Groupoids and an index theorem for conical pseudo-manifolds

We define an analytical index map and a topological index map for conical pseudomanifolds. These constructions generalize the analogous constructions used by Atiyah and Singer in the proof of their topological index theorem for a smooth, compact manifold $M$. A main ingredient is a non-commutative algebra that plays in our setting the role of $C_0(T^*M)$. We prove a Thom isomorphism between non-commutative algebras which gives a new example of wrong way functoriality in $K$-theory. We then give a new proof of the Atiyah-Singer index theorem using deformation groupoids and show how it generalizes to conical pseudomanifolds. We thus prove a topological index theorem for conical pseudomanifolds

Hypocycloid-shaped hollow-core photonic crystal fiber Part II: Cladding effect on confinement and bend loss

We report on numerical and experimental studies on the influence of cladding ring-number on the confinement and bend loss in hypocycloid-shaped Kagome hollow core photonic crystal fiber. The results show that beyond the second ring, the ring number has a minor effect on confinement loss whereas the bend loss is strongly reduced with the ringnumber increase. Finally, the results show that the increase in the cladding ring-number improves the modal content of the fiber

'Mine's a Pint of Bitter': Performativity, gender, class and representations of authenticity in real-ale tourism

Leisure choices are expressive of individual agency around the maintenance of taste, boundaries, identity and community. This research paper is part of a wider project designed to assess the social and cultural value of real ale to tourism in the north of England. This paper explores the performativity of real-ale tourism and debates about belonging in northern English real-ale communities. The research combines an ethnographic case study of a real-ale festival with semi-structured interviews with organisers and volunteers, northern English real-ale brewers and real-ale tourists visiting the festival. It is argued that real-ale tourism, despite its origins in the logic of capitalism, becomes a space where people can perform Habermasian, communicative leisure, and despite the contradictions of preferring some capitalist industries over others on the basis of their perceived smaller size and older age, real-ale fans demonstrate agency in their performativity

Consulta de enfermagem ao recém-nascido na 1.ª semana de vida, no domicílio

Com a precoce alta hospitalar pós-parto, a observação das inseguranças dos pais na prestação de cuidados ao recém-nascido tornou-se mais evidente, levando-nos a identificar uma lacuna. Objetivo: Implementar a Consulta de Enfermagem ao Recém-Nascido na Primeira Semana de Vida, no Domicílio. Metodologia: Foi utilizado o Planeamento em Saúde, recorrendo ao questionário de avaliação da perceção de médicos e enfermeiros. Resultados: Confirmou-se a pertinência desta consulta projetada para o domicílio, visto ser na chegada a casa que os pais se deparam com uma realidade não idealizada. Conclusão: A intervenção local vem aumentar a acessibilidade da comunidade aos Cuidados de Saúde Primários e garantir a igualdade de oportunidades. Readaptar políticas torna-se numa estratégia de ganhos em saúde. Assim, capacitar os pais na prestação de cuidados ao recém-nascido é uma forma de dar continuidade aos mesmos após a alta-hospitalar, promovendo a saúde de quem deles depende; Nursing Consultation for the Newborn in the First Week of Life, at Home ABSTRACT: With the precocious postpartum hospital discharge, the observation of parental insecurities in the delivery of care to the newborn has become more evident, leading us to identify a gap. Objective: To implement Nursing Consultation for the Newborn in the First Week of Life, at Home. Methodology: Health planning was used, applying a questionnaire to evaluate the perception of doctors and nurses. Results: The relevance of this home consultation was confirmed, since it is on the arrival at home that parents face a new reality, often not idealized. Conclusion: Local intervention increases the accessibility of the community to Primary Health Care and guarantees equal opportunities. Readjusting policies becomes a strategy for health gains. Thus, enabling parents to provide this type of care is a way of giving continuity to the newborn care after hospital discharge, promoting the health of those who depend on them

Events in the affective city: Affect, attention and alignment in two ordinary urban events

In a representational regime, planned urban events are used by urban planners to render urban projects visible and acceptable. As a corollary of the focus of urban studies on their representational dimension and in spite of a burgeoning literature on the notion of affective urbanism, the experiential character of events remains surprisingly unexplored. This paper argues that an ordinary regime of events is mobilised by city-makers to act on the embodied, affective experience of the city and on the ways urban dwellers know and act upon the city. By analysing planned urban events in their embodied, experiential dimension, we focus on the ways in which, through the design of ephemeral material dispositives, urbanists attempt to encourage citizens to incorporate ways of knowing and acting on space and on the modalities of knowing and acting that are at play. We stage an encounter between critical event studies and Ingoldian approaches to affect and attention, examining two urban events in a Swiss canton. We show how intense encounters with urban matter are staged in an attempt to modulate affects, guide attention, and produce alignment with a specific political project, asking urban dwellers either to embody a project still in the making or to cultivate expectations regarding an already-written future

