The IMF as a function of supersonic turbulence

Recent studies seem to suggest that the stellar initial mass function (IMF) in early-type galaxies might be different from a classical Kroupa or Chabrier IMF, i.e. contain a larger fraction of the total mass in low-mass stars. From a theoretical point of view, supersonic turbulence has been the subject of interest in many analytical theories proposing a strong correlation with the characteristic mass of the core mass function (CMF) in star forming regions, and as a consequence with the stellar IMF. Performing two suites of smoothed particles hydrodynamics (SPH) simulations with different mass resolutions, we aim at testing the effects of variations in the turbulent properties of a dense, star forming molecular cloud on the shape of the system mass function in different density regimes. While analytical theories predict a shift of the peak of the CMF towards lower masses with increasing velocity dispersion of the cloud, we observe in the low-density regime the opposite trend, with high Mach numbers giving rise to a top-heavy mass distribution. For the high-density regime we do not find any trend correlating the Mach number with the characteristic mass of the resulting IMF, implying that the dynamics of protostellar accretion discs and fragmentation on small scales is not strongly affected by turbulence driven at the scale of the cloud. Furthermore, we suggest that a significant fraction of dense cores are disrupted by turbulence before stars can be formed in their interior through gravitational collapse. Although this particular study has limitations in its numerical resolution, we suggest that our results, along with those from other studies, cast doubt on the turbulent fragmentation models on the IMF that simply map the CMF to the IMF.Comment: 12 pages, 7 figures, accepted by MNRA

The Gaia-ESO Survey: evidence of atomic diffusion in M67?

Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate variations in the surface chemical composition of member stars of the old open cluster M67 as a possible consequence of atomic diffusion effects taking place during the main-sequence phase. The abundances used are obtained from high-resolution UVES/FLAMES spectra within the framework of the Gaia-ESO Survey. We find that the surface abundances of stars on the main sequence decrease with increasing mass reaching a minimum at the turn-off. After deepening of the convective envelope in subgiant branch stars, the initial surface abundances are restored. We found the measured abundances to be consistent with the predictions of stellar evolutionary models for a cluster with the age and metallicity of M67. Our findings indicate that atomic diffusion poses a non-negligible constraint on the achievable precision of chemical tagging methods

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

New massive members of Cygnus OB2

Context. The Cygnus complex is one of the most powerful star forming regions at a close distance from the Sun (~1.4 kpc). Its richest OB association Cygnus OB2 is known to harbor many tens of O-type stars and hundreds of B-type stars, providing a large homogeneous population of OB stars that can be analyzed. Many studies of its massive population have been developed in the last decades, although the total number of OB stars is still incomplete. Aim. Our aim is to increase the sample of O and B members of Cygnus OB2 and its surroundings by spectroscopically classifying 61 candidates as possible OB-type members of Cygnus OB2, using new intermediate resolution spectroscopy. Methods. We have obtained intermediate resolution (R ~ 5000) spectra for all of the OB-type candidates between 2013 and 2017. We thus performed a spectral classification of the sample using HeI-II and metal lines rates, as well as the Marxist Ghost Buster (MGB) software for O-type stars and the IACOB standards catalog for B-type stars. Results. From the whole sample of 61 candidates, we have classified 42 stars as new massive OB-type stars, earlier than B3, in Cygnus OB2 and surroundings, including 11 O-type stars. The other candidates are discarded as they display later spectral types inconsistent with membership in the association. We have also obtained visual extinctions for all the new confirmed massive OB members, placing them in a Hertzsprung-Russell Diagram using calibrations for Teff and luminosity. Finally, we have studied the age and extinction distribution of our sample within the region. Conclusions. We have obtained new blue intermediate-resolution spectra suitable for spectral classification of 61 OB candidates in Cygnus OB2 and surroundings. The confirmation of 42 new OB massive stars (earlier than B3) in the region allows us to increase the young massive population known in the field. We have also confirmed the correlation between age and Galactic longitude previously found in the region. We conclude that many O and early B stars at B > 16 mag are still undiscovered in Cygnus

PNPLA3 I148M polymorphism, etiology, and clinical features of hepatocellular carcinoma

