Spatial Effects of the Social Marketing of Insecticide-Treated Nets on Malaria Morbidity.

Randomized controlled trials have shown that insecticide-treated nets (ITNs) have an impact on both malaria morbidity and mortality. Uniformly high coverage of ITNs characterized these trials and this resulted in some protection of nearby non-users of ITNs. We have now assessed the coverage, distribution pattern and resultant spatial effects in one village in Tanzania where ITNs were distributed in a social marketing programme. The prevalence of parasitaemia, mild anaemia (Hb <11 g/dl) and moderate/severe anaemia (Hb <8 g/dl) in children under five was assessed cross-sectionally. Data on ownership of ITNs were collected and inhabitants' houses were mapped. One year after the start of the social marketing programme, 52% of the children were using a net which had been treated at least once. The ITNs were rather homogeneously distributed throughout the village at an average density of about 118 ITNs per thousand population. There was no evidence of a pattern in the distribution of parasitaemia and anaemia cases, but children living in areas of moderately high ITN coverage were about half as likely to have moderate/severe anaemia (OR 0.5, 95% CI: 0.2, 0.9) and had lower prevalence of splenomegaly, irrespective of their net use. No protective effects of coverage were found for prevalence of mild anaemia nor for parasitaemia. The use of untreated nets had neither coverage nor short distance effects. More efforts should be made to ensure high coverage in ITNs programmes to achieve maximum benefit

Equivalence of two mathematical forms for the bound angular momentum of the electromagnetic field

It is shown that the mathematical form, obtained in a recent paper, for the angular momentum of the electromagnetic field in the vicinity of electric charge is equivalent to another form obtained previously by Cohen-Tannoudji, Dupont-Roc and Gilbert. In this version of the paper an improved derivation is given.Comment: 4 pages pdf, simpler derivatio

Quantum Cosmology for the General Bianchi Type II, VI(Class A) and VII(Class A) vacuum geometries

The canonical quantization of the most general minisuperspace actions --i.e. with all six scale factor as well as the lapse function and the shift vector present-- describing the vacuum type II, VI and VII geometries, is considered. The reduction to the corresponding physical degrees of freedom is achieved through the usage of the linear constraints as well as the quantum version of the entire set of classical integrals of motion.Comment: 23 pages, LaTeX2e, No figure

A note on wavemap-tensor cosmologies

We examine theories of gravity which include finitely many coupled scalar fields with arbitrary couplings to the curvature (wavemaps). We show that the most general scalar-tensor $\sigma$-model action is conformally equivalent to general relativity with a minimally coupled wavemap with a particular target metric. Inflation on the source manifold is then shown to occur in a novel way due to the combined effect of arbitrary curvature couplings and wavemap self-interactions. A new interpretation of the conformal equivalence theorem proved for such `wavemap-tensor' theories through brane-bulk dynamics is also discussed.Comment: 8 pages, LaTeX, to appear in the Proceedings of the 2nd Hellenic Cosmology Workshop, National Observatory of Athens, April 21-22, 2001, (Kluwer 2001

DBpedia's triple pattern fragments: usage patterns and insights

Queryable Linked Data is published through several interfaces, including SPARQL endpoints and Linked Data documents. In October 2014, the DBpedia Association announced an official Triple Pattern Fragments interface to its popular DBpedia dataset. This interface proposes to improve the availability of live queryable data by dividing query execution between clients and servers. In this paper, we present a usage analysis between November 2014 and July 2015. In 9 months time, the interface had an average availability of 99.99 %, handling 16,776,170 requests, 43.0% of which were served from cache. These numbers provide promising evidence that low-cost Triple Pattern Fragments interfaces provide a viable strategy for live applications on top of public, queryable datasets

Strong One-Dimensional Characteristics of Hole-Carriers in ReS2 and ReSe2.

Each plane of layered ReS2 and ReSe2 materials has 1D chain structure, from which intriguing properties such as 1D character of the exciton states and linearly polarized photoluminescence originate. However, systematic studies on the 1D character of charge carriers have not been done yet. Here, we report on systematic and comparative studies on the energy-momentum dispersion relationships of layered transition metal dichalcogenides ReS2 and ReSe2 by angle resolved photoemission. We found that the valence band maximum or the minimum energy for holes is located at the high symmetric Z-point for both materials. However, the out-of-plane ([Formula: see text]) dispersion for ReSe2 (20 meV) is found to be much smaller than that of ReS2 (150 meV). We observe that the effective mass of the hole carriers along the direction perpendicular to the chain is about 4 times larger than that along the chain direction for both ReS2 and ReSe2. Remarkably, the experimentally measured hole effective mass is about twice heavier than that from first principles calculation for ReS2 although the in-plane anisotropy values from the experiment and calculations are comparable. These observation indicate that bulk ReS2 and ReSe2 are unique semiconducting transition metal dichalcogenides having strong one-dimensional characters