Vascular Responses to High-Intensity Battling Rope Exercise between the Sexes

The purpose of the study was to assess high-intensity battling rope exercise (HI-BRE) on hemodynamics, pulse wave reflection and arterial stiffness during recovery and between sexes. Twenty-three young, healthy resistance-trained individuals (men: n = 13; women: n = 10) were assessed for all measures at Rest, as well as 10-, 30-, and 60-minutes following HI-BRE. A one-way repeated measures ANOVA was used to analyze the effects of HI-BRE across time (Rest, 10, 30, and 60-minutes) on all dependent variables. Significant main effects were analyzed using paired t-tests with a Sidak correction factor. Significance was accepted a priori at p 0.05. There were significant reductions in hemodynamic measures of diastolic blood pressure (BP) in women, but not men following HI-BRE at 30 minutes. Further, measures of pulse wave reflection, specifically those of the augmentation index (AIx) and wasted left ventricular energy (ΔEw), were significantly increased in both men and women for 60 minutes, but changes were significantly attenuated in women suggesting less ventricular work. There were also significant increases in arterial stiffness in regard to the aorta and common carotid artery that were fully recovered by 30 and 60 minutes, respectively with no differences between men and women. Thus, the primary findings of this study suggest that measures of hemodynamics and pulse wave reflection are collectively altered for at least 60 minutes following HI-BRE, with women having attenuated responses compared to men

Public crises, public futures

This article begins to map out a novel approach to analyzing contemporary contexts of public crisis, relationships between them and possibilities that these scenes hold out for politics. The article illustrates and analyses a small selection of examples of these kinds of contemporary scenes and calls for greater attention to be given to the conditions and consequences of different forms and practices of public and political mediation. In offering a three-fold typology to delineate differences between ‘abject’, ‘audience’ and ‘agentic’ publics the article begins to draw out how political and public futures may be seen as being bound up with how the potentialities, capacities and qualities that publics are imagined to have and resourced to perform. Public action and future publics are therefore analysed here in relation to different versions of contemporary crisis and the political concerns and publics these crises work to articulate, foreground and imaginatively and practically support

Anti-Nirvana: crime, culture and instrumentalism in the age of insecurity

‘Anti-Nirvana’ explores the relationship between consumer culture, media and criminal motivations. It has appeared consistently on the list of the top-ten most-read articles in this award-winning international journal, and it mounts a serious neo-Freudian challenge to the predominant naturalistic notion of ‘resistance’ at the heart of liberal criminology and media studies. It is also cited in the Oxford Handbook of Criminology and other criminology texts as a persuasive argument in support of the theory that criminality amongst young people is strongly linked to the acquisitive values of consumerism and the images of possessive individualism that dominate mass media

An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor

Selective hits for the glutaredoxin ortholog of Brucella melitensis are determined using STD NMR and verified by trNOE and (15)N-HSQC titration. The most promising hit, RK207, was docked into the target molecule using a scoring function to compare simulated poses to experimental data. After elucidating possible poses, the hit was further optimized into the lead compound by extension with an electrophilic acrylamide warhead. We believe that focusing on selectivity in this early stage of drug discovery will limit cross-reactivity that might occur with the human ortholog as the lead compound is optimized. Kinetics studies revealed that lead compound 5 modified with an ester group results in higher reactivity than an acrylamide control; however, after modification this compound shows little selectivity for bacterial protein versus the human ortholog. In contrast, hydrolysis of compound 5 to the acid form results in a decrease in the activity of the compound. Together these results suggest that more optimization is warranted for this simple chemical scaffold, and opens the door for discovery of drugs targeted against glutaredoxin proteins-a heretofore untapped reservoir for antibiotic agents

The eventization of leisure and the strange death of alternative Leeds

The communicative potential of city spaces as leisure spaces is a central assumption of political activism and the creation of alternative, counter-cultural and subcultural scenes. However, such potential for city spaces is limited by the gentrification, privatization and eventization of city centres in the wake of wider societal and cultural struggles over leisure, work and identity formation. In this paper, we present research on alternative scenes in the city of Leeds to argue that the eventization of the city centre has led to a marginalization and of alternative scenes on the fringes of the city. Such marginalization has not caused the death of alternative Leeds or political activism associated with those scenes—but it has changed the leisure spaces (physical, political and social) in which alternative scenes contest the mainstream