Linking identity and heritage with image and a reputation for competition

Our study investigates the role of identity and heritage of a place in creating competitiveness of the place and its retailers by utilizing its image and reputation to improve its attraction to tourists. We explored the perceptions of tourists to test a conceptual model which was developed using concepts available in current academic literature. Data were collected relating to a famous retail store in London which is a popular destination. Findings from a survey of 294 store tourists visiting the store suggest that place heritage is the key to driver of competitiveness of both the retailer and place, through their image and reputation. The study has important implications for the expansion of current literature, theory development and business practices. Limitations of the study are outlined and directions for future research are considered

A self-sufficient approach for GERB cloudy radiance detection.

Geostationary Earth Radiation Budget (GERB) is the broadband radiometer onboard the Meteosat Second Generation (MSG) platform, launched at the end of August 2002 and still in commissioning phase. GERB data is planned to be used in many applications concerning Earth Radiation Budget (ERB) calculation. In order to evaluate the impact of clouds on ERB, a cloud detection is required and, at present, a cloud mask based on higher spatial and spectral resolution data acquired by Spinning Enhanced Visible and Infrared Imager (SEVIRI), the imager onboard the same MSG platform, is planned to be used in order to identify cloudy GERB soundings. As an alternative, a self-sufficient (only based on GERB data) method (OCA, the One-channel Cloudy-radiance-detection Approach) is proposed, as a time-saving and, probably, more suitable solution than the planned co-location approach. In this paper, preliminary results obtained by using several years of Meteosat data as well as GERB synthetic radiances (produced from Meteosat-7 observations) are presented. It is shown how results obtained by using GERB data alone can be comparable (and better in terms of number and spatial distribution of clear-sky GERB soundings identified) to the ones achieved if the co-location of a higher resolution cloud mask is use

The role of formyl peptide receptors in permanent and low-grade inflammation: Helicobacter pylori infection as a model

Formyl peptide receptors (FPRs) are cell surface pattern recognition receptors (PRRs), belonging to the chemoattractant G protein-coupled receptors (GPCRs) family. They play a key role in the innate immune system, regulating both the initiation and the resolution of the inflammatory response. FPRs were originally identified as receptors with high binding affinity for bacteria or mitochondria N-formylated peptides. However, they can also bind a variety of structurally different ligands. Among FPRs, formyl peptide receptor-like 1 (FPRL1) is the most versatile, recognizing N-formyl peptides, non-formylated peptides, and synthetic molecules. In addition, according to the ligand nature, FPRL1 can mediate either pro-or anti-inflammatory responses. Hp(2-20), a Helicobacter pylori-derived, non-formylated peptide, is a potent FPRL1 agonist, participating in Helicobacter pylori-induced gastric inflammation, thus contributing to the related site or not-site specific diseases. The aim of this review is to provide insights into the role of FPRs in H. pylori-associated chronic inflammation, which suggests this receptor as potential target to mitigate both microbial and sterile inflammatory diseases

The challenge of perioperative pain management in opioid-tolerant patients

The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals. Anesthesiologists, surgeons, and nurses should be familiar with some pharmacological phenomena which are typical of opioid users and abusers, such as tolerance, physical dependence, hyperalgesia, and addiction. Inadequate pain management is very common in these patients, due to common prejudices and fears. The target of preoperative evaluation is to identify comorbidities and risk factors and recognize signs and symptoms of opioid abuse and opioid withdrawal. Clinicians are encouraged to plan perioperative pain medications and to refer these patients to psychiatrists and addiction specialists for their evaluation. The aim of this review was to give practical suggestions for perioperative management of surgical opioid-tolerant patients, together with schemes of opioid conversion for chronic pain patients assuming oral or transdermal opioids, and patients under maintenance programs with methadone, buprenorphine, or naltrexone

Modelling the post-failure stage of rainfall-induced landslides of the flow type

The geomechanical modeling of failure and post failure stages of rainfall induced shallow landslides represents a fundamental issue to properly assess the failure conditions and recognize the potential for long travel distances of the failed soil masses

Consumer perceptions of Sustainable Development Goals: conceptualisation, measurement, and contingent effects

The COVID-19 pandemic has caused drastic disruptions to many multinational companies’ (MNCs’) supply chain management, pushing them to relocate their manufacturing activities to their home countries, a phenomenon known as reshoring. Grounded in moral psychology theory and the resource-based view, the aims of this research are to provide an extended conceptualisation of sustainable development goal (SDG) perceptions from local consumers, develop a scale, and assess this scale in relation to the reliability and validity of consumer perception of SDG antecedents and consequences in reshoring contexts from three industries, with the help of six studies. We conceptualise these perceptions on the basis of seven components (i.e. society/community wellbeing, affordable and clean energy consumption, economic growth, responsible consumption, responsible production, sustainable industrialisation and innovation, and gender equality). Using data from three distinct industries and a sample of 1075 reshoring MNC customers, we also determine how local consumers perceive and react to reshoring initiatives geared towards achieving SDGs and advocacy. The findings offer relevant implications for both the management and research of SDGs in a reshoring context at a scale level, which we describe in the form of future research directions