How to realize a robust practical Majorana chain in a quantum dot-superconductor linear array

Semiconducting nanowires in proximity to superconductors are promising experimental systems for Majorana fermions, which may ultimately be used as building blocks for topological quantum computers. A serious challenge in the experimental realization of the Majorana fermions is the supression of topological superconductivity by disorder. We show that Majorana fermions protected by a robust topological gap can occur at the ends of a chain of quantum dots connected by s-wave superconductors. In the appropriate parameter regime, we establish that the quantum dot/superconductor system is equivalent to a 1D Kitaev chain, which can be tuned to be in a robust topological phase with Majorana end modes even in the case where the quantum dots and superconductors are both strongly disordered. Such a spin-orbit coupled quantum dot - s-wave superconductor array provides an ideal experimental platform for the observation of non-Abelian Majorana modes.Comment: 8 pages; 3 figures; version 2: Supplementary material updated to include more general proof for localized Majorana fermion

Discovery of a strong magnetic field on the O star HD 191612: new clues to the future of theta1 Orionis C?

From observations made with the ESPaDOnS spectropolarimeter, recently installed on the 3.6-m Canada--France--Hawaii Telescope, we report the discovery of a strong magnetic field in the Of?p spectrum variable HD 191612 -- only the second known magnetic O star (following theta1 Ori C). The stability of the observed Zeeman signature over four nights of observation, together with the non-rotational shape of line profiles, argue that the rotation period of HD 191612 is significantly longer than the 9-d value previously proposed. We suggest that the recently identified 538-d spectral-variability period is the rotation period, in which case the observed line-of-sight magnetic field of -220+-38 G implies a large-scale field (assumed dipolar) with a polar strength of about -1.5 kG. If confirmed, this scenario suggests that HD 191612 is, essentially, an evolved version of the near-ZAMS magnetic O star theta1 Ori C, but with an even stronger field (about 15 kG at an age similar to that of theta1Ori C). We suggest that the rotation rate of HD 191612, which is exceptionally slow by accepted O-star standards, could be due to angular-momentum dissipation through a magnetically confined wind.Comment: Accepted by MNRAS Letters, 5 pages, 2 figures, 2 table

Disrupted GABAergic facilitation of working memory performance in people with schizophrenia.

ObjectivesGamma-Amiobutyric acid (GABA) is a primary inhibitory neurotransmitter that facilitates neural oscillations that coordinate neural activity between brain networks to facilitate cognition. The present magnetic resonance spectroscopy (MRS) study tests the hypothesis that GABAergic facilitation of working memory is disrupted in people with schizophrenia (PSZ).Methods51 healthy participants and 40 PSZ from the UC Davis Early Psychosis Program performed an item and temporal order working memory (WM) task and underwent resting MRS to measure GABA and glutamate concentrations in dorsolateral prefrontal (DLPFC) and anterior cingulate (ACC) regions of interest. MRS was acquired on a 3 Tesla Siemens scanner and GABA and glutamate concentrations were referenced to creatine. Percent correct on the WM task indexed performance and correlation coefficients examined GABAergic or Glutamatergic facilitation of WM, with Fisher's Z transformation testing for group differences.ResultsThere were no group differences in GABA or glutamate concentrations, but WM correlations were reversed between groups. In patients, higher DLPFC GABA was associated with worse rather than better WM performance. This pattern was not observed for glutamate or in the ACC. Although under-powered, there was no indication of medication effects.Conclusions and relevanceResults cannot be explained by group differences in DLPFC GABA or glutamate concentrations but, instead, indicate that schizophrenia disrupts the GABAergic facilitation of WM seen in healthy individuals. Results appear to parallel post mortem findings in suggesting that schizophrenia alters the distribution of different classes of GABAergic interneurons rather than producing a general deficit across the total population of neurons

Who Watches the Watchmen? An Appraisal of Benchmarks for Multiple Sequence Alignment

Multiple sequence alignment (MSA) is a fundamental and ubiquitous technique in bioinformatics used to infer related residues among biological sequences. Thus alignment accuracy is crucial to a vast range of analyses, often in ways difficult to assess in those analyses. To compare the performance of different aligners and help detect systematic errors in alignments, a number of benchmarking strategies have been pursued. Here we present an overview of the main strategies--based on simulation, consistency, protein structure, and phylogeny--and discuss their different advantages and associated risks. We outline a set of desirable characteristics for effective benchmarking, and evaluate each strategy in light of them. We conclude that there is currently no universally applicable means of benchmarking MSA, and that developers and users of alignment tools should base their choice of benchmark depending on the context of application--with a keen awareness of the assumptions underlying each benchmarking strategy.Comment: Revie