Background & Aims : Recently, the Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 C>G single nucleotide polymorphism (SNP), encoding for the I148M protein variant, has been recognized as a genetic determinant of liver fat content and to influence severity of liver damage in patients with non-alcoholic and alcoholic fatty liver disease (NAFLD and ALD) and with chronic hepatitis C (CHC). Furthermore, homozygosity for the148M allele has been associated with hepatocellular carcinoma (HCC) in CHC. Aim of the study was to evaluate the prevalence of the PNPLA3 148M variant in Italian patients with HCC and the influence on the natural history liver cancer. Patients and Methods: We studied 265 consecutive patients (M/F 203/62, age 68\ub19 yrs) with HCC referred to tertiary care centres in Italy with available DNA samples. HCC arose during follow up in 207 and was incidental in the remaining 58, in 5 cases HCC occurred in non-cirrhotic liver, and was diagnosed according to EASL criteria. The rs738409 genotype was determined by a Taqman assay. Results: The frequency distribution of the rs738409 SNP was 113 p.148I/I (45%), 119 p.148I/M (47%), and 33 (13%) p.148G/G (p<0.0001 vs. healthy controls). The p.148G variant was significantly more over-represented in patients with metabolic/toxic liver disease (NAFLD, ALD, iron overload, n=42) than in those with chronic viral hepatitis (HBV and HCV, n=223): 24% I/I, 57% I/M, 19% M/M vs. 46% I/I, 43% I/M, 11% M/M, respectively; p=0.02. Length of follow-up before HCC development, age at diagnosis, sex distribution, smoking history, and diabetes prevalence were not significantly different among PNPLA3 genotypes. However, the size of the larger HCC lesion tended to increase, although nonsignificantly, with the number of 148M alleles in patients presenting with multifocal disease (n=28: 2.6\ub11 cm I/I, 2.8\ub11.5 I/M, 4.2\ub11.8 M/M; p=0.06). At cox regression analysis, 148M PNPLA3 alleles were associated with a non significantly higher hazard ratio of death (HR 1.39, 95% c.i 0.94-2.02) independently of age, sex, etiology of liver disease, and smoking status. Conclusions: These data are consistent with previous findings indicating that the 148M PNPLA3 allele is a risk factor for HCC, in particular in the presence of steatosis related to metabolic/toxic liver diseases. A possible association of PNPLA3 genotype with biological features and prognosis of HCC should be evaluated in future larger studie

Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease

Contains fulltext : 98343.pdf (publisher's version ) (Closed access)BACKGROUND AND AIMS: Increased ferritin and body iron stores are frequently observed in nonalcoholic fatty liver disease (NAFLD), associated with heightened susceptibility to vascular damage. Conflicting data have been reported on the role of iron in atherosclerosis, with recent data suggesting that excess iron induces vascular damage by increasing levels of the hormone hepcidin, which would determine iron trapping into macrophages, oxidative stress, and promotion of transformation into foam cells. Aim of this study was to investigate the relationship between iron status and cardiovascular damage in NAFLD. METHODS AND RESULTS: Vascular damage was evaluated by common carotid arteries intima-media thickness (CC-IMT) measurement and plaque detection by ecocolor-doppler ultrasonography in 506 patients with clinical and ultrasonographic diagnosis of NAFLD, hemochromatosis gene (HFE) mutations by restriction analysis in 342 patients. Serum hepcidin-25 was measured by time-of-flight mass spectrometry in 143 patients. At multivariate analysis CC-IMT was associated with systolic blood pressure, glucose, LDL cholesterol, abdominal circumference, age, and ferritin (p=0.048). Carotid plaques were independently associated with age, ferritin, glucose, and hypertension. Ferritin reflected iron stores and metabolic syndrome components, but not inflammation or liver damage. Hyperferritinemia was associated with increased vascular damage only in patients with HFE genotypes associated with hepcidin upregulation by iron stores (p<0.0001), and serum hepcidin-25 was independently associated with carotid plaques (p=0.05). CONCLUSION: Ferritin levels, reflecting iron stores, are independent predictors of vascular damage in NAFLD. The mechanism may involve upregulation of hepcidin by increased iron stores in patients not carrying HFE mutations, and iron compartmentalization into macrophages

Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease

Background and aims: Increased ferritin and body iron stores are frequently observed in nonalcoholic fatty liver disease (NAFLD), associated with heightened susceptibility to vascular damage. Conflicting data have been reported on the role of iron in atherosclerosis, with recent data suggesting that excess iron induces vascular damage by increasing levels of the hormone hepcidin, which would determine iron trapping into macrophages, oxidative stress, and promotion of transformation into foam cells. Aim of this study was to investigate the relationship between iron status and cardiovascular damage in NAFLD. Methods and results: Vascular damage was evaluated by common carotid arteries intima-media thickness (CC-IMT) measurement and plaque detection by ecocolor-doppler ultrasonography in 506 patients with clinical and ultrasonographic diagnosis of NAFLD, hemochromatosis gene (HFE) mutations by restriction analysis in 342 patients. Serum hepcidin-25 was measured by time-of-flight mass spectrometry in 143 patients. At multivariate analysis CC-IMT was associated with systolic blood pressure, glucose, LDL cholesterol, abdominal circumference, age, and ferritin (p = 0.048). Carotid plaques were independently associated with age, ferritin, glucose, and hypertension. Ferritin reflected iron stores and metabolic syndrome components, but not inflammation or liver damage. Hyperferritinemia was associated with increased vascular damage only in patients with HFE genotypes associated with hepcidin upregulation by iron stores (p&lt; 0.0001), and serum hepcidin-25 was independently associated with carotid plaques (p = 0.05). Conclusion: Ferritin levels, reflecting iron stores, are independent predictors of vascular damage in NAFLD. The mechanism may involve upregulation of hepcidin by increased iron stores in patients not carrying HFE mutations, and iron compartmentalization into macrophages. © 2010 Elsevier B.V

PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma

Background &amp; Aims:Aim of this study was to evaluate whether the PNPLA3 I148M polymorphism, previously associated with hepatocellular carcinoma (HCC) risk, influences the clinical presentation of HCC and survival.Methods:we considered 460 consecutive HCC patients referred to tertiary care centers in Northern Italy, 353 with follow-up data.Results:Homozygosity for PNPLA3 148M at risk allele was enriched in HCC patients with alcoholic liver disease or nonalcoholic fatty liver disease (ALD&amp;NAFLD: relative risk 5.9, 95% c.i. 3.5-9.9; other liver diseases: relative risk 1.9, 95% c.i. 1.1-3.4). In ALD&amp;NAFLD patients, the PNPLA3 148M allele was associated with younger age, shorter history of cirrhosis, less advanced (Child A) cirrhosis at HCC diagnosis, and lower HCC differentiation grade (p&lt;0.05). Homozygosity for PNPLA3 148M was associated with reduced survival in the overall series (p = 0.009), and with a higher number of HCC lesions at presentation (p = 0.007) and reduced survival in ALD&amp;NAFLD patients (p = 0.003; median survival 30, 95% c.i. 20-39 vs. 45, 95% c.i. 38-52 months), but not in those with HCC related to other etiologies (p = 0.86; 48, 95% c.i. 32-64 vs. 55, 95% c.i. 43-67 months). At multivariate Cox regression analysis, homozygosity for PNPLA3 148M was the only negative predictor of survival in ALD&amp;NAFLD patients (HR of death 1.57, 95% c.i. 1.12-2.78).Conclusions:PNPLA3 148M is over-represented in ALD&amp;NAFLD HCC patients, and is associated with occurrence at a less advanced stage of liver disease in ALD&amp;NAFLD. In ALD&amp;NAFLD, PNPLA3 148M is associated with more diffuse HCC at presentation, and with reduced survival. © 2013 Valenti et al

New massive members of Cygnus OB2

The Cygnus complex is one of the most powerful star forming regions at a close distance from the Sun (~1.4 kpc). Its richest OB association Cygnus OB2 is known to harbor many tens of O-type stars and hundreds of B-type stars, providing a large homogeneous population of OB stars that can be analyzed. Many studies of its massive population have been developed in the last decades, although the total number of OB stars is still incomplete. Our aim is to increase the sample of O and B members of Cygnus OB2 and its surroundings by spectroscopically classifying 61 candidates as possible OB-type members of Cygnus OB2. We have obtained new blue intermediate-resolution spectra suitable for spectral classification of the 61 candidates in Cygnus OB2 and surroundings. We thus performed a spectral classification of the sample using He I-II and metal lines rates, as well as the Marxist Ghost Buster (MGB) software for O-type stars and the IACOB standards catalog for B-type stars. Out of the 61 candidates, we have classified 42 stars as new massive OB-type stars, earlier than B3, in Cygnus OB2 and surroundings, including 11 O-type stars. The other candidates are discarded as they display later spectral types inconsistent with membership in the association. However, the magnitude cutoff and dust extinction introduce an incompleteness. Many O and early B stars at B > 16 mag are still undiscovered in the region. Finally, we have studied the age and extinction distribution of our sample within the region, placing them in the Hertzsprung-Russell Diagram using different stellar models in order to assess age uncertainties. Massive star formation in Cygnus OB2 seems to have proceeded from lower to higher Galactic longitudes, regardless of the details of the models used. The correlation between age and Galactic longitude previously found in the region is now confirmed.Comment: 20 pages, 12 figures, accepted for publication in Astronomy & Astrophysic