359 research outputs found
Corticosterone and foraging behaviour in a pelagic seabird
Because endocrine mechanisms are thought to mediate behavioral responses to changes in the environment, examining these mechanisms is essential for understanding how long-lived seabirds adjust their foraging decisions to contrasting environmental conditions in order to maximize their fitness. In this context, the hormone corticosterone (CORT) deserves specific attention because of its major connections with locomotor activities. We examined for the first time the relationships between individual CORT levels and measurements of foraging success and behavior using satellite tracking and blood sampling from wandering albatrosses (Diomedea exulans) before (pretrip CORT levels) and after (posttrip CORT levels) foraging trips during the incubation period. Plasma CORT levels decreased after a foraging trip, and the level of posttrip CORT was negatively correlated with individual foraging success, calculated as total mass gain over a foraging trip. Pretrip CORT levels were not linked to time spent at sea but were positively correlated with daily distance traveled and maximum range at sea. In this study, we were able to highlight the sensitivity of CORT levels to variation in energy intake, and we showed for the first time that individual CORT levels can be explained by variation in foraging success. Relationships between pretrip CORT levels and daily distance traveled and maximum range were independent of pretrip body mass, suggesting that slight elevations in pretrip CORT levels might facilitate locomotor activity. However, because both foraging behavior and pretrip CORT levels could be affected by individual quality, future experimental studies including manipulation of CORT levels are needed to test whether CORT can mediate foraging decisions according to foraging conditions
Direct Inversion Method of Fault Slip Analysis to Determine the Orientation of Principal Stresses and Relative Chronology for Tectonic Events in Southwestern White Mountain Region of New Hampshire, USA
The orientation and relative magnitudes of paleo tectonic stresses in the western central region of the White Mountains of New Hampshire is reconstructed using the direct inversion method of fault slip analysis on 1â10-m long fractures exposed on a series of road cuts along Interstate 93, just east of the Hubbard Brook Experimental Forest in North Woodstock, NH, USA. The inversion yields nine stress regimes which identify five tectonic events that impacted the White Mountain region over the last 410 Ma. The inversion method has potential application in basin analysi
Interprétation des images spatiales du secteur de Santa Rosalia (Basse Californie, Mexique) et le problÚme de l'ouverture du Golfe de Californie
Fault tectonics of the Baja California peninsula and the opening of the sea of Cortez, Mexico
Graph-Based Approach for Spatial Heterogeneity Analysis in Tumor Microenvironment
Introduction/ Background
The interaction between tumor and surrounding microenvironment (TME) is recognized as playing
an important role in the progression of the disease. Understanding of the interaction between tumor and
immune system is the focus of several studies dedicated to the improvement of cancer immunotherapy
effectiveness [1]. On the other hand, it has been shown that invasion and metastasis of breast tumors is influenced by collagen organization at the tumor-stromal interface [2]. The characterization of such interactions relies on an efficient spatial distribution quantification of TME. Graph-based analysis tools are the best suitable to answer this question as they have the ability to represent spatial arrangements and neighborhood relationships of different tissue components [3].
Aims
In this work, we propose a novel approach to characterize the spatial relationships between cancer cells and TME components in breast tumors, using graph theory and sparse setsâ mathematical morphology (MM). The tools of morphology on graphs were first used in [4] to study the neighborhood relationships between cells in germinal centers from lymph nodes, then in [5] for semantic spatial configuration modeling in histopathology. In our study, we propose new morphological descriptors characterizing the tumor architecture and the interactions with TME cells.
Methods
Towards a better evaluation and understanding, we use simulated data of different breast tumor types , , where locations of cancer nuclei (CN), fibroblasts (synthesizers of collagen, FN), and lymphocytes (LN) are already known. In order to set neighborhood relationships between different cells, Delaunay graph [3] is first reconstructed on all cells, and alpha-shape filter [5] is applied to circumvent border effects, giving new graph denoted G . The designed features are extracted basically from two different morphological operations. The first operation is composed of successive morphological erosions [4] applied to the subgraph induced by CN (denoted SGC, ), repeated until the subgraph is null. The curve given by the number of CN in terms of erosions provides 3 significant characteristics : I) The origin slope describes the number of CN on the boundary of tumor aggregates (TA) and, thus, the tumor-stromal interface ; II) The area under curve (AUC) reflects the density within TAs, and III) the number of iterations outlines the morphologic radius of the largest TA and, consequently, the geodesic distance of the farthest tumor cell from LN and/or FN. The second morphological operation is composed of successive morphological dilations applied to SGC with non-overlapping control of labeled connected-components . The goal behind this operation is to investigate the TME cells surrounding each TA. The ratio between the number of LN and the number of CN, and the means of the Euclidean and the geodesic distances of LN from CN on the boundary are calculated for each TA .
Results
In this work, we have briefly presented a conceptual framework for analyzing the architecture of breast
tumors and the interactions with the surrounding microenvironment. New graph-based features were
proposed to characterize the spatial distribution of TME components and were tested on simulated data. In our future works, we will include adipose tissue [6], blood vessels and endothelial cells. We will also focus on the anisotropic characterization of collagen, and test the approach on real dataset
Tectonic significance of magnetic susceptibility fabrics in Plio-Quaternary mudstones of southwestern foothills, Taiwan
Structural inheritance and cenozoic stress fields in the Jura fold-and-thrust belt (France)
Multiple expressions of plume-ridge interaction in the Galapagos : volcanic lineaments and ridge jumps
Author Posting. © American Geophysical Union, 2012. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 13 (2012): Q05018, doi:10.1029/2012GC004093.Anomalous volcanism and tectonics between near-ridge mantle plumes and mid-ocean ridges provide important insights into the mechanics of plume-lithosphere interaction. We present new observations and analysis of multibeam, side scan sonar, sub-bottom chirp, and total magnetic field data collected during the R/V Melville FLAMINGO cruise (MV1007; MayâJune, 2010) to the Northern GalĂĄpagos Volcanic Province (NGVP), the region between the GalĂĄpagos Archipelago and the GalĂĄpagos Spreading Center (GSC) on the Nazca Plate, and to the region east of the GalĂĄpagos Transform Fault (GTF) on the Cocos Plate. The NGVP exhibits pervasive off-axis volcanism related to the nearby GalĂĄpagos hot spot, which has dominated the tectonic evolution of the region. Observations indicate that ~94% of the excess volcanism in our survey area occurs on the Nazca Plate in three volcanic lineaments. Identified faults in the NGVP are consistent with normal ridge spreading except for those within a ~60 km wide swath of transform-oblique faults centered on the GTF. These transform-oblique faults are sub-parallel to the elongation direction of larger lineament volcanoes, suggesting that lineament formation is influenced by the lithospheric stress field. We evaluate current models for lineament formation using existing and new observations as well as numerical models of mantle upwelling and melting. The data support a model where the lithospheric stress field controls the location of volcanism along the lineaments while several processes likely supply melt to these eruptions. Synthetic magnetic models and an inversion for crustal magnetization are used to determine the tectonic history of the study area. Results are consistent with creation of the GTF by two southward ridge jumps, part of a series of jumps that have maintained a plume-ridge separation distance of 145 km to 215 km since ~5 Ma.This work was
supported by NSF grant OCE-0926637 and OCE-1030904 to
DF and KH. DGâs work was supported by NSF grants EAR-
0838461 and EAR-1145271. Additional support was provided
to E.M. by the Deep Ocean Exploration Institute at the Woods
Hole Oceanographic Institution.2012-11-3
Expected temporal absolute gravity change across the Taiwanese Orogen, a modeling approach
- âŠ