Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Objectives: Few studies have analyzed factors associated with delirium subtypes. In this study, we investigate factors associated with subtypes of delirium only in patients with dementia to provide insights on the possible prevention and treatments. Design: This is a cross-sectional study nested in the “Delirium Day” study, a nationwide Italian point-prevalence study. Setting and Participants: Older patients admitted to 205 acute and 92 rehabilitation hospital wards. Measures: Delirium was evaluated with the 4-AT and the motor subtypes with the Delirium Motor Subtype Scale. Dementia was defined by the presence of a documented diagnosis in the medical records and/or prescription of acetylcholinesterase inhibitors or memantine prior to admission. Results: Of the 1057 patients with dementia, 35% had delirium, with 25.6% hyperactive, 33.1% hypoactive, 34.5% mixed, and 6.7% nonmotor subtype. There were higher odds of having venous catheters in the hypoactive (OR 1.82, 95% CI 1.18-2.81) and mixed type of delirium (OR 2.23, CI 1.43-3.46), whereas higher odds of urinary catheters in the hypoactive (OR 2.91, CI 1.92-4.39), hyperactive (OR 1.99, CI 1.23-3.21), and mixed types of delirium (OR 2.05, CI 1.36-3.07). We found higher odds of antipsychotics both in the hyperactive (OR 2.87, CI 1.81-4.54) and mixed subtype (OR 1.84, CI 1.24-2.75), whereas higher odds of antibiotics was present only in the mixed subtype (OR 1.91, CI 1.26-2.87). Conclusions and Implications: In patients with dementia, the mixed delirium subtype is the most prevalent followed by the hypoactive, hyperactive, and nonmotor subtype. Motor subtypes of delirium may be triggered by clinical factors, including the use of venous and urinary catheters, and the use of antipsychotics. Future studies are necessary to provide further insights on the possible pathophysiology of delirium in patients with dementia and to address the optimization of the management of potential risk factors

Measurement of electroweak parameters from Z decays into Fermion pairs

We report on the properties of theZ resonance from 62 500Z decays into fermion pairs collected with the ALEPH detector at LEP, the Large Electron-Positron storage ring at CERN. We findM Z=(91.193±0.016exp±0.030LEP) GeV, Γ Z =(2497±31) MeV, σ had 0=(41.86±0.66)nb, and for the partial widths Γinv=(489±24) MeV, Γhad(1754±27) MeV, Γ ee =(85.0±1.6)MeV, Γ μμ =(80.0±2.5) MeV, and Γττ=(81.3±2.5) MeV, all in good agreement with the Standard Model. Assuming lepton universality and using a lepton sample without distinction of the final state we measure Γu=(84.3±1.3) MeV. The forward-backward asymmetry in leptonic decays is used to determine the vector and axial-vector weak coupling constants of leptors,g v 2(M Z 2)=(0.12±0.12)×10−2 andg A 2(M Z 2)=0.2528±0.0040. The number of light neutrino species isN ν=2.91±0.13; the electroweak mixing angle is sin2θW(M Z 2)=0.2291±0.0040

Improved measurements of electroweak parameters fromZ decays into fermion pairs

The properties of theZ resonance are measured on the basis of 190 000Z decays into fermion pairs collected with the ALEPH detector at LEP. Assuming lepton universality,Mz=(91.182±0.009exp±0.020L∶P) GeV,ГZ=(2484±17) MeV, σhad0=(41.44±0.36) nb, andГjad/Гℓℓ=21.00±0.20. The corresponding number of light neutrino species is 2.97±0.07. The forward-back-ward asymmetry in leptonic decays is used to determine the ratio of vector to axial-vector coupling constants of leptons:gv2(MZ2)/gA2(MZ2)=0.0072±0.0027. Combining these results with ALEPH results on quark charge andbb ¯ asymmetries, and τ polarization, sin2θW(MZ2). In the contex of the Minimal Standard Model, limits are placed on the top-quark mass

A precise determination of the number of families with light neutrinos and of the Z boson partial widths

More extensive and precise results are reported on the parameters of Z decay. On the basis of 20 000 Z decays collected with the ALEPH detector at LEP we find Mz=91.182±0.026 (exp.) ±0.030 (beam) GeV, Γz=2.541±0.056 GeV and σhad0=41.4±0.8 nb. The partial widths for the hadronic and leptonic channels are Γhad=1804±44 MeV, Γe+e−=82.1±3.4 MeV, Γμ+μ−=87.9±6.0 MeV and Γτ+τ−=86.1±5.6 MeV, in good agreement with the standard model. On the basis of the average leptonic width Γℓ+ℓ−=83.9±2.2 MeV, the effective weak mixing angle is found to be sin2θw(Mz)=0.231±0.008. Usin g the partial widths calculated in the standard model, the number of light neutrino families is Nν=3.01±0.15 (exp.)±0.05 (theor.)