1,838 research outputs found
Simulating ice core 10Be on the glacial–interglacial timescale
10Be ice core measurements are an important tool for paleoclimate research, e.g., allowing for the reconstruction of past solar activity or changes in the geomagnetic dipole field. However, especially on multi-millennial timescales, the share of production and climate-induced variations of respective 10Be ice core records is still up for debate. Here we present the first quantitative climatological model of the 10Be ice concentration up to the glacial–interglacial timescale. The model approach is composed of (i) a coarse resolution global atmospheric transport model and (ii) a local 10Be air–firn transfer model. Extensive global-scale observational data of short-lived radionuclides as well as new polar 10Be snow-pit measurements are used for model calibration and validation. Being specifically configured for 10Be in polar ice, this tool thus allows for a straightforward investigation of production- and non-production-related modulation of this nuclide. We find that the polar 10Be ice concentration does not immediately record the globally mixed cosmogenic production signal. Using geomagnetic modulation and revised Greenland snow accumulation rate changes as model input, we simulate the observed Greenland Summit (GRIP and GISP2) 10Be ice core records over the last 75 kyr (on the GICC05modelext timescale). We show that our basic model is capable of reproducing the largest portion of the observed 10Be changes. However, model–measurement differences exhibit multi-millennial trends (differences up to 87% in case of normalized to the Holocene records) which call for closer investigation. Focusing on the (12–37) b2k (before the year AD 2000) period, mean model–measurement differences of 30% cannot be attributed to production changes. However, unconsidered climate-induced changes could likely explain the model–measurement mismatch. In fact, the 10Be ice concentration is very sensitive to snow accumulation changes. Here the reconstructed Greenland Summit (GRIP) snow accumulation rate record would require revision of +28% to solely account for the (12–37) b2k model–measurement differences
Self-Pulsating Semiconductor Lasers: Theory and Experiment
We report detailed measurements of the pump-current dependency of the
self-pulsating frequency of semiconductor CD lasers. A distinct kink in this
dependence is found and explained using rate-equation model. The kink denotes a
transition between a region where the self-pulsations are weakly sustained
relaxation oscillations and a region where Q-switching takes place. Simulations
show that spontaneous emission noise plays a crucial role for the cross-over.Comment: Revtex, 16 pages, 7 figure
RAMPART: RowHammer Mitigation and Repair for Server Memory Systems
RowHammer attacks are a growing security and reliability concern for DRAMs
and computer systems as they can induce many bit errors that overwhelm error
detection and correction capabilities. System-level solutions are needed as
process technology and circuit improvements alone are unlikely to provide
complete protection against RowHammer attacks in the future. This paper
introduces RAMPART, a novel approach to mitigating RowHammer attacks and
improving server memory system reliability by remapping addresses in each DRAM
in a way that confines RowHammer bit flips to a single device for any victim
row address. When RAMPART is paired with Single Device Data Correction (SDDC)
and patrol scrub, error detection and correction methods in use today, the
system can detect and correct bit flips from a successful attack, allowing the
memory system to heal itself. RAMPART is compatible with DDR5 RowHammer
mitigation features, as well as a wide variety of algorithmic and probabilistic
tracking methods. We also introduce BRC-VL, a variation of DDR5 Bounded Refresh
Configuration (BRC) that improves system performance by reducing mitigation
overhead and show that it works well with probabilistic sampling methods to
combat traditional and victim-focused mitigation attacks like Half-Double. The
combination of RAMPART, SDDC, and scrubbing enables stronger RowHammer
resistance by correcting bit flips from one successful attack. Uncorrectable
errors are much less likely, requiring two successful attacks before the memory
system is scrubbed.Comment: 16 pages, 13 figures. A version of this paper will appear in the
Proceedings of MEMSYS2
A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome
E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1. Uba1-204 cells exhibit dramatic inhibition of the ubiquitin–proteasome system, resulting in rapid depletion of cellular ubiquitin conjugates and stabilization of multiple substrates. We have employed the tight phenotype of this mutant to investigate the role ubiquitin conjugates play in the dynamic interaction of the UbL/UBA adaptor proteins Rad23 and Dsk2 with the proteasome. Although proteasomes purified from mutant cells are intact and proteolytically active, they are depleted of ubiquitin conjugates, Rad23, and Dsk2. Binding of Rad23 to these proteasomes in vitro is enhanced by addition of either free or substrate-linked ubiquitin chains. Moreover, association of Rad23 with proteasomes in mutant and wild-type cells is improved upon stabilizing ubiquitin conjugates with proteasome inhibitor. We propose that recognition of polyubiquitin chains by Rad23 promotes its shuttling to the proteasome in vivo
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Splanchnic metabolism of nutrients and hormones in steers fed alfalfa under conditions of increased absorption of ammonia and L-arginine supply across the portal-drained viscera
Effects of increased ammonia and/or arginine
absorption on net splanchnic (portal-drained viscera
[PDV] plus liver) metabolism of nonnitrogenous
nutrients and hormones in cattle were examined. Six
Hereford × Angus steers (501 ± 1 kg BW) prepared with
vascular catheters for measurements of net flux across
the splanchnic bed were fed a 75% alfalfa:25% (as-fed
basis) corn and soybean meal diet (0.523 MJ of ME/[kg
BW0.75.d]) every 2 h without (27.0 g of N/kg of DM) and
with 20 g of urea/kg of DM (35.7 g of N/kg of DM) in a
split-plot design. Net flux measurements were made
immediately before and after a 72-h mesenteric vein
infusion of L-arginine (15 mmol/h). There were no treatment
effects onPDVor hepaticO2 consumption. Dietary
urea had no effect on splanchnic metabolism of glucose
or L-lactate, but arginine infusion decreased net hepatic
removal of L-lactate when urea was fed (P < 0.01). Net PDV appearance of n-butyrate was increased by arginine
infusion (P < 0.07), and both dietary urea (P <
0.09) and arginine infusion (P < 0.05) increased net
hepatic removal of n-butyrate. Dietary urea also increased
total splanchnic acetate output (P < 0.06),
tended to increase arterial glucagon concentration (P
< 0.11), and decreased arterial ST concentration (P <
0.03). Arginine infusion increased arterial concentration
(P < 0.07) and net PDV release (P < 0.10) and
tended to increase hepatic removal (P < 0.11) of insulin,
as well as arterial concentration (P < 0.01) and total
splanchnic output (P < 0.01) of glucagon. Despite
changes in splanchnic N metabolism, increased ammonia
and arginine absorption had little measurable effect
on splanchnic metabolism of glucose and other nonnitrogenous
components of splanchnic energy metabolism
Search for the rare decay
A search for the decay is performed, based on a data sample of 1.0 fb of collisions at collected by the LHCb experiment at the Large Hadron Collider. The observed number of candidates is consistent with the background-only hypothesis, yielding an upper limit of at 95 (90)% confidence level. This limit is a factor of thirty below the previous measurement
Commissioning and performance of the LHCb Silicon Tracker
The LHCb Silicon Tracker is a silicon micro-strip detector with a sensitive area of 12 m2 and a total of 272k readout channels. The Silicon Tracker consists of two parts that use different detector modules. The detector installation was completed by early summer 2008 and the commissioning without beam has reached its final stage, successfully overcoming most of the encountered problems. Currently, the detector has more than 99% of the channels fully functioning. Commissioning with particles has started using beam-induced events from the LHC injection tests in 2008 and 2009. These events allowed initial studies of the detector performance. Especially, the detector modules could be aligned with an accuracy of about 20μm. Furthermore, with the first beam collisions that took place end of 2009 we could further study the performance and improve the alignment of the detector
Quantum oscillations of nitrogen atoms in uranium nitride
The vibrational excitations of crystalline solids corresponding to acoustic
or optic one phonon modes appear as sharp features in measurements such as
neutron spectroscopy. In contrast, many-phonon excitations generally produce a
complicated, weak, and featureless response. Here we present time-of-flight
neutron scattering measurements for the binary solid uranium nitride (UN),
showing well-defined, equally-spaced, high energy vibrational modes in addition
to the usual phonons. The spectrum is that of a single atom, isotropic quantum
harmonic oscillator and characterizes independent motions of light nitrogen
atoms, each found in an octahedral cage of heavy uranium atoms. This is an
unexpected and beautiful experimental realization of one of the fundamental,
exactly-solvable problems in quantum mechanics. There are also practical
implications, as the oscillator modes must be accounted for in the design of
generation IV nuclear reactors that plan to use UN as a fuel.Comment: 25 pages, 10 figures, submitted to Nature Communications,
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