mobiles dont la vitesse est inconnue a priori. Cette étude décrit un traitement de type adaptatif, utilisant l'extension spatiale des signaux parasites et fondé sur une mesure de leur vitesse moyenne. La méthode de mesure a fait l'objet d'une attention particulière. Des calculs théoriques et des applications sur signaux simulés tendent à prouver l'intérêt du traitement proposé

Generalized Relax-and-Fix heuristic

This paper introduces a heuristic for mixed-integer mathematical programs, that can be seen as a generalization of the relax-and-fix heuristic: a sequence of derived subproblems is solved, progressively fixing variables in the original problem. We propose a generic implementation and report on numerical results for four well-known operational research applications: lot-sizing, vehicle routing, bin-packing and portfolio optimization. Results show that this heuristic may be competitive depending on the definition of subproblems