AB0844 HAND GRIP STRENGTH EVALUATION IN RHEUMATOLOGIC DISEASES

Background:Handgrip muscle strength test describes the strength of the hand muscles used to grasp or grip. Currently, hand grip evaluation is often used in clinical practice, as a marker of function and disability. In fact, it has already been applied as an outcome measure in arthritis rheumatoid clinical trials, to demonstrate the benefits of several treatments [1]. However, hand disability should also be considered in all other rheumatological diseases.Objectives:The main aim of this study is to assess the handgrip muscle strength test in a rheumatological cohort of patients as compared to a control group.Methods:This is a cross-sectional pilot study. We considered eligible 35 rheumatological consecutive female patients followed at our outpatients' clinic of Internal Medicine (I Policlinico of Naples) and 35 healthy control females (HC). Both groups included only right-handed individuals. Rheumatological patients were distributed as follows: 5 rheumatoid arthritis (14,3%), 9 psoriatic arthritis (25,7%), 4 systemic lupus erythematosus (11,4%), 10 systemic sclerosis (28,6%), 4 fibromyalgia (11,4%), 3 juvenile idiopathic arthritis (8,6%). The course of disease was under optimal treatment in all patients.The type of hand grip used is the power grip, in which an object is held firmly by wrapping the fingers around it, pressing the object against the palm, and using the thumb to apply counter-pressure. We considered as either right or left hand valid measure the mean of three consecutive tests per arm. Between-groups differences were tested both by a uni- and multivariable analysis.Results:The two subgroups were homogeneously distributed for age (median age 42 yrs. [IQR 33-48] vs. 36 yrs. [IQR 30-52] in HC; p=0.902). At univariate analysis, hand grip strength was significantly lower in the rheumatological patients, both at right hand (right 19.5 kg [IQR 13.6-24.8] vs. 24.5 kg [IQR 20.8-29] in HC; p=0.004) and left hand (18.5 kg [IQR 13.9-22.5] vs. 23.7 kg [IQR 19-27.3] in HC; p=0.002), as compared to HC. This finding was further confirmed at multivariable analysis only as for the left hand (OR 0.919, 95%CI: 0.858-0.984; p=0.016).Conclusion:Rheumatological diseases are burdened by hand disability, mostly affecting daily activities performance [2,3]. Beyond an optimal disease control, our pilot study shows a decrease in left hand strength as compared to healthy controls. This might be due to a reduced use of the non-dominant hand, which may lead over time to a higher deficit of strength. As such, these patients should be prescribed to a left hand exercise to improve both mobility and strength and, consequently, hand function.References:[1]Eberhardt K, Sandqvist G, Geborek P (2008) Hand function tests are important and sensitive tools for assessment of treatment response in patients with rheumatoid arthritis. Scand J Rheumatol 37(2):109–112.[2]Feced Olmos CM, Alvarez-Calderon O, Hervás Marín D, et al. Relationship between structural damage with loss of strength and functional disability in psoriatic arthritis patients. Clin Biomech (Bristol, Avon). 2019 Aug;68:169-174. doi: 10.1016/j.clinbiomech.2019.06.009.[3]Maddali-Bongi S, Del Rosso A, Mikhaylova S, et al. Impact of hand and face disabilities on global disability and quality of life in systemic sclerosis patients. Clin Exp Rheumatol. 2014 Nov-Dec;32(6 Suppl 86):S-15-20.Disclosure of Interests:None declare

New Biopsy Forceps for Gastrointestinal Endoscopy

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Assessment of water vapor content from MIVIS TIR data

The main objective of land remotely sensed images is to derive biological, chemical and physical parameters by inverting sample sets of spectral data. For the above aim hyperspectral scanners on airborne platform are a powerful remote sensing instrument for both research and environmental applications because of their spectral resolution and the high operability of the platform. Fine spectral information by MIVIS (airborne hyperspectral scanner operating in 102 channels ranging from VIS to TIR) allows researchers to characterize atmospheric parameters and their effects on measured data which produce undesirable features on surface spectral signatures. These effects can be estimated (and remotely sensed radiances corrected) if atmospheric spectral transmittance is known at each image pixel. Usually ground-based punctual observations (atmospheric sounding balloons, sun photometers, etc.) are used to estimate the main physical parameters (like water vapor and temperature profiles) which permit us to estimate atmospheric spectral transmittance by using suitable radiative transfer model and a specific (often too strong) assumption which enable atmospheric properties measured only in very few points to be extended to the whole image. Several atmospheric gases produce observable absorption features, but only water vapor strongly varies in time and space. In this work the authors customize a self-sufficient «split-window technique» to derive (at each image pixel) atmospheric total columnar water vapor content (TWVC) using only MIVIS data collected by the fourth MIVIS spectrometer (Thermal Infrared band). MIVIS radiances have been simulated by means of MODTRAN4 radiative transfer code and the coefficients of linear regression to estimate TWVC from «split-windows» MIVIS radiances, based on 450 atmospheric water vapor profiles obtained by radiosonde data provided by NOAA\NESDIS. The method has been applied to produce maps describing the spatial variability of the water vapor columnar content along a trial scene. The procedure has been validated by means of the MIVIS data acquired over Venice and the contemporary radiosonde data. A discrepancy within 5% has been measured between the estimate of TWVC derived from the proposed self-sufficient split-window technique and the coincident radiosonde measurements. If confirmed by further analyses such a result will permit us to fully exploit MIVIS TIR capability to offer a more effective (at image pixel level) and self-sufficient (no ancillary observations required) way to obtain atmospherically corrected MIVIS radiances